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Article ; Online: Do lifestyle factors influence risk of breast cancer recurrence in Korean women?: a cross-sectional survey.

Park, So-Jung / Yeom, Hye-Ah

Korean journal of women health nursing

2022 Volume 28, Issue 2, Page(s) 145–153

Abstract: Purpose: This study aimed to investigate the influencing factors of breast cancer recurrence by comparing the risk factors and lifestyle patterns related to breast cancer in Korean women with and without recurrence.: Methods: This cross-sectional ... ...

Abstract	Purpose: This study aimed to investigate the influencing factors of breast cancer recurrence by comparing the risk factors and lifestyle patterns related to breast cancer in Korean women with and without recurrence. Methods: This cross-sectional survey comprised 241 Korean women diagnosed with breast cancer who had received follow-up treatment. Participants were recruited from a university hospital in Seoul and an online social media platform for breast cancer patients. Data were collected either via online or a paper survey, using a structured questionnaire that included general and disease-related characteristics and lifestyle behaviors. Data were analyzed using descriptive statistics, univariate analysis, and logistic regression. Results: Recurrence of breast cancer was influenced by four factors; childbirth experience, consumption of green/yellow vegetables, drinking behavior, and recovery from fatigue after sleep.Prevalence of recurrent breast cancer was associated with no childbirth experience (OR=2.29, Conclusion: Aside from having experienced childbirth, this study identified several modifiable factors that influence breast cancer recurrence. Increasing green/yellow vegetable intake, alleviating fatigue, and reducing alcohol intake are important. Intervention strategies in clinical research and practice can be applied to address risk factors and reduce the prevalence of recurrent breast cancer.
Language	English
Publishing date	2022-06-29
Publishing country	Korea (South)
Document type	Journal Article
ISSN	2093-7695
ISSN (online)	2093-7695
DOI	10.4069/kjwhn.2022.06.08
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Poly(l-alanine-

Park, Jin Kyung / Park, So-Jung / Jeong, Byeongmoon

ACS applied materials & interfaces

2023 Volume 15, Issue 50, Page(s) 58092–58102

Abstract: We synthesized a series of [(l-Ala) ...

Abstract	We synthesized a series of [(l-Ala)
MeSH term(s)	Ice ; Succinic Acid ; Threonine ; Biomimetics ; Cryoprotective Agents/pharmacology ; Cryoprotective Agents/chemistry ; Succinates
Chemical Substances	Ice ; Succinic Acid (AB6MNQ6J6L) ; Threonine (2ZD004190S) ; Cryoprotective Agents ; Succinates
Language	English
Publishing date	2023-12-07
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c11260
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Article: Association between neck circumference and depressive mood among Korean adults.

Park, So-Jung / Hwang, In Cheol / Ahn, Hong Yup

Obesity research & clinical practice

2023 Volume 17, Issue 4, Page(s) 366–368

Abstract: The relationship between central obesity and depression remains of debate. From the 2019 Korea National Health and Nutrition Examination Survey, data of 3768 adults with available information on neck circumference and depressive mood were analyzed. ... ...

Abstract	The relationship between central obesity and depression remains of debate. From the 2019 Korea National Health and Nutrition Examination Survey, data of 3768 adults with available information on neck circumference and depressive mood were analyzed. Multivariate logistic analysis revealed that a small neck circumference was significantly associated with depressive mood among men, but not among women. Our findings indicate that assessing neck circumference among men would help detect depression early.
MeSH term(s)	Male ; Adult ; Humans ; Female ; Depression ; Nutrition Surveys ; Cross-Sectional Studies ; Obesity ; Republic of Korea/epidemiology ; Waist Circumference
Language	English
Publishing date	2023-05-30
Publishing country	Netherlands
Document type	Letter
ZDB-ID	2274031-4
ISSN	1878-0318 ; 1871-403X
ISSN (online)	1878-0318
ISSN	1871-403X
DOI	10.1016/j.orcp.2023.05.011
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Article ; Online: Domain-Selective Enzymatic Cross-linking and Etching for Shape-Morphing DNA-Linked Nanoparticle Films.

