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  1. Article: Nanoscale two-bit/cell NAND silicon-oxide-nitride-oxide-silicon devices with a separated double-gate saddle-type structure.

    Park, Sang Su / You, Joo Hyung / Kwack, Kae Dal / Kim, Tae Whan

    Journal of nanoscience and nanotechnology

    2011  Volume 11, Issue 2, Page(s) 1337–1341

    Abstract: Nanoscale two-bit/cell NAND silicon-oxide-nitride-oxide-silicon flash memory devices based on a separated double-gate (SDG) saddle structure with a recess channel region had two different doping regions in silicon-fin channel to operate two-bit per cell. ...

    Abstract Nanoscale two-bit/cell NAND silicon-oxide-nitride-oxide-silicon flash memory devices based on a separated double-gate (SDG) saddle structure with a recess channel region had two different doping regions in silicon-fin channel to operate two-bit per cell. A simulation results showed that the short channel effect, the cross-talk problem between cells, and the increase in threshold voltage distribution were minimized, resulting in the enhancement of the scaling-down characteristics and the program/erase speed.
    Language English
    Publishing date 2011-02-12
    Publishing country United States
    Document type Journal Article
    ISSN 1533-4880
    ISSN 1533-4880
    DOI 10.1166/jnn.2011.3373
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Prokaryotic soluble expression and purification of bioactive human fibroblast growth factor 21 using maltose-binding protein.

    Nguyen, Anh Ngoc / Song, Jung-A / Nguyen, Minh Tan / Do, Bich Hang / Kwon, Grace G / Park, Sang Su / Yoo, Jiwon / Jang, Jaepyeong / Jin, Jonghwa / Osborn, Mark J / Jang, Yeon Jin / Thi Vu, Thu Trang / Oh, Heung-Bum / Choe, Han

    Scientific reports

    2017  Volume 7, Issue 1, Page(s) 16139

    Abstract: Human fibroblast growth factor 21 (hFGF21) has been characterized as an important regulator of glucose and lipid metabolism homeostasis. Here, to produce hFGF21 efficiently in Escherichia coli, the expression and solubility of hFGF21 were tested and ... ...

    Abstract Human fibroblast growth factor 21 (hFGF21) has been characterized as an important regulator of glucose and lipid metabolism homeostasis. Here, to produce hFGF21 efficiently in Escherichia coli, the expression and solubility of hFGF21 were tested and optimised by fusing the protein with one of eight tags: hexahistidine (His6), thioredoxin (Trx), small ubiquitin-related modifier (Sumo), glutathione S-transferase (GST), maltose-binding protein (MBP), N-utilisation substance protein A (NusA), human protein disulphide isomerase (PDI), and the b'a' domain of PDI (PDIb'a'). Each tag increased solubility of the protein when the expression temperature was 18°C. Unlike many other tags that were tested, MBP significantly enhanced the solubility of the protein also in the culture condition at 37°C. Thus, the MBP-hFGF21 construct was further pursued for optimisation of affinity chromatography purification. After tag removal, 8.1 mg of pure hFGF21 was obtained as a final product from 500 mL of starting culture. The protein was then characterised by mass spectroscopy and an in vitro functional assay using NIH-3T3 cells transfected with a β-klotho reporter gene. These characteristics are similar to those of commercial hFGF21. Thus, the MBP tag is useful for efficient prokaryotic production and purification of bioactive hFGF21.
    MeSH term(s) Escherichia coli/metabolism ; Fibroblast Growth Factors/genetics ; Fibroblast Growth Factors/metabolism ; Humans ; Maltose-Binding Proteins/genetics ; Maltose-Binding Proteins/metabolism ; Prokaryotic Cells/metabolism ; Protein Disulfide-Isomerases/genetics ; Protein Disulfide-Isomerases/metabolism ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Thioredoxins/genetics ; Thioredoxins/metabolism
    Chemical Substances Maltose-Binding Proteins ; Recombinant Fusion Proteins ; fibroblast growth factor 21 ; Thioredoxins (52500-60-4) ; Fibroblast Growth Factors (62031-54-3) ; Protein Disulfide-Isomerases (EC 5.3.4.1)
    Language English
    Publishing date 2017-11-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-017-16167-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Prevalence and Risk Factors for the Peripheral Neuropathy in Patients with Peripheral Arterial Occlusive Disease.

