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Article ; Online: Robust imaging approach for precise prediction of postoperative lung function in lung cancer patients prior to curative operation.

Kim, Suho / Kim, Jonghoon / Jeong, Uichan / Oh, You Jin / Park, Sung Goo / Lee, Ho Yun

2023 Volume 15, Issue 1, Page(s) 35–43

Abstract: Background: To create a combined variable integrating both ventilation and perfusion as measured by preoperative dual-energy computed tomography (DECT), compare the results with predicted postoperative (PPO) lung function as estimated using conventional ...

Abstract	Background: To create a combined variable integrating both ventilation and perfusion as measured by preoperative dual-energy computed tomography (DECT), compare the results with predicted postoperative (PPO) lung function as estimated using conventional methods, and assess agreement with actual postoperative lung function. Methods: A total of 33 patients with lung cancer who underwent curative surgery after DECT and perfusion scan were selected. Ventilation and perfusion values were generated from DECT data. In the "combined variable method," these two variables and clinical variables were linearly regressed to estimate PPO lung function. Six PPO lung function parameters (segment counting, perfusion scan, volume analysis, ventilation map, perfusion map, and combined variable) were compared with actual postoperative lung function using an intraclass correlation coefficient (ICC). Results: The segment counting method produced the highest ICC for forced vital capacity (FVC) at 0.93 (p < 0.05), while the segment counting and perfusion map methods produced the highest ICC for forced expiratory volume in 1 second (FEV Conclusions: Use of DECT image processing to predict postoperative lung function produced better agreement with actual postoperative lung function than conventional methods. The combined variable method produced ICC values of 0.8 or greater for FVC and FEV
MeSH term(s)	Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/surgery ; Lung/diagnostic imaging ; Lung/surgery ; Forced Expiratory Volume ; Respiratory Function Tests ; Vital Capacity ; Pneumonectomy
Language	English
Publishing date	2023-11-15
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2625856-0
ISSN	1759-7714 ; 1759-7706
ISSN (online)	1759-7714
ISSN	1759-7706
DOI	10.1111/1759-7714.15153
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Article ; Online: New radiologic classification of renal angiomyolipoma: frequently asked questions.

Park, Sung Goo / Park, Byung Kwan

Clinical imaging

2019 Volume 55, Page(s) 156–160

Abstract: Recently, a new classification of renal angiomyolipoma (AML) has been introduced to clinical practice. This classification categorizes AMLs into three subtypes (fat-rich, fat-poor, and fat-invisible AMLs) based on quantitative CT and MRI criteria. ... ...

Abstract	Recently, a new classification of renal angiomyolipoma (AML) has been introduced to clinical practice. This classification categorizes AMLs into three subtypes (fat-rich, fat-poor, and fat-invisible AMLs) based on quantitative CT and MRI criteria. Radiologists who get used to previous AML classification may have questions about how to apply a new classification. The purpose of this review is to answer the questions that are frequently asked about the new AML classification.
MeSH term(s)	Angiomyolipoma/classification ; Angiomyolipoma/diagnosis ; Carcinoma, Renal Cell/classification ; Carcinoma, Renal Cell/diagnosis ; Diagnosis, Differential ; Female ; Humans ; Kidney Neoplasms/classification ; Kidney Neoplasms/diagnosis ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Radiologists
Language	English
Publishing date	2019-02-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1028123-x
ISSN	1873-4499 ; 0899-7071
ISSN (online)	1873-4499
ISSN	0899-7071
DOI	10.1016/j.clinimag.2019.01.025
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Zs.A 1469: Show issues

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Article ; Online: Quantification of diffuse parenchymal lung disease in non-small cell lung cancer patients with definitive concurrent chemoradiation therapy for predicting radiation pneumonitis.

An, Ye Chan / Kim, Jong Hoon / Noh, Jae Myung / Yang, Kyung Mi / Oh, You Jin / Park, Sung Goo / Pyo, Hong Ryul / Lee, Ho Yun

Thoracic cancer

2023 Volume 14, Issue 36, Page(s) 3530–3539

Abstract: Background: We sought to quantify diffuse parenchymal lung disease (DPLD) extent using quantitative computed tomography (CT) analysis and to investigate its association with radiation pneumonitis (RP) development in non-small cell lung cancer (NSCLC) ... ...

