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  1. Article: Diagnosis and Treatment of Adenomyosis with Office Hysteroscopy-A Narrative Review of Literature.

    Gkrozou, Fani / Vatopoulou, Anastasia / Skentou, Chara / Paschopoulos, Minas

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 13

    Abstract: Introduction: Adenomyosis is a common chronic disease in women of reproductive age, characterised by the presence of ectopic endometrial tissue within myometrium. Even though adenomyosis presents with chronic pelvic pain, menorrhagia or abnormal uterine ...

    Abstract Introduction: Adenomyosis is a common chronic disease in women of reproductive age, characterised by the presence of ectopic endometrial tissue within myometrium. Even though adenomyosis presents with chronic pelvic pain, menorrhagia or abnormal uterine bleeding, dysmenorrhoea, and dyspareunia and is often recognised after hysterectomies. However, the development of ultrasonography and magnetic resonance imaging has improved the pre-operative diagnosis of the disease. Hysteroscopy provides information in real time from the uterine cavity and the offers the possibility of obtaining direct biopsies.
    Material and methods: The literature was searched via Pubmed and Embase with the following headings: diagnosis of adenomyosis or adenomyoma and office hysteroscopy, hysteroscopy findings of adenomyosis or adenomyoma, treatment of adenomyosis or adenomyoma with office hysteroscopy.
    Results: The literature showed that hysteroscopy can identify superficial adenomyosis. There are a variety of hysteroscopic images that can be connected with the disease. New equipment like the spirotome has been used to access deeper layers of myometrium and obtain biopsies under direct vision from the adenomyotic areas. Different methods of treatment have been also described, like enucleation of focal superficial adenomyoma, coagulation, evacuation of cystic adenomyosis when the lesion is smaller than 1.5 cm, and resection of adenomyotic nodules in case of bigger lesions (>1.5 cm). Diffuse superficial adenomyosis is also managed by resection.
    Conclusions: Hysteroscopy has revolutionised the approach to adenomyosis. It is a useful tool in assessing mainly superficial adenomyosis. The role of hysteroscopy in surgical management of adenomyosis need to be confirmed with further studies.
    Language English
    Publishing date 2023-06-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13132182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hysteroscopic features suggestive of chronic endometritis: a systematic review.

    Tsonis, Orestis / Gkrozou, Fani / Dimitriou, Evangelos / Barmpalia, Zoi / Tsonis, Klarisa / Vatopoulou, Anastasia / Paschopoulos, Minas

    Human fertility (Cambridge, England)

    2024  Volume 26, Issue 6, Page(s) 1530–1543

    Abstract: The purpose of this systematic review is to identify common hysteroscopic findings suggestive of endometritis, chronic or subclinical, based on current scientific evidence. Data sources were MEDLINE, Embase, PubMed and other sources of grey literature. ... ...

    Abstract The purpose of this systematic review is to identify common hysteroscopic findings suggestive of endometritis, chronic or subclinical, based on current scientific evidence. Data sources were MEDLINE, Embase, PubMed and other sources of grey literature. Four (4) authors independently selected studies addressing hysteroscopic detection of CE based on specific and clearly stated hysteroscopic criteria. The diagnosis was confirmed by histologic assessment, as stated in the materials and methods of these studies included. The initial search identified 599 studies, of which 21 met the inclusion criteria. Significant heterogeneity among published studies on Chronic endometritis (CE) remains the main limitation in performing a metanalysis and further analysis of diagnostic accuracy on the subject. Hysteroscopy is an important diagnostic tool in cases of chronic endometritis when accompanied by endometrial biopsies. Clinicians relate hyperaemia and endometrial oedema with chronic endometritis while more than half include micropolyposis as a pathognomonic feature of this subclinical condition. Micropolyps, stromal oedema, haemorrhagic spots, strawberry aspect, and hyperaemia are proposed as adequate indicators of hysteroscopic evidence of CE according to the literature. The impact of CE in long-term reproductive outcomes remain unclear, thus clinicians ought to communicate this to the patients and provide treatment where clinically appropriate. In addition, we present hysteroscopic images of histologically confirmed CE cases that could play the role of a hysteroscopic atlas.
    MeSH term(s) Female ; Humans ; Chronic Disease ; Edema/complications ; Edema/pathology ; Endometritis/complications ; Endometritis/diagnosis ; Endometritis/pathology ; Endometrium/pathology ; Hyperemia/complications ; Hyperemia/pathology ; Hysteroscopy/methods
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2086960-5
    ISSN 1742-8149 ; 1464-7273
    ISSN (online) 1742-8149
    ISSN 1464-7273
    DOI 10.1080/14647273.2023.2265155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Endometriosis Predictive Models Based on Self-Assessment Questionnaire, Evidence from Clinical Examination or Imaging Findings: A Narrative Review.

