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  1. Article ; Online: The voltage-gated K

    Wright, Joy R / Jones, Sarah / Parvathy, Sasikumar / Kaczmarek, Leonard K / Forsythe, Ian / Farndale, Richard W / Gibbins, Jonathan M / Mahaut-Smith, Martyn P

    Platelets

    2021  Volume 33, Issue 3, Page(s) 451–461

    Abstract: Kv1.3 is a voltage-gated ... ...

    Abstract Kv1.3 is a voltage-gated K
    MeSH term(s) Blood Platelets/metabolism ; Collagen/metabolism ; Humans ; Integrin alpha2beta1/metabolism ; Platelet Adhesiveness/physiology ; Platelet Aggregation/physiology ; Potassium Channels, Voltage-Gated/metabolism
    Chemical Substances Integrin alpha2beta1 ; Potassium Channels, Voltage-Gated ; Collagen (9007-34-5)
    Language English
    Publishing date 2021-08-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1034283-7
    ISSN 1369-1635 ; 0953-7104
    ISSN (online) 1369-1635
    ISSN 0953-7104
    DOI 10.1080/09537104.2021.1942818
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Non-genomic effects of the Pregnane X Receptor negatively regulate platelet functions, thrombosis and haemostasis

    Gagan D. Flora / Khaled A. Sahli / Parvathy Sasikumar / Lisa-Marie Holbrook / Alexander R. Stainer / Sarah K. AlOuda / Marilena Crescente / Tanya Sage / Amanda J. Unsworth / Jonathan M. Gibbins

    Scientific Reports, Vol 9, Iss 1, Pp 1-

    2019  Volume 14

    Abstract: Abstract The pregnane X receptor (PXR) is a nuclear receptor (NR), involved in the detoxification of xenobiotic compounds. Recently, its presence was reported in the human vasculature and its ligands were proposed to exhibit anti-atherosclerotic effects. ...

    Abstract Abstract The pregnane X receptor (PXR) is a nuclear receptor (NR), involved in the detoxification of xenobiotic compounds. Recently, its presence was reported in the human vasculature and its ligands were proposed to exhibit anti-atherosclerotic effects. Since platelets contribute towards the development of atherosclerosis and possess numerous NRs, we investigated the expression of PXR in platelets along with the ability of its ligands to modulate platelet activation. The expression of PXR in human platelets was confirmed using immunoprecipitation analysis. Treatment with PXR ligands was found to inhibit platelet functions stimulated by a range of agonists, with platelet aggregation, granule secretion, adhesion and spreading on fibrinogen all attenuated along with a reduction in thrombus formation (both in vitro and in vivo). The effects of PXR ligands were observed in a species-specific manner, and the human-specific ligand, SR12813, was observed to attenuate thrombus formation in vivo in humanised PXR transgenic mice. PXR ligand-mediated inhibition of platelet function was found to be associated with the inhibition of Src-family kinases (SFKs). This study identifies acute, non-genomic regulatory effects of PXR ligands on platelet function and thrombus formation. In combination with the emerging anti-atherosclerotic properties of PXR ligands, these anti-thrombotic effects may provide additional cardio-protective benefits.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2019-11-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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