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  1. Book ; Thesis: The role of oxygen-derived free radicals in the pathogenesis of intestinal ischemia

    Parks, Dale A.

    1983  

    Author's details by Dale Allen Parks
    Size XI, 163 S. : Ill., graph. Darst.
    Publishing country United States
    Document type Book ; Thesis
    Thesis / German Habilitation thesis University of South Alabama, Diss., 1983
    Note Kopie, erschienen im Verl. Univ. Microfilms Internat., Ann Arbor, Mich.
    HBZ-ID HT002811430
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: In Response.

    Lee, Donaldson C / Vetter, Thomas R / Dobyns, Jeffrey B / Crump, Sandra J / Benz, David L / Short, Roland T / Parks, Dale A / Beasley, T Mark / Liwo, Amandiy

    Anesthesia and analgesia

    2024  Volume 138, Issue 4, Page(s) e21–e23

    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000006930
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Sociodemographic Disparities in Postoperative Nausea and Vomiting.

    Lee, Donaldson C / Vetter, Thomas R / Dobyns, Jeffrey B / Crump, Sandra J / Benz, David L / Short, Roland T / Parks, Dale A / Beasley, T Mark / Liwo, Amandiy N

    Anesthesia and analgesia

    2023  Volume 137, Issue 3, Page(s) 665–675

    Abstract: Background: Postoperative nausea and vomiting (PONV) prophylaxis is consistently considered a key indicator of anesthesia care quality. PONV may disproportionately impact disadvantaged patients. The primary objectives of this study were to examine the ... ...

    Abstract Background: Postoperative nausea and vomiting (PONV) prophylaxis is consistently considered a key indicator of anesthesia care quality. PONV may disproportionately impact disadvantaged patients. The primary objectives of this study were to examine the associations between sociodemographic factors and the incidence of PONV and clinician adherence to a PONV prophylaxis protocol.
    Methods: We conducted a retrospective analysis of all patients eligible for an institution-specific PONV prophylaxis protocol (2015-2017). Sociodemographic and PONV risk data were collected. Primary outcomes were PONV incidence and clinician adherence to PONV prophylaxis protocol. We used descriptive statistics to compare sociodemographics, procedural characteristics, and protocol adherence for patients with and without PONV. Multivariable logistic regression analysis followed by Tukey-Kramer correction for multiple comparisons was used to test for associations between patient sociodemographics, procedural characteristics, PONV risk, and (1) PONV incidence and (2) adherence to PONV prophylaxis protocol.
    Results: Within the 8384 patient sample, Black patients had a 17% lower risk of PONV than White patients (adjusted odds ratio [aOR], 0.83; 95% confidence interval [CI], 0.73-0.95; P = .006). When there was adherence to the PONV prophylaxis protocol, Black patients were less likely to experience PONV compared to White patients (aOR, 0.81; 95% CI, 0.70-0.93; P = .003). When there was adherence to the protocol, patients with Medicaid were less likely to experience PONV compared to privately insured patients (aOR, 0.72; 95% CI, 0.64-1.04; P = .017). When the protocol was followed for high-risk patients, Hispanic patients were more likely to experience PONV than White patients (aOR, 2.96; 95% CI, 1.18-7.42; adjusted P = .022). Compared to White patients, protocol adherence was lower for Black patients with moderate (aOR, 0.76; 95% CI, 0.64-0.91; P = .003) and high risk (aOR, 0.57; 95% CI, 0.42-0.78; P = .0004).
    Conclusions: Racial and sociodemographic disparities exist in the incidence of PONV and clinician adherence to a PONV prophylaxis protocol. Awareness of such disparities in PONV prophylaxis could improve the quality of perioperative care.
    MeSH term(s) Humans ; Postoperative Nausea and Vomiting/epidemiology ; Postoperative Nausea and Vomiting/prevention & control ; Postoperative Nausea and Vomiting/drug therapy ; Antiemetics/therapeutic use ; Retrospective Studies ; Anesthesia ; Incidence
    Chemical Substances Antiemetics
    Language English
    Publishing date 2023-05-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000006509
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  4. Article ; Online: Improving Adherence to Intraoperative Lung-Protective Ventilation Strategies Using Near Real-Time Feedback and Individualized Electronic Reporting.