    Gkrozou, Fani / Tsonis, Orestis / Sorrentino, Felice / Nappi, Luigi / Vatopoulou, Anastasia / Skentou, Chara / Pandey, Suruchi / Paschopoulos, Minas / Daniilidis, Angelos

    Journal of clinical medicine

    2024  Volume 13, Issue 2

    Abstract: Objective: The aim of this narrative review is to evaluate existing questionnaires on predictive models for endometriosis. These symptom-based models have the potential to serve as screening tools for adult women to detect endometriosis.: Data sources! ...

    Abstract Objective: The aim of this narrative review is to evaluate existing questionnaires on predictive models for endometriosis. These symptom-based models have the potential to serve as screening tools for adult women to detect endometriosis.
    Data sources: A comprehensive search of PubMed and Embase databases was conducted to identify studies on endometriosis screening.
    Selection of studies: The search targeted predictive models for endometriosis localisation, bowel involvement, need for bowel surgery and fertility. Due to the heterogeneity identified, a systematic review was not possible. A total of 23 studies were identified.
    Data extraction and synthesis: Among these studies, twelve included measures for general endometriosis, two targeted specific sites, four focused on deep infiltrating endometriosis (DIE), and three addressed the need for endometriosis-related bowel surgery. Many measures combined clinical, imaging and laboratory tests with patient questionnaires. Validation of these models as screening tools was lacking in all studies, as the focus was on diagnosis rather than screening.
    Conclusion: This review did not identify any fully validated, symptom-based questionnaires for endometriosis screening in adult women. Substantial validation work remains to establish the efficacy of such tools.
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13020356
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Ovarian Teratomas in Children and Adolescents: Our Own Experience and Review of Literature.

    Gkrozou, Fani / Tsonis, Orestis / Vatopoulou, Anastasia / Galaziou, Georgia / Paschopoulos, Minas

    Children (Basel, Switzerland)

    2022  Volume 9, Issue 10

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2022-10-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children9101571
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hysteroscopic detection of chronic endometritis: Evaluating proposed hysteroscopic features suggestive of chronic endometritis.

    Tsonis, Orestis / Gkrozou, Fani / Dimitriou, Evangelos / Paschopoulos, Minas

    Journal of gynecology obstetrics and human reproduction

    2021  Volume 50, Issue 9, Page(s) 102182

    Abstract: Purpose: To evaluate the proposed criteria in a large sample and in additional subgroups in order to test the validity of the hysteroscopic features widely-accepted as suggestive of CE.: Method(s): All patients (n: 2675) underwent outpatient ... ...

    Abstract Purpose: To evaluate the proposed criteria in a large sample and in additional subgroups in order to test the validity of the hysteroscopic features widely-accepted as suggestive of CE.
    Method(s): All patients (n: 2675) underwent outpatient hysteroscopy, with the vaginoscopic approach technique. Hysteroscopic features such as, stromal oedema, diffuse or focal hyperaemia, "strawberry aspect", micropolyposis and endometrial polyps, are often indicate the presence of chronic endometritis. All hysteroscopic features, alone and in combination were applied in 7 (seven) different subgroups of the sample: total sample, women in reproductive age, women with infertility issues/IVF screening, women with history of recurrent miscarriages, menopausal women, and women with hysteroscopic indication of Abnormal Uterine Bleeding (AUB) in women of reproductive age and postmenopausal bleeding (PMB). From each case, endometrial samples were obtained and immunohistochemistry, identifying CD-138, was applied in order to diagnose CE.
    Result(s): A total of 2675 patients were included of which, 1444 women were found with at least one of the proposed hysteroscopic features mentioned above. Stromal oedema, focal or diffuse hyperaemia and "strawberry aspect" in combination with micropolyposis demonstrated higher rates of diagnostic accuracy in the detection of CE correlated to histologic confirmation. Micropolyposis, stromal oedema, focal or diffuse hyperaemia and "strawberry aspect" offer great diagnostic accuracy in the hysteroscopic detection of Chronic Endometritis, regardless reproductive status and/or clinical presentation. Endometrial polyps are not valid hysteroscopic features in cases of suspected CE.
    Conclusion(s): Diagnostic hysteroscopy can accurately diagnose cases of CE, based on stromal oedema, focal or diffuse hyperaemia and "strawberry aspect", in combination with micropolyposis. In subgroups of infertile women, higher diagnostic accuracy based on the hysteroscopic features mentioned, was more likely to be achieved. Whether endometrial polyps are suggestive of CE, when identified during office hysteroscopy, remains controversial.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Diagnostic Techniques, Obstetrical and Gynecological/standards ; Diagnostic Techniques, Obstetrical and Gynecological/statistics & numerical data ; Endometritis/diagnosis ; Endometritis/diagnostic imaging ; Endometritis/physiopathology ; Female ; Greece ; Humans ; Hysteroscopy/methods ; Hysteroscopy/standards ; Hysteroscopy/statistics & numerical data ; Middle Aged ; Retrospective Studies ; Sensitivity and Specificity
    Language English
    Publishing date 2021-06-07
    Publishing country France
    Document type Journal Article
    ISSN 2468-7847
    ISSN (online) 2468-7847
    DOI 10.1016/j.jogoh.2021.102182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Comparative retrospective study on transvaginal sonography versus office hysteroscopy in the diagnosis of endometrial pathology among different subgroups.

