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Article ; Online: 3D human anatomy augmentation over a mannequin for the training of nursing skills.

Kim, Sun Kyung / Lee, Youngho / Hwang, Hye Ri / Park, Su Yeon

Technology and health care : official journal of the European Society for Engineering and Medicine

2024 Volume 32, Issue 3, Page(s) 1523–1533

Abstract: Background: The in-depth understanding of human anatomy is the foundation for safety in nursing practice. Augmented reality is an emerging technology that can be used for integrative learning in nursing education.: Objective: The study aimed to ... ...

Abstract	Background: The in-depth understanding of human anatomy is the foundation for safety in nursing practice. Augmented reality is an emerging technology that can be used for integrative learning in nursing education. Objective: The study aimed to develop a human anatomy-based skill training system and pilot test its usability and feasibility. Methods: Twenty-seven nursing students participated in 3D anatomy-based skill training for intramuscular injection and Levin tube feeding using HoloLens 2. Various user interfaces including pictures, videos, animation graphics, and annotation boxes assisted users with a comprehensive understanding of the step-by-step procedures for these techniques. A one-group pre-post test was conducted to observe changes in skill performance competency, usability, and learning satisfaction. Results: After study participation, a statistically significant improvement in skill performance competency (p< 0.05) was observed. The usability results showed that students were satisfied with the usefulness of the program (9.55 ± 0.49) and scored highly for the intention to participate in other educational programs (9.62 ± 0.59). A high level of learning satisfaction was achieved (9.55 ± 0.49), with positive responses in fostering students' engagement and excitement in the application of cutting-edge technology. Conclusion: The 3D anatomy-based nursing skill training demonstrated good potential to improve learning outcomes and facilitate engagement in self-directed practice. This can be integrated into undergraduate nursing education as an assistant teaching tool, contributing to the combination of knowledge and practice.
MeSH term(s)	Humans ; Female ; Clinical Competence ; Male ; Students, Nursing ; Manikins ; Anatomy/education ; Education, Nursing/methods ; Augmented Reality ; Young Adult ; Imaging, Three-Dimensional/methods ; Adult ; Injections, Intramuscular/methods ; Education, Nursing, Baccalaureate/methods
Language	English
Publishing date	2024-03-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1159961-3
ISSN	1878-7401 ; 0928-7329
ISSN (online)	1878-7401
ISSN	0928-7329
DOI	10.3233/THC-230586
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Article ; Online: Apoptotic Effect of Isoimpertorin via Inhibition of c-Myc and SIRT1 Signaling Axis.

Ko, Hwan-Joo / Park, Su-Yeon / Sim, Deok Yong / Kim, Sung-Hoon / Hur, Soyoung / Lee, Jang-Hoon / Kim, Youngchul

International journal of molecular sciences

2024 Volume 25, Issue 8

Abstract: Though Isoimperatorin ... ...

Abstract	Though Isoimperatorin from
MeSH term(s)	Humans ; Apoptosis/drug effects ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Liver Neoplasms/drug therapy ; Liver Neoplasms/genetics ; Proto-Oncogene Proteins c-myc/drug effects ; Proto-Oncogene Proteins c-myc/metabolism ; Signal Transduction/drug effects ; Sirtuin 1/drug effects ; Sirtuin 1/metabolism ; Furocoumarins/pharmacology
Language	English
Publishing date	2024-04-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25084248
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Article ; Online: A Novel Model for Predicting the Sagittal Length of the Distal Tibia Using CT Imaging and Statistics.

Chun, Dong-Il / Cho, Jae-Ho / Yi, Young / Kim, Jahyung / Park, Su Yeon / Kim, Jae Heon / Won, Sung Hun

The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons

2023 Volume 63, Issue 2, Page(s) 132–135

Abstract: The purpose of this study was to determine the ratio of sagittal length to coronal length of the distal tibia for predicting the sagittal length of the distal tibia. A total of 202 ankles were measured based on CT imaging availability. We measured the ... ...