    Kim, Young Ae / Kim, Eun Su / Hwang, Ho Kyeong / Lee, Kyung Bok / Lee, Sol / Jung, Ji Woong / Kwon, Yu Jin / Cho, Dong Hui / Park, Sang Su / Yoon, Jin / Jang, Yong-Seog

    Vascular specialist international

    2014  Volume 30, Issue 4, Page(s) 125–132

    Abstract: Purpose: Peripheral neuropathy (PN) is known as a major contributor of the worsening of ischemic symptoms and the foot ulceration in patients with peripheral arterial occlusive disease (PAOD). However, there are few studies reporting the prevalence and ... ...

    Abstract Purpose: Peripheral neuropathy (PN) is known as a major contributor of the worsening of ischemic symptoms and the foot ulceration in patients with peripheral arterial occlusive disease (PAOD). However, there are few studies reporting the prevalence and risk factors for PN in PAOD. This study aimed to evaluate these issues for PN and to establish the importance of screening as additional treatment target for PN in PAOD.
    Materials and methods: A total of 52 limbs with PAOD were enrolled from January 2011 to December 2012. PN was divided into radiculopathy, ischemic PN (IPN), and diabetic PN (DPN), based on electromyographic findings. We investigated the prevalence of overall PN and subtypes of PN and then analyzed the risk factors.
    Results: The prevalence of overall PN in PAOD was 43 of 52 limbs (82.7%). In terms of subtypes of PN, the prevalence rate of radiculopathy and IPN was 30.8% and 23.1%, respectively. DPN showed in 22 limbs (73.3%) among 30 diabetic limbs. There was no significant correlation between each type of PN and ischemic symptoms. Our analysis showed that coronary artery disease (CAD) was a significant risk factor (P=0.01) for IPN, however, did not identify any significant risk factors for DPN.
    Conclusion: This present study indicated that most patients with PAOD had PN and CAD was a risk factor for IPN. In particular, PAOD with diabetes represented a higher prevalence for DPN. Our study suggests that PN should be evaluated and considered as another treatment target in patients with PAOD.
    Language English
    Publishing date 2014-12-31
    Publishing country Korea (South)
    Document type Journal Article
    ISSN 2288-7970
    ISSN 2288-7970
    DOI 10.5758/vsi.2014.30.4.125
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Severe acute pancreatitis due to tamoxifen-induced hypertriglyceridemia with diabetes mellitus.

    Kim, Young Ae / Lee, Sol / Jung, Ji Woong / Kwon, Yu Jin / Lee, Gyeong Bok / Shin, Dong Gue / Park, Sang Su / Yun, Jin / Jang, Yong-Seog / Cho, Dong Hui

    Chinese journal of cancer research = Chung-kuo yen cheng yen chiu

    2013  Volume 26, Issue 3, Page(s) 341–344

    Abstract: The side effects of tamoxifen are generally mild, including the effect on lipoprotein metabolism. However, there are few cases of severe tamoxifen induced hypertriglyceridemia. Hypertriglyceridemia is a marked risk factor for acute pancreatitis and ... ...

    Abstract The side effects of tamoxifen are generally mild, including the effect on lipoprotein metabolism. However, there are few cases of severe tamoxifen induced hypertriglyceridemia. Hypertriglyceridemia is a marked risk factor for acute pancreatitis and approximately 2% to 5% of cases of acute pancreatitis are related to drugs. We report on tamoxifen-induced hypertriglyceridemia and acute pancreatitis in a 40 years old woman with type 2 diabetes mellitus occurred by dexamethasone. She was treated with insulin infusion and fenofibrate, and goserelin acetate was started instead of tamoxifen after discharge from the hospital. Also, probable pathogenic hypotheses about the correlation between tamoxifen and dexamethasone induced type 2 diabetes mellitus on severe acute pancreatitis are provided. Clinicians should take care of risks of severe acute pancreatitis on using tamoxifen, especially for patients with dexamethasone induced diabetes mellitus. These individuals should undergo pre-post tamoxifen lipid screening and careful history taking of drugs, including dexamethasone.
    Language English
    Publishing date 2013-02-03
    Publishing country China
    Document type Case Reports
    ZDB-ID 1067584-x
    ISSN 1993-0631 ; 1000-9604
    ISSN (online) 1993-0631
    ISSN 1000-9604
    DOI 10.3978/j.issn.1000-9604.2014.05.01
    Database MEDical Literature Analysis and Retrieval System OnLINE

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