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Article ; Online: Simultaneous Uptake of 18 F-NaF and 18 F-FDG by Bladder and Prostate Calculi.

Park, Mia Mijung / Park, Peter Sang Uk / Werner, Thomas J / Høilund-Carlsen, Poul F / Alavi, Abass

2023 Volume 48, Issue 12, Page(s) 1105–1106

Abstract: Abstract: Calcification and formation of calculi in the genitourinary system such as the bladder, kidney, and prostate are common processes of aging. Despite being in different parts of the body, these calculi can share risk factors; for instance, ... ...

Abstract	Abstract: Calcification and formation of calculi in the genitourinary system such as the bladder, kidney, and prostate are common processes of aging. Despite being in different parts of the body, these calculi can share risk factors; for instance, bladder and prostate calculi are seen in older men with benign prostatic hyperplasia. There have been increasing reports of detection of calculi using PET tracers such as 18 F-NaF and 18 F-FDG, suggesting their role for detection of extraosseous calcification. In this report, we present simultaneous detection of bladder and prostate calculi with both 18 F-NaF and 18 F-FDG avidity in a 74-year-old man with multiple myeloma.
MeSH term(s)	Male ; Humans ; Aged ; Fluorodeoxyglucose F18 ; Urinary Bladder ; Positron-Emission Tomography ; Prostate ; Prostatic Diseases ; Calcinosis ; Calculi ; Sodium Fluoride
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Sodium Fluoride (8ZYQ1474W7)
Language	English
Publishing date	2023-10-23
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000004917
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Article: Pollen carryover, pollinator movement, and spatial context impact the delivery of pollination services in apple orchards.

Hung, Keng-Lou James / Fan, Sophia L / Strang, Caroline G / Park, Mia G / Thomson, James D

Ecological applications : a publication of the Ecological Society of America

2023 Volume 33, Issue 8, Page(s) e2917

Abstract: Assessing the relative contributions of different pollinator taxa to pollination services is a central task in both basic eco-evolutionary research and applied conservation and agriculture. To that end, many studies have quantified single-visit pollen ... ...

Abstract	Assessing the relative contributions of different pollinator taxa to pollination services is a central task in both basic eco-evolutionary research and applied conservation and agriculture. To that end, many studies have quantified single-visit pollen deposition and visitation frequency, which together determine a pollinator species' rate of conspecific pollen delivery. However, for plant species that require or benefit from outcrossing, pollination service quality further depends upon the ratio of outcross to self-pollen deposited, which is determined by two additional pollinator traits: pollen carryover and movement patterns among genetically compatible plant individuals. Here, we compare the pollination capacities of managed honey bees, native bumble bees, and native mining bees in apple-a varietally self-incompatible commercial crop-when pollen carryover and pollinator movement patterns are considered. We constructed simulation models of outcross pollen deposition parameterized using empirically measured single-visit pollen deposition, visitation frequency, and probabilities of intertree movement exhibited by each pollinator type, as well as pollen carryover patterns simulated based on parameters reported in the literature. In these models, we also explicitly specified the spatial relationships among cross-compatible trees based on field-realistic orchard layout schemes. We found that estimated pollination service delivery was considerably reduced for all pollinator types when pollen carryover and pollinator movement patterns were considered, as compared to when only single-visit pollen deposition and visitation frequency were considered. We also found that the performance of different pollinator types varied greatly across simulated orchard layout schemes and pollen carryover scenarios, including one instance where bumble and mining bees reversed their relative rankings. In all simulations, native bumble and mining bees outperformed managed honey bees in terms of both outcross pollen delivery per unit time and per flower visited, with disparities being greatest under scenarios of low pollen carryover. We demonstrate the degree to which pollination studies may reach inaccurate conclusions regarding pollination service delivery when pollen carryover and pollinator movement patterns are ignored. Our finding of the strong context dependence of pollination efficiency, even within a single plant-pollinator taxon pair, cautions that future studies in both basic and applied pollination biology should explicitly consider the ecological context in which pollination interactions take place.
MeSH term(s)	Humans ; Bees ; Animals ; Pollination ; Malus ; Pollen ; Plants ; Flowers
Language	English
Publishing date	2023-09-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1074505-1
ISSN	1939-5582 ; 1051-0761
ISSN (online)	1939-5582
ISSN	1051-0761
DOI	10.1002/eap.2917
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Article: Novel technique of detecting inflammatory and osseous changes in the glenohumeral joint associated with patient age and weight using FDG- and NaF-PET imaging.

