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  1. Book ; Thesis: Genetische Determinanten in Telomer-Regulationsgenen bei Patientinnen mit Mammakarzinom

    Klampke, Sina / Park-Simon, Tjoung-Won

    2020  

    Institution Medizinische Hochschule Hannover
    Klinik für Frauenheilkunde und Geburtshilfe
    Author's details vorgelegt von Sina Klampke ; aus der Klinik für Frauenheilkunde und Geburtshilfe der Medizinischen Hochschule Hannover ; Betreuerin der Arbeit: Prof.in Dr. med. Tjoung-Won Park-Simon
    Language German
    Size 122 Blätter, Illustrationen, Diagramme
    Publishing place Hannover
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Medizinische Hochschule Hannover, 2022
    HBZ-ID HT030635143
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2024 E 193 order for loan Magazin

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  2. Book ; Thesis: Klinischer Verlauf des zerebral metastasierten Mammakarzinoms in Abhängigkeit der Tumorbiologie

    Öhrlich, Nadja Ella / Park-Simon, Tjoung-Won

    2018  

    Institution Medizinische Hochschule Hannover
    Klinik für Frauenheilkunde und Geburtshilfe
    Author's details vorgelegt von Nadja Ella Öhrlich ; aus der Klinik für Frauenheilkunde und Geburtshilfe der Medizinischen Hochschule Hannover ; wissenschaftliche Betreuung: Prof.'in Dr. med. Tjoung-Won Park-Simon
    Language German ; English
    Size 45 Blätter, Diagramme, 30 cm
    Publishing place Hannover
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Medizinische Hochschule Hannover, 2019
    Note Enthält 1 Sonderabdruck aus: Oncology Letters ; 14.2017. Seite 194-200
    HBZ-ID HT020190016
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2019 E 1025 order for loan Magazin

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  3. Book ; Thesis: The benefit of baseline staging

    Rios, Nelmin Neptali / Park-Simon, Tjoung-Won

    risk assessment of distant breast cancer metastases by tumor stage

    2016  

    Institution Medizinische Hochschule Hannover
    Klinik für Frauenheilkunde und Geburtshilfe
    Author's details vorgelegt von Dr. med. UNAH (HN) Nelmin Rios
    Language German ; English
    Size 35 Blätter, Diagramme, 30 cm
    Publishing place Hannover
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Medizinische Hochschule Hannover, 2017
    Note Deutscher Text, Sonderabdruck in Englisch ; Enthält 1 Sonderabdruck aus: Anticancer research ; 36.2016. Seite 4909-4914
    HBZ-ID HT019725233
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2018 E 749 order for loan Magazin

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  4. Article ; Online: Was ist gesichert in der Prävention, Diagnostik und Therapie des frühen Mammakarzinoms?

    Kuehnle, Elna / Röttger, Marlene / Park-Simon, Tjoung-Won

    Innere Medizin (Heidelberg, Germany)

    2023  Volume 64, Issue 12, Page(s) 1154–1161

    Abstract: With more than 2.3 million newly diagnosed cases worldwide in 2020, breast cancer is still the most frequent cancer in women and despite improved diagnostics and treatment the most frequent cause of death from cancer. Continuous scientific developments ... ...

    Title translation What is confirmed in the prevention, diagnostics and treatment of early breast cancer?
    Abstract With more than 2.3 million newly diagnosed cases worldwide in 2020, breast cancer is still the most frequent cancer in women and despite improved diagnostics and treatment the most frequent cause of death from cancer. Continuous scientific developments in the areas of prevention, the application of modern diagnostic procedures and treatment options for early breast cancer, have led to an improvement in the 5‑year probability of survival. The treatment of early breast cancer is based on a combination of a locoregional and a systemic treatment approach. Depending on the tumor stage and the histological subtype the application of neoadjuvant chemotherapy with or without antibodies or immunotherapy is necessary. This article gives an overview of the current standard in the diagnostics and treatment of early breast cancer, without giving an in-depth elucidation of the differentiated subtype-specific systemic treatment. For this, reference should be made to the relevant literature.
    MeSH term(s) Female ; Humans ; Breast Neoplasms/diagnosis ; Neoadjuvant Therapy ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Chemotherapy, Adjuvant
    Language German
    Publishing date 2023-10-30
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ISSN 2731-7099
    ISSN (online) 2731-7099
    DOI 10.1007/s00108-023-01619-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Recommendations Related to Genetic Testing for Breast Cancer.

