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  1. Article ; Online: Tribute to Professor Stefan Kunz.

    Pascual, Manuel

    Viruses

    2021  Volume 13, Issue 9

    Abstract: It has been a year since Stefan Kunz, a Full Professor since 2017 at the Faculty of Biology and Medicine of the University of Lausanne, Switzerland, passed away [ ... ]. ...

    Abstract It has been a year since Stefan Kunz, a Full Professor since 2017 at the Faculty of Biology and Medicine of the University of Lausanne, Switzerland, passed away [...].
    Language English
    Publishing date 2021-09-18
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13091862
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [No title information]

    Geissbühler, Antoine / Pascual, Manuel

    Revue medicale suisse

    2024  Volume 20, Issue 856-7, Page(s) 5–8

    Title translation Face au désenchantement des étudiants en médecine, les facultés sont prêtes à innover.
    Language French
    Publishing date 2024-01-17
    Publishing country Switzerland
    Document type Interview
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    DOI 10.53738/REVMED.2024.20.856-7.05
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Novel phenotypes of feeding and social behaviour and their relationship with individual rabbit growth and feed efficiency.

    Piles, M / Mora, M / Kyriazakis, I / Tusell, L / Pascual, M / Sánchez, J P

    Animal : an international journal of animal bioscience

    2024  Volume 18, Issue 3, Page(s) 101090

    Abstract: Due to the lack of a recording system for individual consumption of group-housed rabbits, published studies about feeding behaviour are based on information recorded at the group- and not at the individual level and periods covering only a few days or, ... ...

    Abstract Due to the lack of a recording system for individual consumption of group-housed rabbits, published studies about feeding behaviour are based on information recorded at the group- and not at the individual level and periods covering only a few days or, in some cases, only part of a day. Such information could be used to inform rabbit management systems but cannot be used for genetic selection. We aimed to generate and use information from a novel automated feeder for group-housed rabbits to identify new phenotypes for individual animals that could be incorporated into breeding programs to improve feed efficiency and social behaviour under different feeding regimens. At 39 d of age, rabbits from 15 batches were placed in cages and fed ad libitum to become used to the electronic feeder. From 42 to 58-59 d, one group of 1 086 rabbits was fed ad libitum (AL), while another group of 1 134 rabbits was fed on a restricted feeding schedule (R) by limiting the feeding time to the period between 1800 and 0600 h of the following day. We implemented a reliable multivariate method to remove anomalous feeding behaviour records. We then defined novel traits for feeding behaviour that apply to both types of feeding regimes, and for social behaviour that indicates an animal's rank within the cage hierarchy. We based these traits on feeder records and a biologically sound definition of a meal. Finally, we estimated the phenotypic correlations of those traits with growth and feed efficiency traits. Our findings demonstrate that variables about resource distribution among cage mates and an animal's priority for feed access were found to be good indicators of an animal's dominant or subordinate status within the cage. Based on results obtained in R animals (results were similar in AL animals), the most efficient animals were those that ate less frequently (phenotypic correlation with feed conversion ratio, rho = 0.6), and consumed smaller amounts per meal (rho = 0.7), spent less time at the feeder (rho = 0.4), and appeared to be subordinate, as they did not have priority access to the feeder (rho = -0.3), and had the smallest share of resources (range of rho = 0.2-0.6). We conclude that quantifying feeding and social behaviour traits can enhance the understanding of the mechanisms through which individuals exert their effects on the performance of their cage mates.
    MeSH term(s) Rabbits ; Animals ; Feeding Behavior ; Social Behavior ; Phenotype ; Selection, Genetic ; Animal Feed/analysis
    Language English
    Publishing date 2024-01-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2257920-5
    ISSN 1751-732X ; 1751-7311
    ISSN (online) 1751-732X
    ISSN 1751-7311
    DOI 10.1016/j.animal.2024.101090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Impact of school SES on literacy development.

    Salas, Naymé / Pascual, Mariona

    PloS one

    2023  Volume 18, Issue 12, Page(s) e0295606

    Abstract: Effective literacy skills are essential to actively participate in today's society. However, little research has been conducted that examined the impact of contextual variables on literacy development. The present paper addressed whether and how the ... ...