Park, Peter Sang Uk / Jia, Lori / Raynor, William Y / Gandhi, Om H / Park, Mia Mijung / Werner, Thomas J / Høilund-Carlsen, Poul Flemming / Alavi, Abass

American journal of nuclear medicine and molecular imaging

2023 Volume 13, Issue 4, Page(s) 136–146

Abstract: Objective: The glenohumeral (GH) joint is a classic ball-and-socket joint of the shoulder subject to various pathologies including osteoarthritis (OA). Degenerative changes of the OA evident on traditional imaging are proceeded by molecular changes, ... ...

Abstract	Objective: The glenohumeral (GH) joint is a classic ball-and-socket joint of the shoulder subject to various pathologies including osteoarthritis (OA). Degenerative changes of the OA evident on traditional imaging are proceeded by molecular changes, which if detected early could enhance disease prevention and treatment. In this study, we use Methods: FDG and NaF-PET/CT scans of 41 females (mean age of 43.9 ± 14.2 years) and 45 males (mean age of 44.5 ± 13.8 years) were analyzed with a semi-quantitative technique based on predefined region of interest. Results: There was greater FDG uptake in the left side of the GH joint compared to the right in both females (left: 0.79 ± 0.17, right: 0.71 ± 0.2; Conclusion: Our study demonstrates the varying effect of limb laterality and BMI on FDG and NaF uptake at the GH joint. Adoption of molecular imaging will require future studies that correlate tracer uptake with relevant medical and illness history as well as degenerative change evident on traditional imaging.
Language	English
Publishing date	2023-08-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2623515-8
ISSN	2160-8407
ISSN	2160-8407
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Endometriosis-Related Chronic Pelvic Pain.

Song, Soo Youn / Jung, Ye Won / Shin, WonKyo / Park, Mia / Lee, Geon Woo / Jeong, Soohwa / An, Sukjeong / Kim, Kyoungmin / Ko, Young Bok / Lee, Ki Hwan / Kang, Byung Hun / Lee, Mina / Yoo, Heon Jong

Biomedicines

2023 Volume 11, Issue 10

Abstract: Endometriosis, which is the presence of endometrial stroma and glands outside the uterus, is one of the most frequently diagnosed gynecologic diseases in reproductive women. Patients with endometriosis suffer from various pain symptoms such as ... ...

Abstract	Endometriosis, which is the presence of endometrial stroma and glands outside the uterus, is one of the most frequently diagnosed gynecologic diseases in reproductive women. Patients with endometriosis suffer from various pain symptoms such as dysmenorrhea, dyspareunia, and chronic pelvic pain. The pathophysiology for chronic pain in patients with endometriosis has not been fully understood. Altered inflammatory responses have been shown to contribute to pain symptoms. Increased secretion of cytokines, angiogenic factors, and nerve growth factors has been suggested to increase pain. Also, altered distribution of nerve fibers may also contribute to chronic pain. Aside from local contributing factors, sensitization of the nervous system is also important in understanding persistent pain in endometriosis. Peripheral sensitization as well as central sensitization have been identified in patients with endometriosis. These sensitizations of the nervous system can also explain increased incidence of comorbidities related to pain such as irritable bowel disease, bladder pain syndrome, and vulvodynia in patients with endometriosis. In conclusion, there are various possible mechanisms behind pain in patients with endometriosis, and understanding these mechanisms can help clinicians understand the nature of the pain symptoms and decide on treatments for endometriosis-related pain symptoms.
Language	English
Publishing date	2023-10-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11102868
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Article ; Online: Successful delayed delivery of the second twin by evacuating the cord prolapsed first fetus and emergent cerclage: a report of 2 cases.

Park, Mia / Jung, Ye Won / Park, Jiwon / Song, Soo Youn / Lee, Geon Woo / Yoo, Heon Jong / Ko, Young Bok / Lee, Mina / Kang, Byung Hun

BMC pregnancy and childbirth

2022 Volume 22, Issue 1, Page(s) 113

Abstract: Background: In twin pregnancies, the cord prolapse of either fetus during the pre-viable period leads to fetal death but can also cause an intrauterine infection, leading to death or prematu-re birth of the remaining fetus. However, there are no ... ...

