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  1. Article ; Online: Extraction of Individual Spectra from Mixture Data Based on High-Resolution

    Cha, Jin Wook / Park, Sunghyouk

    Analytical chemistry

    2020  Volume 92, Issue 10, Page(s) 7037–7044

    Abstract: In NMR analysis of complex organic molecules, low natural abundance ... ...

    Abstract In NMR analysis of complex organic molecules, low natural abundance of
    Language English
    Publishing date 2020-05-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.0c00277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4033: Show issues Location:
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  2. Article: Extraction of Individual Spectra from Mixture Data Based on High-Resolution ¹³C–¹³C NMR Correlation Spectrum and DECODE Procedure

    Cha, Jin Wook / Park, Sunghyouk

    Analytical chemistry. 2020 May 08, v. 92, no. 10

    2020  

    Abstract: In NMR analysis of complex organic molecules, low natural abundance of ¹³C and the low resolution of two-dimensional (2D) experiments are significant difficulties. Also challenging is the analysis of a mixture spectrum without separation, which has been ... ...

    Abstract In NMR analysis of complex organic molecules, low natural abundance of ¹³C and the low resolution of two-dimensional (2D) experiments are significant difficulties. Also challenging is the analysis of a mixture spectrum without separation, which has been limited to simple molecules. Through nonuniform sampling using modified heteronuclear multiple bond correlation combined with indirect covariance, a high-resolution ¹³C–¹³C correlation spectrum was obtained with ¹H sensitivity. Built on the thus-obtained ¹³C–¹³C connectivities, deconvolution of the mixture spectra was achieved through a new signal-processing procedure, termed DECODE, tailored to the indirect covariance eigendecomposition. When applied to a complex natural product mixture of rotenone and brucine with many quaternary carbons, the method resolved very close carbon peaks and extracted clean individual spectra. Essentially providing molecule-wide ¹³C connectivities for complex molecules from ¹H-detected 2D spectra, our approach should prove useful in many areas of NMR analysis.
    Keywords analytical chemistry ; carbon ; covariance ; rotenone
    Language English
    Dates of publication 2020-0508
    Size p. 7037-7044.
    Publishing place American Chemical Society
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.0c00277
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    In stock of ZB MED Bonn / Germany

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  3. Article ; Online: SCD and MTHFD2 inhibitors for high-risk acute myeloid leukaemia patients, as suggested by ELN2017-pathway association.

    Kim, Han Sun / Kim, Doyeon / Kim, Jiwoo / Park, Sunghyouk / de Guzman, Arvie Camille V

    Clinical and translational medicine

    2023  Volume 13, Issue 7, Page(s) e1311

    MeSH term(s) Humans ; Leukemia, Myeloid, Acute/drug therapy
    Language English
    Publishing date 2023-07-26
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.1311
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  4. Article: Research on Isodon species: still going strong.

    Park, Sunghyouk

    Archives of pharmacal research

    2011  Volume 34, Issue 12, Page(s) 1999–2001

    Abstract: Isodon species have been much studied for their biologically active ingredients, and Sun and co-workers report the isolation, characterization, and biological activities of twenty three compounds, including three new ones. The new compounds from Isodon ... ...

    Abstract Isodon species have been much studied for their biologically active ingredients, and Sun and co-workers report the isolation, characterization, and biological activities of twenty three compounds, including three new ones. The new compounds from Isodon coetsa are neolignan, triterpenoid, and diterpenoid types, showing that Isodon species have diverse types of compounds, in addition to the much-explored kaurane type diterpenoids. They determined the chemical structures based on extensive spectroscopic analyses and comparison with related compounds. Their report is expected to be yet another stepping stone for more exciting compounds from Isodon species.
    MeSH term(s) Antineoplastic Agents, Phytogenic/pharmacology ; Humans ; Isodon/chemistry ; Plant Components, Aerial/chemistry ; Plant Extracts/pharmacology
    Chemical Substances Antineoplastic Agents, Phytogenic ; Plant Extracts
    Language English
    Publishing date 2011-12
    Publishing country Korea (South)
    Document type Comment ; Journal Article
    ZDB-ID 447623-2
    ISSN 1976-3786 ; 0253-6269
    ISSN (online) 1976-3786
    ISSN 0253-6269
    DOI 10.1007/s12272-011-1200-2
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3229: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Metformin Decreases 2-HG Production through the MYC-PHGDH Pathway in Suppressing Breast Cancer Cell Proliferation.

    Oh, Sehyun / Cho, Youngup / Chang, Minsun / Park, Sunghyouk / Kwon, Hyuknam

    Metabolites

    2021  Volume 11, Issue 8

    Abstract: The biguanide drug metformin has been widely used for the treatment of type 2 diabetes, and there is evidence supporting the anticancer effect of metformin despite some controversy. Here, we report the growth inhibitory activity of metformin in the ... ...