Abstract	The purpose of this study was to determine the ratio of sagittal length to coronal length of the distal tibia for predicting the sagittal length of the distal tibia. A total of 202 ankles were measured based on CT imaging availability. We measured the coronal length (Width, W) parallel to the Chaput tubercle from CT scans. Sagittal length was divided into 3 points (Diameter D1, D2, D3) in the axial plane on the same level. The relationship between coronal length and each sagittal length was determined through correlation analysis. A prediction model was then developed using multiple regression. We also analyzed the quality of the prediction model and validated the prediction model with a validation cohort. Each sagittal length (D1, D2, D3) and coronal length had a significant positive correlation (p < .01). In the prediction model, sex, height, and W were significantly associated with D1, D2, and D3 (p < .05). Prediction models were made for each sagittal length (D1, D2, D3). Concordance correlation coefficient (CCC) values of prediction models for D1, D2, and D3 were 0.78, 0.72, and 0.72 for the derivation cohort and 0.69, 0.63, and 0.61 for the validation cohort, respectively. Accuracies of models as ± 2SD for D1, D2, and D3 were 93.9%, 94.9%, and 94.9%, respectively. This study predicted the sagittal length of the distal tibia for preoperative planning by measuring the coronal length of the distal tibia. Prediction of the sagittal length of the distal tibia can help foot and ankle surgeons fixate screws stably to prevent iatrogenic injury of posterior structures of the distal tibia.
MeSH term(s)	Humans ; Tibia/diagnostic imaging ; Tibia/surgery ; Tomography, X-Ray Computed ; Ankle ; Ankle Joint
Language	English
Publishing date	2023-11-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	1146972-9
ISSN	1542-2224 ; 1067-2516
ISSN (online)	1542-2224
ISSN	1067-2516
DOI	10.1053/j.jfas.2022.11.008
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Zs.A 1468: Show issues

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Article ; Online: Astragalus membranaceus

Kim, Seok-Young / Park, Ji Eon / Lee, Hyo-Jung / Sim, Deok Yong / Ahn, Chi-Hoon / Park, Su-Yeon / Shim, Bum-Sang / Kim, Bonglee / Lee, Dae Young / Kim, Sung-Hoon

International journal of molecular sciences

2024 Volume 25, Issue 5

Abstract: ... ...

Abstract	Although
MeSH term(s)	Male ; Humans ; Receptors, Androgen/metabolism ; Prostate-Specific Antigen/metabolism ; HSP27 Heat-Shock Proteins/metabolism ; Reactive Oxygen Species ; Astragalus propinquus/metabolism ; Prostatic Neoplasms/metabolism ; Apoptosis ; Cell Line, Tumor
Chemical Substances	Receptors, Androgen ; Prostate-Specific Antigen (EC 3.4.21.77) ; HSP27 Heat-Shock Proteins ; Reactive Oxygen Species
Language	English
Publishing date	2024-02-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25052799
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Article ; Online: Inhibition of glycolysis and SIRT1/GLUT1 signaling ameliorates the apoptotic effect of Leptosidin in prostate cancer cells.

Park, Youngsang / Lee, Hyo-Jung / Sim, Deok Yong / Park, Ji Eon / Ahn, Chi-Hoon / Park, Su-Yeon / Lee, Yu-Chan / Shim, Bum-Sang / Kim, Bonglee / Kim, Sung-Hoon

Phytotherapy research : PTR

2024 Volume 38, Issue 3, Page(s) 1235–1244

Abstract: Since the silent information regulation 2 homolog-1 (sirtuin, SIRT1) and glucose transporter 1 (GLUT1) are known to modulate cancer cell metabolism and proliferation, the role of SIRT1/GLUT1 signaling was investigated in the apoptotic effect of ... ...

Abstract	Since the silent information regulation 2 homolog-1 (sirtuin, SIRT1) and glucose transporter 1 (GLUT1) are known to modulate cancer cell metabolism and proliferation, the role of SIRT1/GLUT1 signaling was investigated in the apoptotic effect of Leptosidin from Coreopsis grandiflora in DU145 and PC3 human prostate cancer (PCa) cells. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, cell cycle analysis, Western blotting, cBioportal correlation analysis, and co-immunoprecipitation were used in this work. Leptosidin showed cytotoxicity, augmented sub-G1 population, and abrogated the expression of pro-poly (ADP-ribose) polymerase (pro-PARP) and pro-cysteine aspartyl-specific protease (pro-caspase3) in DU145 and PC3 cells. Also, Leptosidin inhibited the expression of SIRT1, GLUT1, pyruvate kinase isozymes M2 (PKM2), Hexokinase 2 (HK2), and lactate dehydrogenase A (LDHA) in DU145 and PC3 cells along with disrupted binding of SIRT1 and GLUT1. Consistently, Leptosidin curtailed lactate, glucose, and ATP in DU145 and PC3 cells. Furthermore, SIRT1 depletion enhanced the decrease of GLUT1, LDHA, and pro-Cas3 by Leptosidin in treated DU145 cells, while pyruvate suppressed the ability of Leptosidin in DU145 cells. These findings suggest that Leptosidin induces apoptosis via inhibition of glycolysis and SIRT1/GLUT1 signaling axis in PCa cells.
MeSH term(s)	Humans ; Male ; Apoptosis ; Benzofurans ; Cell Line, Tumor ; Cell Proliferation ; Glucose Transporter Type 1/metabolism ; Glycolysis/physiology ; Prostatic Neoplasms/metabolism ; Sirtuin 1/metabolism
Chemical Substances	6,3',4'-trihydroxy-7-methoxyaurone ; Benzofurans ; Glucose Transporter Type 1 ; SIRT1 protein, human (EC 3.5.1.-) ; Sirtuin 1 (EC 3.5.1.-) ; SLC2A1 protein, human
Language	English
Publishing date	2024-01-04
Publishing country	England
Document type	Journal Article
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.8115
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Article ; Online: UHPLC-ESI-MS/MS for the Quantification of Eight Major Gingerols and Shogaols in Ginger Products: Effects of Ionization Polarity and Mobile Phase Modifier on the Sensitivity.