Abstract	Background: In twin pregnancies, the cord prolapse of either fetus during the pre-viable period leads to fetal death but can also cause an intrauterine infection, leading to death or prematu-re birth of the remaining fetus. However, there are no validated protocols to prolong the gestational period or decrease the morbidity and mortality of the remaining fetus. Case presentation: The present cases were PPROM and cord prolapse very early during the second trimester (around 17 weeks in the first case and 19 weeks in the second case). The first fetus was evacuated, and cervical cerclage was performed at 23 and 20 weeks in the two cases, respectively. After maintaining the pregnancy, the second baby was born around 27 and 39 weeks in the first and second cases, respectively. The delivery interval between the first and second fetuses was 46 days in the first case and 126 days in the second case. Conclusion: If cord prolapse is identified at a pre-viable time in twin fetuses, evacuation and cerclage should be performed as soon as possible after the cord prolapse to reduce intrauterine infection and increase the survival chances of the remaining fetus.
MeSH term(s)	Adult ; Cerclage, Cervical/methods ; Delivery, Obstetric/methods ; Female ; Fetal Membranes, Premature Rupture/surgery ; Humans ; Live Birth ; Pregnancy ; Pregnancy Outcome ; Pregnancy Trimester, Second ; Pregnancy, Twin ; Prolapse ; Umbilical Cord/surgery
Language	English
Publishing date	2022-02-10
Publishing country	England
Document type	Case Reports
ZDB-ID	2059869-5
ISSN	1471-2393 ; 1471-2393
ISSN (online)	1471-2393
ISSN	1471-2393
DOI	10.1186/s12884-022-04438-z
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Article ; Online: The efficacy of gonadotropin-releasing hormone agonist treatment before hysteroscopic myomectomy for large-sized submucosal leiomyoma.

Park, Mia / Song, Min Soon / Kang, Byung Hun / Song, Soo Youn / Lee, Geon Woo / Jung, Ye Won / Shin, Won Kyo / Ko, Young Bok / Lee, Ki Hwan / Yoo, Heon Jong

Medicine

2022 Volume 101, Issue 31, Page(s) e29726

Abstract: To evaluate the efficacy and safety of a gonadotropin-releasing hormone (GnRH) agonist for treating large-sized submucosal leiomyoma before hysteroscopic myomectomy. The data were retrospectively collected from patients who underwent a hysteroscopic ... ...

Abstract	To evaluate the efficacy and safety of a gonadotropin-releasing hormone (GnRH) agonist for treating large-sized submucosal leiomyoma before hysteroscopic myomectomy. The data were retrospectively collected from patients who underwent a hysteroscopic myomectomy for a submucosal leiomyoma >3.5 cm in size from January 2009 to December 2018. The patients were divided into the GnRH group and the control group according to whether they were pretreated before surgery. A total of 61 patients were included in the study, 31 in the GnRH agonist group and 30 in the control group. At diagnosis, the maximum leiomyoma diameter was similar between the 2 groups (4.67 ± 0.6 cm in the GnRH agonist group vs 3.82 ± 0.6 cm in the control group, P = .061). After pretreatment with the GnRH agonist, the maximum diameter was significantly smaller in the GnRH agonist group compared to the control group (3.82 ± 0.6 vs 4.33 ± 0.8 cm, respectively, P = .004). The leiomyoma volume in the GnRH agonist group decreased by 55.6%, from 41.68 ± 15.7 to 23.19 ± 10.4 cm3, which led to significant differences in leiomyoma volume between the 2 groups (23.19 ± 10.4 cm3 in the GnRH agonist group vs 33.22 ± 24.7 cm3 in the control group, P = .042). The GnRH agonist group showed a shorter operation time (37.7 vs 43.9 minutes, P = .040) and less uterine distention media was used (6800 vs 9373.3 mL, P = .037) compared to the control group. Postoperative complications such as estimated blood loss, remnant leiomyoma, and recurrence were similar between the 2 groups. Treatment with a GnRH agonist before hysteroscopic myomectomy for large submucosal leiomyoma might decrease the volume of the leiomyoma, reduce operation time, and the amount of uterine-distension media used without surgical complications.
MeSH term(s)	Female ; Gonadotropin-Releasing Hormone ; Humans ; Leiomyoma/drug therapy ; Leiomyoma/surgery ; Retrospective Studies ; Uterine Myomectomy ; Uterine Neoplasms/drug therapy ; Uterine Neoplasms/surgery
Chemical Substances	Gonadotropin-Releasing Hormone (33515-09-2)
Language	English
Publishing date	2022-08-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000029726
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: (with research data) The challenge of accurately documenting bee species richness in agroecosystems: bee diversity in eastern apple orchards.

Russo, Laura / Park, Mia / Gibbs, Jason / Danforth, Bryan

Ecology and evolution

2015 Volume 5, Issue 17, Page(s) 3531–3540

Abstract: Bees are important pollinators of agricultural crops, and bee diversity has been shown to be closely associated with pollination, a valuable ecosystem service. Higher functional diversity and species richness of bees have been shown to lead to higher ... ...

