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Article: Performance evaluation of nanofluid-based photovoltaic thermal (PVT) system with regression analysis.

Azad, A K / Parvin, Salma / Hossain, Tahiya

2024 Volume 10, Issue 7, Page(s) e29252

Abstract: The recent global energy crisis has shocked Bangladesh's power sectors, and experts recommend using alternative energy sources to conserve natural gas, fossil fuels, and electricity. Numerous investigations on the photovoltaic thermal (PVT) system have ... ...

Abstract	The recent global energy crisis has shocked Bangladesh's power sectors, and experts recommend using alternative energy sources to conserve natural gas, fossil fuels, and electricity. Numerous investigations on the photovoltaic thermal (PVT) system have been carried out to get the source efficiently. As a result, a parametric evaluation of the PVT system's efficiency in Dhaka, Bangladesh, is investigated numerically using CNT nanofluid as a coolant. The numerical simulation is performed using the Galerkin weighted residual based finite element method. For accurate computations, the meteorological data for Dhaka, Bangladesh, is taken from open sources of Renewables.ninja. The effect of regulating parameters Reynolds number (200 ≤ Re ≤ 1000), solar irradiation (200 W/m
Language	English
Publishing date	2024-04-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e29252
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Article ; Online: Population-based survey of the prevalence and types of glaucoma in Bangladesh.

Mannaf, Sheikh M A / Islam, Md Shafiqul / Islam, M Nazrul / Rahman, Md Mizanur / Parvin, Salma / Rahman, Siddiqur / Sarker, Bipul Kumer De

BMJ open ophthalmology

2024 Volume 9, Issue 1

Abstract: Background: To delineate the epidemiological landscape of glaucoma using a population-based sample representative of Bangladesh.: Methods: Using multistage stratified cluster random sampling, households were selected to identify individuals ≥35 years ...

Abstract	Background: To delineate the epidemiological landscape of glaucoma using a population-based sample representative of Bangladesh. Methods: Using multistage stratified cluster random sampling, households were selected to identify individuals ≥35 years across all 8 divisions of Bangladesh. Sampling frames were derived from the 2011 national census. Fifty-eight study examination sites were set up for comprehensive eye evaluations, including intraocular pressure, gonioscopy and visual field testing when indicated. International Society for Geographic and Epidemiological Ophthalmology definitions were used to define glaucoma and glaucoma suspect cases. Results: One hundred forty clusters (89 rural and 51 urban) were randomly selected, and 13 791 residential households were visited. We invited 17 002 individuals ≥35 years for on-site examination, of which 12 000 (71%) complied, with a male-to-female ratio of 1:1. The prevalence of glaucoma was 3.2% (95% CI 2.79% to 3.64%), and glaucoma suspect was 10.1% (95% CI 9.05% to 11.12%). The majority (78%) had primary open-angle glaucoma (POAG), while angle closure was seen in 16%. Of the POAG, 83% (n=251) were normal-tension glaucoma. Multivariable logistic regression showed increasing age (OR=1.01 for every 5-year increment, 95% CI 1 to 1.01) and male gender (OR=1.43, 95% CI 1.15 to 1.77) to be associated with an increased risk of glaucoma. Conclusions: The prevalence of glaucoma in Bangladesh is 3.2% in ≥35-year-old individuals with older men most at risk. Extrapolating the results, we estimate about 2 million patients with glaucoma. Though normal-tension variety was the most common type, caution should be exercised in generalising these results to other populations.
MeSH term(s)	Adult ; Aged ; Female ; Humans ; Male ; Bangladesh/epidemiology ; Cross-Sectional Studies ; Glaucoma, Angle-Closure/epidemiology ; Glaucoma, Open-Angle/diagnosis ; Ocular Hypertension ; Prevalence
Language	English
Publishing date	2024-03-27
Publishing country	England
Document type	Journal Article
ISSN	2397-3269
ISSN (online)	2397-3269
DOI	10.1136/bmjophth-2023-001609
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Article ; Online: Targeting conditioned media dependencies and FLT-3 in chronic lymphocytic leukemia.

Parvin, Salma / Aryal, Aditi / Yin, Shanye / Fell, Geoffrey G / Davids, Matthew S / Wu, Catherine J / Letai, Anthony

Blood advances

2023 Volume 7, Issue 19, Page(s) 5877–5889

Abstract: The importance of the stromal microenvironment in chronic lymphocytic leukemia (CLL) pathogenesis and drug resistance is well established. Despite recent advances in CLL therapy, identifying novel ways to disrupt interactions between CLL and its ... ...

