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  1. Article ; Online: In-silico analysis of potential anticancer drug for NEK7 and PPP1CA proteins overexpressed in pancreatic ductal adenocarcinoma.

    Adrees, Safa / Imtiaz, Anam / Yaseen, Aiman / Irfan Fareed, Muhammad / Anwar, Waqar / Ashraf, Asma / Shabbir, Rana Muhammad Kamran / Andlib, Shaista / Hussain, Mureed / Tariq, Asma / Mateen, Rana Muhammad / Saqib, Muhammad Arif Nadeem / Parveen, Rukhsana

    Journal of biomolecular structure & dynamics

    2024  , Page(s) 1–17

    Abstract: NIMA-related kinase 7 (NEK7) and phosphoprotein phosphatase-1 catalytic subunit alpha (PPP1CA) are the most common proteins overexpressed in pancreatic ductal adenocarcinoma, which is the most common type of pancreatic cancer. The goal of the current ... ...

    Abstract NIMA-related kinase 7 (NEK7) and phosphoprotein phosphatase-1 catalytic subunit alpha (PPP1CA) are the most common proteins overexpressed in pancreatic ductal adenocarcinoma, which is the most common type of pancreatic cancer. The goal of the current study was to identify a possible NEK7 and PPP1CA therapeutic inhibitor. For this investigation, 5000 compounds were retrieved from the IMPPAT library of phytochemicals, which were docked with our respective target proteins. Also, a reference compound, gemcitabine, which is a Food and Drug Administration (FDA) approved drug, was docked with the target proteins. The binding energy of the reference compound for both the targeted proteins was -6.5 kcal/mol. The common ligand with the lowest binding energy for both targets is boeravinone B (PubChem ID: 14018348) with -9.2 kcal/mol of NEK7 and -7.6 kcal/mol for PPP1CA. The compound was further investigated through density function theory (DFT) and molecular dynamic simulation analysis. The root mean square deviation (RMSD), root mean square fluctuation (RMSF), radius of gyration (Rg), and hydrogen bonding analysis indicated the stability of the boeravinone B with the target proteins (NEK7 and PPP1CA).Communicated by Ramaswamy H. Sarma.
    Language English
    Publishing date 2024-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2024.2318484
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Persistence of Semen on five different fabric types in various water environments

    Nabi, Ahmed Ghulam / Mateen, Rana Muhammad / Khalid, Aqsa / Tariq, Asma / Parveen, Rukhsana

    Forensic science international. 2021 Oct., v. 327

    2021  

    Abstract: Evidence collected from biological fluids obtained from a crime scene is essentially important in forensic cases. A potential profile can be generated from these obtained samples and this can help in identifying the victims and/or suspects of sexual ... ...

    Abstract Evidence collected from biological fluids obtained from a crime scene is essentially important in forensic cases. A potential profile can be generated from these obtained samples and this can help in identifying the victims and/or suspects of sexual assault. The water environments selected for this study are all related to the potential crime scenes from which there is a possibility of finding a dead body or clothing of a sexual assault victim. Tap water, River water, Swimming pool water, and Canal water were selected. Fabric types selected were khaddar, linen, silk, polyester, and chiffon. Detection of seminal stains was carried out by three methods; Alternate Light Source (ALS), Acid phosphatase (AP) testing, and Kernechtrot-Picro-indigo-carmine (KPIC) testing. These tests were performed for each fabric type in each water environment after regular intervals, 24 h, 48 h, 72 h, 4 days, 7 days, and 14 days. This study aimed to compare the ability of five types of fabrics to retain seminal material after immersion in four different types of water environments. Fluorescence was only detected in tap water-soaked silk fabric after 14 days of immersion. Seminal fluid was detected in khaddar, chiffon, silk, and polyester in samples immersed for 14 days in tap water. Spermatozoa were retained by khaddar and silk immersed in tap water, Polyester fabric in tap and river water, Chiffon in only river water and Linen in swimming pool water when immersed for 14 days. However, fluorescence, seminal fluid or spermatozoa were not detected in linen fabric regardless of all the afore mentioned variables.
    Keywords acid phosphatase ; crime ; fluorescence ; forensic sciences ; linen fabric ; polyesters ; river water ; silk ; silk fabric ; tap water
    Language English
    Dates of publication 2021-10
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 424042-x
    ISSN 1872-6283 ; 0379-0738
    ISSN (online) 1872-6283
    ISSN 0379-0738
    DOI 10.1016/j.forsciint.2021.110944
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Persistence of Semen on five different fabric types in various water environments.