    Parks, Dale A / Short, Roland T / McArdle, Philip J / Liwo, Amandiy / Hagood, Joshua M / Crump, Sandra J / Bryant, Ayesha S / Vetter, Thomas R / Morgan, Charity J / Beasley, T Mark / Jones, Keith A

    Anesthesia and analgesia

    2021  Volume 132, Issue 5, Page(s) 1438–1449

    Abstract: Background: Postoperative pulmonary complications can have a significant impact on the morbidity and mortality of patients undergoing major surgeries. Intraoperative lung protective strategies using low tidal volume (TV) ventilation and positive end- ... ...

    Abstract Background: Postoperative pulmonary complications can have a significant impact on the morbidity and mortality of patients undergoing major surgeries. Intraoperative lung protective strategies using low tidal volume (TV) ventilation and positive end-expiratory pressure (PEEP) have been demonstrated to reduce the incidence of pulmonary injury and infection while improving oxygenation and respiratory mechanics. The purpose of this study was to develop decision support systems designed to optimize behavior of the attending anesthesiologist with regards to adherence with established intraoperative lung-protective ventilation (LPV) strategies.
    Methods: Over a 4-year period, data were obtained from 49,386 procedures and 109 attendings. Cases were restricted to patients aged 18 years or older requiring general anesthesia that lasted at least 60 minutes. We defined protective lung ventilation as a TV of 6-8 mL/kg ideal body weight and a PEEP of ≥4 cm H2O. There was a baseline period followed by 4 behavioral interventions: education, near real-time feedback, individualized post hoc feedback, and enhanced multidimensional decision support. Segmented logistic regression using generalized estimating equations was performed in order to assess temporal trends and effects of interventions on adherence to LPV strategies.
    Results: Consistent with improvement in adherence with LPV strategies during the baseline period, the predicted probability of adherence with LPV at the end of baseline was 0.452 (95% confidence interval [CI], 0.422-0.483). The improvements observed for each phase were relative to the preceding phase. Education alone was associated with an 8.7% improvement (P < .01) in adherence to lung-protective protocols and was associated with a 16% increase in odds of adherence (odds ratio [OR] = 1.16; 95% CI, 1.01-1.33; P = .04). Near real-time, on-screen feedback was associated with an estimated 15.5% improvement in adherence (P < .01) with a 69% increase in odds of adherence (OR = 1.69; 95% CI, 1.46-1.96; P < .01) over education alone. The addition of an individualized dashboard with personal adherence and peer comparison was associated with a significant improvement over near real-time feedback (P < .01). Near real-time feedback and dashboard feedback systems were enhanced based on feedback from the in-room attendings, and this combination was associated with an 18.1% (P < .01) increase in adherence with a 2-fold increase in the odds of adherence (OR = 2.23; 95% CI, 1.85-2.69; P < .0001) between the end of the previous on-screen feedback phase and the start of the individualized post hoc dashboard reporting phase. The adherence with lung-protective strategies using the multidimensional approach has been sustained for over 24 months. The difference between the end of the previous phase and the start of this last enhanced multidimensional decision support phase was not significant (OR = 1.08; 95% CI, 0.86-1.34; P = .48).
    Conclusions: Consistent with the literature, near real-time and post hoc reporting are associated with positive and sustained behavioral changes aimed at adopting evidence-based clinical strategies. Many decision support systems have demonstrated impact to behavior, but the effect is often transient. The implementation of near real-time feedback and individualized post hoc decision support tools has resulted in clinically relevant improvements in adherence with LPV strategies that have been sustained for over 24 months, a common limitation of decision support solutions.
    MeSH term(s) Adult ; Aged ; Anesthesia/adverse effects ; Anesthesia/standards ; Anesthesiologists/education ; Anesthesiologists/psychology ; Anesthesiologists/standards ; Decision Support Techniques ; Electronic Health Records ; Female ; Formative Feedback ; Guideline Adherence/standards ; Health Knowledge, Attitudes, Practice ; Hospital Information Systems ; Humans ; Intraoperative Care/adverse effects ; Intraoperative Care/standards ; Lung Diseases/etiology ; Lung Diseases/physiopathology ; Lung Diseases/prevention & control ; Male ; Middle Aged ; Positive-Pressure Respiration/standards ; Practice Guidelines as Topic/standards ; Practice Patterns, Physicians'/standards ; Protective Factors ; Respiration, Artificial/adverse effects ; Respiration, Artificial/standards ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Tidal Volume ; Treatment Outcome
    Language English
    Publishing date 2021-03-16
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000005481
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  5. Article: Cardiovascular protection by alcohol and polyphenols: role of nitric oxide.

