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  1. Book: Changing faces

    Partridge, James

    the challenge of facial disfigurement

    (A Penguin book : Health - Medicine)

    1990  

    Author's details James Partridge
    Series title A Penguin book : Health - Medicine
    Keywords Facial Injuries / surgery ; Surgery, Plastic ; Burns / surgery ; Body Image ; Adaptation, Psychological ; Social Adjustment
    Language English
    Size XI, 132 S.
    Publisher Penguin Books
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT006485466
    ISBN 0-14-011597-8 ; 978-0-14-011597-0
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1995 B 254 order for loan Magazin

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  2. Article ; Online: Psycho-social reflections on craniofacial morphogenesis.

    Partridge, James

    Seminars in cell & developmental biology

    2010  Volume 21, Issue 3, Page(s) 333–338

    Abstract: Psychologists are now increasingly involved in understanding the challenges faced by people who experience facial disfigurements from many causes (congenital, traumatic, oncological, iatrogenic, neurological, ophthalmological or dermatological). This ... ...

    Abstract Psychologists are now increasingly involved in understanding the challenges faced by people who experience facial disfigurements from many causes (congenital, traumatic, oncological, iatrogenic, neurological, ophthalmological or dermatological). This article describes how the author has combined the lessons of his personal recovery after severe facial burns with the rigorous science of psychological research to enable improved psycho-social support and interventions to be developed, through a UK not-for-profit (Changing Faces) and in formal health care services. It suggests that against the background of a culture that is less-than-positive about disfigurement, anyone who experiences it needs access to a range of support, advice, counselling and social skills training to enable them to live full, confident lives.
    MeSH term(s) Adaptation, Psychological ; Body Image ; Burns/psychology ; Burns/therapy ; Craniofacial Abnormalities/psychology ; Craniofacial Abnormalities/therapy ; Cultural Characteristics ; Face/abnormalities ; Face/pathology ; Facial Injuries/psychology ; Humans ; Social Behavior ; Stress, Psychological/psychology ; United Kingdom
    Language English
    Publishing date 2010-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2010.01.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Electrically Tunable, Rapid Spin-Orbit Torque Induced Modulation of Colossal Magnetoresistance in Mn

    Tan, Cheng / Deng, Mingxun / Yang, Yuanjun / An, Linlin / Ge, Weifeng / Albarakati, Sultan / Panahandeh-Fard, Majid / Partridge, James / Culcer, Dimitrie / Lei, Bin / Wu, Tao / Zhu, Xiangde / Tian, Mingliang / Chen, Xianhui / Wang, Rui-Qiang / Wang, Lan

    Nano letters

    2024  Volume 24, Issue 14, Page(s) 4158–4164

    Abstract: As a quasi-layered ferrimagnetic material, ... ...

    Abstract As a quasi-layered ferrimagnetic material, Mn
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.4c00054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: From burns unit to boardroom.

    Partridge, James

    BMJ (Clinical research ed.)

    2006  Volume 332, Issue 7547, Page(s) 956–959

    MeSH term(s) Adaptation, Psychological ; Anecdotes as Topic ; Burns/psychology ; Burns/surgery ; Employment ; Facial Injuries/psychology ; Humans ; Male ; Reconstructive Surgical Procedures
    Language English
    Publishing date 2006-04-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.332.7547.956
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Electrically controlled superconductor-to-failed insulator transition and giant anomalous Hall effect in kagome metal CsV

    Zheng, Guolin / Tan, Cheng / Chen, Zheng / Wang, Maoyuan / Zhu, Xiangde / Albarakati, Sultan / Algarni, Meri / Partridge, James / Farrar, Lawrence / Zhou, Jianhui / Ning, Wei / Tian, Mingliang / Fuhrer, Michael S / Wang, Lan

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 678

    Abstract: The electronic correlations (e.g. unconventional superconductivity (SC), chiral charge order and nematic order) and giant anomalous Hall effect (AHE) in topological kagome metals ... ...

    Abstract The electronic correlations (e.g. unconventional superconductivity (SC), chiral charge order and nematic order) and giant anomalous Hall effect (AHE) in topological kagome metals AV
    Language English
    Publishing date 2023-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-36208-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Synthesis of Spirooxindoles via the tert-Amino Effect.

