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Article ; Online: Crotamine-based recombinant immunotoxin targeting HER2 for enhanced cancer cell specificity and cytotoxicity.

Jang, Jaepyeong / Nguyen, Minh Quan / Park, Sangsu / Ryu, Dayoung / Park, Hyeseon / Lee, Gunsup / Kim, Chong Jai / Jang, Yeon Jin / Choe, Han

Toxicon : official journal of the International Society on Toxinology

2023 Volume 230, Page(s) 107157

Abstract: Crotamine, one of the major toxins present in the venom of the South American rattlesnake Crotalus durissus terrificus, exhibits potent cytotoxic properties and has been suggested for cancer therapy applications. However, its selectivity for cancer cells ...

Abstract	Crotamine, one of the major toxins present in the venom of the South American rattlesnake Crotalus durissus terrificus, exhibits potent cytotoxic properties and has been suggested for cancer therapy applications. However, its selectivity for cancer cells needs to be improved. This study designed and produced a novel recombinant immunotoxin, HER2(scFv)-CRT, composed of crotamine and single-chain Fv (scFv) derived from trastuzumab targeting human epidermal growth factor receptor 2 (HER2). The recombinant immunotoxin was expressed in Escherichia coli and purified using various chromatographic techniques. The cytotoxicity of HER2(scFv)-CRT was assessed in three breast cancer cell lines, demonstrating enhanced specificity and toxicity in HER2-expressing cells. These findings suggest that the crotamine-based recombinant immunotoxin has the potential to expand the repertoire of recombinant immunotoxin applications in cancer therapy.
MeSH term(s)	Animals ; Humans ; Crotalid Venoms/chemistry ; Crotalus ; Immunotoxins/metabolism ; Neoplasms/drug therapy ; Cell Line, Tumor
Chemical Substances	Crotalid Venoms ; crotamine (E58TBP78IH) ; Immunotoxins
Language	English
Publishing date	2023-05-15
Publishing country	England
Document type	Journal Article
ZDB-ID	204479-1
ISSN	1879-3150 ; 0041-0101
ISSN (online)	1879-3150
ISSN	0041-0101
DOI	10.1016/j.toxicon.2023.107157
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Article: Single and Repeated Oral Dose Toxicity and Genotoxicity of the Leaves of Butterbur

Park, Sangsu / Lim, Jeongin / Lee, Kyung Tae / Oh, Myung Sook / Jang, Dae Sik

Foods. 2021 Aug. 23, v. 10, no. 8

2021

Abstract: Butterbur (Petasites japonicus (Siebold & Zucc.) Maxim) leaves are available to consumers in the marketplace, but there is no guarantee that they are safe for human consumption. Previously, we demonstrated that hot water extracts of P. japonicus leaves ( ... ...

Abstract	Butterbur (Petasites japonicus (Siebold & Zucc.) Maxim) leaves are available to consumers in the marketplace, but there is no guarantee that they are safe for human consumption. Previously, we demonstrated that hot water extracts of P. japonicus leaves (KP-1) had anti-inflammatory properties and attenuated memory impairment. However, data regarding KP-1 toxicity are lacking. This study assessed the safety of KP-1 by examining oral and genotoxic effects using in vivo and in vitro tests, respectively. In a single oral dose toxicity and two-week repeated oral dose toxicity study, we observed no toxicologically significant clinical signs or changes in hematology, blood chemistry, and organ weights at any dose during the experiment. Following a thirteen-week repeated oral dose, toxicity, hyperkeratosis, and squamous cell hyperplasia of the limiting ridge in the stomach were observed. The no observable adverse effect level (NOAEL) was found to be 1250 mg/kg/day in male and female rats. However, hyperkeratosis and hyperplasia were not considered to be of toxicological significance when extrapolating the NOAEL to humans because the limiting ridge in the stomach is species-specific to rats. Therefore, in our study, the NOAEL was considered to be 5000 mg/kg/day when the changes in the stomach’s limiting ridge were discounted. Moreover, in vitro bacterial reverse mutations and chromosomal aberrations in Chinese hamster lung (CHL) cells and the in vivo micronucleus in Institute of cancer research (ICR) mice assays showed that KP-1 possessed no mutagenicity. Although additional research is required, these toxicological evaluations suggest that KP-1 could be safe for human consumption.
Keywords	Cricetulus griseus ; Petasites japonicus ; adverse effects ; blood chemistry ; females ; genotoxicity ; hematology ; humans ; hyperkeratosis ; hyperplasia ; lungs ; males ; markets ; memory disorders ; mutagenicity ; mutagens ; oral administration ; stomach ; toxicology
Language	English
Dates of publication	2021-0823
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods10081963
Database	NAL-Catalogue (AGRICOLA)

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Article: Single and Repeated Oral Dose Toxicity and Genotoxicity of the Leaves of Butterbur.