Park, Su Yeon / Jung, Mun Yhung

Journal of food science

2016 Volume 81, Issue 10, Page(s) C2457–C2465

Abstract: We developed and validated an improved ultra high performance liquid chromatography (UHPLC)-electrospray ionization (ESI)-tandem mass spectrometry (MS/MS) method for the fast separation and quantification of 8 major gingerols and shogaols (4-, 6-, 8-, 10- ...

Abstract	We developed and validated an improved ultra high performance liquid chromatography (UHPLC)-electrospray ionization (ESI)-tandem mass spectrometry (MS/MS) method for the fast separation and quantification of 8 major gingerols and shogaols (4-, 6-, 8-, 10-, and 12-gingerols, and 6-, 8-, and 10-shogaols) in gingerol products. The ionization polarity and mobile phase modifier greatly affected the mass ion profiles and sensitivity of the analytes. A mobile phase modifier of 0.05 mM ammonium formate dramatically decreased the sodium adduct ions and greatly increased the protonated ions of the gingerols and shogaols. Positive ion UHPLC-MS/MS with the ammonium formate in mobile phase showed greatly higher (4.5- to 15.7-fold) sensitivities than negative ion UHPLC. The positive ion UHPLC-MS/MS method showed excellent linearities (r
MeSH term(s)	Catechols/analysis ; Chromatography, High Pressure Liquid/methods ; Fatty Alcohols/analysis ; Formates ; Zingiber officinale/chemistry ; Ions ; Mass Spectrometry/methods ; Reproducibility of Results ; Spectrometry, Mass, Electrospray Ionization/methods ; Tandem Mass Spectrometry/methods
Chemical Substances	Catechols ; Fatty Alcohols ; Formates ; Ions ; formic acid (0YIW783RG1) ; shogaol (83DNB5FIRF) ; gingerol (925QK2Z900) ; 8-gingerol (LB0IJB138K)
Language	English
Publishing date	2016-09-02
Publishing country	United States
Document type	Journal Article ; Validation Study
ZDB-ID	241615-3
ISSN	1750-3841 ; 0022-1147
ISSN (online)	1750-3841
ISSN	0022-1147
DOI	10.1111/1750-3841.13429
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Article: Long-term outcomes of adjacent and antagonistic teeth after implant restoration: a focus on patient-related factors.

Park, Su Yeon / Kim, Yong Gun / Suh, Jo Young / Lee, Du Hyeong / Lee, Jae Mok

Journal of periodontal & implant science

2021 Volume 51, Issue 2, Page(s) 135–143

Abstract: Purpose: To investigate factors affecting the antagonistic and adjacent teeth in patients after implant restoration and prosthetic rehabilitation.: Methods: In total, 160 patients who visited Kyungpook National University Dental Hospital for implant ... ...