Choi, Jisu / Kim, Jongwook / Park, Jin-Young / Hyun, Jerome Kartham / Park, So-Jung

Nano letters

2024 Volume 24, Issue 8, Page(s) 2574–2580

Abstract: The highly programmable and responsive molecular recognition properties of DNA provide unparalleled opportunities for fabricating dynamic nanostructures capable of structural transformation in response to various external stimuli. However, they typically ...

Abstract	The highly programmable and responsive molecular recognition properties of DNA provide unparalleled opportunities for fabricating dynamic nanostructures capable of structural transformation in response to various external stimuli. However, they typically operate in tightly controlled environments because certain conditions (ionic strength, pH, temperature, etc.) must be met for DNA duplex formation. In this study, we adopted site-specific enzymatic ligation and DNA-based layer-by-layer thin film fabrication to build shape-morphing DNA-linked nanoparticle films operational in a broad range of environments. The ligated films remained intact in unusual conditions such as pure water and high temperature causing dissociation of DNA duplexes and showed predictable and reversible shape morphing in response to various environmental changes and DNA exchange reactions. Furthermore, domain-selective ligation combined with photoinduced interlayer mixing allowed for the fabrication of unusual edge-sealed double-layered films through midlayer etching, which is difficult to realize by other methods.
MeSH term(s)	DNA/chemistry ; Nanostructures ; Nanoparticles ; Water ; Temperature
Chemical Substances	DNA (9007-49-2) ; Water (059QF0KO0R)
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Journal Article
ISSN	1530-6992
ISSN (online)	1530-6992
DOI	10.1021/acs.nanolett.3c04637
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Article ; Online: p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson-Gilford progeria syndrome.

Son, Sung Min / Park, So Jung / Breusegem, Sophia Y / Larrieu, Delphine / Rubinsztein, David C

Nature cell biology

2024 Volume 26, Issue 2, Page(s) 235–249

Abstract: The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth, metabolism and autophagy. Multiple pathways modulate mTORC1 in response to nutrients. Here we describe that nucleus-cytoplasmic shuttling of p300/EP300 regulates ...

Abstract	The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth, metabolism and autophagy. Multiple pathways modulate mTORC1 in response to nutrients. Here we describe that nucleus-cytoplasmic shuttling of p300/EP300 regulates mTORC1 activity in response to amino acid or glucose levels. Depletion of these nutrients causes cytoplasm-to-nucleus relocalization of p300 that decreases acetylation of the mTORC1 component raptor, thereby reducing mTORC1 activity and activating autophagy. This is mediated by AMP-activated protein kinase-dependent phosphorylation of p300 at serine 89. Nutrient addition to starved cells results in protein phosphatase 2A-dependent dephosphorylation of nuclear p300, enabling its CRM1-dependent export to the cytoplasm to mediate mTORC1 reactivation. p300 shuttling regulates mTORC1 in most cell types and occurs in response to altered nutrients in diverse mouse tissues. Interestingly, p300 cytoplasm-nucleus shuttling is altered in cells from patients with Hutchinson-Gilford progeria syndrome. p300 mislocalization by the disease-causing protein, progerin, activates mTORC1 and inhibits autophagy, phenotypes that are normalized by modulating p300 shuttling. These results reveal how nutrients regulate mTORC1, a cytoplasmic complex, by shuttling its positive regulator p300 in and out of the nucleus, and how this pathway is misregulated in Hutchinson-Gilford progeria syndrome, causing mTORC1 hyperactivation and defective autophagy.
MeSH term(s)	Humans ; Mice ; Animals ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Progeria/genetics ; Progeria/metabolism ; Active Transport, Cell Nucleus ; Regulatory-Associated Protein of mTOR/metabolism ; Amino Acids/metabolism ; Lamin Type A/genetics ; Lamin Type A/metabolism
Chemical Substances	Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1) ; Regulatory-Associated Protein of mTOR ; Amino Acids ; Lamin Type A
Language	English
Publishing date	2024-01-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1474722-4
ISSN	1476-4679 ; 1465-7392
ISSN (online)	1476-4679
ISSN	1465-7392
DOI	10.1038/s41556-023-01338-y
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Zs.A 5169: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 12: Show issues

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Article ; Online: Genome-wide Analysis Identified

Park, Jung-Hyang / Kwag, Eunbin / Jeong, Mi-Kyung / Park, So-Jung / Lee, Sanghun / Yoo, Hwa-Seung

Integrative cancer therapies

2024 Volume 23, Page(s) 15347354241233544

Abstract: Background: In the era of precision medicine, individual temperature sensitivity has been highlighted. This trait has traditionally been used for cold-heat pattern identification to understand the inherent physical characteristics, which are influenced ... ...