Park, Sangsu / Lim, Jeongin / Lee, Kyung Tae / Oh, Myung Sook / Jang, Dae Sik

Foods (Basel, Switzerland)

2021 Volume 10, Issue 8

Abstract: Butterbur ( ...

Abstract	Butterbur (
Language	English
Publishing date	2021-08-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods10081963
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Trichosanthis Semen Suppresses Lipopolysaccharide-Induced Neuroinflammation by Regulating the NF-κB Signaling Pathway and HO-1 Expression in Microglia.

Lee, Seungmin / Ju, In Gyoung / Choi, Yujin / Park, Sangsu / Oh, Myung Sook

Toxins

2021 Volume 13, Issue 12

Abstract: Neuroinflammation, which is mediated by microglia that release various inflammatory cytokines, is a typical feature of neurodegenerative diseases (NDDs), such as Alzheimer's disease and Parkinson's disease. Hence, alleviating neuroinflammation by ... ...

Abstract	Neuroinflammation, which is mediated by microglia that release various inflammatory cytokines, is a typical feature of neurodegenerative diseases (NDDs), such as Alzheimer's disease and Parkinson's disease. Hence, alleviating neuroinflammation by downregulating pro-inflammatory action, and upregulating anti-inflammatory action of microglia is an efficient therapeutic target for NDDs. In this study, we evaluated whether trichosanthis semen (TS), a dried ripe seed of
MeSH term(s)	Animals ; Gene Expression Regulation/drug effects ; Heme Oxygenase-1/genetics ; Heme Oxygenase-1/metabolism ; Inflammation/chemically induced ; Inflammation/drug therapy ; Lipopolysaccharides/toxicity ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; Microglia/drug effects ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type II/metabolism ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Rats ; Seeds/chemistry ; Signal Transduction/drug effects ; Trichosanthes/chemistry
Chemical Substances	Lipopolysaccharides ; Membrane Proteins ; NF-kappa B ; Plant Extracts ; Nitric Oxide (31C4KY9ESH) ; Nitric Oxide Synthase Type II (EC 1.14.13.39) ; Heme Oxygenase-1 (EC 1.14.14.18) ; Hmox1 protein, mouse (EC 1.14.14.18)
Language	English
Publishing date	2021-12-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2518395-3
ISSN	2072-6651 ; 2072-6651
ISSN (online)	2072-6651
ISSN	2072-6651
DOI	10.3390/toxins13120898
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Petasites japonicus

Eo, Hyeyoon / Lee, Seungmin / Kim, Seong Hye / Ju, In Gyoung / Huh, Eugene / Lim, Jeongin / Park, Sangsu / Oh, Myung Sook

Food & function

2022 Volume 13, Issue 20, Page(s) 10811–10822

Abstract: Neuroinflammation is a crucial pathogenic process involved in the development and deterioration of Alzheimer's disease (AD). ...

Abstract	Neuroinflammation is a crucial pathogenic process involved in the development and deterioration of Alzheimer's disease (AD).
MeSH term(s)	Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/metabolism ; Animals ; Calcium/metabolism ; Inflammation/metabolism ; Interleukin-6/genetics ; Interleukin-6/metabolism ; JNK Mitogen-Activated Protein Kinases/metabolism ; Lipopolysaccharides/adverse effects ; Mice ; Microglia ; Nitric Oxide/metabolism ; Petasites ; Plant Extracts/metabolism ; RNA, Messenger/metabolism ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Amyloid beta-Peptides ; Interleukin-6 ; Lipopolysaccharides ; Plant Extracts ; RNA, Messenger ; Tumor Necrosis Factor-alpha ; Nitric Oxide (31C4KY9ESH) ; JNK Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2022-10-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d2fo01989b
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Article ; Online: Soluble Cytoplasmic Expression and Purification of Immunotoxin HER2(scFv)-PE24B as a Maltose Binding Protein Fusion.