    Nabi, Ahmed Ghulam / Mateen, Rana Muhammad / Khalid, Aqsa / Tariq, Asma / Parveen, Rukhsana

    Forensic science international

    2021  Volume 327, Page(s) 110944

    Abstract: Evidence collected from biological fluids obtained from a crime scene is essentially important in forensic cases. A potential profile can be generated from these obtained samples and this can help in identifying the victims and/or suspects of sexual ... ...

    Abstract Evidence collected from biological fluids obtained from a crime scene is essentially important in forensic cases. A potential profile can be generated from these obtained samples and this can help in identifying the victims and/or suspects of sexual assault. The water environments selected for this study are all related to the potential crime scenes from which there is a possibility of finding a dead body or clothing of a sexual assault victim. Tap water, River water, Swimming pool water, and Canal water were selected. Fabric types selected were khaddar, linen, silk, polyester, and chiffon. Detection of seminal stains was carried out by three methods; Alternate Light Source (ALS), Acid phosphatase (AP) testing, and Kernechtrot-Picro-indigo-carmine (KPIC) testing. These tests were performed for each fabric type in each water environment after regular intervals, 24 h, 48 h, 72 h, 4 days, 7 days, and 14 days. This study aimed to compare the ability of five types of fabrics to retain seminal material after immersion in four different types of water environments. Fluorescence was only detected in tap water-soaked silk fabric after 14 days of immersion. Seminal fluid was detected in khaddar, chiffon, silk, and polyester in samples immersed for 14 days in tap water. Spermatozoa were retained by khaddar and silk immersed in tap water, Polyester fabric in tap and river water, Chiffon in only river water and Linen in swimming pool water when immersed for 14 days. However, fluorescence, seminal fluid or spermatozoa were not detected in linen fabric regardless of all the afore mentioned variables.
    MeSH term(s) Clothing ; Fluorescence ; Humans ; Immersion ; Male ; Rivers ; Semen ; Spermatozoa ; Swimming Pools ; Textiles/classification ; Time Factors ; Water
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2021-08-13
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 424042-x
    ISSN 1872-6283 ; 0379-0738
    ISSN (online) 1872-6283
    ISSN 0379-0738
    DOI 10.1016/j.forsciint.2021.110944
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Familial DNA analysis and criminal investigation: Usage, downsides and privacy concerns.

    Mateen, Rana Muhammad / Sabar, Muhammad Farooq / Hussain, Safdar / Parveen, Rukhsana / Hussain, Manzoor

    Forensic science international

    2020  Volume 318, Page(s) 110576

    Abstract: Since the discovery of Deoxyribonucleic acid (DNA) capability in forensic investigation, it has been an important part of the criminal justice system. In most criminal cases DNA profile originating from evidence sample collected from the crime scene is ... ...