    Tsonis, Orestis / Gkrozou, Fani / Dimitriou, Evangelos / Paschopoulos, Minas

    The journal of obstetrics and gynaecology research

    2020  Volume 47, Issue 2, Page(s) 669–678

    Abstract: Background: Transvaginal sonography (TVS) and office hysteroscopy are considered essential diagnostic tool for the gynecologic everyday practice. Through the years equipment developments in both techniques along with cumulative experience gained by the ... ...

    Abstract Background: Transvaginal sonography (TVS) and office hysteroscopy are considered essential diagnostic tool for the gynecologic everyday practice. Through the years equipment developments in both techniques along with cumulative experience gained by the gynecologists result in a disunity among clinicians in choosing optimal diagnostic approach with regards to endometrial pathology.
    Aim: To evaluate the diagnostic accuracy of TVS versus office hysteroscopy (OHSC) in detecting endometrial pathology. Results were compared to available scientific evidence available among similar published studies.
    Methods: Comparative Retrospective study performed at the Endoscopic Unit, Department of Gynecology, University Hospital of Ioannina, Greece. A total of 2675 cases were collected for this study from January 1997 until August 2019. All cases recruited underwent a TVS followed by office hysteroscopy (OHSC) for various indications according to the local protocol. Endometrial samples from all cases were obtained and histology confirmed the diagnosis. Sonographic and hysteroscopic results were correlated with histologic reports to assess the diagnostic accuracy of both techniques.
    Results: In a total of 2675 cases recruited for this study, 23.2% were postmenopausal while the majority (76.7%) was of reproductive age. The commonest indication for hysteroscopy was abnormal uterine bleeding (AUB) accounting for 29.7% of the cases. Overall, TVS demonstrated diagnostic accuracy of 84.7%% in detecting endometrial pathology, compared to 97.3% of OHSC. Sensitivity, specificity, positive prognostic value (PPV) and negative prognostic value (NPV) of TVS detecting endometrial pathology were 84.0, 86.8, 95.3 and 63.0%, respectively. The corresponding values for hysteroscopy were 98.9, 95.1, 98.4 and 93.9%, respectively. Diagnostic value of both techniques was estimated in 6 (six) additional subgroups: total sample with AUB, women of reproductive age, women of reproductive age with AUB, women of reproductive age with infertility issues, postmenopausal women and postmenopausal women suffering from postmenopausal bleeding (PMB). All values were calculated with regards to histologic findings as gold standard technique. All results were correlated with scientific evidence collected from the international literature.
    Conclusion: Office hysteroscopy is a more reliable tool in detecting endometrial pathologies compared to TVS regardless of reproductive status or clinical presentation. TVS is likely to orientate and guide specialists on what to expect prior to an hysteroscopic intervention.
    MeSH term(s) Endometrium/diagnostic imaging ; Female ; Humans ; Hysteroscopy ; Pregnancy ; Retrospective Studies ; Sensitivity and Specificity ; Ultrasonography ; Uterine Hemorrhage/diagnosis
    Language English
    Publishing date 2020-12-01
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1327307-3
    ISSN 1447-0756 ; 1341-8076
    ISSN (online) 1447-0756
    ISSN 1341-8076
    DOI 10.1111/jog.14580
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: In women with chronic or subclinical endometritis is hysteroscopy suitable for setting the diagnosis? A systematic review.

    Gkrozou, Fani / Tsonis, Orestis / Dimitriou, Evangelos / Paschopoulos, Minas

    The journal of obstetrics and gynaecology research

    2020  Volume 46, Issue 9, Page(s) 1639–1650

    Abstract: The role of hysteroscopy in cases of chronic or subclinical endometritis remains uncertain. Reevaluating the clinical relevance of diagnostic hysteroscopic in these cases will improve the level of case in women's health worldwide. The objective of this ... ...