    Abstract Effective literacy skills are essential to actively participate in today's society. However, little research has been conducted that examined the impact of contextual variables on literacy development. The present paper addressed whether and how the socioeconomic status of the school (S-SES) children attend affects their literacy achievements. Eight-hundred and seventy-eight 2nd and 4th grade children participated in the study. Data were collected in low-SES (vulnerable) and in mid-high-SES (non-vulnerable) schools. Children completed a large battery of language, cognitive, and literacy tasks in Catalan, a language spoken in a region in Spain where virtually all children are at least bilingual (they also speak Spanish) and it is the main language of instruction. Results showed that children in vulnerable schools were outperformed by children in non-vulnerable schools across all literacy competencies, but particularly affected higher order skills; that is, text quality and reading comprehension. Differences with their non-vulnerable peers remained, even after controlling for context-level covariates, including familial SES. However, S-SES ceased to exert significant influence once children's cognitive and, especially, linguistic skills were considered. The study adds to previous research claiming that school SES has an effect on students' literacy skills, above and beyond children's home SES. However, our findings also suggest that literacy performance is ultimately mostly dependent on educationally actionable, subject-level skills. Educational implications are discussed.
    MeSH term(s) Child ; Humans ; Literacy ; Reading ; Language ; Schools ; Educational Status
    Language English
    Publishing date 2023-12-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0295606
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Tribute to Professor Stefan Kunz

    Pascual, Manuel

    Viruses. 2021 Sept. 18, v. 13, no. 9

    2021  

    Abstract: It has been a year since Stefan Kunz, a Full Professor since 2017 at the Faculty of Biology and Medicine of the University of Lausanne, Switzerland, passed away [ ... ] ...

    Abstract It has been a year since Stefan Kunz, a Full Professor since 2017 at the Faculty of Biology and Medicine of the University of Lausanne, Switzerland, passed away [...]
    Keywords medicine ; universities ; viruses ; Switzerland
    Language English
    Dates of publication 2021-0918
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13091862
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Prevalence of vascular risk factors in patients with and without type 2 diabetes mellitus admitted to hospital for stroke in the 2011-2013 period.

    González-Pascual, M / Barea, R

    Endocrinologia, diabetes y nutricion

    2019  Volume 66, Issue 3, Page(s) 150–156

    Abstract: Introduction: Stroke and type 2 diabetes mellitus (T2DM) are among the leading causes of morbidity and mortality in Europe.: Objective: To describe the vascular risk factors most prevalent in the Spanish population with and without type 2 diabetes ... ...

    Title translation Prevalencia de los factores de riesgo vascular entre los casos con diabetes mellitus tipo 2 y sin diabetes hospitalizados de 2011 a 2013 por accidentes cerebrovasculares.
    Abstract Introduction: Stroke and type 2 diabetes mellitus (T2DM) are among the leading causes of morbidity and mortality in Europe.
    Objective: To describe the vascular risk factors most prevalent in the Spanish population with and without type 2 diabetes mellitus admitted to hospital for a stroke during the 2011-2013 period.
    Material and methods: Using the Spanish Minimum Basic Data Set from 2011 to 2013, a descriptive, observational epidemiological study was conducted comparing the prevalence rates of vascular risk factors in Spanish patients admitted to hospital for stroke. The sample was stratified by the presence or absence of a diagnosis of type 2 diabetes mellitus. Other variables studied included in-hospital mortality, length of hospital stay, and other clinical and sociodemographic variables.
    Results: Hypertension was the most prevalent vascular risk factor in all population groups. Female sex, age, and T2DM had a statistically significant association (p<0.05) to hospital mortality in stroke.
    Conclusions: Hypertension was the most common vascular risk factor in the study sample, followed by hypercholesterolemia. There were no differences in prevalence of hypertension between patients with and without T2DM. However, T2DM is an independent risk factor for hospital mortality in any hospitalization for stroke.
    MeSH term(s) Aged ; Aged, 80 and over ; Alcohol Drinking/epidemiology ; Comorbidity ; Diabetes Mellitus, Type 2/epidemiology ; Dyslipidemias/epidemiology ; Female ; Hospital Mortality ; Hospitalization ; Humans ; Hypertension/epidemiology ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; Obesity/epidemiology ; Prevalence ; Retrospective Studies ; Risk Factors ; Smoking/epidemiology ; Spain/epidemiology ; Stroke/epidemiology
    Language Spanish
    Publishing date 2019-01-03
    Publishing country Spain
    Document type Journal Article ; Observational Study
    ISSN 2530-0180
    ISSN (online) 2530-0180
    DOI 10.1016/j.endinu.2018.10.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: An immune memory-structured SIS epidemiological model for hyperdiverse pathogens.

    de Roos, André M / He, Qixin / Pascual, Mercedes

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 45, Page(s) e2218499120

    Abstract: A hyperdiverse class of pathogens of humans and wildlife, including the malaria ... ...

    Abstract A hyperdiverse class of pathogens of humans and wildlife, including the malaria parasite
    MeSH term(s) Animals ; Humans ; Epidemiological Models ; Immunologic Memory ; Malaria, Falciparum/parasitology ; Plasmodium falciparum/genetics ; Malaria ; Parasites ; Genetic Variation
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2218499120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: In a split second: Handwriting pauses in typical and struggling writers.

