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  1. Article ; Online: Body-temperature softening electronic ink for additive manufacturing of transformative bioelectronics via direct writing.

    Kwon, Do A / Lee, Simok / Kim, Choong Yeon / Kang, Inho / Park, Steve / Jeong, Jae-Woong

    Science advances

    2024  Volume 10, Issue 9, Page(s) eadn1186

    Abstract: Mechanically transformative electronic systems (TESs) built using gallium have emerged as an innovative class of electronics due to their ability to switch between rigid and flexible states, thus expanding the versatility of electronics. However, the ... ...

    Abstract Mechanically transformative electronic systems (TESs) built using gallium have emerged as an innovative class of electronics due to their ability to switch between rigid and flexible states, thus expanding the versatility of electronics. However, the challenges posed by gallium's high surface tension and low viscosity have substantially hindered manufacturability, limiting high-resolution patterning of TESs. To address this challenge, we introduce a stiffness-tunable gallium-copper composite ink capable of direct ink write printing of intricate TES circuits, offering high-resolution (~50 micrometers) patterning, high conductivity, and bidirectional soft-rigid convertibility. These features enable transformative bioelectronics with design complexity akin to traditional printed circuit boards. These TESs maintain rigidity at room temperature for easy handling but soften and conform to curvilinear tissue surfaces at body temperature, adapting to dynamic tissue deformations. The proposed ink with direct ink write printing makes TES manufacturing simple and versatile, opening possibilities in wearables, implantables, consumer electronics, and robotics.
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adn1186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Precise and selective macroscopic assembly of a dual lock-and-key structured hydrogel.

    Heo, Eunseok / Hwang, Wooseop / Koo, Hye Been / Park, Steve / Kim, Do-Nyun / Kim, Ho-Young / Kim, YongJoo / Chang, Jae-Byum

    Materials horizons

    2024  Volume 11, Issue 2, Page(s) 428–441

    Abstract: Macroscopic assembly offers immense potential for constructing complex systems due to the high design flexibility of the building blocks. In such assembly systems, hydrogels are promising candidates for building blocks due to their versatile chemical ... ...

    Abstract Macroscopic assembly offers immense potential for constructing complex systems due to the high design flexibility of the building blocks. In such assembly systems, hydrogels are promising candidates for building blocks due to their versatile chemical compositions and ease of property tuning. However, two major challenges must be addressed to facilitate application in a broader context: the precision of assembly and the quantity of orthogonally matching pairs must both be increased. Although previous studies have attempted to address these challenges, none have successfully dealt with both simultaneously. Here, we propose topology-based design criteria for the selective assembly of hydrogel building blocks. By introducing the dual lock-and-key structures, we demonstrate highly precise assembly exclusively between the matching pairs. We establish principles for selecting multiple orthogonally matching pairs and achieve selective assembly involving simple one-to-one matching and complex assemblies with multiple orthogonal matching points. Moreover, by harnessing hydrogel tunability and the abundance of matching pairs, we synthesize complementary single-stranded structures for programmable assembly and successfully assemble them in the correct order. Finally, we demonstrate a hydrogel-based self-assembled logic gate system, including a YES gate, an OR gate, and an AND gate. The output is generated only when the corresponding inputs are provided according to each logic.
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2744250-0
    ISSN 2051-6355 ; 2051-6347
    ISSN (online) 2051-6355
    ISSN 2051-6347
    DOI 10.1039/d3mh00995e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Electrochemically driven stereoselective approach to

    Chung, Da Sol / Park, Steve H / Lee, Sang-Gi / Kim, Hyunwoo

    Chemical science

    2021  Volume 12, Issue 16, Page(s) 5892–5897

    Abstract: We have developed an electrochemically driven strategy for the stereoselective synthesis of ... ...

    Abstract We have developed an electrochemically driven strategy for the stereoselective synthesis of protected
    Language English
    Publishing date 2021-03-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d1sc00760b
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  4. Article ; Online: Bending Sensor Based on Controlled Microcracking Regions for Application toward Wearable Electronics and Robotics.

    Lee, Do Hoon / Yang, Jun Chang / Sim, Joo Yong / Kang, Heemin / Kim, Hyung-Ryong / Park, Steve

    ACS applied materials & interfaces

    2022  Volume 14, Issue 27, Page(s) 31312–31320

    Abstract: A soft bending sensor based on the inverse pyramid structure is demonstrated, revealing that it can effectively suppress microcrack formation in designated regions, thus allowing the cracks to open gradually with bending in a controlled manner. Such a ... ...

    Abstract A soft bending sensor based on the inverse pyramid structure is demonstrated, revealing that it can effectively suppress microcrack formation in designated regions, thus allowing the cracks to open gradually with bending in a controlled manner. Such a feature enabled the bending sensor to simultaneously have a wide dynamic range of bending strain (0.025-5.4%), high gauge factor (∼74), and high linearity (
    Language English
    Publishing date 2022-06-28
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.2c07795
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Bidirectional thermo-regulating hydrogel composite for autonomic thermal homeostasis.