Park, Sangsu / Nguyen, Minh Quan / Ta, Huynh Kim Khanh / Nguyen, Minh Tan / Lee, Gunsup / Kim, Chong Jai / Jang, Yeon Jin / Choe, Han

International journal of molecular sciences

2021 Volume 22, Issue 12

Abstract: Human epidermal growth factor receptor 2 (HER-2) is overexpressed in many malignant tumors. The anti-HER2 antibody trastuzumab has been approved for treating HER2-positive early and metastatic breast cancers. ...

Abstract	Human epidermal growth factor receptor 2 (HER-2) is overexpressed in many malignant tumors. The anti-HER2 antibody trastuzumab has been approved for treating HER2-positive early and metastatic breast cancers.
MeSH term(s)	ADP Ribose Transferases/genetics ; Antineoplastic Agents, Immunological/pharmacology ; Bacterial Toxins/genetics ; Cell Line, Tumor ; Cell Survival ; Dose-Response Relationship, Drug ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Exotoxins/genetics ; Gene Expression ; Genetic Engineering ; Genetic Vectors/genetics ; Humans ; Immunotoxins/genetics ; Immunotoxins/isolation & purification ; Immunotoxins/pharmacology ; Maltose-Binding Proteins/genetics ; Mass Spectrometry ; Receptor, ErbB-2/antagonists & inhibitors ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/isolation & purification ; Recombinant Fusion Proteins/pharmacology ; Single-Chain Antibodies/genetics ; Virulence Factors/genetics ; Pseudomonas aeruginosa Exotoxin A
Chemical Substances	Antineoplastic Agents, Immunological ; Bacterial Toxins ; Exotoxins ; Immunotoxins ; Maltose-Binding Proteins ; Recombinant Fusion Proteins ; Single-Chain Antibodies ; Virulence Factors ; ADP Ribose Transferases (EC 2.4.2.-) ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1)
Language	English
Publishing date	2021-06-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22126483
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Phytochemicals from the flowers of Prunus persica (L.) Batsch: Anti-adipogenic effect of mandelamide on 3T3-L1 preadipocytes.

Lee, Dahae / Kim, Ji-Young / Qi, Yutong / Park, Sangsu / Lee, Hye Lim / Yamabe, Noriko / Kim, Hocheol / Jang, Dae Sik / Kang, Ki Sung

Bioorganic & medicinal chemistry letters

2021 Volume 49, Page(s) 128326

Abstract: Flowers of Prunus persica (L.) Batsch (Rosaceae), known as peach blossoms, have been reported to exert anti-obesity effects by improving hepatic lipid metabolism in obese mice. However, little is known regarding the anti-adipogenic effects of the ... ...

Abstract	Flowers of Prunus persica (L.) Batsch (Rosaceae), known as peach blossoms, have been reported to exert anti-obesity effects by improving hepatic lipid metabolism in obese mice. However, little is known regarding the anti-adipogenic effects of the phenolic compounds isolated from P. persica flowers. This study investigated the inhibitory effects of compounds extracted from P. persica flowers (PPF) on adipogenesis in 3T3-L1 murine preadipocytes using adipogenic differentiation assays. Additionally, we compared the anti-adipogenic effects of the phenolic compounds isolated from PPF, such as prunasin amide (1), amygdalin amide (2), prunasin acid (3), mandelamide (4), methyl caffeate (5), ferulic acid (6), chlorogenic acid (7), benzyl α-l-xylpyranosyl-(1 → 6)-β-d-glucopyranoside (8), prunin (9), naringenin (10), nicotiflorin (11), astragalin (12), afzelin (13), and uridine (14), on adipogenesis in 3T3-L1 murine preadipocytes. PPF and compounds 4-7 and 10 significantly inhibited adipogenesis. Among them, mandelamide (4) exhibited the maximum inhibitory activity with an IC
MeSH term(s)	3T3-L1 Cells ; Adipogenesis/drug effects ; Animals ; Anti-Obesity Agents/pharmacology ; CCAAT-Enhancer-Binding Protein-alpha/metabolism ; Cell Differentiation/drug effects ; Flowers/chemistry ; Lipid Droplets/metabolism ; MAP Kinase Signaling System/drug effects ; Mandelic Acids/pharmacology ; Mice ; PPAR gamma/metabolism ; Phenols/pharmacology ; Phytochemicals/pharmacology ; Prunus persica/chemistry
Chemical Substances	Anti-Obesity Agents ; CCAAT-Enhancer-Binding Protein-alpha ; Mandelic Acids ; PPAR gamma ; Phenols ; Phytochemicals ; mandelamide (4410-31-5)
Language	English
Publishing date	2021-08-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2021.128326
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Jg. 1995 - 2021: Lesesall (2.OG)
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Article ; Online: Conductive-bridging random-access memories for emerging neuromorphic computing.