    Ramakumar, Kinthada / Maji, Tapan / Partridge, James J / Tunge, Jon A

    Organic letters

    2017  Volume 19, Issue 15, Page(s) 4014–4017

    Abstract: A new method is developed for the synthesis of spirooxindoles from amines and isatins via C-H functionalization. The reaction leverages the tert-amino effect to form an enolate-iminium intermediate via [1,5]-hydride shift followed by cyclization. ... ...

    Abstract A new method is developed for the synthesis of spirooxindoles from amines and isatins via C-H functionalization. The reaction leverages the tert-amino effect to form an enolate-iminium intermediate via [1,5]-hydride shift followed by cyclization. Interestingly the hydride migrates to the N atom of a C═N, which is atypical for hydride additions to imines.
    MeSH term(s) Amines/chemistry ; Catalysis ; Cyclization ; Imines/chemistry ; Isatin/chemistry ; Isomerism ; Molecular Structure ; Oxindoles/chemical synthesis ; Solvents ; Spiro Compounds/chemical synthesis ; Stereoisomerism
    Chemical Substances Amines ; Imines ; Oxindoles ; Solvents ; Spiro Compounds ; 2-oxindole (0S9338U62H) ; Isatin (82X95S7M06)
    Language English
    Publishing date 2017-07-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.7b01752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: GBT021601 improves red blood cell health and the pathophysiology of sickle cell disease in a murine model.

    Dufu, Kobina / Alt, Carsten / Strutt, Steven / Partridge, James / Tang, Tzechiang / Siu, Vincent / Liao-Zou, Hilary / Rademacher, Peter / Williams, Alexander T / Muller, Cynthia R / Geng, Xin / Pochron, Mira Patel / Dang, Annie Nguyen / Cabrales, Pedro / Li, Zhe / Oksenberg, Donna / Cathers, Brian E

    British journal of haematology

    2023  Volume 202, Issue 1, Page(s) 173–183

    Abstract: The pathophysiologic mechanism of sickle cell disease (SCD) involves polymerization of deoxygenated haemoglobin S (HbS), leading to red blood cell (RBC) sickling, decreased RBC deformability, microvascular obstruction, haemolysis, anaemia and downstream ... ...

    Abstract The pathophysiologic mechanism of sickle cell disease (SCD) involves polymerization of deoxygenated haemoglobin S (HbS), leading to red blood cell (RBC) sickling, decreased RBC deformability, microvascular obstruction, haemolysis, anaemia and downstream clinical complications. Pharmacological increase in the concentration of oxygenated HbS in RBCs has been shown to be a novel approach to inhibit HbS polymerization and reduce RBC sickling and haemolysis. We report that GBT021601, a small molecule that increases HbS-oxygen affinity, inhibits HbS polymerization and prevents RBC sickling in blood from patients with SCD. Moreover, in a murine model of SCD (SS mice), GBT021601 reduces RBC sickling, improves RBC deformability, prolongs RBC half-life and restores haemoglobin levels to the normal range, while improving oxygen delivery and increasing tolerance to severe hypoxia. Notably, oral dosing of GBT021601 in animals results in higher levels of Hb occupancy than voxelotor and suggests the feasibility of once-daily dosing in humans. In summary, GBT021601 improves RBC health and normalizes haemoglobin in SS mice, suggesting that it may be useful for the treatment of SCD. These data are being used as a foundation for clinical research and development of GBT021601.
    MeSH term(s) Humans ; Animals ; Mice ; Hemolysis ; Disease Models, Animal ; Oxygen ; Anemia, Sickle Cell/drug therapy ; Erythrocytes ; Hemoglobins ; Hemoglobin, Sickle
    Chemical Substances Oxygen (S88TT14065) ; Hemoglobins ; Hemoglobin, Sickle
    Language English
    Publishing date 2023-03-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18771
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  8. Article ; Online: Electric Control of Exchange Bias Effect in FePS

    Albarakati, Sultan / Xie, Wen-Qiang / Tan, Cheng / Zheng, Guolin / Algarni, Meri / Li, Junbo / Partridge, James / Spencer, Michelle J S / Farrar, Lawrence / Xiong, Yimin / Tian, Mingliang / Wang, Xiaolin / Zhao, Yu-Jun / Wang, Lan

    Nano letters

    2022  Volume 22, Issue 15, Page(s) 6166–6172

    Abstract: Manipulating the exchange bias (EB) effect using an electronic gate is a significant goal in spintronics. The emergence of van der Waals (vdW) magnetic heterostructures has provided improved means to study interlayer magnetic coupling, but to date, these ...