Abstract	The importance of the stromal microenvironment in chronic lymphocytic leukemia (CLL) pathogenesis and drug resistance is well established. Despite recent advances in CLL therapy, identifying novel ways to disrupt interactions between CLL and its microenvironment may identify new combination partners for the drugs currently in use. To understand the role of microenvironmental factors on primary CLL cells, we took advantage of an observation that conditioned media (CM) collected from stroma was protective of CLL cells from spontaneous cell death ex vivo. The cytokine in the CM-dependent cells that most supports CLL survival in short-term ex vivo culture was CCL2. Pretreatment of CLL cells with anti-CCL2 antibody enhanced venetoclax-mediated killing. Surprisingly, we found a group of CLL samples (9/23 cases) that are less likely to undergo cell death in the absence of CM support. Functional studies revealed that CM-independent (CMI) CLL cells are less sensitive to apoptosis than conventional stroma-dependent CLL. In addition, a majority of the CMI CLL samples (80%) harbored unmutated immunoglobulin heavy-chain variable (IGHV) region. Bulk-RNA sequence analysis revealed upregulation of the focal adhesion and RAS signaling pathways in this group, along with expression of fms-like tyrosine kinase 3 (FLT3) and CD135. Treatment with FLT3 inhibitors caused a significant reduction in cell viability among CMI samples. In summary, we were able to discriminate and target 2 biologically distinct subgroups of CLL based on CM dependence with distinct microenvironmental vulnerabilities.
MeSH term(s)	Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Culture Media, Conditioned/pharmacology ; fms-Like Tyrosine Kinase 3/therapeutic use ; Immunoglobulin Variable Region/genetics ; Immunoglobulin Variable Region/therapeutic use ; Signal Transduction ; Tumor Microenvironment
Chemical Substances	Culture Media, Conditioned ; fms-Like Tyrosine Kinase 3 (EC 2.7.10.1) ; Immunoglobulin Variable Region
Language	English
Publishing date	2023-07-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2022008207
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Article ; Online: Steroid-free combination of 5-azacytidine and venetoclax for the treatment of multiple myeloma.

Flanagan, Lyndsey / Coughlan, Aisling / Cosgrove, Nicola / Roe, Andrew / Wang, Yu / Gilmore, Stephanie / Drozdz, Izabela / Comerford, Claire / Ryan, Jeremy / Minihane, Emma / Parvin, Salma / O'Dwyer, Michael / Quinn, John / Murphy, Philip / Furney, Simon / Glavey, Siobhan / Chonghaile, Tríona Ní

Haematologica

2024

Abstract: Multiple Myeloma (MM) is an incurable plasma cell malignancy, that despite an unprecedented increase in overall survival, lacks truly risk-adapted or targeted treatments. A proportion of patients with MM depend on BCL-2 for survival and recently the BCL- ... ...

Abstract	Multiple Myeloma (MM) is an incurable plasma cell malignancy, that despite an unprecedented increase in overall survival, lacks truly risk-adapted or targeted treatments. A proportion of patients with MM depend on BCL-2 for survival and recently the BCL-2 antagonist venetoclax has shown clinical efficacy and safety in t(11;14) and BCL-2 overexpressing MM. However, only a small proportion of MM patients rely on BCL-2 (~20%), there is a need to broaden the patient population outside of t(11;14) that can be treated with venetoclax. Therefore, we took an unbiased screening approach and screened epigenetic modifiers to enhance venetoclax sensitivity in two non-BCL-2 dependent MM cell lines. The demethylase inhibitor 5-azacytidine was one of the lead hits from the screen, and the enhanced cell killing of the combination was confirmed in additional MM cell lines. Using dynamic BH3 profiling and immunoprecipitations we identified the potential mechanism of synergy is due to increased NOXA expression, through the integrated stress response. Knockdown of PMAIP1 or PKR partially rescues cell death of the venetoclax and 5-azacytidine combination treatment. The addition of a steroid to the combination treatment did not enhance the cell death and interestingly we found enhanced death of the immune cells with steroid addition, suggesting that a steroid-sparing regimen may be more beneficial in MM. Lastly, we show for the first time in primary MM patient samples, that 5-azacytidine enhances the response to venetoclax ex-vivo, across diverse anti-apoptotic dependencies (BCL-2 or MCL-1) and diverse cytogenetic backgrounds. Overall, our data identifies 5-azacytidine and venetoclax as an effective treatment combination and this could be a tolerable steroid-sparing regimen, particularly for elderly MM patients.
Language	English
Publishing date	2024-03-21
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2333-4
ISSN	1592-8721 ; 0017-6567 ; 0390-6078
ISSN (online)	1592-8721
ISSN	0017-6567 ; 0390-6078
DOI	10.3324/haematol.2023.283771
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Article: Finite element analysis of double-diffusive natural convection in a porous triangular enclosure filled with Al2O3 -water nanofluid in presence of heat generation.