    Parks, Dale A / Booyse, Francois M

    Annals of the New York Academy of Sciences

    2002  Volume 957, Page(s) 115–121

    Abstract: Cardiovascular disease, and in particular coronary heart disease (CHD), remains the leading cause of death in both men and women in the United States. Much epidemiologic evidence indicates that alcoholic beverages, and in particular red wine, results in ... ...

    Abstract Cardiovascular disease, and in particular coronary heart disease (CHD), remains the leading cause of death in both men and women in the United States. Much epidemiologic evidence indicates that alcoholic beverages, and in particular red wine, results in a reduction in cardiovascular risk factors and decreases mortality; however, the mechanisms of this cardiovascular protection remains elusive. This review discusses evidence to suggest that *NO plays a critical role in cardiovascular protection and that nitric oxide synthase (NOS) is the responsible cardioprotective protein (see Bolli et al. 1998. Basic Res. Cardiol. 93: 325-338).
    MeSH term(s) Cardiovascular Diseases/prevention & control ; Ethanol/pharmacology ; Flavonoids ; Humans ; Models, Cardiovascular ; Nitric Oxide/physiology ; Phenols/pharmacology ; Polymers/pharmacology ; Polyphenols
    Chemical Substances Flavonoids ; Phenols ; Polymers ; Polyphenols ; Nitric Oxide (31C4KY9ESH) ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2002-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 211003-9
    ISSN 1749-6632 ; 0077-8923
    ISSN (online) 1749-6632
    ISSN 0077-8923
    DOI 10.1111/j.1749-6632.2002.tb02910.x
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  6. Article: Moderate Wine and Alcohol Consumption: Beneficial Effects on Cardiovascular Disease

    Booyse, Francois M. / Parks, Dale A.

    Thrombosis and Haemostasis

    2001  Volume 85, Issue 02, Page(s) 517–528

    Abstract: Cardiovascular disease, in particular coronary heart disease (CHD) and associated myocardial infarction (MI), is the leading cause of death among adults in the Western world (1). Although CHD is a complex multi-factorial disease, major insights have been ...

    Abstract Cardiovascular disease, in particular coronary heart disease (CHD) and associated myocardial infarction (MI), is the leading cause of death among adults in the Western world (1). Although CHD is a complex multi-factorial disease, major insights have been gained in our understanding of the etiology underlying the initiation and progression of CHD. The pathogenesis of CHD and the ensuing atherothrombotic complications resulting in MI, involves the complex and often synergistic interplay between multiple dysfunctional cellular and molecular mechanisms that have been altered through interactions with various environmental and/or systemic factors (i. e. CHD risk factors). Typically, these deleterious effects are exerted at the level of the heart muscle, blood vessels and blood components and result in dysfunction in endothelial cells (ECs), smooth muscle cells, cardiac myocytes, blood cells (platelets and monocytes) and plasma components (lipoproteins, fibrinogen, clotting factors, etc.). These combined effects will then contribute further to the initiation and progression of CHD and eventual MI. Consequently, any systemic factors (such as alcohol or wine components) that will reduce, minimize or inhibit these induced dysfunctions will be expected to reduce the overall risk for cardiovascular disease and CHD-related mortality.
    Keywords Alcohol ; polyphenols ; endothelial cells ; platelets ; CHD
    Language English
    Publishing date 2001-01-01
    Publisher Schattauer GmbH
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/s-0037-1616080
    Database Thieme publisher's database

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  7. Article: Decreased hepatic ischemia-reperfusion injury by manganese-porphyrin complexes.

