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  1. Article ; Online: Anti-LGI1 Encephalitis Presented With Prominent Psychosis Without Loss of Consciousness.

    Cho, Ja Hyeon / Kim, Sun Jung / Park, Kyung Won

    Dementia and neurocognitive disorders

    2023  Volume 22, Issue 2, Page(s) 78–80

    Language English
    Publishing date 2023-04-27
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3015713-4
    ISSN 2384-0757 ; 1738-1495
    ISSN (online) 2384-0757
    ISSN 1738-1495
    DOI 10.12779/dnd.2023.22.2.78
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  2. Article ; Online: Quantitative comparative analysis of amyloid PET images using three radiopharmaceuticals.

    Jeong, Young Jin / Yoon, Hyun Jin / Kang, Do-Young / Park, Kyung Won

    Annals of nuclear medicine

    2023  Volume 37, Issue 5, Page(s) 271–279

    Abstract: Objective: Amyloid positron emission tomography (PET) with F-18 florbetaben (FBB), F-18 flutemetamol (FMM), and F-18 florapronol (FPN) is being used clinically for the evaluation of dementia. These radiopharmaceuticals are commonly used to evaluate the ... ...

    Abstract Objective: Amyloid positron emission tomography (PET) with F-18 florbetaben (FBB), F-18 flutemetamol (FMM), and F-18 florapronol (FPN) is being used clinically for the evaluation of dementia. These radiopharmaceuticals are commonly used to evaluate the accumulation of beta-amyloid plaques in the brain, but there are structural differences between them. We investigated whether there are any differences in the imaging characteristics.
    Methods: A total of 605 subjects were enrolled retrospectively in this study, including healthy subjects (HS) and patients with mild cognitive impairment or Alzheimer's disease. Participants underwent amyloid PET imaging using one of the three radiopharmaceuticals. The PET images were analyzed visually and semi-quantitatively using a standardized uptake value ratio (SUVR). In addition, we calculated and compared the cut-off SUVR of the representative regions for each radiopharmaceutical that can distinguish between positive and negative scans.
    Results: In the negative images of the HS group, the contrast between the white matter and the gray matter was high in the FMM PET images, while striatal uptake was relatively higher in the FPN PET images. The SUVR showed significant differences across the radiopharmaceuticals in all areas except the temporal lobe, but the range of differences was relatively small. Accuracy levels for the global cut-off SUVR to discriminate between positive and negative images were highest in FMM PET, with a value of 0.989. FBB PET also showed a high value of 0.978, while FPN PET showed a relatively low value of 0.901.
    Conclusions: Negative amyloid PET images using the three radiopharmaceuticals showed visually and quantitatively similar imaging characteristics except in the striatum. Binary classification using the cut-off of the global cortex showed high accuracy overall, although there were some differences between the three PET images.
    MeSH term(s) Humans ; Radiopharmaceuticals ; Retrospective Studies ; Positron-Emission Tomography/methods ; Alzheimer Disease/diagnostic imaging ; Amyloid/metabolism ; Brain/diagnostic imaging ; Brain/metabolism ; Amyloid beta-Peptides/metabolism ; Aniline Compounds
    Chemical Substances Radiopharmaceuticals ; Amyloid ; flutemetamol (0F3M7032P5) ; Amyloid beta-Peptides ; Aniline Compounds
    Language English
    Publishing date 2023-02-07
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1146984-5
    ISSN 1864-6433 ; 0914-7187
    ISSN (online) 1864-6433
    ISSN 0914-7187
    DOI 10.1007/s12149-023-01824-1
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3657: Show issues Location:
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  3. Article: Extensive accumulation of misfolded protein aggregates during natural aging and senescence.

    Cuanalo-Contreras, Karina / Schulz, Jonathan / Mukherjee, Abhisek / Park, Kyung-Won / Armijo, Enrique / Soto, Claudio

    Frontiers in aging neuroscience

    2023  Volume 14, Page(s) 1090109

    Abstract: Accumulation of misfolded protein aggregates is a hallmark event in many age-related protein misfolding disorders, including some of the most prevalent and insidious neurodegenerative diseases. Misfolded protein aggregates produce progressive cell damage, ...