Chowdhury, Raju / Parvin, Salma / Khan, Md Abdul Hakim

Heliyon

2016 Volume 2, Issue 8, Page(s) e00140

Abstract: The problem of double-diffusive natural convection of Al2O3 -water nanofluid in a porous triangular enclosure in presence of heat generation has been studied numerically in this paper. The bottom wall of the cavity is heated isothermally, the left ... ...

Abstract	The problem of double-diffusive natural convection of Al2O3 -water nanofluid in a porous triangular enclosure in presence of heat generation has been studied numerically in this paper. The bottom wall of the cavity is heated isothermally, the left inclined wall is non-isothermal and the right inclined wall is considered to be cold. The concentration is higher at bottom wall, lower at right inclined wall and non-isoconcentration at left inclined wall of the cavity. The governing equations are transformed to the dimensionless form and solved numerically using Galerkin weighted residual technique of finite element method. The results are obtained in terms of streamlines, isotherms, isoconcentrations, average Nueeslt number (Nu) and average Sherwood number (Sh) for the parameters thermal Rayleigh number (RaT ), dimensionless heat generation parameter (λ), solid volume fraction (ϕ) and Lewis number (Le) while Prandtl number (Pr), Buoyancy ratio (N) and Darcy number (Da) are considered to be fixed. It is observed that flow pattern, temperature fields and concentration fields are affected by the variation of above considered parameters.
Language	English
Publishing date	2016-08-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2016.e00140
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Article: Finite element analysis of double-diffusive natural convection in a porous triangular enclosure filled with Al2O3-water nanofluid in presence of heat generation

Chowdhury, Raju / Parvin, Salma / Khan, Md. Abdul Hakim

Heliyon. 2016 Aug., v. 2, no. 8

2016

Abstract: The problem of double-diffusive natural convection of Al₂O₃-water nanofluid in a porous triangular enclosure in presence of heat generation has been studied numerically in this paper. The bottom wall of the cavity is heated isothermally, the left ... ...

Abstract	The problem of double-diffusive natural convection of Al₂O₃-water nanofluid in a porous triangular enclosure in presence of heat generation has been studied numerically in this paper. The bottom wall of the cavity is heated isothermally, the left inclined wall is non-isothermal and the right inclined wall is considered to be cold. The concentration is higher at bottom wall, lower at right inclined wall and non-isoconcentration at left inclined wall of the cavity. The governing equations are transformed to the dimensionless form and solved numerically using Galerkin weighted residual technique of finite element method. The results are obtained in terms of streamlines, isotherms, isoconcentrations, average Nueeslt number (Nu) and average Sherwood number (Sh) for the parameters thermal Rayleigh number (RaT), dimensionless heat generation parameter (λ), solid volume fraction (ϕ) and Lewis number (Le) while Prandtl number (Pr), Buoyancy ratio (N) and Darcy number (Da) are considered to be fixed. It is observed that flow pattern, temperature fields and concentration fields are affected by the variation of above considered parameters.
Keywords	cold ; convection ; finite element analysis ; nanofluids ; rats ; temperature
Language	English
Dates of publication	2016-08
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2016.e00140
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Article ; Online: Association of BRCA1, BRCA2, RAD51, and HER2 gene polymorphisms with the breast cancer risk in the Bangladeshi population.

Parvin, Salma / Islam, Md Siddiqul / Al-Mamun, Mir Md Abdullah / Islam, Mohammad Safiqul / Ahmed, Maizbha Uddin / Kabir, Eva Rahman / Hasnat, Abul

Breast cancer (Tokyo, Japan)

2017 Volume 24, Issue 2, Page(s) 229–237

Abstract: Purpose: Breast cancer is considered as the most frequent female malignancy. Altered gene expressions due to genetic polymorphisms in the BRCA1, BRCA2, RAD51, and HER2 contribute toward the development of breast cancer, and yet, no such type of study ... ...