    Wu, Tzong-Jin / Khoo, Nicholas H / Zhou, Fen / Day, Brian J / Parks, Dale A

    Free radical research

    2007  Volume 41, Issue 2, Page(s) 127–134

    Abstract: Reactive oxygen and nitrogen species have been implicated in ischemia-reperfusion (I/R) injury. Metalloporphyrins (MP) are stable catalytic antioxidants that can scavenge superoxide, hydrogen peroxide, peroxynitrite and lipid peroxyl radicals. Studies ... ...

    Abstract Reactive oxygen and nitrogen species have been implicated in ischemia-reperfusion (I/R) injury. Metalloporphyrins (MP) are stable catalytic antioxidants that can scavenge superoxide, hydrogen peroxide, peroxynitrite and lipid peroxyl radicals. Studies were conducted with three manganese-porphyrin (MnP) complexes with varying superoxide dimutase (SOD) and catalase catalytic activity to determine if the MnP attenuates I/R injury in isolated perfused mouse livers. The release of the hepatocellular enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) was maximal at 1 min reperfusion, decreased rapidly and increased gradually by 90 min. Manganese tetrakis-(N-ethyl-2 pyridyl) porphyrin (MnTE-2-PyP) decreased ALT, AST, LDH at 1-90 min reperfusion, while manganese tetrakis-(N-methyl-2 pyridyl) porphyrin (MnTM-2-PyP) and manganese tetrakis-(ethoxycarbonyl) porphyrin (MnTECP) decreased ALT and LDH from 5 to 90 min reperfusion. The release of thiobarbituric acid-reacting substances (TBARS) was diminished by MnTE-2-PyP and MnTM-2-PyP at 90 min. The extent of protein nitration (nitrotyrosine, NT) was decreased in all three MnPs treated livers. These results demonstrate that MnP complexes can attenuate hepatic I/R injury and may have therapeutic implications in disease states involving oxidants.
    MeSH term(s) Alanine Transaminase/secretion ; Animals ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Aspartate Aminotransferases/secretion ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Ischemia/drug therapy ; L-Lactate Dehydrogenase/secretion ; Lipid Peroxidation/drug effects ; Liver/blood supply ; Liver/drug effects ; Liver Diseases/prevention & control ; Male ; Metalloporphyrins/pharmacology ; Metalloporphyrins/therapeutic use ; Mice ; Mice, Inbred C57BL ; Nitrosation/drug effects ; Reactive Oxygen Species/metabolism ; Reperfusion Injury/prevention & control ; Thiobarbituric Acid Reactive Substances/analysis ; Tyrosine/analogs & derivatives ; Tyrosine/analysis
    Chemical Substances Antioxidants ; Metalloporphyrins ; Reactive Oxygen Species ; Thiobarbituric Acid Reactive Substances ; manganese tetrakis-(N-ethyl-2 pyridyl) porphyrin ; manganese tetrakis-(N-methyl-2 pyridyl) porphyrin ; manganese tetrakis-(ethoxycarbonyl) porphyrin ; 3-nitrotyrosine (3604-79-3) ; Tyrosine (42HK56048U) ; L-Lactate Dehydrogenase (EC 1.1.1.27) ; Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2)
    Language English
    Publishing date 2007-02
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 1194130-3
    ISSN 1029-2470 ; 1071-5762
    ISSN (online) 1029-2470
    ISSN 1071-5762
    DOI 10.1080/10715760600801298
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  8. Article: Xanthine oxidase activity in the dexamethasone-induced hypertensive rat.

    Wallwork, Camille J / Parks, Dale A / Schmid-Schönbein, Geert W

    Microvascular research

    2003  Volume 66, Issue 1, Page(s) 30–37

    Abstract: Hypertension may be associated with an increase in oxidative stress as a possible mechanism for the increased vascular tone and organ injury. Previously, we reported an increased production of reactive oxygen species and endothelial cell death in the ... ...