Abstract	Background: In the era of precision medicine, individual temperature sensitivity has been highlighted. This trait has traditionally been used for cold-heat pattern identification to understand the inherent physical characteristics, which are influenced by genetic factors, of an individual. However, genome-wide association studies (GWASs) on this trait are limited. Methods: Using genotype data from 90 patients with advanced non-small cell lung cancer (NSCLC) and epidermal growth factor receptor mutations, we performed a GWAS to assess the association between single nucleotide polymorphisms (SNPs) and temperature sensitivity, such as cold and heat scores. The score of each participant was evaluated using self-administered questionnaires on common symptoms and a 15-item symptom-based cold-heat pattern identification questionnaire. Results: The GWAS was adjusted for confounding factors, including age and sex, and significant associations were identified for cold and heat scores: SNP rs145814326, located on the intron of Conclusions: SEMA4D
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/genetics ; Lung Neoplasms/genetics ; Genome-Wide Association Study ; Temperature ; Antigens, CD ; Semaphorins
Chemical Substances	CD100 antigen ; Antigens, CD ; Semaphorins
Language	English
Publishing date	2024-03-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2182320-0
ISSN	1552-695X ; 1534-7354
ISSN (online)	1552-695X
ISSN	1534-7354
DOI	10.1177/15347354241233544
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Zs.A 6026: Show issues

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bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Characteristics Associated with Survival in Patients Receiving Continuous Deep Sedation in a Hospice Care Unit.

Ahn, Hee Kyung / Ahn, Hong Yup / Park, So Jung / Hwang, In Cheol

Journal of hospice and palliative care

2023 Volume 24, Issue 4, Page(s) 254–260

Abstract: Continuous deep sedation (CDS) is an extreme form of palliative sedation to relieve refractory symptoms at the end of life. In this study, we shared our experiences with CDS and examined the clinical characteristics associated with survival in patients ... ...

Abstract	Continuous deep sedation (CDS) is an extreme form of palliative sedation to relieve refractory symptoms at the end of life. In this study, we shared our experiences with CDS and examined the clinical characteristics associated with survival in patients with terminal cancer who received CDS. We conducted a chart audit of 106 consecutive patients with terminal cancer who received CDS at a single hospice care unit between January 2014 and December 2016. Survival was defined as the first day of admission to the date of death. The associations between clinical characteristics and survival were presented as hazard ratios and 95% confidence intervals using a Cox proportional hazard model. The mean age of participants was 65.2 years, and 33.0% (n=35) were women. Diazepam was the most commonly administered drug, and haloperidol or lorazepam were also used if needed. One sedative was enough for a majority of the patients. Stepwise multivariate analysis identified poor functioning, a high Palliative Prognostic Index score, hyperbilirubinemia, high serum ferritin levels, and a low number of sedatives as independent poor prognostic factors. Our experiences and findings are expected to be helpful for shared decision-making and further research on palliative sedation.
Language	English
Publishing date	2023-08-22
Publishing country	Korea (South)
Document type	Journal Article
ISSN	2765-3080
ISSN (online)	2765-3080
DOI	10.14475/jhpc.2021.24.4.254
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Article ; Online: Oligonucleotides as Inhibitors of Ice Recrystallization.

Kim, Seyeon / Park, Jin Kyung / Park, So-Jung / Jeong, Byeongmoon

Biomacromolecules

2023 Volume 24, Issue 5, Page(s) 2118–2126

Abstract: Oligonucleotides of adenine (A20), guanine (G20), cytosine (C20), thymine (T20), cytosine-guanine ((CG)20), and adenine-thymine ((AT)20) were investigated as model compounds for ice recrystallization inhibition (IRI). Dehydroxy uracil (dU20), U20, and ... ...

