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Article ; Online: Natural killer cells and BNT162b2 mRNA vaccine reactogenicity and durability.

Graydon, Elizabeth K / Conner, Tonia L / Dunham, Kim / Olsen, Cara / Goguet, Emilie / Coggins, Si'Ana A / Rekedal, Marana / Samuels, Emily / Jackson-Thompson, Belinda / Moser, Matthew / Lindrose, Alyssa / Hollis-Perry, Monique / Wang, Gregory / Maiolatesi, Santina / Alcorta, Yolanda / Reyes, Anatalio / Wong, Mimi / Ramsey, Kathy / Davies, Julian /

Parmelee, Edward / Ortega, Orlando / Sanchez, Mimi / Moller, Sydney / Inglefield, Jon / Tribble, David / Burgess, Timothy / O'Connell, Robert / Malloy, Allison M W / Pollett, Simon / Broder, Christopher C / Laing, Eric D / Anderson, Stephen K / Mitre, Edward

Frontiers in immunology

2023 Volume 14, Page(s) 1225025

Abstract: Introduction: Natural killer (NK) cells can both amplify and regulate immune responses to vaccination. Studies in humans and animals have observed NK cell activation within days after mRNA vaccination. In this study, we sought to determine if baseline ... ...

Abstract	Introduction: Natural killer (NK) cells can both amplify and regulate immune responses to vaccination. Studies in humans and animals have observed NK cell activation within days after mRNA vaccination. In this study, we sought to determine if baseline NK cell frequencies, phenotype, or function correlate with antibody responses or inflammatory side effects induced by the Pfizer-BioNTech COVID-19 vaccine (BNT162b2). Methods: We analyzed serum and peripheral blood mononuclear cells (PBMCs) from 188 participants in the Prospective Assessment of SARS-CoV-2 Seroconversion study, an observational study evaluating immune responses in healthcare workers. Baseline serum samples and PBMCs were collected from all participants prior to any SARS-CoV-2 infection or vaccination. Spike-specific IgG antibodies were quantified at one and six months post-vaccination by microsphere-based multiplex immunoassay. NK cell frequencies and phenotypes were assessed on pre-vaccination PBMCs from all participants by multi-color flow cytometry, and on a subset of participants at time points after the 1 Results: Key observations include: 1) circulating NK cells exhibit evidence of activation in the week following vaccination, 2) individuals with high symptom scores after 1 Discussion: These results suggest that NK cell activation by BNT162b2 vaccination may contribute to vaccine-induced inflammatory symptoms and reduce durability of vaccine-induced antibody responses.
MeSH term(s)	Animals ; Humans ; BNT162 Vaccine ; Leukocytes, Mononuclear ; Prospective Studies ; COVID-19/prevention & control ; SARS-CoV-2 ; Drug-Related Side Effects and Adverse Reactions ; Immunoglobulin G ; mRNA Vaccines
Chemical Substances	BNT162 Vaccine ; Immunoglobulin G
Language	English
Publishing date	2023-08-25
Publishing country	Switzerland
Document type	Observational Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1225025
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Immune and behavioral correlates of protection against symptomatic post-vaccination SARS-CoV-2 infection.

Goguet, Emilie / Olsen, Cara H / Meyer, William A / Ansari, Sara / Powers, John H / Conner, Tonia L / Coggins, Si'Ana A / Wang, Wei / Wang, Richard / Illinik, Luca / Sanchez Edwards, Margaret / Jackson-Thompson, Belinda M / Hollis-Perry, Monique / Wang, Gregory / Alcorta, Yolanda / Wong, Mimi A / Saunders, David / Mohammed, Roshila / Balogun, Bolatito /