Abstract	Purpose: Breast cancer is considered as the most frequent female malignancy. Altered gene expressions due to genetic polymorphisms in the BRCA1, BRCA2, RAD51, and HER2 contribute toward the development of breast cancer, and yet, no such type of study has been conducted in the Bangladeshi population. This study was designed to evaluate the role of BRCA1rs80357713, BRCA1rs80357906, BRCA2rs11571653, RAD51rs1801320, and HER2rs1136201 polymorphisms as risk factors in the development of breast cancer in the Bangladeshi population. Methods: A total 310 patients with invasive breast cancers were recruited as cases from different public and private hospitals of Bangladesh, and 250 Bangladeshi healthy women matching age with the patients were recruited as controls. Polymerase chain reaction-restriction fragment length polymorphism method was used to analyze the genetic polymorphisms. Results: Patients carrying BRCA1/2 mutations, GC and GC plus CC genotypes of RAD51rs1801320, and AG plus GG genotype of HER2rs1136201 polymorphisms were found to be associated with breast cancer. In subgroup analysis, AG plus GG genotype of HER2rs1136201 was found to be associated with the breast cancer risk in the patients younger than 45 years of age compared with the older patients having more than 45 years of age, and RAD51rs1801320 was related to the tumor size and tumor aggressiveness (higher graded tumor). Conclusion: Our results indicate that BRCA1/BRCA2, RAD51rs1801320 and HER2rs1136201 polymorphisms were associated with breast cancer in the studied population.
MeSH term(s)	Adult ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Bangladesh ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Case-Control Studies ; Female ; Genetic Predisposition to Disease ; Genetics, Population ; Humans ; Middle Aged ; Mutation ; Polymorphism, Single Nucleotide ; Rad51 Recombinase/genetics ; Receptor, ErbB-2/genetics
Chemical Substances	BRCA1 Protein ; BRCA1 protein, human ; BRCA2 Protein ; BRCA2 protein, human ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1) ; RAD51 protein, human (EC 2.7.7.-) ; Rad51 Recombinase (EC 2.7.7.-)
Language	English
Publishing date	2017-03
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2052429-8
ISSN	1880-4233 ; 1340-6868
ISSN (online)	1880-4233
ISSN	1340-6868
DOI	10.1007/s12282-016-0692-5
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Article ; Online: Combined EZH2 and Bcl-2 inhibitors as precision therapy for genetically defined DLBCL subtypes.

Scholze, Hanna / Stephenson, Regan E / Reynolds, Raymond / Shah, Shivem / Puri, Rishi / Butler, Scott D / Trujillo-Alonso, Vicenta / Teater, Matthew R / van Besien, Herman / Gibbs-Curtis, Destini / Ueno, Hideki / Parvin, Salma / Letai, Anthony / Mathew, Susan / Singh, Ankur / Cesarman, Ethel / Melnick, Ari / Giulino-Roth, Lisa

Blood advances

2020 Volume 4, Issue 20, Page(s) 5226–5231

Abstract: Molecular alterations in the histone methyltransferase EZH2 and the antiapoptotic protein Bcl-2 frequently co-occur in diffuse large B-cell lymphoma (DLBCL). Because DLBCL tumors with these characteristics are likely dependent on both oncogenes, dual ... ...

Abstract	Molecular alterations in the histone methyltransferase EZH2 and the antiapoptotic protein Bcl-2 frequently co-occur in diffuse large B-cell lymphoma (DLBCL). Because DLBCL tumors with these characteristics are likely dependent on both oncogenes, dual targeting of EZH2 and Bcl-2 is a rational therapeutic approach. We hypothesized that EZH2 and Bcl-2 inhibition would be synergistic in DLBCL. To test this, we evaluated the EZH2 inhibitor tazemetostat and the Bcl-2 inhibitor venetoclax in DLBCL cells, 3-dimensional lymphoma organoids, and patient-derived xenografts (PDXs). We found that tazemetostat and venetoclax are synergistic in DLBCL cells and 3-dimensional lymphoma organoids that harbor an EZH2 mutation and an IGH/BCL2 translocation but not in wild-type cells. Tazemetostat treatment results in upregulation of proapoptotic Bcl-2 family members and priming of mitochondria to BH3-mediated apoptosis, which may sensitize cells to venetoclax. The combination of tazemetostat and venetoclax was also synergistic in vivo. In DLBCL PDXs, short-course combination therapy resulted in complete remissions that were durable over time and associated with superior overall survival compared with either drug alone.
MeSH term(s)	Antineoplastic Agents/therapeutic use ; Apoptosis ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Enhancer of Zeste Homolog 2 Protein/antagonists & inhibitors ; Humans ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/genetics ; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors ; Sulfonamides/pharmacology
Chemical Substances	Antineoplastic Agents ; BCL2 protein, human ; Bridged Bicyclo Compounds, Heterocyclic ; Proto-Oncogene Proteins c-bcl-2 ; Sulfonamides ; EZH2 protein, human (EC 2.1.1.43) ; Enhancer of Zeste Homolog 2 Protein (EC 2.1.1.43)
Language	English
Publishing date	2020-10-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2020002580
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Article ; Online: Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics.