    Pascual, Mariona / Soler, Olga / Salas, Naymé

    Frontiers in psychology

    2023  Volume 13, Page(s) 1052264

    Abstract: Introduction: A two-second threshold has been typically used when analyzing the writing processes. However, there is only a weak empirical basis to claim that specific average numbers and durations of pauses may be associated with specific writing ... ...

    Abstract Introduction: A two-second threshold has been typically used when analyzing the writing processes. However, there is only a weak empirical basis to claim that specific average numbers and durations of pauses may be associated with specific writing processes. We focused on handwriting execution pauses, because immature writers are known to struggle with transcription skills. We aimed to provide an evidence-based account of the average number and duration of handwriting pauses in the mid-Primary grades and to identify process-level markers of writing difficulties.
    Methods: Eighty 3rd and 5th graders, with and without writing difficulties, participated in the study. We examined pauses in a handwriting-only task, to be able to isolate those which could only be attributed to handwriting processes. Letter features were considered, as well as children's handwriting fluency level.
    Results: The average duration of handwriting pauses was around 400ms, in line with assumptions that transcription pauses would fall under the 2,000ms threshold. We found that 3rd graders made more and longer pauses than 5th graders. Struggling writers made a similar number of pauses across grades than typically-developing children, although they were significantly longer, even after controlling for the effect of handwriting fluency.
    Discussion: Our findings provide an evidence-based account of the duration of handwriting pauses. They also suggest that children need fewer and shorter handwriting pauses as they progress in automatizing transcription. However, some young writers struggle with letter formation even after 3 to 5 years of instruction.
    Language English
    Publishing date 2023-01-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.1052264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Going beyond a reference genome in conservation genomics.

    Pegueroles, Cinta / Pascual, Marta / Carreras, Carlos

    Trends in ecology & evolution

    2023  Volume 39, Issue 1, Page(s) 13–15

    Abstract: The current biodiversity crisis demands scientifically based management. The generation of reference genomes is crucial in conservation, but is not enough to capture species diversity. By incorporating whole-genome sequencing (WGS) at the population ... ...

    Abstract The current biodiversity crisis demands scientifically based management. The generation of reference genomes is crucial in conservation, but is not enough to capture species diversity. By incorporating whole-genome sequencing (WGS) at the population level, Nigenda-Morales et al. provide key genomic information for the conservation of fin whale populations in the Pacific.
    MeSH term(s) Genome ; Genomics ; Biodiversity
    Language English
    Publishing date 2023-11-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 284965-3
    ISSN 1872-8383 ; 0169-5347
    ISSN (online) 1872-8383
    ISSN 0169-5347
    DOI 10.1016/j.tree.2023.11.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Evaluating restriction enzyme selection for reduced representation sequencing in conservation genomics.

    López, Ainhoa / Carreras, Carlos / Pascual, Marta / Pegueroles, Cinta

    Molecular ecology resources

    2023  

    Abstract: Conservation genomic studies in non-model organisms generally rely on reduced representation sequencing techniques based on restriction enzymes to identify population structure as well as candidate loci for local adaptation. While the expectation is that ...

    Abstract Conservation genomic studies in non-model organisms generally rely on reduced representation sequencing techniques based on restriction enzymes to identify population structure as well as candidate loci for local adaptation. While the expectation is that the reduced representation of the genome is randomly distributed, the proportion of the genome sampled might depend on the GC content of the recognition site of the restriction enzyme used. Here, we evaluated the distribution and functional composition of loci obtained after a reduced representation approach using Genotyping-by-Sequencing (GBS). To do so, we compared experimental data from two endemic fish species (Symphodus ocellatus and Symphodus tinca, EcoT22I enzyme) and two ecosystem engineer sea urchins (Paracentrotus lividus and Arbacia lixula, ApeKI enzyme). In brief, we mapped the sequenced loci to the phylogenetically closest reference genome available (Labrus bergylta in the fish and Strongylocentrotus purpuratus in the sea urchin datasets), classified them as exonic, intronic and intergenic, and studied their function by using Gene Ontology (GO) terms. We also simulated the effect of using both enzymes in the two reference genomes. In both simulated and experimental data, we detected an enrichment towards exonic or intergenic regions depending on the restriction enzyme used and failed to detect differences between total loci and candidate loci for adaptation in the empirical dataset. Most of the functions assigned to the mapped loci were shared between the four species and involved a myriad of general functions. Our results highlight the importance of restriction enzyme selection and the need for high-quality annotated genomes in conservation genomic studies.
    Language English
    Publishing date 2023-09-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2406833-0
    ISSN 1755-0998 ; 1755-098X
    ISSN (online) 1755-0998
    ISSN 1755-098X
    DOI 10.1111/1755-0998.13865
    Database MEDical Literature Analysis and Retrieval System OnLINE

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