Abstract	Purpose: To investigate factors affecting the antagonistic and adjacent teeth in patients after implant restoration and prosthetic rehabilitation. Methods: In total, 160 patients who visited Kyungpook National University Dental Hospital for implant surgery, prosthesis placement, and supportive periodontal therapy (SPT) were included in this study. The average follow-up period was 88.06 months, and the maximum was 175 months. Patients' history of smoking, diabetes, hypertension, and osteoporosis was investigated, and panoramic radiographs were taken after surgery and prosthetic treatment. During the follow-up period, extraction and prosthetic/endodontic treatments of the antagonistic and adjacent teeth were analyzed. The statistical analyses were performed using descriptive statistics, the chi-square test, the Fisher exact test, and multiple logistic regression analyses. Results: Treatment was performed on 29.4% of the studied antagonistic teeth with extraction performed in 20.0% and prosthetic treatment in 10.0%. Furthermore, 19.4% of the studied adjacent teeth underwent treatment, of which extraction was performed in 12.5% and prosthetic treatment in 7.5%. The treatment rate for adjacent teeth was 25.3% in smokers, which was higher than that of non-smokers (12.3%) ( Conclusions: Implant restoration can affect the adjacent and antagonistic teeth. Smoking, osteoporosis history, and absence of SPT may be risk factors for the treatment of the adjacent and antagonistic teeth.
Language	English
Publishing date	2021-04-29
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2557339-1
ISSN	2093-2286 ; 2093-2278
ISSN (online)	2093-2286
ISSN	2093-2278
DOI	10.5051/jpis.2005100255
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Article: Ethyl Carbamate Formation from Cyanate in Model System of Ethanol-Water Media Using Response Surface Methodology.

Magollah, Tabu Mungia / Go, Ji-Yeun / Kim, Hyo-Lim / Park, Su-Yeon / Kwon, Seo-Yeon / Lee, Ji-Hyo / Yang, Ji-Young / Lee, Yang-Bong

Preventive nutrition and food science

2022 Volume 27, Issue 1, Page(s) 127–135

Abstract: Ethyl carbamate (EC) has been identified as a possible human carcinogen belonging to Group 2A. EC is naturally formed during the fermentation and storage of alcoholic drinks and fermented foods. When ingested in large amounts, EC can cause various health ...

Abstract	Ethyl carbamate (EC) has been identified as a possible human carcinogen belonging to Group 2A. EC is naturally formed during the fermentation and storage of alcoholic drinks and fermented foods. When ingested in large amounts, EC can cause various health problems, such as gastroenteric hemorrhage, vomiting, and cancer. In this study, optimization of EC formation from cyanate was examined using response surface methodology (RSM), a central composite design that includes variables such as alcohol concentration (10, 15, 20, 25, and 30%), pH (2.5, 3.0, 3.5, 4.0, and 4.5), storage temperature (5, 10, 15, 20, and 25°C), and storage duration (2, 4, 6, 8, and 10 days). EC content was determined using gas chromatography with flame ionization detection and the results were optimized using RSM. EC formation from cyanate degradation was found to increase with storage duration and temperature, acidity, and alcohol concentration. Cy-anate degradation was associated with the formation of EC. Approximately 83.1±0.1% of cyanate was degraded to 538±9 μM of EC. However, not all of the cyanate reacted with ethanol during fermentation to form EC. This study aimed to develop the ideal conditions for EC analysis to reduce EC production in alcoholic drinks and fermented foods.
Language	English
Publishing date	2022-04-07
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2668373-8
ISSN	2287-8602 ; 2287-1098
ISSN (online)	2287-8602
ISSN	2287-1098
DOI	10.3746/pnf.2022.27.1.127
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Article ; Online: Retinopathy of Prematurity Requiring Treatment Is Closely Related to Head Growth during Neonatal Intensive Care Unit Hospitalization in Very Low Birth Weight Infants.

Bae, Seong Phil / Kim, Ee-Kyung / Yun, Jungha / Yoon, Young Mi / Shin, Seung Han / Park, Su Yeon

Neonatology

2022 Volume 119, Issue 2, Page(s) 176–183

Abstract: Background: Retinopathy of prematurity (ROP) is caused by prenatal sensitization and postnatal insults to the immature retina. This process can be associated with the postnatal growth of preterm infants. We investigated whether ROP requiring treatment ... ...