Abstract	Background: We sought to quantify diffuse parenchymal lung disease (DPLD) extent using quantitative computed tomography (CT) analysis and to investigate its association with radiation pneumonitis (RP) development in non-small cell lung cancer (NSCLC) patients receiving definitive concurrent chemoradiation therapy (CCRT). Methods: A total of 82 NSCLC patients undergoing definitive CCRT were included in this prospective cohort study. Pretreatment CT scans were analyzed using quantitative CT analysis software. Low-attenuation area (LAA) features based on lung density and texture features reflecting interstitial lung disease (ILD) were extracted from the whole lung. Clinical and dosimetric factors were also evaluated. RP development was assessed using the Common Terminology Criteria for Adverse Events version 5.0. Univariable and multivariable logistic regression analyses were performed to identify independent risk factors for grade ≥3 (≥GR3) RP. Results: RP was identified in 68 patients (73.9%), with nine patients (10.9%) experiencing ≥GR3 RP. Univariable logistic regression analysis identified excess kurtosis and high-attenuation area (HAA)_volume (cc) as significantly associated with ≥GR3 RP. Multivariable logistic regression analysis showed that the combined use of imaging features and clinical factors (forced expiratory volume in 1 second [FEV1], forced vital capacity [FVC], and CHEMO regimen) demonstrated the best performance (area under the receiver operating characteristic curve = 0.924) in predicting ≥GR3 RP. Conclusion: Quantified imaging features of DPLD obtained from pretreatment CT scans would predict the occurrence of RP in NSCLC patients undergoing definitive CCRT. Combining imaging features with clinical factors could improve the accuracy of the predictive model for severe RP.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/radiotherapy ; Radiation Pneumonitis/etiology ; Radiation Pneumonitis/epidemiology ; Lung Neoplasms/drug therapy ; Prospective Studies ; Lung Diseases, Interstitial/diagnostic imaging ; Lung Diseases, Interstitial/complications ; Retrospective Studies
Language	English
Publishing date	2023-11-12
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2625856-0
ISSN	1759-7714 ; 1759-7706
ISSN (online)	1759-7714
ISSN	1759-7706
DOI	10.1111/1759-7714.15156
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Zs.A 6921: Show issues

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Article ; Online: Differentiation Between Invasive Adenocarcinoma and Focal Interstitial Fibrosis among Persistent Pulmonary Part-solid Nodules: With Emphasis on the CT Morphologic Analysis.

Woo, Jung Han / Kim, Jong Hee / Jeong, Dong Young / Park, Sung Goo / Jung, Moonki / Kim, Chu Hyun / Lee, Junghee / Kim, Hong Kwan / Han, Joungho / Kim, Tae Jung / Chung, Myung Jin / Cha, Yoon Ki

Journal of thoracic imaging

2024

Abstract: Purpose: Focal interstitial fibrosis (FIF) manifesting as a persistent part-solid nodule (PSN) has been mistakenly treated surgically due to similar imaging features to invasive adenocarcinoma (ADC). The purpose of this study was to observe predictive ... ...

Abstract	Purpose: Focal interstitial fibrosis (FIF) manifesting as a persistent part-solid nodule (PSN) has been mistakenly treated surgically due to similar imaging features to invasive adenocarcinoma (ADC). The purpose of this study was to observe predictive imaging features correlated with FIF through CT morphologic analysis. Materials and methods: From January 2009 to December 2020, 44 patients with surgically proven FIF in a single institution were enrolled and compared with 88 ADC patients through propensity score matching. Patient characteristics and CT morphologic analysis of persistent PSNs were used to identify predictive imaging features of FIF. Receiver operating characteristic (ROC) curve analysis was used to quantify the performance of imaging features. Results: A total of 132 patients with 132 PSNs (44 FIF, 88 ADC; mean age, 67.7±7.58; 75 females) were involved in our analysis. Multivariable analysis demonstrated that preserved peritumoral vascular margin (preserved vascular margin), preserved secondary pulmonary lobule margin (preserved lobular margin), and lower coronal to axial ratio (C/A ratio; cutoff: 1.005) were significant independent predictors of FIF (P<0.05). ROC curve analysis to evaluate the predictive value of the logistic model based on the imaging features of FIF, and the AUC value was 0.881. Conclusion: CT imaging features of preserved vascular margin, preserved lobular margin, and lower C/A ratio (cutoff, <1.005) might be helpful imaging features in discriminating FIF over ADC among persistent PSN in clinical practice.
Language	English
Publishing date	2024-04-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	632900-7
ISSN	1536-0237 ; 0883-5993
ISSN (online)	1536-0237
ISSN	0883-5993
DOI	10.1097/RTI.0000000000000786
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Zs.A 2187: Show issues

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Article ; Online: Serine 389 phosphorylation of 3-phosphoinositide-dependent kinase 1 by UNC-51-like kinase 1 affects its ability to regulate Akt and p70 S6kinase.