Cha, Jun-Hwe / Yang, Sang Yoon / Oh, Jungyeop / Choi, Shinhyun / Park, Sangsu / Jang, Byung Chul / Ahn, Wonbae / Choi, Sung-Yool

Nanoscale

2020 Volume 12, Issue 27, Page(s) 14339–14368

Abstract: With the increasing utilisation of artificial intelligence, there is a renewed demand for the development of novel neuromorphic computing owing to the drawbacks of the existing computing paradigm based on the von Neumann architecture. Extensive studies ... ...

Abstract	With the increasing utilisation of artificial intelligence, there is a renewed demand for the development of novel neuromorphic computing owing to the drawbacks of the existing computing paradigm based on the von Neumann architecture. Extensive studies have been performed on memristors as their electrical nature is similar to those of biological synapses and neurons. However, most hardware-based artificial neural networks (ANNs) have been developed with oxide-based memristors owing to their high compatibility with mature complementary metal-oxide-semiconductor (CMOS) processes. Considering the advantages of conductive-bridging random-access memories (CBRAMs), such as their high scalability, high on-off current with a wide dynamic range, and low off-current, over oxide-based memristors, extensive studies on CBRAMs are required. In this review, the basics of operation of CBRAMs are examined in detail, from the formation of metal nanoclusters to filament bridging. Additionally, state-of-the-art experimental demonstrations of CBRAM-based artificial synapses and neurons are presented. Finally, CBRAM-based ANNs are discussed, including deep neural networks and spiking neural networks, along with other emerging computing applications. This review is expected to pave the way toward further development of large-scale CBRAM array systems.
Language	English
Publishing date	2020-05-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d0nr01671c
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Article ; Online: Butterbur Leaves Attenuate Memory Impairment and Neuronal Cell Damage in Amyloid Beta-Induced Alzheimer's Disease Models.

Kim, Namkwon / Choi, Jin Gyu / Park, Sangsu / Lee, Jong Kil / Oh, Myung Sook

International journal of molecular sciences

2018 Volume 19, Issue 6

Abstract: Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, and is characterized by the accumulation of amyloid beta (Aβ) as a pathological hallmark. Aβ plays a central role in neuronal degeneration and synaptic dysfunction through the ... ...

Abstract	Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, and is characterized by the accumulation of amyloid beta (Aβ) as a pathological hallmark. Aβ plays a central role in neuronal degeneration and synaptic dysfunction through the generation of excessive oxidative stress. In the present study, we explored whether leaves of
MeSH term(s)	Alzheimer Disease/complications ; Amyloid beta-Peptides ; Animals ; Apoptosis ; Cells, Cultured ; Disease Models, Animal ; Male ; Memory Disorders/drug therapy ; Memory Disorders/etiology ; Memory Disorders/prevention & control ; Mice ; Neurons/drug effects ; Neurons/metabolism ; Neurons/pathology ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Oxidative Stress ; Peptide Fragments ; Petasites/chemistry ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Plant Leaves/chemistry ; Plaque, Amyloid
Chemical Substances	Amyloid beta-Peptides ; Neuroprotective Agents ; Peptide Fragments ; Plant Extracts ; amyloid beta-protein (25-35)
Language	English
Publishing date	2018-06-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms19061644
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Article ; Online: In situ TEM observation on the interface-type resistive switching by electrochemical redox reactions at a TiN/PCMO interface.

Baek, Kyungjoon / Park, Sangsu / Park, Jucheol / Kim, Young-Min / Hwang, Hyunsang / Oh, Sang Ho

Nanoscale

2017 Volume 9, Issue 2, Page(s) 582–593

Abstract: The interface-type resistive switching devices exhibiting bipolar and multi-level resistive switching have been considered as the key component for neuromorphic device applications. To directly observe the microscopic details of underlying ... ...

Abstract	The interface-type resistive switching devices exhibiting bipolar and multi-level resistive switching have been considered as the key component for neuromorphic device applications. To directly observe the microscopic details of underlying electrochemical redox reactions occuring at a metal/oxide interface, we implemented in situ resistive switching of TiN/Pr
Language	English
Publishing date	2017-01-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/c6nr06293h
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