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  1. Book: The role of the Utah Artificial Ear Project in the development of the modern cochlear implant

    Dorman, Michael F. / Parkin, James L.

    (Cochlear implants internatioinal ; 16, Suppl. 2)

    2015  

    Author's details Michael F. Dorman ; James L. Parkin
    Series title Cochlear implants internatioinal ; 16, Suppl. 2
    Cochlear implants international
    Collection Cochlear implants international
    Language English
    Size S11 S. : Ill.
    Publisher Maney
    Publishing place London
    Publishing country United States
    Document type Book
    HBZ-ID HT018675577
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7034 -16,Suppl.2- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Oral and maxillofacial injuries associated with e-scooter use at Broomfield Hospital: a cohort study of 24 months of data since e-scooter legalisation in the UK.

    Jones, Kate / Parkin, James / Rathod, Neelam / Bhatt, Vyomesh

    British dental journal

    2023  

    Abstract: Introduction Rental electronic scooters (e-scooters) were legalised in July 2020 in the UK for use on public roads. This has led to higher numbers of emergency department (ED) attendances for head and neck injuries managed by the oral and maxillofacial ... ...

    Abstract Introduction Rental electronic scooters (e-scooters) were legalised in July 2020 in the UK for use on public roads. This has led to higher numbers of emergency department (ED) attendances for head and neck injuries managed by the oral and maxillofacial surgical (OMFS) department.Aim The aim of this research is to assess the increase in e-scooter injuries requiring OMFS input and analyse factors and management associated.Method Data were collected over a 24-month period. A total of 212 e-scooter-related ED presentations were recorded, with 34 patients requiring input from the OMFS department. For the patients referred to OMFS, numerical and categorical factors used independent T-tests and one-way Analysis of Variance tests, respectively, to determine statistical significance at the 5% confidence level (p <0.05).Results The mean age was 32.8 years (SD = 15.9) in a predominately male cohort (79.4%). Alcohol intoxication was observed in 55.8% of accidents. Injuries were most common on Saturdays (41.2%). Soft tissue injuries were present in 64.7% of patients, bony injuries in 38.2% of patients and dental injuries in 11.8% of patients. Imaging was required for 76.5% of patients. In total, 44% of patients required surgical treatment, 5.9% required major surgery and 38.2% required minor surgery.Conclusion This research supports the literature suggesting significant growth in e-scooter-related injuries and their associated burden of conditions managed by the OMFS department.
    Language English
    Publishing date 2023-02-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/s41415-023-5506-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ul III Zs.143: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 447: Show issues

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  3. Article ; Conference proceedings: From DICOM to Reality: Modular and Reproducible 3D Printing for Endovascular Simulations

    Mohamud, Abdullahi / Saada, Louis / Parkin, James

    The Arab Journal of Interventional Radiology

    2024  Volume 08, Issue S 01

    Event/congress PAIRS 2024 Annual Congress, World Trade Center, Dubai, UAE, 2024-02-10
    Language English
    Publishing date 2024-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ISSN 2542-7083 ; 2542-7075
    ISSN (online) 2542-7083
    ISSN 2542-7075
    DOI 10.1055/s-0044-1785839
    Database Thieme publisher's database

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  4. Article: A Gender-Bias-Mitigated, Data-Driven Precision Medicine System to Assist in the Selection of Biological Treatments of Grade 3 and 4 Knee Osteoarthritis: Development and Preliminary Validation of precisionKNEE.

    Heidari, Nima / Olgiati, Stefano / Meloni, Davide / Parkin, James / Fish, Brady / Slevin, Mark / Azamfirei, Leonard

    Cureus

    2024  Volume 16, Issue 3, Page(s) e55832

    Abstract: Objective To identify key variables predictive of patient responses to microfragmented adipose tissue (MFAT) treatment in knee osteoarthritis (KOA) and evaluate its potential to delay or mitigate the need for total knee replacement (TKR). Methods We ... ...