Kim, Kidae / Park, Sung Goo / Park, Byoung Chul / Kim, Jeong-Hoon / Kim, Sunhong

BMB reports

2020 Volume 53, Issue 7, Page(s) 373–378

Abstract: Phosphorylation of the signaling component by protein kinase often leads to a kinase cascade or feedback loop. 3-Phosphoinositide- dependent kinase 1 (PDK1) signaling pathway diverges into various kinases including Akt and p70 S6 kinase (p70S6k). However, ...

Abstract	Phosphorylation of the signaling component by protein kinase often leads to a kinase cascade or feedback loop. 3-Phosphoinositide- dependent kinase 1 (PDK1) signaling pathway diverges into various kinases including Akt and p70 S6 kinase (p70S6k). However, the PDK1 feedback mechanism remains elusive. Here, we demonstrated that UNC-51-like kinase (ULK1), an autophagy initiator kinase downstream of mechanistic target of rapamycin (mTOR), directly phosphorylated PDK1 on serine 389 at the linker region. Furthermore, our data showed that this phosphorylation affected the kinase activity of PDK1 toward downstream substrates. These results suggest a possible negative feedback loop between PDK1 and ULK1. [BMB Reports 2020; 53(7): 373-378].
MeSH term(s)	3-Phosphoinositide-Dependent Protein Kinases/metabolism ; Autophagy ; Autophagy-Related Protein-1 Homolog/metabolism ; HEK293 Cells ; Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; Phosphatidylinositol 3-Kinase/metabolism ; Phosphatidylinositols ; Phosphorylation ; Proto-Oncogene Proteins c-akt/metabolism ; Ribosomal Protein S6 Kinases, 70-kDa/metabolism ; Serine/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases
Chemical Substances	Intracellular Signaling Peptides and Proteins ; Phosphatidylinositols ; Serine (452VLY9402) ; MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; 3-Phosphoinositide-Dependent Protein Kinases (EC 2.7.11.1) ; Autophagy-Related Protein-1 Homolog (EC 2.7.11.1) ; PDPK1 protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Ribosomal Protein S6 Kinases, 70-kDa (EC 2.7.11.1) ; ULK1 protein, human (EC 2.7.11.1)
Language	English
Publishing date	2020-04-21
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2410389-5
ISSN	1976-670X ; 1976-6696
ISSN (online)	1976-670X
ISSN	1976-6696
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Zs.A 4202: Show issues

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Article: Neuroprotective Effects of Licochalcone D in Oxidative-Stress-Induced Primitive Neural Stem Cells from Parkinson's Disease Patient-Derived iPSCs.

Oh, Minyoung / Nam, Juhyeon / Baek, Areum / Seo, Ji-Hye / Chae, Jung-Il / Lee, Seo-Young / Chung, Sun-Ku / Park, Byoung Chul / Park, Sung Goo / Kim, Janghwan / Jeon, Young-Joo

Biomedicines

2023 Volume 11, Issue 1

Abstract: Parkinson's disease (PD) is one of the most common neurodegenerative diseases caused by the loss of dopaminergic neurons in the substantia nigra pars compacta. Although the etiology of PD is still unclear, the death of dopaminergic neurons during PD ... ...

Abstract	Parkinson's disease (PD) is one of the most common neurodegenerative diseases caused by the loss of dopaminergic neurons in the substantia nigra pars compacta. Although the etiology of PD is still unclear, the death of dopaminergic neurons during PD progression was revealed to be associated with abnormal aggregation of α-synuclein, elevation of oxidative stress, dysfunction of mitochondrial functions, and increased neuroinflammation. In this study, the effects of Licochalcone D (LCD) on MG132-induced neurotoxicity in primitive neural stem cells (pNSCs) derived from reprogrammed iPSCs were investigated. A cell viability assay showed that LCD had anti-apoptotic properties in MG132-induced oxidative-stressed pNSCs. It was confirmed that apoptosis was reduced in pNSCs treated with LCD through 7-AAD/Annexin Ⅴ staining and cleaved caspase3. These effects of LCD were mediated through an interaction with JunD and through the EGFR/AKT and JNK signaling pathways. These findings suggest that LCD could be a potential antioxidant reagent for preventing disease-related pathological phenotypes of PD.
Language	English
Publishing date	2023-01-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11010228
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Article ; Online: Construction of deep learning-based disease detection model in plants.

