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  1. Article: Salmonella Bloodstream Infection Secondary to Treatment with Baricitinib in COVID-19.

    Amos, Shoshana / Elinav, Hila / Parnasa, Elchanan

    The Israel Medical Association journal : IMAJ

    2023  Volume 25, Issue 1, Page(s) 78

    MeSH term(s) Humans ; COVID-19 ; COVID-19 Drug Treatment ; Salmonella ; Sepsis
    Chemical Substances baricitinib (ISP4442I3Y)
    Language English
    Publishing date 2023-02-19
    Publishing country Israel
    Document type Letter ; Comment
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
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  2. Article: Inflammatory Sarcoma Presented as a Case of Fever of Unknown Origin.

    Parnasa, Elchanan / Kharouf, Fadi / Rubin, Limor

    The Israel Medical Association journal : IMAJ

    2023  Volume 25, Issue 8, Page(s) 575–576

    MeSH term(s) Humans ; Fever of Unknown Origin/etiology ; Sarcoma/complications ; Sarcoma/diagnosis
    Language English
    Publishing date 2023-08-26
    Publishing country Israel
    Document type Case Reports ; Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
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  3. Article: Glucose-6-Phosphate Dehydrogenase Deficiency and COVID-19 Mortality, ICU Admission, and Length of Hospitalization.

    Parnasa, Elchanan / Perzon, Ofer / Klinger, Aviad / Ezkoria, Tehila / Fischer, Matan

    The Israel Medical Association journal : IMAJ

    2023  Volume 25, Issue 2, Page(s) 88–90

    Abstract: Background: The coronavirus disease 2019 (COVID-19) pandemic has severe consequences in terms of mortality and morbidity. Knowledge of factors that impact COVID-19 may be useful in the search for treatments.: Objectives: To determine the effect of ... ...

    Abstract Background: The coronavirus disease 2019 (COVID-19) pandemic has severe consequences in terms of mortality and morbidity. Knowledge of factors that impact COVID-19 may be useful in the search for treatments.
    Objectives: To determine the effect of glucose-6-phosphate dehydrogenase (G6PD) deficiency on morbidly and mortality associated with COVID-19.
    Methods: All patients admitted to Hadassah Hebrew University Medical Center between 01 March 2020 and 03 May 2021 with a diagnosis of COVID-19 were included. We retrospectively retrieved demographic, clinical, and laboratory data from the hospital's electronic medical records. The main outcomes were mortality, intensive care unit (ICU) admission, and severity of COVID-19.
    Results: The presence of G6PD deficiency emerged as an independent protective predictor for ICU admission (odds ratio [OR] 0.258, 95% confidence interval [95%CI] 0.077-0.619, P = 0.003) and the development of critical illness (OR 0.121, 95%CI 0.005-0.545, P = 0.006). Moreover, patients with G6PD deficiency had a trend toward lower mortality rates that did not reach statistical significance (OR 0.541, 95%CI 0.225-1.088, P = 0.10).
    Conclusions: Patients with G6PD deficiency were less likely to have a severe disease, had lower rates of ICU admission, and trended toward lower mortality rates.
    MeSH term(s) Humans ; COVID-19/epidemiology ; COVID-19/therapy ; Glucosephosphate Dehydrogenase Deficiency/complications ; Glucosephosphate Dehydrogenase Deficiency/epidemiology ; SARS-CoV-2 ; Retrospective Studies ; Hospitalization ; Intensive Care Units
    Language English
    Publishing date 2023-02-25
    Publishing country Israel
    Document type Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
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  4. Article: [FROM OPTIC NERVE EDEMA TO POLYSOMNOGRAPHY - ANOTHER WAY TO DIAGNOSE OBSTRUCTIVE SLEEP APNEA].

    Luski, Shahar / Parnasa, Elchanan / Kruger, Josh M

    Harefuah

    2022  Volume 161, Issue 10, Page(s) 642–644

    Abstract: Introduction: Some systemic diseases have ophthalmic manifestations. Findings on examination of the fundus can assist in the diagnosis and treatment of these diseases. In this manuscript, we present two ophthalmic conditions that cause optic disc edema ... ...

    Abstract Introduction: Some systemic diseases have ophthalmic manifestations. Findings on examination of the fundus can assist in the diagnosis and treatment of these diseases. In this manuscript, we present two ophthalmic conditions that cause optic disc edema and are highly associated with obstructive sleep apnea (OSA). The conditions are non-arteritic anterior ischemic optic neuropathy (NAION), and Papilledema associated with the Pickwickian syndrome. When these conditions are suspected, the patient should be referred for a polysomnography examination.
    MeSH term(s) Humans ; Polysomnography/adverse effects ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/therapy ; Optic Neuropathy, Ischemic/diagnosis ; Optic Neuropathy, Ischemic/etiology ; Optic Nerve ; Edema
    Language Hebrew
    Publishing date 2022-10-31
    Publishing country Israel
    Document type English Abstract ; Journal Article
    ZDB-ID 953872-0
    ISSN 0017-7768
    ISSN 0017-7768
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  5. Article: Autoimmune Encephalitis Secondary to COVID-19 Infection.