Kobi, Priscilla / Kosh, Lakeesha / Bishop-Lilly, Kimberly / Cer, Regina Z / Arnold, Catherine E / Voegtly, Logan J / Fitzpatrick, Maren / Luquette, Andrea E / Malagon, Francisco / Ortega, Orlando / Parmelee, Edward / Davies, Julian / Lindrose, Alyssa R / Haines-Hull, Hannah / Moser, Matthew S / Samuels, Emily C / Rekedal, Marana S / Graydon, Elizabeth K / Malloy, Allison M W / Tribble, David R / Burgess, Timothy H / Campbell, Wesley / Robinson, Sara / Broder, Christopher C / O'Connell, Robert J / Weiss, Carol D / Pollett, Simon / Laing, Eric D / Mitre, Edward

Frontiers in immunology

2024 Volume 15, Page(s) 1287504

Abstract: Introduction: We sought to determine pre-infection correlates of protection against SARS-CoV-2 post-vaccine inzfections (PVI) acquired during the first Omicron wave in the United States.: Methods: Serum and saliva samples from 176 vaccinated adults ... ...

Abstract	Introduction: We sought to determine pre-infection correlates of protection against SARS-CoV-2 post-vaccine inzfections (PVI) acquired during the first Omicron wave in the United States. Methods: Serum and saliva samples from 176 vaccinated adults were collected from October to December of 2021, immediately before the Omicron wave, and assessed for SARS-CoV-2 Spike-specific IgG and IgA binding antibodies (bAb). Sera were also assessed for bAb using commercial assays, and for neutralization activity against several SARS-CoV-2 variants. PVI duration and severity, as well as risk and precautionary behaviors, were assessed by questionnaires. Results: Serum anti-Spike IgG levels assessed by research assay, neutralization titers against Omicron subvariants, and low home risk scores correlated with protection against PVIs after multivariable regression analysis. Commercial assays did not perform as well as research assay, likely due to their lower dynamic range. Discussion: In the 32 participants that developed PVI, anti-Spike IgG bAbs correlated with lower disease severity and shorter duration of illness.
MeSH term(s)	Adult ; Humans ; COVID-19/prevention & control ; SARS-CoV-2 ; COVID-19 Vaccines ; Antibodies, Viral ; Immunoglobulin G
Chemical Substances	COVID-19 Vaccines ; Antibodies, Viral ; Immunoglobulin G
Language	English
Publishing date	2024-03-19
Publishing country	Switzerland
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1287504
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Article ; Online: Durability of Antibody Response and Frequency of SARS-CoV-2 Infection 6 Months after COVID-19 Vaccination in Healthcare Workers.

Laing, Eric D / Weiss, Carol D / Samuels, Emily C / Coggins, Si'Ana A / Wang, Wei / Wang, Richard / Vassell, Russell / Sterling, Spencer L / Tso, Marana S / Conner, Tonia / Goguet, Emilie / Moser, Matthew / Jackson-Thompson, Belinda M / Illinik, Luca / Davies, Julian / Ortega, Orlando / Parmelee, Edward / Hollis-Perry, Monique / Maiolatesi, Santina E /

Wang, Gregory / Ramsey, Kathleen F / Reyes, Anatalio E / Alcorta, Yolanda / Wong, Mimi A / Lindrose, Alyssa R / Duplessis, Christopher A / Tribble, David R / Malloy, Allison M W / Burgess, Timothy H / Pollett, Simon D / Olsen, Cara H / Broder, Christopher C / Mitre, Edward

Emerging infectious diseases

2022 Volume 28, Issue 4, Page(s) 828–832

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies decay but persist 6 months postvaccination; lower levels of neutralizing titers persist against Delta than wild-type virus. Of 227 vaccinated healthcare workers tested, only 2 ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies decay but persist 6 months postvaccination; lower levels of neutralizing titers persist against Delta than wild-type virus. Of 227 vaccinated healthcare workers tested, only 2 experienced outpatient symptomatic breakthrough infections, despite 59/227 exhibiting serologic evidence of SARS-CoV-2 infection, defined as presence of nucleocapsid protein antibodies.
MeSH term(s)	Antibodies, Viral ; Antibody Formation ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines ; Health Personnel ; Humans ; SARS-CoV-2 ; Vaccination
Chemical Substances	Antibodies, Viral ; COVID-19 Vaccines
Language	English
Publishing date	2022-02-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid2804.212037
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Article: Adverse effects and antibody titers in response to the BNT162b2 mRNA COVID-19 vaccine in a prospective study of healthcare workers.