    Abstract The role of hysteroscopy in cases of chronic or subclinical endometritis remains uncertain. Reevaluating the clinical relevance of diagnostic hysteroscopic in these cases will improve the level of case in women's health worldwide. The objective of this systematic review was to assess the suitability of hysteroscopy in detecting and diagnosing female patients with chronic or subclinical endometritis, as a first-line diagnostic tool. For this systematic review, five major search engines PubMed, Embase, MEDLINE, Google Scholar, as well as ResearchGate were searched using MeSH (medical subject headings) without language or year restrictions up to November 2019. All types of scientific papers were taken into consideration, with a priority to randomized control trials enrolling women with chronic or subclinical endometritis and compared with standard diagnostic tools such as histology or immunohistochemistry, in order to ensure the efficacy of the method. Risk of bias was assessed using the recommended Cochrane Collaboration criteria. In order to gather more information and data, we have decided to include all the scientific evidence regardless of study design. Data collection and analysis were performed according to PRISMA protocol. Hysteroscopy is an important diagnostic tool in cases of endometritis when accompanied by endometrial samples assessment techniques. In cases of high suspicion endometritis facilitates greater diagnostic accuracy. Hysteroscopy facilitates also the assessment of antibiotic administration efficacy in cases of confirmed endometritis. Micropolyposis, stromal edema or congestion, diffuse or focal hyperemia are the dominant hysteroscopic features that are considered by most studies as suggestive of chronic or subclinical endometritis. The heterogeneity of the included studies presents a high risk of bias as assessed according to Cochrane Collaboration criteria. Hysteroscopy is not suitable as a first-line diagnostic tool in cases of chronic or subclinical endometritis. Further randomized controlled trials need to be conducted in order to define the role of hysteroscopy as a first-line diagnostic tool in cases of chronic or subclinical endometritis.
    MeSH term(s) Endometritis/diagnosis ; Endometrium ; Female ; Humans ; Hysteroscopy ; Pregnancy ; Sensitivity and Specificity
    Language English
    Publishing date 2020-06-23
    Publishing country Australia
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 1327307-3
    ISSN 1447-0756 ; 1341-8076
    ISSN (online) 1447-0756
    ISSN 1341-8076
    DOI 10.1111/jog.14360
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Medical Liability in Obstetrics/Gynecology and Co-liability With Anesthesiology in Greece: A Retrospective Study.

    Samara, Evangelia / Tzoumas, Lambros / Tzoumas, Konstantinos / Paschopoulos, Minas / Tzimas, Petros / Papadopoulos, Georgios

    Cureus

    2022  Volume 14, Issue 10, Page(s) e30931

    Abstract: Objective To evaluate the current landscape regarding medical liability in obstetric-gynecology (OB/GYN) physicians in Greece. Materials and methods Published court decisions of criminal, civil, administrative, and disciplinary content were searched in ... ...

    Abstract Objective To evaluate the current landscape regarding medical liability in obstetric-gynecology (OB/GYN) physicians in Greece. Materials and methods Published court decisions of criminal, civil, administrative, and disciplinary content were searched in legal information banks for the years 1988-2021. The causes that led to the adverse outcome and the decisions were analyzed. Results A total of 184 decisions were directed against OB/GYNs. One hundred seventeen records concerned criminal cases and 67 civil cases. Thirty-four decisions concerned criminal cases of negligent homicide, 35 criminal cases of bodily harm, and 19 were acquittals. The most common causes of bodily injuries were neonatal encephalopathy, obstetric paralysis - quadriplegia and brachial plexus paralysis, and obstetric bleeding. Conclusion According to our results, there is a great need and challenge to maintain high standards in daily practice with continuous training and the use of international protocols. Furthermore, for each case, continuous monitoring of parturients and newborns and coordinated cooperation are necessary to reduce mortality and morbidity.
    Language English
    Publishing date 2022-10-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.30931
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Uterine sparing management in patients with endometrial cancer: a narrative literature review.

    Zisi, Maria / Zygouris, Dimitrios / Tsonis, Orestis / Papadimitriou, Sofia / George, Mastorakos / Kalantaridou, Sophia / Paschopoulos, Minas

    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology

    2022  Volume 42, Issue 5, Page(s) 823–829

    Abstract: Endometrial cancer is the most common malignancy of the female genital tract. Approximately 25% of cases occur in premenopausal women, and up to 5% of cases occur in women who are younger than 40 years old. The survival rate in these cases is 99%; ... ...