    Abstract Objective To identify key variables predictive of patient responses to microfragmented adipose tissue (MFAT) treatment in knee osteoarthritis (KOA) and evaluate its potential to delay or mitigate the need for total knee replacement (TKR). Methods We utilised a dataset comprising 329 patients treated with MFAT for KOA, incorporating variables such as gender, age, BMI, arthritic aetiology, radiological grade, and Oxford Knee Scores (OKS) pre- and post-treatment. We employed random forest regressors for model training and testing, with gender bias mitigation and outlier detection to enhance prediction accuracy. Model performance was assessed through root mean squared error (RMSE) and mean absolute error (MAE), with further validation in a TKR-suitable patient subset. Results The model achieved a test RMSE of 6.72 and an MAE of 5.38, reflecting moderate predictive accuracy across the patient cohort. Stratification by gender revealed no statistically significant differences between actual and predicted OKS improvements (p-values: males = 0.93, females = 0.92). For the subset of patients suitable for TKR, the model presented an increased RMSE of 9.77 and MAE of 7.81, indicating reduced accuracy in this group. The decision tree analysis identified pre-operative OKS, radiological grade, and gender as significant predictors of post-treatment outcomes, with pre-operative OKS being the most critical determinant. Patients with lower pre-operative OKS showed varying responses based on radiological severity and gender, suggesting a nuanced interaction between these factors in determining treatment efficacy. Conclusion This study highlights the potential of MFAT as a non-surgical alternative for KOA treatment, emphasising the importance of personalised patient assessments. While promising, the predictive model warrants further refinement and validation with a larger, more diverse dataset to improve its utility in clinical decision-making for KOA management.
    Language English
    Publishing date 2024-03-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.55832
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: Lasers in otolaryngology

    Parkin, James L.

    (The otolaryngologic clinics of North America ; 23,1)

    1990  

    Author's details James L. Parkin, guest ed
    Series title The otolaryngologic clinics of North America ; 23,1
    Otolaryngologic clinics of North America
    Collection Otolaryngologic clinics of North America
    Keywords Otorhinolaryngologic Diseases / surgery ; Laser Surgery
    Size XI, 174 S. : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT003567791
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs B 183 -23,1- verfügbar in Königswinter Königswinter

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  6. Article: ERS International Congress 2022: highlights from the Epidemiology and Environment Assembly.

    Parkin, James G H / Delgado-Ortiz, Laura / Delvert, Rosalie / Ghosh, Manosij / Korkontzelou, Aliki / Patil, Sarang / Savouré, Marine / Jankowski, Mateusz / Dumas, Orianne

    ERJ open research

    2023  Volume 9, Issue 2

    Abstract: In this article, early career members of the Epidemiology and Environment Assembly of the European Respiratory Society summarise a selection of five sessions from the Society's 2022 International Congress, with a focus on areas of specific interest for ... ...

    Abstract In this article, early career members of the Epidemiology and Environment Assembly of the European Respiratory Society summarise a selection of five sessions from the Society's 2022 International Congress, with a focus on areas of specific interest for the Assembly,
    Language English
    Publishing date 2023-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00574-2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Experience of being chair and co-chair of the ECMC and reasons why you should be the NEXT.

    Parkin, James / Devulder, Justine / Vijverberg, Susanne J H / Ubags, Niki / Patout, Maxime / Cuevas Ocaña, Sara / Gille, Thomas / Cruz, Joana

    Breathe (Sheffield, England)

    2023  Volume 19, Issue 2, Page(s) 230089

    Abstract: This article provides testimonials of the past and current chairs and co-chairs of the ECMC (@EarlyCareerERS) and a glimpse of the NEXT programme, along with participants' experiences. ...

    Abstract This article provides testimonials of the past and current chairs and co-chairs of the ECMC (@EarlyCareerERS) and a glimpse of the NEXT programme, along with participants' experiences.
    Language English
    Publishing date 2023-06-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2562899-9
    ISSN 2073-4735 ; 1810-6838
    ISSN (online) 2073-4735
    ISSN 1810-6838
    DOI 10.1183/20734735.0089-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The role of the Utah Artificial Ear project in the development of the modern cochlear implant.

    Dorman, Michael F / Parkin, James L

    Cochlear implants international

    2015  Volume 16 Suppl 2, Page(s) S1–S11

    Abstract: The cochlear implant has provided the first substantial restoration of a human sense by a medical intervention. This accomplishment was brought about by the efforts, over a 50+ year period, of many individuals in laboratories around the world. In this ... ...

