Article ; Online: Structural modulation of insulin by hydrophobic and hydrophilic molecules.
RSC advances
2023 Volume 13, Issue 48, Page(s) 34097–34106
Abstract: In the bloodstream, insulin interacts with various kinds of molecules, which can alter its structure and modulate its function. In this work, we have synthesized two molecules having extremely hydrophilic and hydrophobic side chains. The effects of ... ...
| Abstract | In the bloodstream, insulin interacts with various kinds of molecules, which can alter its structure and modulate its function. In this work, we have synthesized two molecules having extremely hydrophilic and hydrophobic side chains. The effects of hydrophilic and hydrophobic molecules on the binding with insulin have been investigated through a multi-spectroscopic approach. We found that hydrophilic molecules have a slightly higher binding affinity towards insulin. Insulin can bind with the hydrophilic molecules as it binds glucose. The high insulin binding affinity of a hydrophobic molecule indicates its dual nature. The hydrophobic molecule binds at the hydrophobic pocket of the insulin surface, where hydrophilic molecules interact at the polar surface of the insulin. Such binding with the hydrophobic molecule perturbs strongly the secondary structure of the insulin much more in comparison to hydrophilic molecules. Therefore, the stability of insulin decreases in the presence of hydrophobic molecules. |
|---|---|
| Language | English |
| Publishing date | 2023-11-21 |
| Publishing country | England |
| Document type | Journal Article |
| ISSN | 2046-2069 |
| ISSN (online) | 2046-2069 |
| DOI | 10.1039/d3ra06647a |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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