    Parnasa, Elchanan / Kupietzky, Amram / Korem, Maya / Daana, Morad

    The Israel Medical Association journal : IMAJ

    2021  Volume 23, Issue 6, Page(s) 335

    MeSH term(s) Brain/diagnostic imaging ; COVID-19/diagnosis ; COVID-19/physiopathology ; COVID-19/psychology ; Cerebrospinal Fluid/immunology ; Cerebrospinal Fluid/virology ; Confusion/diagnosis ; Confusion/etiology ; Dose-Response Relationship, Drug ; Encephalitis/diagnosis ; Encephalitis/etiology ; Encephalitis/immunology ; Encephalitis/therapy ; Glucocorticoids/administration & dosage ; Hashimoto Disease/diagnosis ; Hashimoto Disease/etiology ; Hashimoto Disease/immunology ; Hashimoto Disease/therapy ; Humans ; Male ; Middle Aged ; Neurologic Examination/methods ; SARS-CoV-2/isolation & purification ; Tomography, X-Ray Computed/methods ; Treatment Outcome
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2021-06-22
    Publishing country Israel
    Document type Case Reports ; Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
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  6. Article ; Online: HLA binding-groove motifs are associated with myocarditis induction after Pfizer-BioNTech BNT162b2 vaccination.

    Aharon, Aviran / Benedek, Gil / Barhoum, Barhoum / Parnasa, Elchanan / Magadle, Nur / Perzon, Ofer / Mevorach, Dror

    European journal of clinical investigation

    2023  Volume 54, Issue 4, Page(s) e14142

    Abstract: Background and aims: We found a higher incidence of myocarditis in young males who had received at least two Pfizer-BioNTech BNT162b2 vaccinations. The human leukocyte antigens (HLA) are known to play an important role in infectious and autoinflammatory ...

    Abstract Background and aims: We found a higher incidence of myocarditis in young males who had received at least two Pfizer-BioNTech BNT162b2 vaccinations. The human leukocyte antigens (HLA) are known to play an important role in infectious and autoinflammatory diseases. We hypothesized that certain HLA alleles might be associated with vaccination-induced myocarditis.
    Methods: HLA typing was performed using next-generation sequencing technology with the Illumina Iseq100 platform. HLA class I and II loci were genotyped in 29 patients with post-vaccination myocarditis and compared with HLA data from 300 healthy controls.
    Results: We demonstrate that the DRB1*14:01, DRB1*15:03 alleles and the motifs in HLA-A - Leu62 and Gln63, which are part of binding pocket B and HLA-DR Tyr47, His60, Arg70 and Glu74, which are part of binding pockets P4, P7 and P9, were significantly associated with disease susceptibility.
    Conclusions: Our findings suggest that immunogenetic fingerprints in HLA peptide-binding grooves may affect the presentation of peptides derived from the Pfizer-BioNTech BNT162b2 vaccination to T cells and induce an inflammatory process that results in myocarditis.
    MeSH term(s) Male ; Humans ; BNT162 Vaccine ; Myocarditis/chemically induced ; Myocarditis/genetics ; HLA-DRB1 Chains/metabolism ; HLA Antigens ; Disease Susceptibility ; Peptides
    Chemical Substances BNT162 Vaccine ; HLA-DRB1 Chains ; HLA Antigens ; Peptides
    Language English
    Publishing date 2023-12-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.14142
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    Zs.A 677: Show issues Location:
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  7. Article: Immune Thrombocytopenia Secondary to COVID-19 Infection.

    Kupietzky, Amram / Parnasa, Elchanan / Fischer, Matan / Kuint, Rottem / Daana, Murad

    The Israel Medical Association journal : IMAJ

    2021  Volume 23, Issue 6, Page(s) 342–343

    MeSH term(s) Aged ; Autoantibodies/blood ; COVID-19/blood ; COVID-19/complications ; COVID-19/physiopathology ; COVID-19/therapy ; Cardiolipins/immunology ; Diagnosis, Differential ; Humans ; Hydrocortisone ; Immunoglobulins, Intravenous/administration & dosage ; Immunologic Factors/administration & dosage ; Male ; Middle Aged ; Patient Acuity ; Platelet Count/methods ; Purpura, Thrombocytopenic, Idiopathic/diagnosis ; Purpura, Thrombocytopenic, Idiopathic/etiology ; Purpura, Thrombocytopenic, Idiopathic/therapy ; SARS-CoV-2/isolation & purification ; Treatment Outcome
    Chemical Substances Autoantibodies ; Cardiolipins ; Immunoglobulins, Intravenous ; Immunologic Factors ; Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2021-06-22
    Publishing country Israel
    Document type Case Reports ; Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
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  8. Article ; Online: Pathogenic Variants of Scavenger Receptor