    Park, Gyeongsuk / Park, Hyunmin / Seo, Junyong / Yang, Jun Chang / Kim, Min / Lee, Bong Jae / Park, Steve

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 3049

    Abstract: Thermal homeostasis is an essential physiological function for preserving the optimal state of complex organs within the human body. Inspired by this function, here, we introduce an autonomous thermal homeostatic hydrogel that includes infrared wave ... ...

    Abstract Thermal homeostasis is an essential physiological function for preserving the optimal state of complex organs within the human body. Inspired by this function, here, we introduce an autonomous thermal homeostatic hydrogel that includes infrared wave reflecting and absorbing materials for improved heat trapping at low temperatures, and a porous structure for enhanced evaporative cooling at high temperatures. Moreover, an optimized auxetic pattern was designed as a heat valve to further amplify heat release at high temperatures. This homeostatic hydrogel provides effective bidirectional thermoregulation with deviations of 5.04 °C ± 0.55 °C and 5.85 °C ± 0.46 °C from the normal body temperature of 36.5 °C, when the external temperatures are 5 °C and 50 °C, respectively. The autonomous thermoregulatory characteristics of our hydrogel may provide a simple solution to people suffering from autonomic nervous system disorders and soft robotics that are susceptible to sudden temperature fluctuations.
    MeSH term(s) Humans ; Hydrogels ; Body Temperature Regulation/physiology ; Hot Temperature ; Cold Temperature
    Chemical Substances Hydrogels
    Language English
    Publishing date 2023-05-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-38779-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Electrocatalytic Access to Azetidines via Intramolecular Allylic Hydroamination: Scrutinizing Key Oxidation Steps through Electrochemical Kinetic Analysis.

    Park, Steve H / Bae, Geunsu / Choi, Ahhyeon / Shin, Suyeon / Shin, Kwangmin / Choi, Chang Hyuck / Kim, Hyunwoo

    Journal of the American Chemical Society

    2023  Volume 145, Issue 28, Page(s) 15360–15369

    Abstract: Azetidines are prominent structural scaffolds in bioactive molecules, medicinal chemistry, and ligand design for transition metals. However, state-of-the-art methods cannot be applied to intramolecular hydroamination of allylic amine derivatives despite ... ...

    Abstract Azetidines are prominent structural scaffolds in bioactive molecules, medicinal chemistry, and ligand design for transition metals. However, state-of-the-art methods cannot be applied to intramolecular hydroamination of allylic amine derivatives despite their underlying potential as one of the most prevalent synthetic precursors to azetidines. Herein, we report an electrocatalytic method for intramolecular hydroamination of allylic sulfonamides to access azetidines for the first time. The merger of cobalt catalysis and electricity enables the regioselective generation of key carbocationic intermediates, which could directly undergo intramolecular C-N bond formation. The mechanistic investigations including electrochemical kinetic analysis suggest that either the catalyst regeneration by nucleophilic cyclization or the second electrochemical oxidation to access the carbocationic intermediate is involved in the rate-determining step (RDS) of our electrochemical protocol and highlight the ability of electrochemistry in providing ideal means to mediate catalyst oxidation.
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c03172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
    Z 7.3: Show issues

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  7. Article ; Online: Micrometer-thick and porous nanocomposite coating for electrochemical sensors with exceptional antifouling and electroconducting properties.

    Lee, Jeong-Chan / Kim, Su Yeong / Song, Jayeon / Jang, Hyowon / Kim, Min / Kim, Hanul / Choi, Siyoung Q / Kim, Sunjoo / Jolly, Pawan / Kang, Taejoon / Park, Steve / Ingber, Donald E

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 711

    Abstract: Development of coating technologies for electrochemical sensors that consistently exhibit antifouling activities in diverse and complex biological environments over extended time is vital for effective medical devices and diagnostics. Here, we describe a ...

    Abstract Development of coating technologies for electrochemical sensors that consistently exhibit antifouling activities in diverse and complex biological environments over extended time is vital for effective medical devices and diagnostics. Here, we describe a micrometer-thick, porous nanocomposite coating with both antifouling and electroconducting properties that enhances the sensitivity of electrochemical sensors. Nozzle printing of oil-in-water emulsion is used to create a 1 micrometer thick coating composed of cross-linked albumin with interconnected pores and gold nanowires. The layer resists biofouling and maintains rapid electron transfer kinetics for over one month when exposed directly to complex biological fluids, including serum and nasopharyngeal secretions. Compared to a thinner (nanometer thick) antifouling coating made with drop casting or a spin coating of the same thickness, the thick porous nanocomposite sensor exhibits sensitivities that are enhanced by 3.75- to 17-fold when three different target biomolecules are tested. As a result, emulsion-coated, multiplexed electrochemical sensors can carry out simultaneous detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid, antigen, and host antibody in clinical specimens with high sensitivity and specificity. This thick porous emulsion coating technology holds promise in addressing hurdles currently restricting the application of electrochemical sensors for point-of-care diagnostics, implantable devices, and other healthcare monitoring systems.
    MeSH term(s) Biofouling ; Porosity ; Emulsions ; Antibodies ; Nanocomposites ; Electrochemical Techniques ; Biosensing Techniques
    Chemical Substances Emulsions ; Antibodies
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-44822-1
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  8. Article ; Online: Self-Mixed Biphasic Liquid Metal Composite with Ultra-High Stretchability and Strain-Insensitivity for Neuromorphic Circuits.

