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Article ; Online: Hypericum perforatum L. and the Underlying Molecular Mechanisms for Its Choleretic, Cholagogue, and Regenerative Properties

Ala Mohagheghzadeh / Parmis Badr / Abdolali Mohagheghzadeh / Shiva Hemmati

Pharmaceuticals, Vol 16, Iss 887, p

2023 Volume 887

Abstract: Any defects in bile formation, secretion, or flow may give rise to cholestasis, liver fibrosis, cirrhosis, and hepatocellular carcinoma. As the pathogenesis of hepatic disorders is multifactorial, targeting parallel pathways potentially increases the ... ...

Abstract	Any defects in bile formation, secretion, or flow may give rise to cholestasis, liver fibrosis, cirrhosis, and hepatocellular carcinoma. As the pathogenesis of hepatic disorders is multifactorial, targeting parallel pathways potentially increases the outcome of therapy. Hypericum perforatum has been famed for its anti-depressive effects. However, according to traditional Persian medicine, it helps with jaundice and acts as a choleretic medication. Here, we will discuss the underlying molecular mechanisms of Hypericum for its use in hepatobiliary disorders. Differentially expressed genes retrieved from microarray data analysis upon treatment with safe doses of Hypericum extract and intersection with the genes involved in cholestasis are identified. Target genes are located mainly at the endomembrane system with integrin-binding ability. Activation of α5β1 integrins, as osmo-sensors in the liver, activates a non-receptor tyrosine kinase, c-SRC, which leads to the insertion of bile acid transporters into the canalicular membrane to trigger choleresis. Hypericum upregulates CDK6 that controls cell proliferation, compensating for the bile acid damage to hepatocytes. It induces ICAM1 to stimulate liver regeneration and regulates nischarin, a hepatoprotective receptor. The extract targets the expression of conserved oligomeric Golgi (COG) and facilitates the movement of bile acids toward the canalicular membrane via Golgi-derived vesicles. In addition, Hypericum induces SCP2, an intracellular cholesterol transporter, to maintain cholesterol homeostasis. We have also provided a comprehensive view of the target genes affected by Hypericum ’s main metabolites, such as hypericin, hyperforin, quercitrin, isoquercitrin, quercetin, kaempferol, rutin, and p -coumaric acid to enlighten a new scope in the management of chronic liver disorders. Altogether, standard trials using Hypericum as a neo-adjuvant or second-line therapy in ursodeoxycholic-acid-non-responder patients define the future trajectories of cholestasis treatment ...
Keywords	bile acid ; bioactive compounds ; cholesterol ; p -coumaric acid ; hypericin ; hyperforin ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
Subject code	616
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Survey on Ethnic Foods and Desserts of Mohr City in Fars

Parmis Badr / Sedigheh Khademian

Traditional and Integrative Medicine, Vol 4, Iss

2019 Volume 1

Abstract: Ethnic foods, a distinctive part of a cultural group or nation, have recently attracted scientists' attention because of their potential health benefits. The city of Mohr in Fars province has an old record in history, dating back to periods of ... ...

Abstract	Ethnic foods, a distinctive part of a cultural group or nation, have recently attracted scientists' attention because of their potential health benefits. The city of Mohr in Fars province has an old record in history, dating back to periods of Achaemenids and Sasanids. To collect local data about ethnic foods and desserts of Mohr city, a questionnaire was designed and handed out to students of one high school. Thirty female students, familiar with the city culture and rituals, answered the questionnaire. The average age of respondents was 16.04 ± 0.84 years. The references were women in the families, mostly mothers. Thirteen desserts and fourteen types of food were extracted from questionnaires. Among local foods, Sorou, Sholak, Reshtakou, and Gevzeh were highly mentioned. Halva Khorma, Ranginak, Jollab, Kaster, and Dishou had higher numbers among Mohr ethnic desserts. Using local products like date, fish, and wheat as food ingredients was more common. Recording old recipes and eating behaviors of ethnic groups are of great importance. For the next step, health benefits of these dishes are suggested to be deeply studied in further research.
Keywords	Ethnic food ; Ethnic dessert ; Mohr ; Fars ; Iran ; Public aspects of medicine ; RA1-1270
Subject code	390
Language	English
Publishing date	2019-03-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Potentials of Antitussive Traditional Persian Functional Foods for COVID-19 Therapy†

Ghazaleh Mosleh / Parmis Badr / Meysam Zaeri / Abdolali Mohagheghzadeh

Frontiers in Pharmacology, Vol

2021 Volume 12

Abstract: Coronavirus disease 2019 is a worldwide pandemic resulting in a severe acute respiratory syndrome. Remdesivir is the only FDA-approved drug for hospitalized patients older than age 12. It shows the necessity of finding new therapeutic strategies. ... ...