    Abstract Accumulation of misfolded protein aggregates is a hallmark event in many age-related protein misfolding disorders, including some of the most prevalent and insidious neurodegenerative diseases. Misfolded protein aggregates produce progressive cell damage, organ dysfunction, and clinical changes, which are common also in natural aging. Thus, we hypothesized that aging is associated to the widespread and progressive misfolding and aggregation of many proteins in various tissues. In this study, we analyzed whether proteins misfold, aggregate, and accumulate during normal aging in three different biological systems, namely senescent cells,
    Language English
    Publishing date 2023-01-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2022.1090109
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  4. Article ; Online: Correction: Temporal and spatially controlled APP transgene expression using Cre-dependent alleles.

    Koller, Emily J / Comstock, Melissa / Bean, Jonathan C / Escobedo, Gabriel / Park, Kyung-Won / Jankowsky, Joanna L

    Disease models & mechanisms

    2023  Volume 16, Issue 3

    Language English
    Publishing date 2023-03-08
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.050136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Generation of a Dcx-CreER

    Perez, Gabriella A / Park, Kyung-Won / Lanza, Denise / Cicardo, Jenna / Uddin, M Danish / Jankowsky, Joanna L

    Genesis (New York, N.Y. : 2000)

    2023  Volume 62, Issue 1, Page(s) e23584

    Abstract: A wide variety of ... ...

    Abstract A wide variety of CreER
    MeSH term(s) Mice ; Animals ; Mice, Transgenic ; Neurons/metabolism ; Neural Stem Cells/metabolism ; Neurogenesis/genetics ; Brain
    Language English
    Publishing date 2023-12-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2004544-X
    ISSN 1526-968X ; 1526-954X
    ISSN (online) 1526-968X
    ISSN 1526-954X
    DOI 10.1002/dvg.23584
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2772: Show issues Location:
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  6. Article ; Online: Antioxidant Activity of Hydrogen Water Mask Pack Composed of Gel-Type Emulsion and Hydrogen Generation Powder.

    Kwon, Hye-Jin / Han, Sang-Beom / Park, Kyung-Won

    International journal of molecular sciences

    2020  Volume 21, Issue 24

    Abstract: In this study, hydrogen generation powder samples were prepared using zinc carbonate as a precursor, at a temperature varying from 400 to 700 °C in ... ...

    Abstract In this study, hydrogen generation powder samples were prepared using zinc carbonate as a precursor, at a temperature varying from 400 to 700 °C in H
    MeSH term(s) Antioxidants/chemistry ; Antioxidants/pharmacology ; Carbonates/chemistry ; Emulsions/chemistry ; Emulsions/pharmacology ; Humans ; Hydrogen/chemistry ; Hydroxyl Radical/chemistry ; Iron/chemistry ; Powders/chemistry ; Powders/pharmacology ; Skin/drug effects ; Skin/pathology ; Skin Aging/drug effects ; Temperature ; Water/chemistry ; Zinc Compounds/chemistry
    Chemical Substances Antioxidants ; Carbonates ; Emulsions ; Powders ; Zinc Compounds ; Water (059QF0KO0R) ; Hydroxyl Radical (3352-57-6) ; Hydrogen (7YNJ3PO35Z) ; Iron (E1UOL152H7) ; zinc carbonate (EQR32Y7H0M)
    Language English
    Publishing date 2020-12-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21249731
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  7. Article ; Online: Temporal and spatially controlled APP transgene expression using Cre-dependent alleles.

    Koller, Emily J / Comstock, Melissa / Bean, Jonathan C / Escobedo, Gabriel / Park, Kyung-Won / Jankowsky, Joanna L

    Disease models & mechanisms

    2022  Volume 15, Issue 5

    Abstract: Although a large number of mouse models have been made to study Alzheimer's disease, only a handful allow experimental control over the location or timing of the protein being used to drive pathology. Other fields have used the Cre and the tamoxifen- ... ...