    Abstract Endometrial cancer is the most common malignancy of the female genital tract. Approximately 25% of cases occur in premenopausal women, and up to 5% of cases occur in women who are younger than 40 years old. The survival rate in these cases is 99%; therefore, uterine-sparing management could be considered under strict criteria selection and the strong desire of the woman to preserve uterus and fertility. Diagnosis should be performed after a hysteroscopic biopsy instead of dilatation and curettage. The highest remission rate was achieved after combining a hysteroscopic resection with hormonal therapy compared to single hormonal treatment. The most common regiments are the following progestins: megestrol acetate (MA) and medroxyprogesterone acetate (MPA) taken orally with a daily dosage of 160 mg-320 mg for MA and 250 mg-600 mg for MP. Evaluations at three and six months could be performed by office endometrial biopsy and/or hysteroscopic directed biopsy especially in the presence of levonorgestrel intrauterine system, and in cases of remission, either a pregnancy attempt or maintenance therapy should be considered. After childbearing, hysterectomy with bilateral salpingo-oophorectomy is recommended, whereas ovarian preservation could be considered depending on the patient's age and whether they fulfil the strict criteria selection.
    MeSH term(s) Adult ; Antineoplastic Agents, Hormonal/therapeutic use ; Endometrial Hyperplasia/surgery ; Endometrial Neoplasms/pathology ; Female ; Fertility Preservation ; Humans ; Hysteroscopy ; Levonorgestrel ; Pregnancy ; Uterus/pathology
    Chemical Substances Antineoplastic Agents, Hormonal ; Levonorgestrel (5W7SIA7YZW)
    Language English
    Publishing date 2022-01-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 604639-3
    ISSN 1364-6893 ; 0144-3615
    ISSN (online) 1364-6893
    ISSN 0144-3615
    DOI 10.1080/01443615.2021.2006164
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The expression of corticotropin-releasing hormone family peptides in premalignant and malignant vulvar lesions.

    Dimas, Angelos / Goussia, Anna / Papoudou-Bai, Alexandra / Politi, Anastasia / Paschopoulos, Minas / Navrozoglou, Iordanis / Makrigiannakis, Antonis / Vrekoussis, Thomas

    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

    2023  Volume 26, Issue 1, Page(s) 260–268

    Abstract: Objectives: To examine the relation of corticotropin-releasing hormone (CRH) family peptides with inflammatory processes and oncogenesis, emphasizing in vulvar inflammatory, premalignant and malignant lesions, as well as to investigate the possibility ... ...

    Abstract Objectives: To examine the relation of corticotropin-releasing hormone (CRH) family peptides with inflammatory processes and oncogenesis, emphasizing in vulvar inflammatory, premalignant and malignant lesions, as well as to investigate the possibility of lesion cells immunoescaping, utilizing FAS/FAS-L complex.
    Methods: Immunohistochemical expression of CRH, urocortin (UCN), FasL and their receptors CRHR1, CRHR2 and Fas was studied in vulvar tissue sections obtained from patients with histologically confirmed diagnosis of lichen, vulvar intraepithelial neoplasia (VIN) and vulvar squamous cell carcinoma (VSCC). The patient cohort was selected from a tertiary teaching Hospital in Greece, between 2005 and 2015. For each of the disease categories, immunohistochemical staining was evaluated and the results were statistically compared.
    Results: A progressive increase of the cytoplasmic immunohistochemical expression of CRH and UCN, from precancerous lesions to VSCC was observed. A similar increase was detected for Fas and FasL expression. Nuclear localization of UCN was demonstrated in both premalignant and VSCC lesions, with staining being significantly intensified in carcinomas, particularly in the less differentiated tumor areas or in the areas at invasive tumor front.
    Conclusions: Stress response system and CRH family peptides seem to have a role in inflammation maintenance and progression of vulvar premalignant lesions to malignancy. It seems that stress peptides may locally modulate the stroma through Fas/FasL upregulation, possibly contributing to vulvar cancer development.
    MeSH term(s) Female ; Humans ; Corticotropin-Releasing Hormone/genetics ; Corticotropin-Releasing Hormone/metabolism ; Precancerous Conditions ; Vulvar Neoplasms ; Up-Regulation ; Carcinoma, Squamous Cell ; Urocortins/genetics ; Urocortins/metabolism
    Chemical Substances Corticotropin-Releasing Hormone (9015-71-8) ; Urocortins
    Language English
    Publishing date 2023-06-29
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2397359-6
    ISSN 1699-3055 ; 1699-048X
    ISSN (online) 1699-3055
    ISSN 1699-048X
    DOI 10.1007/s12094-023-03249-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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