Abstract	Coronavirus disease 2019 is a worldwide pandemic resulting in a severe acute respiratory syndrome. Remdesivir is the only FDA-approved drug for hospitalized patients older than age 12. It shows the necessity of finding new therapeutic strategies. Functional foods (FFs) could have co-therapeutic and protective effects against COVID-19 infection. Traditional Persian medicine (TPM), one of the safest and most popular schools of medicine for hundreds of years, has recommended potential FF candidates to manage such a global pandemic. To reveal the potential of TPM in terms of antitussive FFs, traditional Persian pharmacopoeia “Qarabadin-e-Salehi” was searched using the keywords “Soaal” and “Sorfeh.” Also, a search of MEDLINE, PubMed Central, Google Scholar, and Science Direct was performed for the relevant literature published from the inception up to March 2021. A combination of search terms including “cough, antitussive, antioxidant, anti-inflammation, antiviral, COVID-19, mucoactive, mucolytic, expectorant, and mucoregulatory” was also applied. The potential mechanism of action in SARS-CoV-2 infection was discussed. Twelve TPM FFs were found including Laooqs, Morabbas, a Saviq, a soup, and a syrup. They are combinations of two to seven ingredients. Natural compounds of mentioned formulations have the main pharmacological mechanisms including antiviral, anti-inflammatory, antioxidant, antihistamine, bronchodilator, immunomodulatory, and mucoactive effects as well as central or peripheral antitussive activities. FFs are cost-effective, easily accessible, and safe options for both treatment and prevention of COVID-19. They might have positive psychological effects along with their pharmacological effects and nutritional virtues. They could also manage persistent respiratory discomforts after recovery from COVID-19.
Keywords	antitussive ; functional foods ; traditional Persian medicine ; phytochemical ; COVID-19 ; Therapeutics. Pharmacology ; RM1-950
Subject code	610
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Compote-Like Nutraceutical of Naqoa

Parmis Badr / Forough Afsari Sardari

Traditional and Integrative Medicine, Vol 4, Iss

A Traditional Cholagogue Agent

2019 Volume 4

Abstract: The system of medieval medicine was based on the four humors (blood, yellow bile, black bile, and phlegm) theory that connected disorders to disturbance of humor balance. Herbal infusions containing fruits in a sugary solvent were one of the preferences ... ...

Abstract	The system of medieval medicine was based on the four humors (blood, yellow bile, black bile, and phlegm) theory that connected disorders to disturbance of humor balance. Herbal infusions containing fruits in a sugary solvent were one of the preferences when bile exceeded. Current study aimed to introduce the traditional nutraceutical of naqoa and analyze the formulations suited for bilious disorders. Formulations of naqoa were extracted from three main multi-component encyclopedias of Traditional Iranian pharmacy, Qarabadin Salehi, Qarabadin Kabir, and Qarabadin Azam. Fifteen compote-like formulations were selected and analyzed. The scientific names of ingredients were authenticated, and the constituents and pharmacology of highly-used ingredients were discussed. Frequent indications among 53 formulations of naqoa were fever, and bilious disorders such as hot-temperament headache, warmth in liver or stomach, and thirst. Highly-repeated ingredients in naqoa were fruits of Prunus domestica, Ziziphus jujube, Tamarindus indica, Prunus armeniaca, the flower of Viola odorata, and the manna of Alhagi maurorum. All things considered, the compote-like formulation of naqoa is a multi-fruit nutraceutical in a sugary solvent, that has been traditionally prescribed for bilious disorders as an efficient cholagogue.
Keywords	Nutraceutical ; Naqoa ; Cholagogue ; Traditional iranian pharmacy ; Public aspects of medicine ; RA1-1270
Subject code	001
Language	English
Publishing date	2019-12-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Burn Wound Healing Effect of a Sterilized Traditional Formulation of Boswellia carteri vs. Silver Sulfadiazine Cream 1% in Patients Presenting Second-degree Burn Wounds

Parmis Badr / Suleiman Afsharypuor / Hamid Reza Tohidinik / Ali Akbar Mohammadi / Saeid Daneshamouz

Iranian Journal of Medical Sciences, Vol 48, Iss 2, Pp 137-

A Randomized, Double-blind Clinical Trial

2023 Volume 145

Abstract: Background: Burn wounds rank among the most serious healthcare issues. Many studies reported the effectiveness of natural products in the wound-healing process. The present study compared the effects of a standardized herbal formulation derived from ... ...