    Abstract Since the discovery of Deoxyribonucleic acid (DNA) capability in forensic investigation, it has been an important part of the criminal justice system. In most criminal cases DNA profile originating from evidence sample collected from the crime scene is compared with the DNA profile from the reference sample. However, when a reference sample is not available for comparison, familial DNA analysis can provide important investigation leads in a criminal investigation process by identifying an individual. Moreover, this analysis is also proving effective in the identification of ethnicity and ancestry of an individual. A number of different methodologies and software are being used for familial DNA analysis. This review describes the importance of familial DNA analysis, methodologies used for familial DNA searching and identification, and its advantages in forensic. Moreover, ethical, legal and social issues associated with familial DNA analysis have also been discussed along with future directions for the proper implementation of this technology.
    MeSH term(s) Chromosomes, Human, Y ; Continental Population Groups/genetics ; DNA Fingerprinting/ethics ; DNA Fingerprinting/legislation & jurisprudence ; DNA, Mitochondrial ; Databases, Genetic ; Forensic Genetics/ethics ; Forensic Genetics/legislation & jurisprudence ; Genetic Privacy ; Genotype ; Humans ; Microsatellite Repeats ; Pedigree ; Polymorphism, Single Nucleotide
    Chemical Substances DNA, Mitochondrial
    Language English
    Publishing date 2020-11-04
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 424042-x
    ISSN 1872-6283 ; 0379-0738
    ISSN (online) 1872-6283
    ISSN 0379-0738
    DOI 10.1016/j.forsciint.2020.110576
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: In silico identification of potential drug-like molecules against G glycoprotein of Nipah virus by molecular docking, DFT studies, and molecular dynamic simulation.

    Naeem, Iqra / Mateen, Rana Muhammad / Sibtul Hassan, Syed / Tariq, Asma / Parveen, Rukhsana / Saqib, Muhammad Arif Nadeem / Fareed, Muhammad Irfan / Hussain, Mureed / Afzal, Muhammad Sohail

    Journal of biomolecular structure & dynamics

    2022  Volume 41, Issue 15, Page(s) 7104–7118

    Abstract: Nipah virus (NiV) is a novel zoonotic pathogen that belongs to ... ...

    Abstract Nipah virus (NiV) is a novel zoonotic pathogen that belongs to the
    Language English
    Publishing date 2022-08-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2022.2115557
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Microsatellites' mutation modeling through the analysis of the Y-chromosomal transmission: Results of a GHEP-ISFG collaborative study.

    Antão-Sousa, Sofia / Gusmão, Leonor / Modesti, Nidia M / Feliziani, Sofía / Faustino, Marisa / Marcucci, Valeria / Sarapura, Claudia / Ribeiro, Julyana / Carvalho, Elizeu / Pereira, Vania / Tomas, Carmen / de Pancorbo, Marian M / Baeta, Miriam / Alghafri, Rashed / Almheiri, Reem / Builes, Juan José / Gouveia, Nair / Burgos, German / Pontes, Maria de Lurdes /
    Ibarra, Adriana / da Silva, Claudia Vieira / Parveen, Rukhsana / Benitez, Marc / Amorim, António / Pinto, Nadia

    Forensic science international. Genetics

    2023  Volume 69, Page(s) 102999

    Abstract: The Spanish and Portuguese Speaking Working Group of the International Society for Forensic Genetics (GHEP-ISFG) organized a collaborative study on mutations of Y-chromosomal short tandem repeats (Y-STRs). New data from 2225 father-son duos and data from ...