Coggins, Siâ Ana A / Laing, Eric D / Olsen, Cara H / Goguet, Emilie / Moser, Matthew / Jackson-Thompson, Belinda M / Samuels, Emily C / Pollett, Simon D / Tribble, David R / Davies, Julian / Illinik, Luca / Hollis-Perry, Monique / Maiolatesi, Santina E / Duplessis, Christopher A / Ramsey, Kathleen F / Reyes, Anatalio E / Alcorta, Yolanda / Wong, Mimi A / Wang, Gregory /

Ortega, Orlando / Parmelee, Edward / Lindrose, Alyssa R / Snow, Andrew L / Malloy, Allison M W / Letizia, Andrew G / Powers, John H / Burgess, Timothy H / Broder, Christopher C / Mitre, Edward

medRxiv : the preprint server for health sciences

2021

Abstract: Background: mRNA COVID-19 vaccines are playing a key role in controlling the COVID-19 pandemic. The relationship between post-vaccination symptoms and strength of antibody responses is unclear.: Objective: To determine whether adverse effects caused ... ...

Abstract	Background: mRNA COVID-19 vaccines are playing a key role in controlling the COVID-19 pandemic. The relationship between post-vaccination symptoms and strength of antibody responses is unclear. Objective: To determine whether adverse effects caused by vaccination with the Pfizer/BioNTech BNT162b2 vaccine are associated with the magnitude of vaccine-induced antibody levels. Design: Single center, prospective, observational cohort study. Setting: Participants worked at Walter Reed National Military Medical Center and were seen monthly at the Naval Medical Research Center Clinical Trials Center. Participants: Generally healthy adults that were not severely immunocompromised, had no history of COVID-19, and were seronegative for SARS-CoV-2 spike protein prior to vaccination. Measures: Severity of vaccine-associated symptoms was obtained through participant completed questionnaires. Testing for IgG antibodies against SARS-CoV-2 spike protein and receptor binding domain was conducted using microsphere-based multiplex immunoassays. Results: 206 participants were evaluated (69.4% female, median age 41.5 years old). We found no correlation between vaccine-associated symptom severity scores and vaccine-induced antibody titers one month after vaccination. We also observed that 1) post-vaccination symptoms were inversely correlated with age and weight and more common in women, 2) systemic symptoms were more frequent after the second vaccination, 3) high symptom scores after first vaccination were predictive of high symptom scores after second vaccination, and 4) older age was associated with lower titers. Limitations: Study only observes antibody responses and consists of healthy participants. Conclusions: Lack of post-vaccination symptoms following receipt of the BNT162b2 vaccine does not equate to lack of vaccine-induced antibodies one month after vaccination. This study also suggests that it may be possible to design future mRNA vaccines that confer robust antibody responses with lower frequencies of vaccine-associated symptoms. Funding: This study was executed by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) program executed by the Uniformed Services University of the Health Sciences (USUHS) through a cooperative agreement by the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (HJF). This project has been funded by the Defense Health Program, U.S. DoD, under award HU00012120067. Project funding for JHP was in whole or in part with federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261200800001E. The funding bodies have had no role in the study design or the decision to submit the manuscript for publication.
Language	English
Publishing date	2021-07-02
Publishing country	United States
Document type	Preprint
DOI	10.1101/2021.06.25.21259544
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: COVID-19 Outcomes Among US Military Health System Beneficiaries Include Complications Across Multiple Organ Systems and Substantial Functional Impairment.