    Abstract Manipulating the exchange bias (EB) effect using an electronic gate is a significant goal in spintronics. The emergence of van der Waals (vdW) magnetic heterostructures has provided improved means to study interlayer magnetic coupling, but to date, these heterostructures have not exhibited electrical gate-controlled EB effects. Here, we report electrically controllable EB effects in a vdW heterostructure, FePS
    Language English
    Publishing date 2022-07-31
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.2c01370
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  9. Article: Synthesis of Spirooxindoles via the tert-Amino Effect

    Ramakumar, Kinthada / Maji Tapan / Partridge James J / Tunge Jon A

    Organic letters. 2017 Aug. 04, v. 19, no. 15

    2017  

    Abstract: A new method is developed for the synthesis of spirooxindoles from amines and isatins via C–H functionalization. The reaction leverages the tert-amino effect to form an enolate–iminium intermediate via [1,5]-hydride shift followed by cyclization. ... ...

    Abstract A new method is developed for the synthesis of spirooxindoles from amines and isatins via C–H functionalization. The reaction leverages the tert-amino effect to form an enolate–iminium intermediate via [1,5]-hydride shift followed by cyclization. Interestingly the hydride migrates to the N atom of a C=N, which is atypical for hydride additions to imines.
    Keywords amines ; carbon-hydrogen bond activation ; chemical reactions ; chemical structure ; hydrides ; imines ; methodology
    Language English
    Dates of publication 2017-0804
    Size p. 4014-4017.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1523-7052
    DOI 10.1021/acs.orglett.7b01752
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: The stoichiometry of the nucleoporin 62 subcomplex of the nuclear pore in solution.

    Ulrich, Alexander / Partridge, James R / Schwartz, Thomas U

    Molecular biology of the cell

    2014  Volume 25, Issue 9, Page(s) 1484–1492

    Abstract: The nuclear pore complex (NPC) regulates transport between the nucleus and cytoplasm. Soluble cargo-protein complexes navigate through the pore by binding to phenylalanine-glycine (FG)-repeat proteins attached to the channel walls. The Nup62 complex ... ...

    Abstract The nuclear pore complex (NPC) regulates transport between the nucleus and cytoplasm. Soluble cargo-protein complexes navigate through the pore by binding to phenylalanine-glycine (FG)-repeat proteins attached to the channel walls. The Nup62 complex contains the FG-repeat proteins Nup62, Nup54, and Nup58 and is located in the center of the NPC. The three proteins bind each other via conserved coiled-coil segments. To determine the stoichiometry of the Nup62 complex, we undertook an in vitro study using gel filtration and analytical ultracentrifugation. Our results reveal a 1:1:1 stoichiometry of the Nup62 complex, where Nup54 is central with direct binding to Nup62 and Nup58. At high protein concentration, the complex forms larger assemblies while maintaining the Nup62:Nup54:Nup58 ratio. For the homologous Nsp1 complex from Saccharomyces cerevisiae, we determine the same stoichiometry, indicating evolutionary conservation. Furthermore, we observe that eliminating one binding partner can result in the formation of complexes with noncanonical stoichiometry, presumably because unpaired coiled-coil elements tend to find a promiscuous binding partner. We suggest that these noncanonical stoichiometries observed in vitro are unlikely to be physiologically relevant.
    MeSH term(s) Animals ; Membrane Glycoproteins/chemistry ; Nuclear Pore/ultrastructure ; Nuclear Pore Complex Proteins/chemistry ; Protein Binding ; Protein Multimerization ; Protein Structure, Quaternary ; Rats ; Saccharomyces cerevisiae Proteins/chemistry ; Solutions
    Chemical Substances Membrane Glycoproteins ; Nuclear Pore Complex Proteins ; Nup54 protein, rat ; Nup58 protein, rat ; Saccharomyces cerevisiae Proteins ; Solutions ; nuclear pore protein p62
    Language English
    Publishing date 2014-02-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1098979-1
    ISSN 1939-4586 ; 1059-1524
    ISSN (online) 1939-4586
    ISSN 1059-1524
    DOI 10.1091/mbc.E13-12-0745
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2853: Show issues Location:
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    Zs.MO 410: Show issues

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