    Dörk, Thilo / Park-Simon, Tjoung-Won / Hillemanns, Peter

    JAMA

    2020  Volume 323, Issue 2, Page(s) 188

    MeSH term(s) Breast Neoplasms/genetics ; Genes, BRCA1 ; Genetic Counseling ; Genetic Testing ; Humans ; Risk Assessment
    Language English
    Publishing date 2020-01-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2019.18214
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.88: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: The Safety and Efficacy of the Combination of Sacituzumab Govitecan and Palliative Radiotherapy-A Retrospective Multi-Center Cohort Study.

    Krug, David / Tio, Joke / Abaci, Ali / Beurer, Björn / Brügge, Sandra / Elsayad, Khaled / Meixner, Eva / Park-Simon, Tjoung-Won / Smetanay, Katharina / Winkelmann, Franziska / Wittig, Andrea / Wöckel, Achim

    Cancers

    2024  Volume 16, Issue 9

    Abstract: Sacituzumab govitecan (SG) is a new treatment option for patients with metastatic triple-negative and hormone receptor-positive, HER2-negative breast cancer. This antibody-drug conjugate is currently approved as monotherapy. Palliative radiotherapy is ... ...

    Abstract Sacituzumab govitecan (SG) is a new treatment option for patients with metastatic triple-negative and hormone receptor-positive, HER2-negative breast cancer. This antibody-drug conjugate is currently approved as monotherapy. Palliative radiotherapy is frequently used to treat symptomatic metastases locally. Concurrent use of SG and irradiation was excluded in clinical trials of SG, and there are currently limited published data. We report here a systematic review, as well as a retrospective multi-center study of 17 patients with triple-negative breast cancer who received concurrent SG and radiotherapy. In these patients, concurrent use was found to be efficient, safe and well tolerated. There were no apparent differences in moderate or severe acute toxicity according to the timing of SG administration.
    Language English
    Publishing date 2024-04-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16091649
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Exome sequencing identifies RASSF1 and KLK3 germline variants in an Iranian multiple-case breast cancer family.

    Radmanesh, Hoda / Liu, Di / Geffers, Robert / Shandiz, Fatemeh Homaei / Sadr-Nabavi, Ariane / Hillemanns, Peter / Park-Simon, Tjoung-Won / Dörk, Thilo

    European journal of medical genetics

    2022  Volume 65, Issue 3, Page(s) 104425

    Abstract: Breast cancer is the most frequent malignancy among women in both developed and developing countries. Although several genes have been identified to harbor germline variants contributing to breast cancer risk, much of the heritability for breast cancer ... ...