    Abstract Hypertension may be associated with an increase in oxidative stress as a possible mechanism for the increased vascular tone and organ injury. Previously, we reported an increased production of reactive oxygen species and endothelial cell death in the microcirculation of hypertensive rats. We hypothesize that xanthine oxidase (XO) may be a potential source of oxidants induced by glucocorticoid-induced hypertension. Male Wistar rats were administered dexamethasone (0.5 mg/kg/day) for 5 days to induce hypertension. After general anesthesia, cremaster muscle was collected for analysis of XO and xanthine dehydrogenase (XDH) activities. The mean blood pressure and XO levels in cremaster muscle were significantly increased in the dexamethasone-treated rats compared with controls. There was a strong age-dependent rise in total XO + XDH activity in all groups. To inhibit XO, we administered allopurinol (ALLO, 0.4 mg/mL) in the drinking water to a subset of control and dexamethasone-treated rats during a 5-day treatment. The ALLO significantly reduced the mean arterial blood pressure in the dexamethasone-treated rats. Although in the cremaster muscle the total XO + XDH levels were not completely reduced with ALLO, the XO levels of the dexamethasone-treated + ALLO rats were reduced to levels of the control + ALLO group. These results suggest that dexamethasone induces an elevated level of XO activity in the cremaster muscle. The enhanced XO activity can be attenuated by chronic allopurinol treatment.
    MeSH term(s) Allopurinol/pharmacology ; Animals ; Blood Pressure ; Chromatography, High Pressure Liquid ; Dexamethasone/pharmacology ; Free Radicals ; Glucocorticoids/metabolism ; Hypertension/metabolism ; Male ; Muscle, Skeletal/metabolism ; Oxidants/metabolism ; Oxygen/metabolism ; Rats ; Rats, Wistar ; Time Factors ; Xanthine Dehydrogenase/metabolism ; Xanthine Oxidase/metabolism
    Chemical Substances Free Radicals ; Glucocorticoids ; Oxidants ; Allopurinol (63CZ7GJN5I) ; Dexamethasone (7S5I7G3JQL) ; Xanthine Dehydrogenase (EC 1.17.1.4) ; Xanthine Oxidase (EC 1.17.3.2) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2003-04-28
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 80307-8
    ISSN 1095-9319 ; 0026-2862
    ISSN (online) 1095-9319
    ISSN 0026-2862
    DOI 10.1016/s0026-2862(03)00019-0
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  9. Article ; Online: Dietary flavonoid quercetin stimulates vasorelaxation in aortic vessels.

    Khoo, Nicholas K H / White, C Roger / Pozzo-Miller, Lucas / Zhou, Fen / Constance, Chad / Inoue, Takafumi / Patel, Rakesh P / Parks, Dale A

    Free radical biology & medicine

    2010  Volume 49, Issue 3, Page(s) 339–347

    Abstract: Considerable epidemiological evidence indicates that dietary consumption of moderate levels of polyphenols decreases both the incidence of cardiovascular disease and the mortality associated with myocardial infarction. Molecular mechanisms of this ... ...

    Abstract Considerable epidemiological evidence indicates that dietary consumption of moderate levels of polyphenols decreases both the incidence of cardiovascular disease and the mortality associated with myocardial infarction. Molecular mechanisms of this cardiovascular protection remain uncertain but can involve changes in rates of nitric oxide (NO) generation by endothelial nitric oxide synthase (eNOS). We examined the vascular responses to quercetin using a combination of biochemical and vessel function criteria. Quercetin treatment for 30min enhanced relaxation of rat aortic ring segments. Moreover, the addition of L-NAME (100muM) or charybdotoxin (ChTx) blocked quercetin-mediated vasorelaxation thus demonstrating the effect was partially dependent on NOS and endothelium-derived hyperpolarizing factor (EDHF). Additionally, bovine aortic endothelial cells (BAEC) treated with quercetin showed a rapid increase of intracellular Ca(2+) concentrations as well as a dose- and time-dependent stimulation of eNOS phosphorylation with a concomitant increase in NO production. These results demonstrate that quercetin-mediated stimulation of eNOS phosphorylation increases NO bioavailability in endothelial cells and can thus play a role in the vascular protective effects associated with improved endothelial cell function.
    MeSH term(s) Animals ; Aorta/drug effects ; Aorta/physiology ; Biological Factors/physiology ; Cattle ; Charybdotoxin/pharmacology ; Cyclic GMP/metabolism ; Diet ; Endothelium, Vascular/drug effects ; In Vitro Techniques ; NG-Nitroarginine Methyl Ester/pharmacology ; Nitric Oxide Synthase Type III/metabolism ; Phosphorylation ; Quercetin/pharmacology ; Rats ; Rats, Sprague-Dawley ; Vasodilation/drug effects
    Chemical Substances Biological Factors ; endothelium-dependent hyperpolarization factor ; Charybdotoxin (115422-61-2) ; Quercetin (9IKM0I5T1E) ; Nitric Oxide Synthase Type III (EC 1.14.13.39) ; Cyclic GMP (H2D2X058MU) ; NG-Nitroarginine Methyl Ester (V55S2QJN2X)
    Language English
    Publishing date 2010-04-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2010.04.022
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  10. Article: Peroxynitrite inactivates tissue plasminogen activator.