    Abstract Although a large number of mouse models have been made to study Alzheimer's disease, only a handful allow experimental control over the location or timing of the protein being used to drive pathology. Other fields have used the Cre and the tamoxifen-inducible CreER driver lines to achieve precise spatial and temporal control over gene deletion and transgene expression, yet these tools have not been widely used in studies of neurodegeneration. Here, we describe two strategies for harnessing the wide range of Cre and CreER driver lines to control expression of disease-associated amyloid precursor protein (APP) in modeling Alzheimer's amyloid pathology. We show that CreER-based spatial and temporal control over APP expression can be achieved with existing lines by combining a Cre driver with a tetracycline-transactivator (tTA)-dependent APP responder using a Cre-to-tTA converter line. We then describe a new mouse line that places APP expression under direct control of Cre recombinase using an intervening lox-stop-lox cassette. Mating this allele with a CreER driver allows both spatial and temporal control over APP expression, and with it, amyloid onset. This article has an associated First Person interview with the first author of the paper.
    MeSH term(s) Alleles ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Humans ; Integrases/metabolism ; Mice ; Mice, Transgenic ; Tetracycline/pharmacology ; Transgenes
    Chemical Substances Amyloid beta-Protein Precursor ; Cre recombinase (EC 2.7.7.-) ; Integrases (EC 2.7.7.-) ; Tetracycline (F8VB5M810T)
    Language English
    Publishing date 2022-05-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.049330
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  8. Article ; Online: Clinical Characteristics and Follow-up Assessment in Patients Diagnosed With Alzheimer's Dementia Through Regional Dementia Centers and Conventional Hospital System.

    Jeong, Eunhwan / Park, Dougho / Lee, Su Yun / Kim, Haejong / Kwon, Heum Dai / Kim, Mun-Chul / Park, Kyung Won

    Journal of Korean medical science

    2023  Volume 38, Issue 33, Page(s) e257

    Abstract: Background: The rapidly increasing socioeconomic strain caused by dementia represents a significant public health concern. Regional dementia centers (RDCs) have been established nationwide, and they aim to provide timely screening and diagnosis of ... ...

    Abstract Background: The rapidly increasing socioeconomic strain caused by dementia represents a significant public health concern. Regional dementia centers (RDCs) have been established nationwide, and they aim to provide timely screening and diagnosis of dementia. This study investigated the clinical characteristics and progression of patients diagnosed with Alzheimer's dementia (AD), who underwent treatment in RDCs or conventional community-based hospital systems.
    Methods: This retrospective single-center cohort study included patients who were diagnosed with AD between January 2019 and March 2022. This study compared two groups of patients: the hospital group, consisting of patients who presented directly to the hospital, and the RDC group, those who were referred to the hospital from the RDCs in Pohang city. The clinical courses of the patients were monitored for a year after AD diagnosis.
    Results: A total of 1,209 participants were assigned to the hospital (n = 579) or RDC group (n = 630). The RDC group had a mean age of 80.1 years ± 6.6 years, which was significantly higher than that of the hospital group (
    Conclusion: Patients in the RDC group were older, had more advanced stages of conditions, and exhibited a more rapid rate of cognitive decline than patients diagnosed through the conventional hospital system. Our results suggested that RDC contributed to the screening of AD in a local region, and further nationwide study with the RDC database of various areas of Korea is needed.
    MeSH term(s) Female ; Humans ; Aged, 80 and over ; Alzheimer Disease/diagnosis ; Cohort Studies ; Follow-Up Studies ; Retrospective Studies ; Hospitals
    Language English
    Publishing date 2023-08-21
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 639262-3
    ISSN 1598-6357 ; 1011-8934
    ISSN (online) 1598-6357
    ISSN 1011-8934
    DOI 10.3346/jkms.2023.38.e257
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3163: Show issues Location:
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  9. Article ; Online: Effect of Dietary Habits on Alzheimer's Disease Progression.

    Ahn, So Hyun / Jeong, Jee Hyang / Park, Kyung Won / Kim, Eun-Joo / Yoon, Soo Jin / Yoon, Bora / Jang, Jae-Won / Minn, Yangki / Choi, Seong Hye

    Yonsei medical journal

    2024  Volume 65, Issue 4, Page(s) 217–226

    Abstract: Purpose: Research on the relationship between diet and dementia among Koreans are lacking. This study investigated the association between dietary habits and dementia progression over 3 years in patients with Alzheimer's disease dementia (ADD).: ... ...

