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  1. Article ; Online: Limited bedding and nesting increases ethanol drinking in female rats.

    Parks, B J / Salazar, P / Morrison, L / McGraw, M K / Gunnell, M / Tobacyk, J / Brents, L K / Berquist, M D

    Pharmacology, biochemistry, and behavior

    2024  Volume 239, Page(s) 173756

    Abstract: Prenatal opioid exposure (POE) and postnatal adverse experiences are early life adversities (ELA) that often co-occur and increase problematic alcohol (EtOH) drinking during adolescence. We investigated the relationship between POE, postnatal adversity, ... ...

    Abstract Prenatal opioid exposure (POE) and postnatal adverse experiences are early life adversities (ELA) that often co-occur and increase problematic alcohol (EtOH) drinking during adolescence. We investigated the relationship between POE, postnatal adversity, and adolescent EtOH drinking in rats. We also sought to determine whether ELAs affect alpha-adrenoceptor density in the brain because the noradrenergic system is involved in problematic alcohol drinking and its treatment. We hypothesized that the combination of POE and postnatal adversity will increase alcohol drinking in rats compared to rats with exposure to either adversity alone or to control. We also predicted that POE and postnatal adversity would increase α
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 191042-5
    ISSN 1873-5177 ; 0091-3057
    ISSN (online) 1873-5177
    ISSN 0091-3057
    DOI 10.1016/j.pbb.2024.173756
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    Zs.A 1060: Show issues Location:
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  2. Article ; Online: Spatio-Temporal Variation in the Concentration of Inhalable Particulate Matter (PM

    Onyango, Silver / Parks, Beth / Anguma, Simon / Meng, Qingyu

    International journal of environmental research and public health

    2019  Volume 16, Issue 10

    Abstract: Long-term particulate matter ( ... ...

    Abstract Long-term particulate matter (PM
    MeSH term(s) Air Pollutants/analysis ; Air Pollution/analysis ; Dust/analysis ; Environmental Monitoring ; Particulate Matter/analysis ; Seasons ; Uganda
    Chemical Substances Air Pollutants ; Dust ; Particulate Matter
    Language English
    Publishing date 2019-05-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph16101752
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  3. Article: Immediate and sustained terminal complement inhibition with ravulizumab in patients with anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder.

    Ortiz, Stephan / Pittock, Sean J / Berthele, Achim / Levy, Michael / Nakashima, Ichiro / Oreja-Guevara, Celia / Allen, Kerstin / Mashhoon, Yasmin / Parks, Becky / Kim, Ho Jin

    Frontiers in neurology

    2024  Volume 15, Page(s) 1332890

    Abstract: Objective: To assess the pharmacokinetics and pharmacodynamics of the long-acting terminal complement 5 (C5) inhibitor ravulizumab in adults with anti-aquaporin-4 antibody-positive (AQP4+) neuromyelitis optica spectrum disorder (NMOSD) in the phase 3, ... ...

    Abstract Objective: To assess the pharmacokinetics and pharmacodynamics of the long-acting terminal complement 5 (C5) inhibitor ravulizumab in adults with anti-aquaporin-4 antibody-positive (AQP4+) neuromyelitis optica spectrum disorder (NMOSD) in the phase 3, open-label CHAMPION-NMOSD trial (NCT04201262).
    Methods: Patients aged 18 years or older received a weight-based intravenous loading dose of ravulizumab (2,400-3,000 mg) on day 1, followed by weight-based maintenance doses (3,000-3,600 mg) on day 15 and once every 8 weeks thereafter. Pharmacokinetic assessments were maximum observed concentration (
    Results: The pharmacokinetic/pharmacodynamic analysis included 58 patients treated with ravulizumab. Serum ravulizumab concentrations at or above the therapeutic threshold (175 μg/mL) were achieved in all patients after administration of the first dose and maintained for 50 weeks. At week 50, the mean (standard deviation)
    Conclusions: Serum ravulizumab concentrations were maintained above the therapeutic threshold in all patients through 50 weeks of treatment. Ravulizumab achieved immediate and complete terminal complement inhibition that was sustained throughout the treatment period in adults with AQP4+ NMOSD.
    Language English
    Publishing date 2024-01-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2024.1332890
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  4. Article ; Online: PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape.