    Canavati, Christina / Siam, Ahmad / Labes, Sapir / Trabelsi, Nirit / Regev, Eshcar / Parnasa, Elchanan / Barhoum, Barhoum / Magadle, Nur / Perzon, Ofer / Braun, Maya / Mor-Shaked, Hagar / Schueler-Furman, Ora / Tabach, Yuval / Mevorach, Dror

    Circulation

    2024  Volume 149, Issue 3, Page(s) 270–273

    MeSH term(s) Humans ; BNT162 Vaccine/adverse effects ; COVID-19/prevention & control ; Efferocytosis ; Myocarditis/chemically induced ; Vaccination/adverse effects
    Chemical Substances BNT162 Vaccine
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.123.064884
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  9. Article ; Online: Desensitization protocol to lenalidomide: An effective and safe treatment modality for delayed hypersensitivity-induced rash in patients with multiple myeloma.

    Shamriz, Oded / Parnasa, Elchanan / Rubin, Limor / Talmon, Aviv / Ribak, Yaarit / Lebel, Eyal / Vainstein, Vladimir / Aumann, Shlomzion / Saban, Revital / Gatt, Moshe E / Tal, Yuval

    European journal of haematology

    2023  Volume 110, Issue 4, Page(s) 407–413

    Abstract: Introduction and objectives: Lenalidomide is considered a standard of care in multiple myeloma (MM) Some MM patients will develop delayed hypersensitivity to lenalidomide, which can lead to treatment discontinuation. Desensitization to lenalidomide can ... ...

    Abstract Introduction and objectives: Lenalidomide is considered a standard of care in multiple myeloma (MM) Some MM patients will develop delayed hypersensitivity to lenalidomide, which can lead to treatment discontinuation. Desensitization to lenalidomide can help these patients to complete treatment courses. Here, we aimed to review lenalidomide-treated MM patients who developed delayed hypersensitivity-induced rash and were treated with desensitization.
    Methods: A retrospective analysis of medical files of MM patients, who were desensitized to lenalidomide due to delayed hypersensitivity rash. Patients were treated between 2018 and 2022 at Hadassah Medical Center, Jerusalem, Israel.
    Results: Search of patients yielded 16 patients that underwent desensitization to lenalidomide within the study period. The desensitization protocol consisted of a slow, 3-week-long protocol with lenalidomide's target doses of 10, 15, and 25 mg/day. Of the 16 patients, 10 (62.5%) succeeded to complete the protocol and thus were able to complete lenalidomide treatment cycles. One patient with unsuccessful desensitization was subsequently treated with first-generation IMiD thalidomide, with no rash appearing. None of the patients that were treated with desensitization had severe immune-mediated or non-dermatological adverse reactions.
    Conclusions: Desensitization to lenalidomide is safe and effective. Discontinuation of lenalidomide in MM patients with delayed hypersensitivity and no contraindication to desensitization should be discouraged. Collaboration between hematologists and allergists is needed.
    MeSH term(s) Humans ; Lenalidomide/therapeutic use ; Multiple Myeloma/drug therapy ; Retrospective Studies ; Exanthema/chemically induced ; Exanthema/therapy ; Hypersensitivity, Delayed/chemically induced ; Hypersensitivity, Delayed/therapy
    Chemical Substances Lenalidomide (F0P408N6V4)
    Language English
    Publishing date 2023-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 392482-8
    ISSN 1600-0609 ; 0902-4441
    ISSN (online) 1600-0609
    ISSN 0902-4441
    DOI 10.1111/ejh.13918
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    Zs.A 323: Show issues Location:
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  10. Article ; Online: Myocarditis after BNT162b2 Vaccination in Israeli Adolescents.

    Mevorach, Dror / Anis, Emilia / Cedar, Noa / Hasin, Tal / Bromberg, Michal / Goldberg, Lital / Parnasa, Elchanan / Dichtiar, Rita / Hershkovitz, Yael / Ash, Nachman / Green, Manfred S / Keinan-Boker, Lital / Alroy-Preis, Sharon

    The New England journal of medicine

    2022  Volume 386, Issue 10, Page(s) 998–999

    MeSH term(s) Adolescent ; BNT162 Vaccine/adverse effects ; Child ; Female ; Hospitalization/statistics & numerical data ; Humans ; Immunization, Secondary/adverse effects ; Incidence ; Israel/epidemiology ; Male ; Myocarditis/chemically induced ; Myocarditis/epidemiology ; Risk ; Sex Distribution
    Chemical Substances BNT162 Vaccine (N38TVC63NU)
    Language English
    Publishing date 2022-01-26
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2116999
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