Abstract	Bees are important pollinators of agricultural crops, and bee diversity has been shown to be closely associated with pollination, a valuable ecosystem service. Higher functional diversity and species richness of bees have been shown to lead to higher crop yield. Bees simultaneously represent a mega-diverse taxon that is extremely challenging to sample thoroughly and an important group to understand because of pollination services. We sampled bees visiting apple blossoms in 28 orchards over 6 years. We used species rarefaction analyses to test for the completeness of sampling and the relationship between species richness and sampling effort, orchard size, and percent agriculture in the surrounding landscape. We performed more than 190 h of sampling, collecting 11,219 specimens representing 104 species. Despite the sampling intensity, we captured <75% of expected species richness at more than half of the sites. For most of these, the variation in bee community composition between years was greater than among sites. Species richness was influenced by percent agriculture, orchard size, and sampling effort, but we found no factors explaining the difference between observed and expected species richness. Competition between honeybees and wild bees did not appear to be a factor, as we found no correlation between honeybee and wild bee abundance. Our study shows that the pollinator fauna of agroecosystems can be diverse and challenging to thoroughly sample. We demonstrate that there is high temporal variation in community composition and that sites vary widely in the sampling effort required to fully describe their diversity. In order to maximize pollination services provided by wild bee species, we must first accurately estimate species richness. For researchers interested in providing this estimate, we recommend multiyear studies and rarefaction analyses to quantify the gap between observed and expected species richness.
Language	English
Publishing date	2015-08-05
Publishing country	England
Document type	Journal Article
ISSN	2045-7758
ISSN	2045-7758
DOI	10.1002/ece3.1582
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Article ; Online: Effects of Temperature and Wildflower Strips on Survival and Macronutrient Stores of the Alfalfa Leafcutting Bee (Hymenoptera: Megachilidae) Under Extended Cold Storage.

Park, Mia G / Delphia, Casey M / Prince, Cassandra / Yocum, George D / Rinehart, Joseph P / O'Neill, Kevin M / Burkle, Laura A / Bowsher, Julia H / Greenlee, Kendra J

Environmental entomology

2022 Volume 51, Issue 5, Page(s) 958–968

Abstract: Megachile rotundata (F.) is an important pollinator of alfalfa in the United States. Enhancing landscapes with wildflowers is a primary strategy for conserving pollinators and may improve the sustainability of M. rotundata. Changing cold storage ... ...

Abstract	Megachile rotundata (F.) is an important pollinator of alfalfa in the United States. Enhancing landscapes with wildflowers is a primary strategy for conserving pollinators and may improve the sustainability of M. rotundata. Changing cold storage temperatures from a traditionally static thermal regime (STR) to a fluctuating thermal regime (FTR) improves overwintering success and extends M. rotundata's shelf life and pollination window. Whether floral resources enhance overwintering survival and/or interact with a thermal regime are unknown. We tested the combined effects of enhancing alfalfa fields with wildflowers and thermal regime on survival and macronutrient stores under extended cold storage (i.e., beyond one season). Megachile rotundata adults were released in alfalfa plots with and without wildflower strips. Completed nests were harvested in September and stored in STR. After a year, cells were randomly assigned to remain in STR for 6 months or in FTR for a year of extended cold storage; emergence rates were observed monthly. Macronutrient levels of emerged females were assessed. FTR improved M. rotundata survival but there was no measurable effect of wildflower strips on overwintering success or nutrient stores. Timing of nest establishment emerged as a key factor: offspring produced late in the season had lower winter survival and dry body mass. Sugars and glycogen stores increased under FTR but not STR. Trehalose levels were similar across treatments. Total lipid stores depleted faster under FTR. While wildflowers did not improve M. rotundata survival, our findings provide mechanistic insight into benefits and potential costs of FTR for this important pollinator.
MeSH term(s)	Female ; Bees ; Animals ; Temperature ; Hymenoptera ; Medicago sativa ; Trehalose ; Nutrients ; Glycogen ; Lipids
Chemical Substances	Trehalose (B8WCK70T7I) ; Glycogen (9005-79-2) ; Lipids
Language	English
Publishing date	2022-08-11
Publishing country	England
Document type	Randomized Controlled Trial, Veterinary ; Journal Article
ZDB-ID	120799-4
ISSN	1938-2936 ; 0046-2268 ; 0046-225X
ISSN (online)	1938-2936
ISSN	0046-2268 ; 0046-225X
DOI	10.1093/ee/nvac062
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Article ; Online: Effects of Temperature and Wildflower Strips on Survival and Macronutrient Stores of the Alfalfa Leafcutting Bee (Hymenoptera: Megachilidae) Under Extended Cold Storage

Park, Mia G. / Delphia, Casey M. / Prince, Cassandra / Yocum, George D. / Rinehart, Joseph P. / O'Neill, Kevin M. / Burkle, Laura A. / Bowsher, Julia H. / Greenlee, Kendra J.