Abstract	Background: Burn wounds rank among the most serious healthcare issues. Many studies reported the effectiveness of natural products in the wound-healing process. The present study compared the effects of a standardized herbal formulation derived from Boswellia carteri (B. carteri) and silver sulfadiazine (SSD) cream 1% on the healing of burn wounds.Methods: This randomized double-blind clinical trial was conducted at Shiraz Burn Hospital (Shiraz, Iran) between July 2012 to August 2013. A sterilized formulation comprising B. carteri 40% was prepared. 54 second-degree burn patients of both sexes with age ranges of 20 to 60 were invited to participate in this double-blind, randomized clinical trial. They were randomly divided into two groups and given either the Boswellia formulation or SSD cream. The healing index was determined based on the wound area assessment using the planimetry technique. The Kaplan-Meier survival analysis was used to assess the primary outcome, which was the amount of time until complete healing.Results: The trial was completed by 17 patients from the SSD group and 15 patients from the Boswellia group. During the study period, both groups showed a progressive healing trend. The mean (95% CI) healing time in the SSD group was 10.94 (9.03-12.85) days and 10.73 (9.23-12.23) days in the Boswellia group (P=0.71), indicating no significant difference. On the 17th day, the healing index of all patients in the Boswellia group reached 1.Conclusion: Boswellia topical formulation had a burn wound healing effect comparable to that of the standard SSD 1% treatment. Based on the findings of this study, the likelihood of contact dermatitis with Boswellia should be taken into consideration.
Keywords	boswellia ; burns ; wound healing ; clinical trial ; medicine ; traditional ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Shiraz University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Traditional Nutraceutical from Ardakan (Fars)

Mehdi Niazi / Parmis Badr

Traditional and Integrative Medicine, Vol 3, Iss

Sohan Halva

2018 Volume 1

Abstract: Halva, one of the most common nutraceuticals in Traditional Iranian Medicine, is prepared with grains flour, nuts, fruits, spices, oils, and sweeteners. According to Qarabadin Salehi, Sohan Halva is a 17-ingredient confectionary which is suitable for ... ...

Abstract	Halva, one of the most common nutraceuticals in Traditional Iranian Medicine, is prepared with grains flour, nuts, fruits, spices, oils, and sweeteners. According to Qarabadin Salehi, Sohan Halva is a 17-ingredient confectionary which is suitable for cold temperament, backache, impotency, and nervous system disorders. Also, a product with nearly similar features is prepared in Ardakan city in Fars province, Iran. This study is going to compare and analyze similarities and differences between both products. Ingredients, preparation methods, side effects, and contraindications of Sohan Halva were extracted from Qarabadin Salehi and also were obtained from local producers. Clinical studies of each materia medica of Halva were collected. In spite of similar cooking methods of Sohan Halva, there are some differences in spices used in two products. Generally, only four of them including cinnamon, ginger, pepper, and cardamom are similar. Sohan Halva is considered a tonic nutraceutical according to Qarabadin Salehi and local Ardakani producers. Numerous recent studies confirm the effects of this local food. Traditional recipes are valuable heritage of cultures and nations; therefore, reporting such data helps maintaining ancient knowledge not to be forgotten.
Keywords	Sohan Halva ; Ardakan (Fars) ; Qarabadin Salehi ; Ethnic food ; Nutraceutical ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2018-03-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: SWOT Framework of Academic Traditional Iranian Pharmacy (TIP)

Parmis Badr / Mojtaba Taghvafard

Trends in Pharmaceutical Sciences, Vol 2, Iss 3, Pp 183-

2016 Volume 194

Abstract: Traditional Iranian Pharmacy (TIP) is a rarity which has not been introduced to the world. In fact, this branch of pharmacy can benefit Iranians and all people right across the world. It is a new field in Iran, on which a lot of research has not been ... ...

Abstract	Traditional Iranian Pharmacy (TIP) is a rarity which has not been introduced to the world. In fact, this branch of pharmacy can benefit Iranians and all people right across the world. It is a new field in Iran, on which a lot of research has not been done. In other words, this field suffers from scarcity of research. This paper tries to analyze the current situation of TIP in Iran by using the SWOT framework so as to come up with strengths, weaknesses, opportunities, and threats which are associated with this field at the moment. It is believed that this new field has a lot of potentials which can benefit the health care system substantially. Moreover, it can help the economy to a great extent if the schemes and strategies presented by TIP are taken into consideration.
Keywords	Traditional Iranian Pharmacy ; SWOT ; Complementary and Alternative Medicine ; Pharmacy and materia medica ; RS1-441
Subject code	001
Language	English
Publishing date	2016-08-01T00:00:00Z
Publisher	Shiraz University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: SWOT Framework of Academic Traditional Iranian Pharmacy (TIP)