    Abstract Purpose: Research on the relationship between diet and dementia among Koreans are lacking. This study investigated the association between dietary habits and dementia progression over 3 years in patients with Alzheimer's disease dementia (ADD).
    Materials and methods: This study included 705 patients with mild-to-moderate ADD. Dietary habits were assessed using the Mini Dietary Assessment Index, comprising 10 questions. Outcome measures included the Clinical Dementia Rating scale-Sum of Boxes (CDR-SB), Seoul-Instrumental Activities of Daily Living, Caregiver-Administered Neuropsychiatric Inventory (CGA-NPI), and neuropsychological test battery (NTB) z-scores, which were evaluated annually over 3 years.
    Results: In Q10 (eat all food evenly without being picky), the 3-year mean differences in CDR-SB (increases in scores represent worsening) compared to the "rarely" group were -1.86 [95% confidence interval (CI)=-3.64 - -0.09,
    Conclusion: Eating a balanced diet and reducing salt intake were associated with a slower decline in dementia severity, cognition, and behavioral alterations in patients with ADD.
    MeSH term(s) Humans ; Alzheimer Disease ; Activities of Daily Living ; Neuropsychological Tests ; Cognition ; Feeding Behavior ; Disease Progression
    Language English
    Publishing date 2024-03-07
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 303740-x
    ISSN 1976-2437 ; 0513-5796
    ISSN (online) 1976-2437
    ISSN 0513-5796
    DOI 10.3349/ymj.2023.0119
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    Zs.B 944: Show issues Location:
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  10. Article ; Online: Subsequent correlated changes in complement component 3 and amyloid beta oligomers in the blood of patients with Alzheimer's disease.

    Shim, Kyu Hwan / Kim, Danyeong / Kang, Min Ju / Pyun, Jung-Min / Park, Young Ho / Youn, Young Chul / Park, Kyung Won / Suk, Kyoungho / Lee, Ho-Won / Gomes, Bárbara Fernandes / Zetterberg, Henrik / An, Seong Soo A / Kim, SangYun

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    2024  Volume 20, Issue 4, Page(s) 2731–2741

    Abstract: Introduction: Alzheimer's disease (AD) involves the complement cascade, with complement component 3 (C3) playing a key role. However, the relationship between C3 and amyloid beta (Aβ) in blood is limited.: Methods: Plasma C3 and Aβ oligomerization ... ...

    Abstract Introduction: Alzheimer's disease (AD) involves the complement cascade, with complement component 3 (C3) playing a key role. However, the relationship between C3 and amyloid beta (Aβ) in blood is limited.
    Methods: Plasma C3 and Aβ oligomerization tendency (AβOt) were measured in 35 AD patients and 62 healthy controls. Correlations with cerebrospinal fluid (CSF) biomarkers, cognitive impairment, and amyloid positron emission tomography (PET) were analyzed. Differences between biomarkers were compared in groups classified by concordances of biomarkers.
    Results: Plasma C3 and AβOt were elevated in AD patients and in CSF or amyloid PET-positive groups. Weak positive correlation was found between C3 and AβOt, while both had strong negative correlations with CSF Aβ
    Discussion: Increased plasma C3 in AD are associated with amyloid pathology, possibly reflecting a defense response for Aβ clearance. Further studies on Aβ-binding proteins will enhance understanding of Aβ mechanisms in blood.
    MeSH term(s) Humans ; Alzheimer Disease/cerebrospinal fluid ; Amyloid ; Amyloid beta-Peptides/cerebrospinal fluid ; Biomarkers/cerebrospinal fluid ; Complement C3 ; Peptide Fragments/cerebrospinal fluid ; Positron-Emission Tomography/methods ; tau Proteins/cerebrospinal fluid
    Chemical Substances Amyloid ; Amyloid beta-Peptides ; Biomarkers ; Complement C3 ; Peptide Fragments ; tau Proteins ; APP protein, human ; C3 protein, human
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2211627-8
    ISSN 1552-5279 ; 1552-5260
    ISSN (online) 1552-5279
    ISSN 1552-5260
    DOI 10.1002/alz.13734
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    Zs.MO 540: Show issues

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