Environmental Entomology 2022 Oct., v. 51, no. 5, p. 958-968

2022 , Page(s) 958–968

Abstract	Megachile rotundata (F.) is an important pollinator of alfalfa in the United States. Enhancing landscapes with wildflowers is a primary strategy for conserving pollinators and may improve the sustainability of M. rotundata. Changing cold storage temperatures from a traditionally static thermal regime (STR) to a fluctuating thermal regime (FTR) improves overwintering success and extends M. rotundata’s shelf life and pollination window. Whether floral resources enhance overwintering survival and/or interact with a thermal regime are unknown. We tested the combined effects of enhancing alfalfa fields with wildflowers and thermal regime on survival and macronutrient stores under extended cold storage (i.e., beyond one season). Megachile rotundata adults were released in alfalfa plots with and without wildflower strips. Completed nests were harvested in September and stored in STR. After a year, cells were randomly assigned to remain in STR for 6 months or in FTR for a year of extended cold storage; emergence rates were observed monthly. Macronutrient levels of emerged females were assessed. FTR improved M. rotundata survival but there was no measurable effect of wildflower strips on overwintering success or nutrient stores. Timing of nest establishment emerged as a key factor: offspring produced late in the season had lower winter survival and dry body mass. Sugars and glycogen stores increased under FTR but not STR. Trehalose levels were similar across treatments. Total lipid stores depleted faster under FTR. While wildflowers did not improve M. rotundata survival, our findings provide mechanistic insight into benefits and potential costs of FTR for this important pollinator.
Keywords	Megachile rotundata ; alfalfa ; body weight ; cold storage ; entomology ; glycogen ; lipids ; nests ; overwintering ; pollination ; pollinators ; progeny ; shelf life ; temperature ; trehalose ; wild flowers
Language	English
Dates of publication	2022-0814
Size	p. 958-968
Publishing place	Oxford University Press (OUP)
Document type	Article ; Online
Note	Resource is Open Access ; CHORUS License Information
ISSN	0046-225X
DOI	10.1093/ee/nvac062
Database	NAL-Catalogue (AGRICOLA)

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Article: Distribution of lymphocele following lymphadenectomy in patients with gynecological malignancies.

Song, Soo Youn / Park, Mia / Kang, Byung Hun / Yang, Jung Bo / Ko, Young Bok / Lee, Mina / Lee, Ki Hwan / Yoo, Heon Jong

Obstetrics & gynecology science

2020 Volume 63, Issue 6, Page(s) 700–708

Abstract: Objective: This study identified the distribution of lymphocele, as well as the factors associated with lymphocele formation, in patients undergoing pelvic and/or para-aortic lymph node dissection (PLND and/or PALND) for gynecologic malignancies.: ... ...

Abstract	Objective: This study identified the distribution of lymphocele, as well as the factors associated with lymphocele formation, in patients undergoing pelvic and/or para-aortic lymph node dissection (PLND and/or PALND) for gynecologic malignancies. Methods: This study was retrospective, and data were collected from patients who underwent surgical procedures including lymphadenectomy due to gynecologic malignancies from March 2013 to May 2016. Lymphocele was defined by postoperative computer tomography within 2 weeks after surgery. Results: A total of 116 patients underwent lymphadenectomy, of whom, 47 (42.0%) developed lymphocele and 14 (12.1%) had symptomatic lymphocele formation. The affecting factors of lymphocele formation were PLND concomitant with PALND and a large amount of blood loss ≥600 mL (P=0.030 and P=0.006, respectively). All clinical factors were not significantly different between patients with symptomatic and asymptomatic lymphocele. Lymphocele developed more frequently in the left side (67.1%) of the body compared to the right side (48.7%), and in the pelvic area (75.9%) compared to the para-aortic area (24.1%, P<0.001, both). Conclusion: Lymphocele formation is more prevalent in the left and pelvic area of the body compared to the right and paraaortic side. PLND concurrent with PALND and large amounts of blood loss were significant risk factors for lymphocele formation.
Language	English
Publishing date	2020-08-20
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2814367-X
ISSN	2287-8580 ; 2287-8572
ISSN (online)	2287-8580
ISSN	2287-8572
DOI	10.5468/ogs.20110
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