Richard, Stephanie A / Pollett, Simon D / Lanteri, Charlotte A / Millar, Eugene V / Fries, Anthony C / Maves, Ryan C / Utz, Gregory C / Lalani, Tahaniyat / Smith, Alfred / Mody, Rupal M / Ganesan, Anuradha / Colombo, Rhonda E / Colombo, Christopher J / Lindholm, David A / Madar, Cristian / Chi, Sharon / Huprikar, Nikhil / Larson, Derek T / Bazan, Samantha E /

English, Caroline / Parmelee, Edward / Mende, Katrin / Laing, Eric D / Broder, Christopher C / Blair, Paul W / Chenoweth, Josh G / Simons, Mark P / Tribble, David R / Agan, Brian K / Burgess, Timothy H

Open forum infectious diseases

2021 Volume 8, Issue 12, Page(s) ofab556

Abstract: Background: We evaluated clinical outcomes, functional burden, and complications 1 month after coronavirus disease 2019 (COVID-19) infection in a prospective US Military Health System (MHS) cohort of active duty, retiree, and dependent populations using ...

Abstract	Background: We evaluated clinical outcomes, functional burden, and complications 1 month after coronavirus disease 2019 (COVID-19) infection in a prospective US Military Health System (MHS) cohort of active duty, retiree, and dependent populations using serial patient-reported outcome surveys and electronic medical record (EMR) review. Methods: MHS beneficiaries presenting at 9 sites across the United States with a positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test, a COVID-19-like illness, or a high-risk SARS-CoV-2 exposure were eligible for enrollment. Medical history and clinical outcomes were collected through structured interviews and International Classification of Diseases-based EMR review. Risk factors associated with hospitalization were determined by multivariate logistic regression. Results: A total of 1202 participants were enrolled. There were 1070 laboratory-confirmed SARS-CoV-2 cases and 132 SARS-CoV-2-negative participants. In the first month post-symptom onset among the SARS-CoV-2-positive cases, there were 212 hospitalizations, 80% requiring oxygen, 20 ICU admissions, and 10 deaths. Risk factors for COVID-19-associated hospitalization included race (increased for Asian, Black, and Hispanic compared with non-Hispanic White), age (age 45-64 and 65+ compared with <45), and obesity (BMI≥30 compared with BMI<30). Over 2% of survey respondents reported the need for supplemental oxygen, and 31% had not returned to normal daily activities at 1 month post-symptom onset. Conclusions: Older age, reporting Asian, Black, or Hispanic race/ethnicity, and obesity are associated with SARS-CoV-2 hospitalization. A proportion of acute SARS-CoV-2 infections require long-term oxygen therapy; the impact of SARS-CoV-2 infection on short-term functional status was substantial. A significant number of MHS beneficiaries had not yet returned to normal activities by 1 month.
Language	English
Publishing date	2021-11-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofab556
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Article: Adverse Effects and Antibody Titers in Response to the BNT162b2 mRNA COVID-19 Vaccine in a Prospective Study of Healthcare Workers.

Coggins, Si'Ana A / Laing, Eric D / Olsen, Cara H / Goguet, Emilie / Moser, Matthew / Jackson-Thompson, Belinda M / Samuels, Emily C / Pollett, Simon D / Tribble, David R / Davies, Julian / Illinik, Luca / Hollis-Perry, Monique / Maiolatesi, Santina E / Duplessis, Christopher A / Ramsey, Kathleen F / Reyes, Anatalio E / Alcorta, Yolanda / Wong, Mimi A / Wang, Gregory /

Ortega, Orlando / Parmelee, Edward / Lindrose, Alyssa R / Snow, Andrew L / Malloy, Allison M W / Letizia, Andrew G / Ewing, Daniel / Powers, John H / Schully, Kevin L / Burgess, Timothy H / Broder, Christopher C / Mitre, Edward

Open forum infectious diseases

2021 Volume 9, Issue 1, Page(s) ofab575

Abstract: Background: The relationship between postvaccination symptoms and strength of antibody responses is unclear. The goal of this study was to determine whether adverse effects caused by vaccination with the Pfizer/BioNTech BNT162b2 vaccine are associated ... ...