Abstract	Background: Retinopathy of prematurity (ROP) is caused by prenatal sensitization and postnatal insults to the immature retina. This process can be associated with the postnatal growth of preterm infants. We investigated whether ROP requiring treatment was associated with the postnatal growth failure of very low birth weight (VLBW) infants. Method: From a cohort of VLBW infants (birth weight <1,500 g) registered in the Korean Neonatal Network from January 2013 to December 2017, 3,133 infants with gestational age (GA) between 24 and 28 weeks were included in the study. Postnatal growth failure was defined when the change in each anthropometric z-score between birth and discharge was <10th percentile of the total population. Propensity score matching (PSM) at 1:1 was performed to match the distribution of GA and postnatal morbidities between infants with and without ROP requiring treatment. Prenatal factors and ROP were analyzed by conditional logistic regression. Results: Of 3,133 enrolled infants, 624 (19.9%) were diagnosed with ROP requiring treatment. After PSM, ROP requiring treatment was associated with postnatal growth failure assessed by head circumference (adjusted odds ratio [aOR] 1.91, 95% confidence interval [CI] 1.18-3.09), but not weight (aOR 1.45, 95% CI 0.97-2.17) and length (aOR 1.21, 95% CI 0.81-1.82). Conclusion: ROP requiring treatment was associated with poor head circumference growth, not with weight and length. Our findings suggest that ROP requiring treatment and poor head growth during NICU hospitalization are fundamentally related.
MeSH term(s)	Birth Weight ; Female ; Gestational Age ; Growth Disorders/complications ; Hospitalization ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Infant, Very Low Birth Weight ; Intensive Care Units, Neonatal ; Pregnancy ; Retinopathy of Prematurity/epidemiology ; Retinopathy of Prematurity/etiology ; Retinopathy of Prematurity/therapy ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2022-02-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2266911-5
ISSN	1661-7819 ; 1661-7800
ISSN (online)	1661-7819
ISSN	1661-7800
DOI	10.1159/000519714
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Article ; Online: SH‐PRO extract alleviates benign prostatic hyperplasia via ROS‐mediated activation of PARP/caspase 3 and inhibition of FOXO3a/AR/PSA signaling in vitro and in vivo

Park, Ji Eon / Shin, Woo‐Cheol / Lee, Hyo‐Jung / Yoon, Dahye / Sim, Deok Yong / Ahn, Chi‐Hoon / Park, Su‐Yeon / Shim, Bum Sang / Park, So Jung / Kim, Kyung Seok / Park, Geum Duck / Kim, Sung‐Hoon / Lee, Dae Young

Phytotherapy Research. 2023 Feb., v. 37, no. 2 p.452-463

2023

Abstract: To target benign prostatic hyperplasia (BPH) as a common urinary disease in old men, in the current study, the antiproliferative and apoptotic mechanism of SH‐PRO, a mixture of Angelica gigas and Astragalus membranaceus (2:1), was evaluated in BPH‐1 ... ...

Abstract	To target benign prostatic hyperplasia (BPH) as a common urinary disease in old men, in the current study, the antiproliferative and apoptotic mechanism of SH‐PRO, a mixture of Angelica gigas and Astragalus membranaceus (2:1), was evaluated in BPH‐1 cells and rats with testosterone‐induced BPH. Herein, SH‐PRO significantly reduced the viability of BPH‐1 cells and dihydrotestosterone (DHT)‐treated RWPE‐1 cells. Also, SH‐PRO increased the sub‐G1 population in BPH‐1 cells and consistently attenuated the expression of pro‐PARP, pro‐caspase 3, Bcl2, FOXO3a, androgen receptor (AR), and prostate‐specific antigen (PSA) in BPH‐1 cells and DHT‐treated RWPE‐1 cells. Of note, SH‐PRO generated reactive oxygen species (ROS) in BPH‐1 cells, while ROS inhibitor N‐acetyl‐l‐cysteine (NAC) disturbed the ability of SH‐PRO to reduce the expression of pro‐PARP, FOXO3a, catalase, SOD, and increase sub‐G1 population in BPH‐1 cells. Furthermore, oral treatment of SH‐PRO significantly abrogated the weight of the prostate in testosterone‐treated rats compared to BPH control with the reduced expression of AR, PSA, and DHT and lower plasma levels of DTH, bFGF, and EGF with no toxicity. Overall, these findings highlight the antiproliferative and apoptotic potential of SH‐PRO via ROS‐mediated activation of PARP and caspase 3 and inhibition of FOXO3a/AR/PSA signaling as a potent anti‐BPH candidate.
Keywords	Angelica gigas ; Astragalus membranaceus ; acetylcysteine ; androgen receptors ; apoptosis ; caspase-3 ; catalase ; dihydrotestosterone ; hyperplasia ; oral administration ; phytotherapy ; prostate-specific antigen ; reactive oxygen species ; research ; toxicity ; viability
Language	English
Dates of publication	2023-02
Size	p. 452-463.
Publishing place	John Wiley & Sons, Ltd.
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.7626
Database	NAL-Catalogue (AGRICOLA)

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