    Abstract The biguanide drug metformin has been widely used for the treatment of type 2 diabetes, and there is evidence supporting the anticancer effect of metformin despite some controversy. Here, we report the growth inhibitory activity of metformin in the breast cancer (MCF-7) cells, both in vitro and in vivo, and the associated metabolic changes. In particular, a decrease in a well-known oncometabolite 2-hydroxyglutarate (2-HG) was discovered by a metabolomics approach. The decrease in 2-HG by metformin was accompanied by the reduction in histone methylation, consistent with the known tumorigenic mechanism of 2-HG. The relevance of 2-HG inhibition in breast cancer was also supported by a higher level of 2-HG in human breast cancer tissues. Genetic knockdown of PHGDH identified the PHGDH pathway as the producer of 2-HG in the MCF-7 cells that do not carry isocitrate dehydrogenase 1 and 2 (IDH1/IDH2) mutations, the conventional producer of 2-HG. We also showed that metformin's inhibitory effect on the PHGDH-2HG axis may occur through the regulation of the AMPK-MYC pathway. Overall, our results provide an explanation for the coherent pathway from complex I inhibition to epigenetic changes for metformin's anticancer effect.
    Language English
    Publishing date 2021-07-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo11080480
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  6. Article ; Online: Differential Background Music as Attentional Resources Interacting with Cognitive Control.

    Yoo, Ga Eul / Lee, Sujin / Kim, Aimee Jeehae / Choi, Seung Hong / Chong, Hyun Ju / Park, Sunghyouk

    International journal of environmental research and public health

    2022  Volume 19, Issue 22

    Abstract: We examined the effects of background music on cognitive task performances using different musical arrangements from an excerpt of Mozart's Piano Sonata K.448. The participants were 126 university students: 70 music majors and 56 nonmusic majors. Three ... ...

    Abstract We examined the effects of background music on cognitive task performances using different musical arrangements from an excerpt of Mozart's Piano Sonata K.448. The participants were 126 university students: 70 music majors and 56 nonmusic majors. Three types of musical arrangements were used as background conditions: rhythm-only, melody, and original music conditions. Participants were asked to perform cognitive tasks in the presence of each music condition. The participants' percentage of completed items and accuracy on these tasks were compared for music and nonmusic majors, controlling for the effect of perceived level of arousal and their performance during no background music. Whether a participant's perceptions of background music predicted their cognitive performance was also analyzed. We found that music majors demonstrated decreased task performance for the original background condition, while nonmusic majors demonstrated no significant differences in performance across the arrangements. When pitch or rhythm information was modified, emotional valence and arousal were perceived differently. Perception of the complexity of the background music depending on the arrangement type differed between music majors and nonmusic majors. While the perceived complexity significantly predicted nonmusic majors' cognitive performance, its predictive effect was not found in music majors. The findings imply that perceptions of musical arrangements in terms of expectancy and complexity can be critical factors in determining how arrangements affect concurrent cognitive activity, while suggesting that music itself is not a facilitating or detrimental factor for cognitive performance.
    MeSH term(s) Humans ; Music/psychology ; Attention ; Task Performance and Analysis ; Arousal ; Cognition
    Language English
    Publishing date 2022-11-16
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph192215094
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  7. Article ; Online: Non-bioenergetic roles of mitochondrial GPD2 promote tumor progression.

    Oh, Sehyun / Jo, Sihyang / Bajzikova, Martina / Kim, Han Sun / Dao, Thien T P / Rohlena, Jakub / Kim, Jin-Mo / Neuzil, Jiri / Park, Sunghyouk

    Theranostics

    2023  Volume 13, Issue 2, Page(s) 438–457

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Energy Metabolism ; Ethers/metabolism ; Glycerolphosphate Dehydrogenase/genetics ; Glycerolphosphate Dehydrogenase/metabolism ; Mitochondria/enzymology ; Proto-Oncogene Proteins c-akt/metabolism ; Animals ; Mice ; Neoplasms/enzymology ; Neoplasms/pathology ; Humans
    Chemical Substances Ethers ; Glycerolphosphate Dehydrogenase (EC 1.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2023-01-01
    Publishing country Australia
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592097-2
    ISSN 1838-7640 ; 1838-7640
    ISSN (online) 1838-7640
    ISSN 1838-7640
    DOI 10.7150/thno.75973
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Evaluation of Bacterial and Fungal Biomarkers for Differentiation and Prognosis of Patients with Inflammatory Bowel Disease.

    Yoon, Hyuk / Park, Sunghyouk / Jun, Yu Kyung / Choi, Yonghoon / Shin, Cheol Min / Park, Young Soo / Kim, Nayoung / Lee, Dong Ho

    Microorganisms

    2023  Volume 11, Issue 12

    Abstract: This study aimed to evaluate bacterial and fungal biomarkers to differentiate patients with inflammatory bowel disease (IBD), predict the IBD prognosis, and determine the relationship of these biomarkers with IBD pathogenesis. The composition and ... ...