Abstract	Background: The relationship between postvaccination symptoms and strength of antibody responses is unclear. The goal of this study was to determine whether adverse effects caused by vaccination with the Pfizer/BioNTech BNT162b2 vaccine are associated with the magnitude of vaccine-induced antibody levels. Methods: We conducted a single-center, observational cohort study consisting of generally healthy adult participants that were not severely immunocompromised, had no history of coronavirus disease 2019, and were seronegative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein before vaccination. Severity of vaccine-associated symptoms was obtained through participant-completed questionnaires. Testing for immunoglobulin G antibodies against SARS-CoV-2 spike protein and receptor-binding domain was conducted using microsphere-based multiplex immunoassays performed on serum samples collected at monthly visits. Neutralizing antibody titers were determined by microneutralization assays. Results: Two hundred six participants were evaluated (69.4% female, median age 41.5 years old). We found no correlation between vaccine-associated symptom severity scores and vaccine-induced antibody titers 1 month after vaccination. We also observed that (1) postvaccination symptoms were inversely correlated with age and weight and more common in women, (2) systemic symptoms were more frequent after the second vaccination, (3) high symptom scores after first vaccination were predictive of high symptom scores after second vaccination, and (4) older age was associated with lower titers. Conclusions: Lack of postvaccination symptoms after receipt of the BNT162b2 vaccine does not equate to lack of vaccine-induced antibodies 1 month after vaccination.
Language	English
Publishing date	2021-11-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofab575
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Article ; Online: Prospective Assessment of SARS-CoV-2 Seroconversion (PASS) study: an observational cohort study of SARS-CoV-2 infection and vaccination in healthcare workers.

Jackson-Thompson, Belinda M / Goguet, Emilie / Laing, Eric D / Olsen, Cara H / Pollett, Simon / Hollis-Perry, K Monique / Maiolatesi, Santina E / Illinik, Luca / Ramsey, Kathleen F / Reyes, Anatalio E / Alcorta, Yolanda / Wong, Mimi A / Davies, Julian / Ortega, Orlando / Parmelee, Edward / Lindrose, Alyssa R / Moser, Matthew / Graydon, Elizabeth / Letizia, Andrew G /

Duplessis, Christopher A / Ganesan, Anuradha / Pratt, Kathleen P / Malloy, Allison M / Scott, David W / Anderson, Stephen K / Snow, Andrew L / Dalgard, Clifton L / Powers, John H / Tribble, David / Burgess, Timothy H / Broder, Christopher C / Mitre, Edward

BMC infectious diseases

2021 Volume 21, Issue 1, Page(s) 544

Abstract: Background: SARS-CoV-2 is a recently emerged pandemic coronavirus (CoV) capable of causing severe respiratory illness. However, a significant number of infected people present as asymptomatic or pauci-symptomatic. In this prospective assessment of at- ... ...