    Abstract The cochlear implant has provided the first substantial restoration of a human sense by a medical intervention. This accomplishment was brought about by the efforts, over a 50+ year period, of many individuals in laboratories around the world. In this paper, we recount the history of one of the early projects - the Utah Artificial Ear project. In 1970 researchers at the University of Utah began work on an auditory prosthesis. A critical early decision was to create a 'transparent' link between external signal processing and the electrodes implanted in the cochlea, i.e., a percutaneous pedestal. The pedestal allowed D. Eddington, then a graduate student, to conduct, in 1975-1978, the first thorough, parametric, psychophysical studies of electrical stimulation of the cochlea in multiple human volunteers. The early work by Eddington and colleagues evolved in 1983 into the 4-channel, Ineraid cochlear implant. Many years later, highly effective, modern signal processing algorithms, e.g., continuous interleaved sampling (CIS), fine structure processing (FSP), and virtual channel processing, were first tested and developed with the aid of Ineraid patients fit with pedestals of the Utah design. Because for many years the Ineraid provided as high a level of speech understanding as that provided by other devices and because the percutaneous pedestal allowed the first testing of many modern signal processing algorithms, the Utah Artificial Ear project may be viewed as one of the most valuable research projects in the history of cochlear implants.
    MeSH term(s) Cochlear Implantation/history ; Cochlear Implantation/instrumentation ; Cochlear Implants/history ; Correction of Hearing Impairment/history ; Correction of Hearing Impairment/instrumentation ; Deafness/rehabilitation ; Electric Stimulation/instrumentation ; History, 20th Century ; History, 21st Century ; Humans ; Signal Processing, Computer-Assisted/instrumentation ; Speech Perception ; Utah
    Language English
    Publishing date 2015-05
    Publishing country England
    Document type Historical Article ; Journal Article
    ZDB-ID 2079515-4
    ISSN 1754-7628 ; 1467-0100
    ISSN (online) 1754-7628
    ISSN 1467-0100
    DOI 10.1179/1467010015Z.000000000246
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7034: Show issues Location:
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  9. Article ; Online: Enzyme-free nucleic acid dynamical systems.

    Srinivas, Niranjan / Parkin, James / Seelig, Georg / Winfree, Erik / Soloveichik, David

    Science (New York, N.Y.)

    2017  Volume 358, Issue 6369

    Abstract: Chemistries exhibiting complex dynamics-from inorganic oscillators to gene regulatory networks-have been long known but either cannot be reprogrammed at will or rely on the sophisticated enzyme chemistry underlying the central dogma. Can simpler ... ...

    Abstract Chemistries exhibiting complex dynamics-from inorganic oscillators to gene regulatory networks-have been long known but either cannot be reprogrammed at will or rely on the sophisticated enzyme chemistry underlying the central dogma. Can simpler molecular mechanisms, designed from scratch, exhibit the same range of behaviors? Abstract chemical reaction networks have been proposed as a programming language for complex dynamics, along with their systematic implementation using short synthetic DNA molecules. We developed this technology for dynamical systems by identifying critical design principles and codifying them into a compiler automating the design process. Using this approach, we built an oscillator containing only DNA components, establishing that Watson-Crick base-pairing interactions alone suffice for complex chemical dynamics and that autonomous molecular systems can be designed via molecular programming languages.
    MeSH term(s) Base Pairing ; Base Sequence ; DNA/chemistry ; Programming Languages
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2017--15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aal2052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 27: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MG 77: Show issues

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  10. Article ; Online: qFlow Cytometry-Based Receptoromic Screening: A High-Throughput Quantification Approach Informing Biomarker Selection and Nanosensor Development.

    Chen, Si / Weddell, Jared / Gupta, Pavan / Conard, Grace / Parkin, James / Imoukhuede, Princess I

    Methods in molecular biology (Clifton, N.J.)

    2017  Volume 1570, Page(s) 117–138

    Abstract: Nanosensor-based detection of biomarkers can improve medical diagnosis; however, a critical factor in nanosensor development is deciding which biomarker to target, as most diseases present several biomarkers. Biomarker-targeting decisions can be informed ...

    Abstract Nanosensor-based detection of biomarkers can improve medical diagnosis; however, a critical factor in nanosensor development is deciding which biomarker to target, as most diseases present several biomarkers. Biomarker-targeting decisions can be informed via an understanding of biomarker expression. Currently, immunohistochemistry (IHC) is the accepted standard for profiling biomarker expression. While IHC provides a relative mapping of biomarker expression, it does not provide cell-by-cell readouts of biomarker expression or absolute biomarker quantification. Flow cytometry overcomes both these IHC challenges by offering biomarker expression on a cell-by-cell basis, and when combined with calibration standards, providing quantitation of biomarker concentrations: this is known as qFlow cytometry. Here, we outline the key components for applying qFlow cytometry to detect biomarkers within the angiogenic vascular endothelial growth factor receptor family. The key aspects of the qFlow cytometry methodology include: antibody specificity testing, immunofluorescent cell labeling, saturation analysis, fluorescent microsphere calibration, and quantitative analysis of both ensemble and cell-by-cell data. Together, these methods enable high-throughput quantification of biomarker expression.
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-6840-4_8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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