Jung, Minah / Song, Jong Seob / Shin, Ah-Young / Choi, Beomjo / Go, Sangjin / Kwon, Suk-Yoon / Park, Juhan / Park, Sung Goo / Kim, Yong-Min

Scientific reports

2023 Volume 13, Issue 1, Page(s) 7331

Abstract: Accurately detecting disease occurrences of crops in early stage is essential for quality and yield of crops through the decision of an appropriate treatments. However, detection of disease needs specialized knowledge and long-term experiences in plant ... ...

Abstract	Accurately detecting disease occurrences of crops in early stage is essential for quality and yield of crops through the decision of an appropriate treatments. However, detection of disease needs specialized knowledge and long-term experiences in plant pathology. Thus, an automated system for disease detecting in crops will play an important role in agriculture by constructing early detection system of disease. To develop this system, construction of a stepwise disease detection model using images of diseased-healthy plant pairs and a CNN algorithm consisting of five pre-trained models. The disease detection model consists of three step classification models, crop classification, disease detection, and disease classification. The 'unknown' is added into categories to generalize the model for wide application. In the validation test, the disease detection model classified crops and disease types with high accuracy (97.09%). The low accuracy of non-model crops was improved by adding these crops to the training dataset implicating expendability of the model. Our model has the potential to apply to smart farming of Solanaceae crops and will be widely used by adding more various crops as training dataset.
MeSH term(s)	Neural Networks, Computer ; Deep Learning ; Algorithms ; Crops, Agricultural ; Agriculture/methods
Language	English
Publishing date	2023-05-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-34549-2
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Article ; Online: Phosphorylation of REPS1 at Ser709 by RSK attenuates the recycling of transferrin receptor.

Kim, Seong Heon / Cho, Jin-Hwa / Park, Bi-Oh / Park, Byoung Chul / Kim, Jeong-Hoon / Park, Sung Goo / Kim, Sunhong

BMB reports

2021 Volume 54, Issue 5, Page(s) 272–277

Abstract: RalBP1 associated EPS domain containing 1 (REPS1) is conserved from Drosophila to humans and implicated in the endocytic system. However, an exact role of REPS1 remains largely unknown. Here, we demonstrated that mitogen activated protein kinase kinase ( ... ...

Abstract	RalBP1 associated EPS domain containing 1 (REPS1) is conserved from Drosophila to humans and implicated in the endocytic system. However, an exact role of REPS1 remains largely unknown. Here, we demonstrated that mitogen activated protein kinase kinase (MEK)-p90 ribosomal S6 Kinase (RSK) signaling pathway directly phosphorylated REPS1 at Ser709 upon stimulation by epidermal growth factor (EGF) and amino acid. While REPS2 is known to be involved in the endocytosis of EGF receptor (EGFR), REPS1 knockout (KO) cells did not show any defect in the endocytosis of EGFR. However, in the REPS1 KO cells and the KO cells reconstituted with a non-phosphorylatable REPS1 (REPS1 S709A), the recycling of transferrin receptor (TfR) was attenuated compared to the cells reconstituted with wild type REPS1. Collectively, we suggested that the phosphorylation of REPS1 at S709 by RSK may have a role of the trafficking of TfR. [BMB Reports 2021; 54(5): 272-277].
MeSH term(s)	Calcium-Binding Proteins/metabolism ; Cells, Cultured ; Humans ; Phosphorylation ; Receptors, Transferrin/metabolism ; Ribosomal Protein S6 Kinases, 90-kDa/metabolism ; Serine/metabolism
Chemical Substances	Calcium-Binding Proteins ; REPS1 protein, human ; Receptors, Transferrin ; Serine (452VLY9402) ; Ribosomal Protein S6 Kinases, 90-kDa (EC 2.7.11.1)
Language	English
Publishing date	2021-01-07
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2410389-5
ISSN	1976-670X ; 1976-6696
ISSN (online)	1976-670X
ISSN	1976-6696
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Zs.A 4202: Show issues

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Article ; Online: Sjögren Syndrome antigen B regulates LIN28-let-7 axis in Caenorhabditis elegans and human.

Kim, Seong Heon / Park, Bi-Oh / Kim, Kidae / Park, Byoung Chul / Park, Sung Goo / Kim, Jeong-Hoon / Kim, Sunhong

Biochimica et biophysica acta. Gene regulatory mechanisms

2021 Volume 1864, Issue 3, Page(s) 194684

Abstract: LIN28 protein and let-7 family micro RNAs (miRNAs) that are an evolutionarily conserved from nematodes to humans are the important regulators of developmental timing by dynamically interacting with each other. However, regulators of LIN28 remain largely ... ...