    Lee, Do Hoon / Lim, Taesu / Pyeon, Jeongsu / Park, Hyunmin / Lee, Sang-Won / Lee, Seungkyu / Kim, Wonsik / Kim, Min / Lee, Jeong-Chan / Kim, Do-Wan / Han, Seungmin / Kim, Hyoungsoo / Park, Steve / Choi, Yang-Kyu

    Advanced materials (Deerfield Beach, Fla.)

    2024  Volume 36, Issue 16, Page(s) e2310956

    Abstract: Neuromorphic circuits that can function under extreme deformations are important for various data-driven wearable and robotic applications. Herein, biphasic liquid metal particle (BMP) with unprecedented stretchability and strain-insensitivity (ΔR/ ... ...

    Abstract Neuromorphic circuits that can function under extreme deformations are important for various data-driven wearable and robotic applications. Herein, biphasic liquid metal particle (BMP) with unprecedented stretchability and strain-insensitivity (ΔR/R
    Language English
    Publishing date 2024-01-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202310956
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  9. Article: Bending Sensor Based on Controlled Microcracking Regions for Application toward Wearable Electronics and Robotics

    Lee, Do Hoon / Yang, Jun Chang / Sim, Joo Yong / Kang, Heemin / Kim, Hyung-Ryong / Park, Steve

    ACS applied materials & interfaces. 2022 June 28, v. 14, no. 27

    2022  

    Abstract: A soft bending sensor based on the inverse pyramid structure is demonstrated, revealing that it can effectively suppress microcrack formation in designated regions, thus allowing the cracks to open gradually with bending in a controlled manner. Such a ... ...

    Abstract A soft bending sensor based on the inverse pyramid structure is demonstrated, revealing that it can effectively suppress microcrack formation in designated regions, thus allowing the cracks to open gradually with bending in a controlled manner. Such a feature enabled the bending sensor to simultaneously have a wide dynamic range of bending strain (0.025–5.4%), high gauge factor (∼74), and high linearity (R² ∼ 0.99). Furthermore, the bending sensor can capture repeated instantaneous changes in strain and various types of vibrations, owing to its fast response time. Moreover, the bending direction can be differentiated with a single layer of the sensor, and using an array of sensors integrated on a glove, object recognition was demonstrated via machine learning. Finally, a self-monitoring proprioceptive ionic electroactive polymer (IEAP) actuator capable of operating in liquid was demonstrated. Such features of our bending sensor will enable a simple and effective way of detecting sophisticated motion, thus potentially advancing wearable healthcare monitoring electronics and enabling proprioceptive soft robotics.
    Keywords electronics ; gloves ; health services ; liquids ; polymers
    Language English
    Dates of publication 2022-0628
    Size p. 31312-31320.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1944-8252
    DOI 10.1021/acsami.2c07795
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Neuromorphic Processing of Pressure Signal Using Integrated Sensor-Synaptic Device Capable of Selective and Reversible Short- and Long-Term Plasticity Operation.

    Kim, Da Won / Yang, Jun Chang / Lee, Seungkyu / Park, Steve

    ACS applied materials & interfaces

    2020  Volume 12, Issue 20, Page(s) 23207–23216

    Abstract: To mimic the tactile sensing properties of the human skin, signals from tactile sensors need to be processed in an efficient manner. The integration of the tactile sensor with a neuromorphic device can potentially address this issue, as the neuromorphic ... ...

    Abstract To mimic the tactile sensing properties of the human skin, signals from tactile sensors need to be processed in an efficient manner. The integration of the tactile sensor with a neuromorphic device can potentially address this issue, as the neuromorphic device has both signal processing and memory capability through which parallel and efficient processing of information is possible. In this article, an intelligent haptic perception device (IHPD) is presented that combines pressure sensing with an organic electrochemical transistor-based synaptic device into a simple device architecture. More importantly, the IHPD is capable of rapid and reversible switching between short-term plasticity (STP) and long-term plasticity (LTP) operation through which accelerated learning, processing of new information, and distinctive operation of STP and LTP are possible. Various types of pressure information such as magnitude, rate, and duration were processed utilizing STP by which error-tolerant perception was demonstrated. Meanwhile, memorization and learning of pressure through a stepwise change in a conductive state was demonstrated using LTP. These demonstrations present unique approaches to process and learn tactile information, which can potentially be utilized in various electronic skin applications in the future.
    MeSH term(s) Gels/chemistry ; Polypropylenes/chemistry ; Polyvinyls/chemistry ; Pressure ; Signal Processing, Computer-Assisted ; Smart Materials/chemistry ; Transistors, Electronic ; Wearable Electronic Devices
    Chemical Substances Gels ; Polypropylenes ; Polyvinyls ; Smart Materials
    Language English
    Publishing date 2020-05-08
    Publishing country United States
    Document type Journal Article ; Video-Audio Media
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.0c03904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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