    Abstract The Spanish and Portuguese Speaking Working Group of the International Society for Forensic Genetics (GHEP-ISFG) organized a collaborative study on mutations of Y-chromosomal short tandem repeats (Y-STRs). New data from 2225 father-son duos and data from 44 previously published reports, corresponding to 25,729 duos, were collected and analyzed. Marker-specific mutation rates were estimated for 33 Y-STRs. Although highly dependent on the analyzed marker, mutations compatible with the gain or loss of a single repeat were 23.2 times more likely than those involving a greater number of repeats. Longer alleles (relatively to the modal one) showed to be nearly twice more mutable than the shorter ones. Within the subset of longer alleles, the loss of repeats showed to be nearly twice more likely than the gain. Conversely, shorter alleles showed a symmetrical trend, with repeat gains being twofold more frequent than reductions. A positive correlation between the paternal age and the mutation rate was observed, strengthening previous findings. The results of a machine learning approach, via logistic regression analyses, allowed the establishment of algebraic formulas for estimating the probability of mutation depending on paternal age and allele length for DYS389I, DYS393 and DYS627. Algebraic formulas could also be established considering only the allele length as predictor for DYS19, DYS389I, DYS389II-I, DYS390, DYS391, DYS393, DYS437, DYS439, DYS449, DYS456, DYS458, DYS460, DYS481, DYS518, DYS533, DYS576, DYS626 and DYS627 loci. For the remaining Y-STRs, a lack of statistical significance was observed, probably as a consequence of the small effective size of the subsets available, a common difficulty in the modeling of rare events as is the case of mutations. The amount of data used in the different analyses varied widely, depending on how the data were reported in the publications analyzed. This shows a regrettable waste of produced data, due to inadequate communication of the results, supporting an urgent need of publication guidelines for mutation studies.
    MeSH term(s) Humans ; DNA Fingerprinting ; Chromosomes, Human, Y ; Microsatellite Repeats ; Ethnicity/genetics ; Mutation ; Haplotypes ; Genetics, Population
    Language English
    Publishing date 2023-12-14
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2493339-9
    ISSN 1878-0326 ; 1872-4973
    ISSN (online) 1878-0326
    ISSN 1872-4973
    DOI 10.1016/j.fsigen.2023.102999
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Allele frequency distribution of 10 MiniSTRs in the Pashtun population of Pakistan.

    Shafique, Muhammad / Shahzad, Muhammad Saqib / Perveen, Uzma / Parveen, Rukhsana / Ali, Azam / Hussain, Manzoor / Rehman, Ziaur / Shahid, Ahmad Ali / Husnain, Tayyab

    International journal of legal medicine

    2015  Volume 129, Issue 3, Page(s) 467–468

    Abstract: Two hundred individual samples of Pashtun population from Khyber Pakhtunkhwa province of Pakistan were randomly evaluated through 10 MiniSTR loci (CSF1PO, D7S820, TPOX, D18S51, D2S1338, D13S317, FGA, D5S818, D21S11, and D16S539). The PCR product size was ...

    Abstract Two hundred individual samples of Pashtun population from Khyber Pakhtunkhwa province of Pakistan were randomly evaluated through 10 MiniSTR loci (CSF1PO, D7S820, TPOX, D18S51, D2S1338, D13S317, FGA, D5S818, D21S11, and D16S539). The PCR product size was reduced in the range of 65 to 280 bp. A total of 112 alleles were observed containing allelic frequency ranging from 0.0025 to 0.4325. Statistical values for forensic and parentage analysis were calculated including combined power of discrimination (PD), combined power of exclusion (PE), and cumulative probability of matching (PM) and equaled to 0.99999999999768, 0.99984944, and 2.33 × 10(-12), respectively. These MiniSTRs show a high degree of polymorphism information content and discriminatory power which would be helpful to resolve forensic cases and establish DNA database for major population groups of Pakistan. In contrast to different populations, significant differences were also observed on these loci.
    MeSH term(s) ABO Blood-Group System/genetics ; Ethnic Groups/genetics ; Exons/genetics ; Gene Frequency/genetics ; Genetic Carrier Screening ; Genetics, Population ; Haplotypes ; Humans ; Introns/genetics ; Male ; Microsatellite Repeats/genetics ; Pakistan ; Paternity ; Phenotype ; Polymorphism, Single Nucleotide/genetics ; Sequence Analysis, DNA
    Chemical Substances ABO Blood-Group System
    Language English
    Publishing date 2015-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1055109-8
    ISSN 1437-1596 ; 0937-9827
    ISSN (online) 1437-1596
    ISSN 0937-9827
    DOI 10.1007/s00414-015-1179-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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