Article ; Online: Normothermic and hypothermic oxygenated perfusion for donation after circulatory death in kidney transplantation: do we pay higher risk of severe infection after transplantation?: a case report.
BMC infectious diseases
2020 Volume 20, Issue 1, Page(s) 115
Abstract: Background: Normothermic and hypothermic oxygenated perfusion for donation after circulatory death in kidney transplantation are becoming popular in Italy, with the purpose of reducing the risk of primary non function and delayed graft function due to ... ...
| Abstract | Background: Normothermic and hypothermic oxygenated perfusion for donation after circulatory death in kidney transplantation are becoming popular in Italy, with the purpose of reducing the risk of primary non function and delayed graft function due to the prolonged warm ischemia time. Potential complications related to these procedures are currently under investigation and are continuously emerging with the increasing experience. Post-operative infections - in particular graft arteritis - are a rare complication but determine high risk of mortality and of graft loss. The acute onset of the arterial complications makes it very difficult to find an effective treatment, and early diagnosis is crucial for saving both patient and graft. Prevention of such infections in this particular setting are advisable. Case presentation: We present a patient with an acute arterial rupture after transplantation of a DCD graft treated in-vivo hypothermic oxygenated perfusion. The cause was a severe arteritis of the renal artery caused by Candida krusei and Pseudomonas aeruginosa. We discussed our treatment and we compared it to the other reported series. Conclusion: Fungal infections in DCD transplant may be treacherous and strategies to prevent them should be advocated. |
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| MeSH term(s) | Arteritis/microbiology ; Cold Ischemia/methods ; Delayed Graft Function/etiology ; Extracorporeal Membrane Oxygenation ; Follow-Up Studies ; Graft Survival ; Humans ; Italy ; Kidney Transplantation/adverse effects ; Kidney Transplantation/methods ; Male ; Middle Aged ; Mycoses/diagnosis ; Organ Preservation/methods ; Perfusion/methods ; Renal Artery/microbiology ; Renal Artery/pathology ; Tissue Donors ; Treatment Outcome ; Warm Ischemia/adverse effects |
| Language | English |
| Publishing date | 2020-02-10 |
| Publishing country | England |
| Document type | Case Reports ; Journal Article |
| ISSN | 1471-2334 |
| ISSN (online) | 1471-2334 |
| DOI | 10.1186/s12879-020-4835-0 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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