Abstract	Oligonucleotides of adenine (A20), guanine (G20), cytosine (C20), thymine (T20), cytosine-guanine ((CG)20), and adenine-thymine ((AT)20) were investigated as model compounds for ice recrystallization inhibition (IRI). Dehydroxy uracil (dU20), U20, and T20 were also compared to investigate the effect of minute changes in the hydrophobicity of the oligonucleotides on the IRI activity. Among the oligonucleotides considered in this study, T20 exhibited the best performance for IRI. In addition, the degree of polymerization of oligothymines varied over 5, 10, 20, 30, 50, and 100, and T20 was found to be the most effective for IRI. The IRI mechanism was investigated by comparing U20 and T20, which exhibited the lowest and highest IRI activity, respectively, among the oligonucleotides for their dynamic ice-shaping, thermal hysteresis, and ice nucleation inhibition. Little or no dynamic ice-shaping activity and small thermal hysteresis were observed for both nucleotides. All of the findings suggest that not the ice-polymer adhesion but the hydrophobic interactions of T20 in the interface layer might interfere with the water deposition on the ice crystal surfaces and contribute to the IRI activity of the T20 oligonucleotide.
MeSH term(s)	Ice ; Oligonucleotides ; Thymine ; Crystallization ; Water ; Antifreeze Proteins/chemistry
Chemical Substances	Ice ; Oligonucleotides ; Thymine (QR26YLT7LT) ; Water (059QF0KO0R) ; Antifreeze Proteins
Language	English
Publishing date	2023-04-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1526-4602
ISSN (online)	1526-4602
DOI	10.1021/acs.biomac.2c01526
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Article ; Online: Directional Self-Assembly of Nanoparticles Coated with Thermoresponsive Block Copolymers and Charged Small Molecules.

Kim, Ga-Hyun / Kim, Minji / Hyun, Jerome K / Park, So-Jung

ACS macro letters

2023 Volume 12, Issue 7, Page(s) 986–992

Abstract: Herein, we report the directional stimuli-responsive self-assembly of gold nanoparticles (AuNPs) coated with a thermoresponsive block copolymer (BCP), poly(ethylene glycol)- ...

Abstract	Herein, we report the directional stimuli-responsive self-assembly of gold nanoparticles (AuNPs) coated with a thermoresponsive block copolymer (BCP), poly(ethylene glycol)-
Language	English
Publishing date	2023-07-03
Publishing country	United States
Document type	Journal Article
ISSN	2161-1653
ISSN (online)	2161-1653
DOI	10.1021/acsmacrolett.3c00221
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Article ; Online: Alternating Gyroid in Block Polymer Blends.

Park, So Jung / Bates, Frank S / Dorfman, Kevin D

ACS macro letters

2022 Volume 11, Issue 5, Page(s) 643–650

Abstract: Alternating gyroid is a lower symmetry variant of the double gyroid morphology, where the left-handed and right-handed chiral networks are physically distinct. This structure is of particular interest for photonic applications owing to predictions of a ... ...

Abstract	Alternating gyroid is a lower symmetry variant of the double gyroid morphology, where the left-handed and right-handed chiral networks are physically distinct. This structure is of particular interest for photonic applications owing to predictions of a complete photonic band gap subject to the requirement of a large dielectric contrast between the individual networks and sufficient optical matching between one of the networks and the matrix. We provide evidence, via self-consistent field theory (SCFT), that stoichiometric blends of double-gyroid-forming AB and BC diblock copolymers with relatively immiscible A and C blocks should form an alternating gyroid morphology with complementary three-dimensional A and C networks that have a free energy that is nearly degenerate with two phase-separated double gyroid states. Solvent casting offers the potential for trapping this binary mixture of diblock copolymers in this metastable alternating gyroid phase. Theory further predicts that the addition of a minuscule amount (<1%) of ABC triblock terpolymer will open an alternating gyroid stability window in the resulting ternary-phase diagram. The surfactant-like stabilization produced by the triblock is relatively insensitive to its exact composition provided the B-block forms a sufficiently long bridge between the A-rich and C-rich networks. This blending strategy provides significant synthetic and material processing advantages compared to prevailing methods to produce an alternating gyroid phase in block polymers.
MeSH term(s)	Polymers/chemistry
Chemical Substances	Polymers
Language	English
Publishing date	2022-04-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2161-1653
ISSN (online)	2161-1653
DOI	10.1021/acsmacrolett.2c00115
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