Abstract	Background: SARS-CoV-2 is a recently emerged pandemic coronavirus (CoV) capable of causing severe respiratory illness. However, a significant number of infected people present as asymptomatic or pauci-symptomatic. In this prospective assessment of at-risk healthcare workers (HCWs) we seek to determine whether pre-existing antibody or T cell responses to previous seasonal human coronavirus (HCoV) infections affect immunological or clinical responses to SARS-CoV-2 infection or vaccination. Methods: A cohort of 300 healthcare workers, confirmed negative for SARS-CoV-2 exposure upon study entry, will be followed for up to 1 year with monthly serology analysis of IgM and IgG antibodies against the spike proteins of SARS-CoV-2 and the four major seasonal human coronavirus - HCoV-OC43, HCoV-HKU1, HCoV-229E, and HCoV-NL63. Participants will complete monthly questionnaires that ask about Coronavirus Disease 2019 (COVID-19) exposure risks, and a standardized, validated symptom questionnaire (scoring viral respiratory disease symptoms, intensity and severity) at least twice monthly and any day when any symptoms manifest. SARS-CoV-2 PCR testing will be performed any time participants develop symptoms consistent with COVID-19. For those individuals that seroconvert and/or test positive by SARS-CoV-2 PCR, or receive the SARS-CoV-2 vaccine, additional studies of T cell activation and cytokine production in response to SARS-CoV-2 peptide pools and analysis of Natural Killer cell numbers and function will be conducted on that participant's cryopreserved baseline peripheral blood mononuclear cells (PBMCs). Following the first year of this study we will further analyze those participants having tested positive for COVID-19, and/or having received an authorized/licensed SARS-CoV-2 vaccine, quarterly (year 2) and semi-annually (years 3 and 4) to investigate immune response longevity. Discussion: This study will determine the frequency of asymptomatic and pauci-symptomatic SARS-CoV-2 infection in a cohort of at-risk healthcare workers. Baseline and longitudinal assays will determine the frequency and magnitude of anti-spike glycoprotein antibodies to the seasonal HCoV-OC43, HCoV-HKU1, HCoV-229E, and HCoV-NL63, and may inform whether pre-existing antibodies to these human coronaviruses are associated with altered COVID-19 disease course. Finally, this study will evaluate whether pre-existing immune responses to seasonal HCoVs affect the magnitude and duration of antibody and T cell responses to SARS-CoV-2 vaccination, adjusting for demographic covariates.
MeSH term(s)	Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Asymptomatic Infections ; COVID-19/immunology ; COVID-19 Vaccines/immunology ; Coronavirus/immunology ; Cross Reactions ; Health Personnel/statistics & numerical data ; Humans ; Prospective Studies ; SARS-CoV-2/immunology ; Seroconversion ; Spike Glycoprotein, Coronavirus/immunology ; T-Lymphocytes/immunology ; Vaccination/statistics & numerical data
Chemical Substances	Antibodies, Viral ; COVID-19 Vaccines ; Spike Glycoprotein, Coronavirus
Language	English
Publishing date	2021-06-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-021-06233-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Prospective Assessment of Symptoms to Evaluate Asymptomatic SARS-CoV-2 Infections in a Cohort of Health Care Workers.

Goguet, Emilie / Powers, John H / Olsen, Cara H / Tribble, David R / Davies, Julian / Illinik, Luca / Jackson-Thompson, Belinda M / Hollis-Perry, Monique / Maiolatesi, Santina E / Pollett, Simon / Duplessis, Christopher A / Wang, Gregory / Ramsey, Kathleen F / Reyes, Anatalio E / Alcorta, Yolanda / Wong, Mimi A / Ortega, Orlando / Parmelee, Edward / Lindrose, Alyssa R /

Moser, Matthew / Samuels, Emily C / Coggins, Si'Ana A / Graydon, Elizabeth / Robinson, Sara / Campbell, Wesley / Malloy, Allison M W / Voegtly, Logan J / Arnold, Catherine E / Cer, Regina Z / Malagon, Francisco / Bishop-Lilly, Kimberly A / Burgess, Timothy H / Broder, Christopher C / Laing, Eric D / Mitre, Edward

Open forum infectious diseases

2022 Volume 9, Issue 3, Page(s) ofac030

Abstract: Background: The frequency of asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is unclear and may be influenced by how symptoms are evaluated. In this study, we sought to determine the frequency of asymptomatic SARS- ... ...