    Gamble, Noah / Bradu, Alexandra / Caldwell, Jason A / McKeever, Joshua / Bolonduro, Olubusayo / Ermis, Ebru / Kaiser, Caroline / Kim, YeEun / Parks, Benjamin / Klemm, Sandy / Greenleaf, William J / Crabtree, Gerald R / Koh, Andrew S

    Nature immunology

    2024  

    Abstract: Adaptive immunity relies on specialized effector functions elicited by lymphocytes, yet how antigen recognition activates appropriate effector responses through nonspecific signaling intermediates is unclear. Here we examined the role of chromatin ... ...

    Abstract Adaptive immunity relies on specialized effector functions elicited by lymphocytes, yet how antigen recognition activates appropriate effector responses through nonspecific signaling intermediates is unclear. Here we examined the role of chromatin priming in specifying the functional outputs of effector T cells and found that most of the cis-regulatory landscape active in effector T cells was poised early in development before the expression of the T cell antigen receptor. We identified two principal mechanisms underpinning this poised landscape: the recruitment of the nucleosome remodeler mammalian SWItch/Sucrose Non-Fermentable (mSWI/SNF) by the transcription factors RUNX1 and PU.1 to establish chromatin accessibility at T effector loci; and a 'relay' whereby the transcription factor BCL11B succeeded PU.1 to maintain occupancy of the chromatin remodeling complex mSWI/SNF together with RUNX1, after PU.1 silencing during lineage commitment. These mechanisms define modes by which T cells acquire the potential to elicit specialized effector functions early in their ontogeny and underscore the importance of integrating extrinsic cues to the developmentally specified intrinsic program.
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-024-01807-y
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  5. Article: Advanced directives: do they really mean what they mean?

    Parks, B

    Journal of emergency nursing

    1998  Volume 24, Issue 5, Page(s) 382–383

    MeSH term(s) Advance Directives ; Aged ; Heart Arrest/therapy ; Humans ; Male ; Patient Advocacy ; Patient Education as Topic
    Language English
    Publishing date 1998-10
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 604632-0
    ISSN 0099-1767
    ISSN 0099-1767
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  6. Article ; Online: NEAT-seq: simultaneous profiling of intra-nuclear proteins, chromatin accessibility and gene expression in single cells.

    Chen, Amy F / Parks, Benjamin / Kathiria, Arwa S / Ober-Reynolds, Benjamin / Goronzy, Jorg J / Greenleaf, William J

    Nature methods

    2022  Volume 19, Issue 5, Page(s) 547–553

    Abstract: In this work, we describe NEAT-seq (sequencing of nuclear protein epitope abundance, chromatin accessibility and the transcriptome in single cells), enabling interrogation of regulatory mechanisms spanning the central dogma. We apply this technique to ... ...

    Abstract In this work, we describe NEAT-seq (sequencing of nuclear protein epitope abundance, chromatin accessibility and the transcriptome in single cells), enabling interrogation of regulatory mechanisms spanning the central dogma. We apply this technique to profile CD4 memory T cells using a panel of master transcription factors (TFs) that drive T cell subsets and identify examples of TFs with regulatory activity gated by transcription, translation and regulation of chromatin binding. We also link a noncoding genome-wide association study single-nucleotide polymorphism (SNP) within a GATA motif to a putative target gene, using NEAT-seq data to internally validate SNP impact on GATA3 regulation.
    MeSH term(s) Chromatin/genetics ; Gene Expression Profiling ; Genome-Wide Association Study ; Nuclear Proteins/genetics ; Transcriptome
    Chemical Substances Chromatin ; Nuclear Proteins
    Language English
    Publishing date 2022-05-02
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2169522-2
    ISSN 1548-7105 ; 1548-7091
    ISSN (online) 1548-7105
    ISSN 1548-7091
    DOI 10.1038/s41592-022-01461-y
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  7. Article: "It's for seniors": an acute-care geriatric unit.

    Parks, B

    Nursing management

    1994  Volume 25, Issue 11, Page(s) 62, 64

    Abstract: To meet the unique needs of older adults over the age of 62, one hospital established a senior care unit. Here patients are encouraged to maintain current physical and mental abilities while recovering from an acute illness. The unit is specifically ... ...

    Abstract To meet the unique needs of older adults over the age of 62, one hospital established a senior care unit. Here patients are encouraged to maintain current physical and mental abilities while recovering from an acute illness. The unit is specifically promoted for patients who live at home and wish to maintain their current status.
    MeSH term(s) Activities of Daily Living ; Acute Disease/nursing ; Aged ; Geriatric Nursing/organization & administration ; Hospital Departments/organization & administration ; Hospitals, Community/organization & administration ; Humans ; Indiana ; Middle Aged ; Patient Education as Topic
    Language English
    Publishing date 1994-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605889-9
    ISSN 1538-8670 ; 0744-6314
    ISSN (online) 1538-8670
    ISSN 0744-6314
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    Zs.B 2735: Show issues Location:
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  8. Article: Safety and efficacy of daclizumab beta in patients with relapsing multiple sclerosis in a 5-year open-label study (EXTEND): final results following early termination.