    Nielsen, Vance G / Crow, John P / Zhou, Fen / Parks, Dale A

    Anesthesia and analgesia

    2002  Volume 98, Issue 5, Page(s) 1312–7, table of contents

    Abstract: Unlabelled: Tissue plasminogen activator (tPA) has a prominent role in physiological fibrinolysis in vivo. Thrombosis has been associated with clinical scenarios (e.g., atherosclerotic disease) known to involve local decreases in tPA activity with ... ...

    Abstract Unlabelled: Tissue plasminogen activator (tPA) has a prominent role in physiological fibrinolysis in vivo. Thrombosis has been associated with clinical scenarios (e.g., atherosclerotic disease) known to involve local decreases in tPA activity with concomitant formation of reactive nitrogen species such as peroxynitrite (OONO(-)), a molecule formed from nitric oxide and superoxide. We hypothesized that exposure of tPA to OONO(-) would result in a decrease in tPA activity. OONO(-) was generated with 3-morpholinosydnonimine (SIN-1), a molecule that produces both nitric oxide and superoxide. Recombinant tPA was incubated at 37 degrees C for 60 min with 0 microM SIN-1; 100 microM SIN-1; 100 microM SIN-1 and 4000 U/mL recombinant human superoxide dismutase; or 4000 U/mL recombinant human superoxide dismutase (n = 8 separate reactions per condition). Changes in tPA activity were assessed by addition of tPA samples to tissue factor-exposed human plasma and measuring clot fibrinolysis with a thrombelastograph. Exposure to SIN-1 resulted in a decrease in tPA-mediated fibrinolysis (<1% activity of tPA not exposed to SIN-1) that was significantly (P < 0.001) different from the other three conditions. There were no significant differences between the other conditions. We conclude that tPA is inhibited by OONO(-), and that OONO(-) may have a role in clinical thrombotic scenarios.
    Implications: Tissue plasminogen activator (tPA) has a prominent role in fibrinolysis in vivo. Thrombosis has been associated with clinical scenarios involving decreases in tPA activity with concomitant formation of the oxidant peroxynitrite. We determined that peroxynitrite decreased tPA activity via thrombelastography. Peroxynitrite-mediated tPA inactivation may have a role in thrombotic states.
    MeSH term(s) Antioxidants/pharmacology ; Blotting, Western ; Dose-Response Relationship, Drug ; Humans ; Molsidomine/analogs & derivatives ; Molsidomine/pharmacology ; Nitric Oxide/metabolism ; Peroxynitrous Acid/pharmacology ; Recombinant Proteins/pharmacology ; Superoxide Dismutase/pharmacology ; Superoxides/metabolism ; Thrombelastography ; Tissue Plasminogen Activator/antagonists & inhibitors
    Chemical Substances Antioxidants ; Recombinant Proteins ; Superoxides (11062-77-4) ; Peroxynitrous Acid (14691-52-2) ; Nitric Oxide (31C4KY9ESH) ; linsidomine (5O5U71P6VQ) ; Molsidomine (D46583G77X) ; Superoxide Dismutase (EC 1.15.1.1) ; Tissue Plasminogen Activator (EC 3.4.21.68)
    Language English
    Publishing date 2002-08-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/01.ane.0000111105.38836.f6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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