Abstract	Background: The frequency of asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is unclear and may be influenced by how symptoms are evaluated. In this study, we sought to determine the frequency of asymptomatic SARS-CoV-2 infections in a prospective cohort of health care workers (HCWs). Methods: A prospective cohort of HCWs, confirmed negative for SARS-CoV-2 exposure upon enrollment, were evaluated for SARS-CoV-2 infection by monthly analysis of SARS-CoV-2 antibodies as well as referral for polymerase chain reaction testing whenever they exhibited symptoms of coronavirus disease 2019 (COVID-19). Participants completed the standardized and validated FLU-PRO Plus symptom questionnaire scoring viral respiratory disease symptom intensity and frequency at least twice monthly during baseline periods of health and each day they had any symptoms that were different from their baseline. Results: Two hundred sixty-three participants were enrolled between August 25 and December 31, 2020. Through February 28, 2021, 12 participants were diagnosed with SARS-CoV-2 infection. Symptom analysis demonstrated that all 12 had at least mild symptoms of COVID-19, compared with baseline health, near or at time of infection. Conclusions: These results suggest that asymptomatic SARS-CoV-2 infection in unvaccinated, immunocompetent adults is less common than previously reported. While infectious inoculum doses and patient factors may have played a role in the clinical manifestations of SARS-CoV-2 infections in this cohort, we suspect that the high rate of symptomatic disease was due primarily to participant attentiveness to symptoms and collection of symptoms in a standardized, prospective fashion. These results have implications for studies that estimate SARS-CoV-2 infection prevalence and for public health measures to control the spread of this virus.
Language	English
Publishing date	2022-02-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofac030
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Article ; Online: Immune and behavioral correlates of protection against symptomatic post-vaccination SARS-CoV-2 infection

Goguet, Emilie / Olsen, Cara / Meyer, William A / Ansari, Sara / Powers, John H / Conner, Tonia L / Coggins, Si'Ana A / Wang, Wei / Wang, Richard / Illinik, Luca / Sanchez Edwards, Margaret / Jackson-Thompson, Belinda M / Hollis-Perry, Monique / Wang, Gregory / Alcorta, Yolanda / Wong, Mimi A / Saunders, David / Mohammed, Roshila / Balogun, Bolatito /

Kobi, Priscilla / Kosh, Lakeesha / Bishop-Lilly, Kimberly / Cer, Regina Z / Arnold, Catherine E / Voegtly, Logan J / Fitzpatrick, Maren / Luquette, Andrea E / Malagon, Francisco / Ortega, Orlando / Parmelee, Edward / Davies, Julian / Lindrose, Alyssa R / Haines-Hull, Hannah / Moser, Matthew S / Samuels, Emily C / Tso, Marana S / Graydon, Elizabeth / Malloy, Allison M.W / Tribble, David R / Burgess, Timothy H / Campbell, Wesley / Robinson, Sara / Broder, Christopher C / O'Connell, Robert J / Weiss, Carol D / Pollett, Simon / Laing, Eric D / Mitre, Edward

medRxiv

Abstract: Background: We sought to determine immune and behavioral pre-infection correlates of protection against SARS-CoV-2 post-vaccine infections in a joint analysis of epidemiological and immunological cohort data. Methods: Serum and saliva samples from 176 ... ...