    Kappos, Ludwig / Cohan, Stanley / Arnold, Douglas L / Robinson, Randy R / Holman, Joan / Fam, Sami / Parks, Becky / Xiao, Shan / Castro-Borrero, Wanda

    Therapeutic advances in neurological disorders

    2021  Volume 14, Page(s) 1756286420987941

    Abstract: Background: EXTEND (NCT01797965), an open-label extension study, evaluated the safety and efficacy of daclizumab beta in participants with relapsing multiple sclerosis (MS) who had completed the randomized DECIDE study.: Methods: Eligible ... ...

    Abstract Background: EXTEND (NCT01797965), an open-label extension study, evaluated the safety and efficacy of daclizumab beta in participants with relapsing multiple sclerosis (MS) who had completed the randomized DECIDE study.
    Methods: Eligible participants who received either daclizumab beta or interferon beta-1a in DECIDE received daclizumab beta 150 mg subcutaneously every 4 weeks for up to 5 years in EXTEND, followed by 24 weeks of post-dosing follow-up. Safety and tolerability were evaluated, as were clinical efficacy and magnetic resonance imaging (MRI). EXTEND was terminated ahead of schedule by the sponsors.
    Results: The total safety population (
    Conclusion: Results from the combined DECIDE-EXTEND study elucidate outcomes of longer-term treatment with daclizumab beta in the clinical trial setting and underscore the importance of pharmacovigilance with immunomodulatory therapies in the real-world setting.
    Language English
    Publishing date 2021-02-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2442245-9
    ISSN 1756-2864 ; 1756-2856
    ISSN (online) 1756-2864
    ISSN 1756-2856
    DOI 10.1177/1756286420987941
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  9. Article ; Online: Concurrent stimulation and sensing in bi-directional brain interfaces: a multi-site translational experience.

    Ansó, Juan / Benjaber, Moaad / Parks, Brandon / Parker, Samuel / Oehrn, Carina Renate / Petrucci, Matthew / Gilron, Ro'ee / Little, Simon / Wilt, Robert / Bronte-Stewart, Helen / Gunduz, Aysegul / Borton, David / Starr, Philip A / Denison, Timothy

    Journal of neural engineering

    2022  Volume 19, Issue 2

    Abstract: ... ...

    Abstract Objective
    MeSH term(s) Algorithms ; Brain ; Deep Brain Stimulation/methods ; Feedback ; Humans
    Language English
    Publishing date 2022-03-31
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2170901-4
    ISSN 1741-2552 ; 1741-2560
    ISSN (online) 1741-2552
    ISSN 1741-2560
    DOI 10.1088/1741-2552/ac59a3
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  10. Article ; Online: Pathfinding on the Frontier.

    Sylvia, Eldonna / Parks, Burlay / Grund, Chrysanne

    The American journal of nursing

    2015  Volume 115, Issue 10, Page(s) 58–63

    Abstract: Overview: In rural settings, referrals to specialists from primary care providers can be difficult for patients and families to follow up on, sometimes requiring that patients travel great distances. Patient care coordination has been shown to decrease ... ...

    Abstract Overview: In rural settings, referrals to specialists from primary care providers can be difficult for patients and families to follow up on, sometimes requiring that patients travel great distances. Patient care coordination has been shown to decrease the number of ED visits and hospitalizations, but little is known about its effectiveness in assisting with referrals in rural primary care. This article presents three case studies showing how a nurse care coordinator at a rural primary care practice resolved complex issues involving medications, specialists, and diagnoses.
    MeSH term(s) Aged ; Case Management/organization & administration ; Continuity of Patient Care/organization & administration ; Female ; Humans ; Middle Aged ; Patient Navigation/organization & administration ; Primary Health Care ; Referral and Consultation/organization & administration ; Rural Health Services
    Language English
    Publishing date 2015-10
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 390780-6
    ISSN 1538-7488 ; 0002-936X
    ISSN (online) 1538-7488
    ISSN 0002-936X
    DOI 10.1097/01.NAJ.0000471946.51739.b5
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