    Abstract Breast cancer is the most frequent malignancy among women in both developed and developing countries. Although several genes have been identified to harbor germline variants contributing to breast cancer risk, much of the heritability for breast cancer is yet undefined. In the present study, we have performed exome sequencing to detect susceptibility genes in an Iranian family with five first-degree family members affected with breast cancer. We identified novel candidate variants with predicted pathogenicity in RASSF1, KLK3 and FAM81B. The RASSF1 and KLK3 variants, but not the FAM81B variant, partially co-segregated with disease in the investigated pedigree and were not found in additional screenings outside the specific family. RASSF1 p.S135F is a missense substitution abolishing the ATM phosphorylation site, and KLK3 variant p.M1? is a deletion at the initiation codon that is predicted to abolish translation to the functional kallikrein protease, PSA. Our study suggests germline variation in RASSF1 and KLK3 as potential candidate contributors to familial breast cancer predisposition and illustrates the difficulties to determine the causal genetic risk factor among novel variants restricted to a single family.
    MeSH term(s) Breast Neoplasms/genetics ; Exome ; Female ; Genetic Predisposition to Disease ; Germ Cells ; Humans ; Iran ; Kallikreins ; Pedigree ; Prostate-Specific Antigen ; Tumor Suppressor Proteins/genetics
    Chemical Substances RASSF1 protein, human ; Tumor Suppressor Proteins ; KLK3 protein, human (EC 3.4.21.-) ; Kallikreins (EC 3.4.21.-) ; Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2022-01-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2184135-4
    ISSN 1878-0849 ; 1769-7212
    ISSN (online) 1878-0849
    ISSN 1769-7212
    DOI 10.1016/j.ejmg.2022.104425
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 84/9: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Book ; Online ; Thesis: Identification of novel breast cancer susceptibility genes and first steps towards mutation-specific cell culture models

    Radmanesh, Hoda [Verfasser] / Park-Simon, Tjoung-Won [Akademischer Betreuer] / Illig, Thomas [Akademischer Betreuer]

    2020  

    Author's details Hoda Radmanesh ; Akademische Betreuer: Tjoung-Won Park-Simon, Thomas Illig ; Klinik für Frauenheilkunde und Geburtshilfe
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Bibliothek der Medizinischen Hochschule Hannover
    Publishing place Hannover
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  9. Article: Chronic unilateral arm lymphedema correlates with increased intima-media thickness in the brachial artery.

    Klüsch, Victoria / Boyle, Erin C / Rustum, Saad / Franz, Maximilian / Park-Simon, Tjoung-Won / Haverich, Axel / Bara, Christoph

    VASA. Zeitschrift fur Gefasskrankheiten

    2021  Volume 51, Issue 1, Page(s) 19–23

    Abstract: Drainage of the arterial wall via adventitial lymphatic vessels has been shown to play a pivotal role for vessel wall homeostasis. Also, retrograde cholesterol transport is ensured via this route, but no studies exist to demonstrate that lymphatic stasis ...

    Abstract Drainage of the arterial wall via adventitial lymphatic vessels has been shown to play a pivotal role for vessel wall homeostasis. Also, retrograde cholesterol transport is ensured via this route, but no studies exist to demonstrate that lymphatic stasis would represent a mechanism to initiate atherosclerotic lesion formation in human arteries. To test this hypothesis, we embarked on a simple clinical experiment, assessing wall thickness in limb arteries with lymphedema after surgical intervention, with the contralateral limb serving as control. Using ultrasound imaging, the differential thickness was assessed separately for the three arterial wall layers. The potential of disease progression by lymphostasis was addressed by depiction of longitudinal results according to the time after lymph dissection.
    MeSH term(s) Arm ; Brachial Artery ; Carotid Intima-Media Thickness ; Humans ; Lymphedema/diagnostic imaging ; Ultrasonography
    Language English
    Publishing date 2021-12-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 120977-2
    ISSN 1664-2872 ; 0301-1526
    ISSN (online) 1664-2872
    ISSN 0301-1526
    DOI 10.1024/0301-1526/a000982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 808: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Book ; Online ; Thesis: Prognose und Prädiktion bei nodalpositivem Mammakarzinom am Brustzentrum des Universitätsklinikums Halle an der Saale

    Spinda, Anne-Katrin [Verfasser] / Thomssen, Christoph [Gutachter] / Wickenhauser, Claudia Gutachter] / [Park-Simon, Tjoung-Won [Gutachter]

    2021  

    Author's details Anne-Katrin Spinda ; Gutachter: Christoph Thomssen, Claudia Wickenhauser, Tjoung-Won Park-Simon
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Landesbibliothek Sachsen-Anhalt
    Publishing place Halle (Saale)
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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