Parmis Badr / Mojtaba Taghvafard

Trends in Pharmaceutical Sciences, Vol 2, Iss 3, Pp 183-

2016 Volume 194

Abstract	Traditional Iranian Pharmacy (TIP) is a rarity which has not been introduced to the world. In fact, this branch of pharmacy can benefit Iranians and all people right across the world. It is a new field in Iran, on which a lot of research has not been done. In other words, this field suffers from scarcity of research. This paper tries to analyze the current situation of TIP in Iran by using the SWOT framework so as to come up with strengths, weaknesses, opportunities, and threats which are associated with this field at the moment. It is believed that this new field has a lot of potentials which can benefit the health care system substantially. Moreover, it can help the economy to a great extent if the schemes and strategies presented by TIP are taken into consideration.
Keywords	traditional iranian pharmacy ; swot ; complementary and alternative medicine ; Pharmacy and materia medica ; RS1-441
Language	English
Publishing date	2016-09-01T00:00:00Z
Publisher	Shiraz University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Roast Natural Products for Gastrointestinal Disorders

Mastoureh Nazari / Amir Azadi / Hajar Ashrafi / Parmis Badr

Traditional and Integrative Medicine, Vol 3, Iss

2018 Volume 2

Abstract: The intensive heat treatment of roasting, a cooking method using hot air, has a major role in food industries. In Traditional Pharmacy of Iran, roasting was a common treatment for natural products. Therein, specific parts of medicinal plants and some ... ...

Abstract	The intensive heat treatment of roasting, a cooking method using hot air, has a major role in food industries. In Traditional Pharmacy of Iran, roasting was a common treatment for natural products. Therein, specific parts of medicinal plants and some minerals were necessarily roasted in order to obtain special characteristics. Qarabadin Salehi was searched to extract multi-component products which included roast ingredients. Effects and indications of each multi-ingredient, used part of ingredients, their proportion in formulation, and the percentage of roast part were mentioned. Thirty formulations which had at least one roast herbal or mineral component were found. They had been suggested for diarrhea, dysentery (Zahir), emesis, enteritis (Sahj), enteric ulcers, gastritis, gripe (maghs), hemorrhoid, and rectal hemorrhage. Other effects were carminative, digestive, liver tonic, stomachic, and tonic. Thirty cases of roast seeds, and ten cases of roast fruits were reported. Twenty-five compounds out of 30 improve abnormal fluid secretion into the small bowl and electrolyte imbalance symptoms. The formulations can be more effective in the case of liquid absorption. Generally, roasting has been a valuable treatment for processing natural products which are used in compounds for gastrointestinal disorders.
Keywords	Roasting ; Traditional Persian Pharmacy ; Gastrointestinal ; Diarrhea ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2018-06-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Startup-Based Learning as an Innovative Method for Pharmacy Education

Ehsan Amiri-Ardekani / Mohammad Hasan Keshavarzi / Seyed Aliakbar Faghihi / Parmis Badr / Mohammad Mehdi Zarshenas / Zohreh Abolhassanzadeh / Abdolali Mohagheghzadeh

Iranian Journal of Medical Sciences, Vol 47, Iss 3, Pp 264-

Medicinal Plants Course Model

2022 Volume 271

Abstract: Background: Familiarizing students with knowledge-based businesses is one of the goals emphasized in the developed educational systems worldwide. This study aimed to design a startup-based learning model )SBL(.Methods: As a qualitative research study, ... ...

Abstract	Background: Familiarizing students with knowledge-based businesses is one of the goals emphasized in the developed educational systems worldwide. This study aimed to design a startup-based learning model )SBL(.Methods: As a qualitative research study, startup teams were formed by the pharmacy students of Shiraz University of Medical Sciences in 2020. This model was used to train 120 students as pharmaceutical entrepreneurs through related lectures, simulations, and field activities. We employed this model for students to become familiar with the various stages of examining market needs, knowledge-based company registration, intellectual property, logo design, and even pharmaceutical product development. Students’ feedback was assessed with a questionnaire designed by the team of researchers, and its results were used to analyze the course and improve the quality of the proposed model. Results: Most of the studied indices revealed that the students rated this model as good or excellent. Satisfaction with more important indices includes student creativity and ideation in educational activity (60.7%), attractive presentation (60.4%), teamwork among learners (62.2%), appropriateness of evaluation method (65.4%), understanding how to make herbal remedies (49.1%), learner participation in the educational activity (74.8%), entrepreneurial motivation (60.7%), and applicability (64.4%).Conclusion: We found this model effective in boosting students’ satisfaction, creativity, and entrepreneurial spirit. Lecturers also play a facilitator role in addition to specialized training. Therefore, in this model, both lecturers and students can grow more and make education more attractive. This study, for the first time, demonstrated that SBL could be applied in education systems and make the students more interested in educational content and help them to prepare for the job market.
Keywords	models ; educational ; entrepreneurship ; pharmacy ; education ; Medicine (General) ; R5-920
Subject code	370
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Shiraz University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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