    Abstract This study aimed to evaluate bacterial and fungal biomarkers to differentiate patients with inflammatory bowel disease (IBD), predict the IBD prognosis, and determine the relationship of these biomarkers with IBD pathogenesis. The composition and function of bacteria and fungi in stool from 100 IBD patients and 97 controls were profiled using next-generation sequencing. We evaluated the cumulative risk of relapse according to bacterial and fungal enterotypes. The microbiome and mycobiome alpha diversity in IBD patients were significantly lower and higher than in the controls, respectively; the micro/mycobiome beta diversity differed significantly between IBD patients and the controls.
    Language English
    Publishing date 2023-11-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11122882
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  9. Article ; Online: Metabolomic profiling of overnight peritoneal dialysis effluents predicts the peritoneal equilibration test type.

    Kim, Hyo Jin / Choo, Munki / Kwon, Hyuk Nam / Yoo, Kyung Don / Kim, Yunmi / Tsogbadrakh, Bodokhsuren / Kang, Eunjeong / Park, Sunghyouk / Oh, Kook-Hwan

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 3803

    Abstract: This study primarily aimed to evaluate whether peritoneal equilibration test (PET) results can be predicted through the metabolomic analysis of overnight peritoneal dialysis (PD) effluents. From a total of 125 patients, overnight PD effluents on the day ... ...

    Abstract This study primarily aimed to evaluate whether peritoneal equilibration test (PET) results can be predicted through the metabolomic analysis of overnight peritoneal dialysis (PD) effluents. From a total of 125 patients, overnight PD effluents on the day of the first PET after PD initiation were analyzed. A modified 4.25% dextrose PET was performed, and the PET type was categorized according to the dialysate-to-plasma creatinine ratio at the 4-h dwell time during the PET as follows: high, high average, low average, or low transporter. Nuclear magnetic resonance (NMR)-based metabolomics was used to analyze the effluents and identify the metabolites. The predictive performances derived from the orthogonal projection to latent structure discriminant analysis (OPLS-DA) modeling of the NMR spectrum were estimated by calculating the area under the curve (AUC) using receiver operating characteristic curve analysis. The OPLS-DA score plot indicated significant metabolite differences between high and low PET types. The relative concentrations of alanine and creatinine were greater in the high transporter type than in the low transporter type. The relative concentrations of glucose and lactate were greater in the low transporter type than in the high transporter type. The AUC of a composite of four metabolites was 0.975 in distinguish between high and low PET types. Measured PET results correlated well with the total NMR metabolic profile of overnight PD effluents.
    MeSH term(s) Humans ; Creatinine ; Metabolomics ; Peritoneal Dialysis ; Dialysis Solutions ; Lactic Acid ; Membrane Transport Proteins
    Chemical Substances Creatinine (AYI8EX34EU) ; Dialysis Solutions ; Lactic Acid (33X04XA5AT) ; Membrane Transport Proteins
    Language English
    Publishing date 2023-03-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-29741-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Acetyl-CoA synthetase 2 contributes to a better prognosis for liver cancer by switching acetate-glucose metabolism.

    Jung, Kyung Hee / Lee, Sujin / Kim, Han Sun / Kim, Jin-Mo / Lee, Yun Ji / Park, Min Seok / Seo, Myeong-Seong / Lee, Misu / Yun, Mijin / Park, Sunghyouk / Hong, Soon-Sun

    Experimental & molecular medicine

    2024  Volume 56, Issue 3, Page(s) 721–733

    Abstract: Acetyl-CoA synthetase 2 (ACSS2)-dependent acetate usage has generally been associated with tumorigenesis and increased malignancy in cancers under nutrient-depleted conditions. However, the nutrient usage and metabolic characteristics of the liver differ ...

    Abstract Acetyl-CoA synthetase 2 (ACSS2)-dependent acetate usage has generally been associated with tumorigenesis and increased malignancy in cancers under nutrient-depleted conditions. However, the nutrient usage and metabolic characteristics of the liver differ from those of other organs; therefore, the mechanism of ACSS2-mediated acetate metabolism may also differ in liver cancer. To elucidate the underlying mechanisms of ACSS2 in liver cancer and acetate metabolism, the relationships between patient acetate uptake and metabolic characteristics and between ACSS2 and tumor malignancies were comprehensively studied in vitro, in vivo and in humans. Clinically, we initially found that ACSS2 expression was decreased in liver cancer patients. Moreover, PET-CT imaging confirmed that lower-grade cancer cells take up more
    MeSH term(s) Humans ; Acetyl Coenzyme A/metabolism ; Glucose/metabolism ; Positron Emission Tomography Computed Tomography ; Cell Line, Tumor ; Acetates ; Liver Neoplasms ; Ligases
    Chemical Substances Acetyl Coenzyme A (72-89-9) ; Glucose (IY9XDZ35W2) ; Acetates ; Ligases (EC 6.-)
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1328915-9
    ISSN 2092-6413 ; 1226-3613 ; 0378-8512
    ISSN (online) 2092-6413
    ISSN 1226-3613 ; 0378-8512
    DOI 10.1038/s12276-024-01185-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4775: Show issues Location:
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