Abstract	Background: We sought to determine immune and behavioral pre-infection correlates of protection against SARS-CoV-2 post-vaccine infections in a joint analysis of epidemiological and immunological cohort data. Methods: Serum and saliva samples from 176 BNT162b2-vaccinated adults in the Prospective Assessment of SARS-CoV-2 Seroconversion study were collected between October and December 2021 and assessed for serum and saliva levels of Wuhan-1 wild-type (WT) SARS-CoV-2 Spike (S)-specific IgG and IgA binding antibodies (bAb) using a multiplex microsphere-based immunoassay (MMIA). Serum samples were also assessed for WT receptor binding domain (RBD)-specific bAb by two commercial assays, BA.1 S-specific IgG bAb by MMIA, and neutralization activity against D614G, Delta (B.1.617.2), and Omicron BA.1 and BA.1.1 variants using a lentiviral pseudovirus neutralization assay. After the Fall 2021 visit, participants reported all positive PCR and/or antigen tests for SARS-CoV-2. Duration, severity, and type of symptoms, as well as risk exposures and adherence to precautionary measures, were assessed by questionnaires during the Spring 2022 visit. Results: Thirty-two participants (18.2%) developed symptomatic post-vaccination SARS-CoV-2 infections (PVI) between December 7, 2021 and April 1, 2022. Pre-infection WT (geometric mean (GM) of 3,863 vs 2,736 binding antibody unit [BAU]/ml, uninfected vs PVI, p=0.0098) and BA.1 (GM of 276.9 vs 179.9 arbitrary bAb unit [AU]/ml, uninfected vs PVI, p=0.04) anti-S IgG bAb levels measured by MMIA and neutralizing titers (NT) against BA.1 (GM titer [GMT] of 493.6 vs 286.2, uninfected vs PVI, p=0.0313) and BA.1.1 (GMT of 552.0 vs 302.5, uninfected vs PVI, p=0.021) were significantly higher in individuals that did not develop PVIs. WT anti-S bAb levels greater than 5,000 BAU/ml were associated with > 90% protection against symptomatic PVI. In individuals that developed PVI, WT anti-S IgG bAb levels correlated with lower disease severity scores (ρ= -0.3859, p=0.032) and shorter duration of clinical disease (ρ= -0.5273, p=0.0023). WT anti-RBD bAb levels measured by commercial assays correlated strongly with bAb levels measured by MMIA (ρ=0.8239, p<0.0001 and ρ=0.6929, p<0.0001, Roche and Siemens assays, respectively), but did not reach statistical significance for correlation with protection against PVI. Home risk score, but neither work nor home precautionary measures, correlated strongly with risk of PVI (mean score of 20.77 vs 47.33, uninfected vs PVI respectively, p<0.0001). Conclusions: Anti-S IgG bAb levels (directed against either WT or Omicron BA.1 subvariant) and NTs served as correlates of protection against symptomatic SARS-CoV-2 infection. Anti-S (WT) IgG bAb levels remained a significant correlate of protection against PVIs when adjusting for demography and risk behavior. Results of this study also suggest that commercial assays for anti-S bAb may need to be reformatted to enable detection of higher maximum values for use as predictors of increased susceptibility to SARS-CoV-2 infection.
Keywords	covid19
Language	English
Publishing date	2023-08-28
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2023.08.25.23294626
Database	COVID19

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Article ; Online: Durability of antibody responses and frequency of clinical and subclinical SARS-CoV-2 infection six months after BNT162b2 COVID-19 vaccination in healthcare workers

Laing, Eric D / Weiss, Carol D / Samuels, Emily C / Coggins, Si'Ana A / Wang, Wei / Wang, Richard / Vassell, Russell / Sterling, Spencer L / Tso, Marana A / Conner, Tonia / Goguet, Emilie / Jackson-Thompson, Belinda M / Illinik, Luca / Davies, Julian / Ortega, Orlando / Parmelee, Edward / Hollis-Perry, Monique / Maiolatesi, Santina E / Wang, Gregory /

Ramsey, Kathleen F / Reyes, Anatalio E / Alcorta, Yolanda / Wong, Mimi A / Lindrose, Alyssa R / Duplessis, Christopher A / Tribble, David R / Malloy, Allison MW / Burgess, Timothy H / Pollett, Simon D / Olsen, Cara H / Broder, Christopher C / Mitre, Edward

medRxiv

Abstract: Antibodies against SARS-CoV-2 decay but persist six months post-vaccination, with lower levels of neutralizing titers against Delta than wild-type. Only 2 of 227 vaccinated healthcare workers experienced outpatient symptomatic breakthrough infections ... ...

Abstract	Antibodies against SARS-CoV-2 decay but persist six months post-vaccination, with lower levels of neutralizing titers against Delta than wild-type. Only 2 of 227 vaccinated healthcare workers experienced outpatient symptomatic breakthrough infections despite 59 of 227 exhibiting serological evidence of exposure to SARS-CoV-2 as defined by development of anti-nucleocapsid protein antibodies.
Keywords	covid19
Language	English
Publishing date	2021-10-18
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2021.10.16.21265087
Database	COVID19

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