Daniels, Veerle W / Zoeller, Jason J / van Gastel, Nick / McQueeney, Kelley E / Parvin, Salma / Potter, Danielle S / Fell, Geoffrey G / Ferreira, Vinícius G / Yilma, Binyam / Gupta, Rajat / Spetz, Johan / Bhola, Patrick D / Endress, Jennifer E / Harris, Isaac S / Carrilho, Emanuel / Sarosiek, Kristopher A / Scadden, David T / Brugge, Joan S / Letai, Anthony

Science signaling

2021 Volume 14, Issue 686

Abstract: Cancer cells have differential metabolic dependencies compared to their nonmalignant counterparts. However, few metabolism-targeting compounds have been successful in clinical trials. Here, we investigated the metabolic vulnerabilities of triple-negative ...

Abstract	Cancer cells have differential metabolic dependencies compared to their nonmalignant counterparts. However, few metabolism-targeting compounds have been successful in clinical trials. Here, we investigated the metabolic vulnerabilities of triple-negative breast cancer (TNBC), particularly those metabolic perturbations that increased mitochondrial apoptotic priming and sensitivity to BH3 mimetics (drugs that antagonize antiapoptotic proteins). We used high-throughput dynamic BH3 profiling (HT-DBP) to screen a library of metabolism-perturbing small molecules, which revealed inhibitors of the enzyme nicotinamide phosphoribosyltransferase (NAMPT) as top candidates. In some TNBC cells but not in nonmalignant cells, NAMPT inhibitors increased overall apoptotic priming and induced dependencies on specific antiapoptotic BCL-2 family members. Treatment of TNBC cells with NAMPT inhibitors sensitized them to subsequent treatment with BH3 mimetics. The combination of a NAMPT inhibitor (FK866) and an MCL-1 antagonist (S63845) reduced tumor growth in a TNBC patient-derived xenograft model in vivo. We found that NAMPT inhibition reduced NAD
MeSH term(s)	Apoptosis ; Apoptosis Regulatory Proteins ; Cell Line, Tumor ; Humans ; Mitochondria ; Myeloid Cell Leukemia Sequence 1 Protein ; Proto-Oncogene Proteins c-bcl-2 ; Triple Negative Breast Neoplasms/drug therapy
Chemical Substances	Apoptosis Regulatory Proteins ; Myeloid Cell Leukemia Sequence 1 Protein ; Proto-Oncogene Proteins c-bcl-2
Language	English
Publishing date	2021-06-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2417226-1
ISSN	1937-9145 ; 1945-0877
ISSN (online)	1937-9145
ISSN	1945-0877
DOI	10.1126/scisignal.abc7405
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Article ; Online: Multifunctional barcoding with ClonMapper enables high-resolution study of clonal dynamics during tumor evolution and treatment.

Nature cancer

2021 Volume 2, Issue 7, Page(s) 758–772

Abstract: Lineage-tracing methods have enabled characterization of clonal dynamics in complex populations, but generally lack the ability to integrate genomic, epigenomic and transcriptomic measurements with live-cell manipulation of specific clones of interest. ... ...

Abstract	Lineage-tracing methods have enabled characterization of clonal dynamics in complex populations, but generally lack the ability to integrate genomic, epigenomic and transcriptomic measurements with live-cell manipulation of specific clones of interest. We developed a functionalized lineage-tracing system, ClonMapper, which integrates DNA barcoding with single-cell RNA sequencing and clonal isolation to comprehensively characterize thousands of clones within heterogeneous populations. Using ClonMapper, we identified subpopulations of a chronic lymphocytic leukemia cell line with distinct clonal compositions, transcriptional signatures and chemotherapy survivorship trajectories; patterns that were also observed in primary human chronic lymphocytic leukemia. The ability to retrieve specific clones before, during and after treatment enabled direct measurements of clonal diversification and durable subpopulation transcriptional signatures. ClonMapper is a powerful multifunctional approach to dissect the complex clonal dynamics of tumor progression and therapeutic response.
MeSH term(s)	Cell Line ; Clone Cells ; Genomics ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Transcriptome
Language	English
Publishing date	2021-07-12
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	2662-1347
ISSN (online)	2662-1347
DOI	10.1038/s43018-021-00222-8
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