Abstract	LIN28 protein and let-7 family micro RNAs (miRNAs) that are an evolutionarily conserved from nematodes to humans are the important regulators of developmental timing by dynamically interacting with each other. However, regulators of LIN28 remain largely elusive. Here, we show the evidences that Sjögren Syndrome antigen B (SSB) protein associates and cooperates with LIN28A and LIN28B, mammalian orthologues of Caenorhabditis elegans lin-28, proteins in the nucleus. Knockdown of SSB in HEK293 cell line resulted in the decrease of the amount of LIN28B mRNAs and proteins, and the increase of the level of mature let-7 miRNAs. Furthermore, RNA interference of ssb-1 gene, a worm SSB orthologue, was sufficient to cause a heterochronic defect in seam cells of C. elegans, recapitulating the phenotype of lin-28 downregulation. Collectively, we suggest that SSB is an important regulator for the LIN28-let-7 axis.
MeSH term(s)	Animals ; Autoantigens/genetics ; Autoantigens/metabolism ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Ribonucleoproteins/genetics ; Ribonucleoproteins/metabolism ; Signal Transduction ; SS-B Antigen
Chemical Substances	Autoantigens ; Caenorhabditis elegans Proteins ; Lin28A protein, human ; MicroRNAs ; RNA-Binding Proteins ; Ribonucleoproteins ; let-7 microRNA, C elegans ; mirnlet7 microRNA, human
Language	English
Publishing date	2021-01-21
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2918786-2
ISSN	1876-4320 ; 1874-9399
ISSN (online)	1876-4320
ISSN	1874-9399
DOI	10.1016/j.bbagrm.2021.194684
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Article ; Online: Hypoxia stabilizes SETDB1 to maintain genome stability.

Park, Sungryul / Cho, Jin Hwa / Kim, Jong-Hwan / Park, Mijin / Park, Seulki / Kim, Seon-Young / Kim, Seon-Kyu / Kim, Kidae / Park, Sung Goo / Park, Byoung Chul / Moon, Jeong Hee / Lee, Gaseul / Kim, Sunhong / Kim, Jung-Ae / Kim, Jeong-Hoon

Nucleic acids research

2023 Volume 51, Issue 20, Page(s) 11178–11196

Abstract: Von Hippel-Lindau (VHL) is a tumor suppressor that functions as the substrate recognition subunit of the CRL2VHL E3 complex. While substrates of VHL have been identified, its tumor suppressive role remains to be fully understood. For further ... ...

Abstract	Von Hippel-Lindau (VHL) is a tumor suppressor that functions as the substrate recognition subunit of the CRL2VHL E3 complex. While substrates of VHL have been identified, its tumor suppressive role remains to be fully understood. For further determination of VHL substrates, we analyzed the physical interactome of VHL and identified the histone H3K9 methyltransferase SETBD1 as a novel target. SETDB1 undergoes oxygen-dependent hydroxylation by prolyl hydroxylase domain proteins and the CRL2VHL complex recognizes hydroxylated SETDB1 for ubiquitin-mediated degradation. Under hypoxic conditions, SETDB1 accumulates by escaping CRL2VHL activity. Loss of SETDB1 in hypoxia compared with that in normoxia escalates the production of transposable element-derived double-stranded RNAs, thereby hyperactivating the immune-inflammatory response. In addition, strong derepression of TEs in hypoxic cells lacking SETDB1 triggers DNA damage-induced death. Our collective results support a molecular mechanism of oxygen-dependent SETDB1 degradation by the CRL2VHL E3 complex and reveal a role of SETDB1 in genome stability under hypoxia.
MeSH term(s)	Humans ; Genes, Tumor Suppressor ; Genomic Instability ; Histone-Lysine N-Methyltransferase/metabolism ; Hypoxia/genetics ; Hypoxia/metabolism ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Oxygen/metabolism ; Ubiquitin-Protein Ligases/genetics ; Von Hippel-Lindau Tumor Suppressor Protein/genetics ; Von Hippel-Lindau Tumor Suppressor Protein/metabolism
Chemical Substances	Histone-Lysine N-Methyltransferase (EC 2.1.1.43) ; Hypoxia-Inducible Factor 1, alpha Subunit ; Oxygen (S88TT14065) ; SETDB1 protein, human (EC 2.1.1.43) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Von Hippel-Lindau Tumor Suppressor Protein (EC 2.3.2.27)
Language	English
Publishing date	2023-10-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkad796
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