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  1. Article ; Online: NMR Characterization of Polyethylene Glycol Conjugates for Nanoparticle Functionalization.

    Pasek-Allen, Jacqueline L / Wilharm, Randall K / Bischof, John C / Pierre, Valérie C

    ACS omega

    2023  Volume 8, Issue 4, Page(s) 4331–4336

    Abstract: The molecular weight, purity, and functionalization of polyethylene glycols are often characterized ... ...

    Abstract The molecular weight, purity, and functionalization of polyethylene glycols are often characterized by
    Language English
    Publishing date 2023-01-18
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c07669
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Phosphonate coating of commercial iron oxide nanoparticles for nanowarming cryopreserved samples.

    Pasek-Allen, Jacqueline L / Wilharm, Randall K / Gao, Zhe / Pierre, Valerie C / Bischof, John C

    Journal of materials chemistry. B

    2022  Volume 10, Issue 19, Page(s) 3734–3746

    Abstract: New preservation technologies may allow for organ banking similar to blood and biomaterial banking approaches. Using cryoprotective agents (CPAs), aqueous solutions with organic components such as DMSO, propylene glycol, and added salts and sugars, ... ...

    Abstract New preservation technologies may allow for organ banking similar to blood and biomaterial banking approaches. Using cryoprotective agents (CPAs), aqueous solutions with organic components such as DMSO, propylene glycol, and added salts and sugars, organs can be used to vitrify and store organs at -140 °C. When needed, these organs can be rewarmed in a rapid and uniform manner if CPAs are supplemented with iron oxide nanoparticles (IONPs) in an applied radiofrequency field. Speed and uniformity of warming are both IONP concentration and CPA suspension dependent. Here we present a coating method of small molecule phosphonate linker (PLink) and biocompatible polymer (
    MeSH term(s) Cryopreservation/methods ; Cryoprotective Agents/chemistry ; Cryoprotective Agents/pharmacology ; Humans ; Ligands ; Magnetic Iron Oxide Nanoparticles ; Organophosphonates ; Water
    Chemical Substances Cryoprotective Agents ; Ligands ; Organophosphonates ; Water (059QF0KO0R)
    Language English
    Publishing date 2022-05-18
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d1tb02483c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Engineering Magnetic Nanoclusters for Highly Efficient Heating in Radio-Frequency Nanowarming.

    Ye, Zuyang / Tai, Youyi / Han, Zonghu / Liu, Sangmo / Etheridge, Michael L / Pasek-Allen, Jacqueline L / Shastry, Chaitanya / Liu, Yun / Li, Zhiwei / Chen, Chen / Wang, Zhongxiang / Bischof, John C / Nam, Jin / Yin, Yadong

    Nano letters

    2024  Volume 24, Issue 15, Page(s) 4588–4594

    Abstract: Effective thawing of cryopreserved samples requires rapid and uniform heating. This is achievable through nanowarming, an approach that heats magnetic nanoparticles by using alternating magnetic fields. Here we demonstrate the synthesis and surface ... ...

    Abstract Effective thawing of cryopreserved samples requires rapid and uniform heating. This is achievable through nanowarming, an approach that heats magnetic nanoparticles by using alternating magnetic fields. Here we demonstrate the synthesis and surface modification of magnetic nanoclusters for efficient nanowarming. Magnetite (Fe
    MeSH term(s) Swine ; Animals ; Heating ; Magnetics ; Cryopreservation ; Ferrosoferric Oxide ; Magnetic Fields
    Chemical Substances Ferrosoferric Oxide (XM0M87F357)
    Language English
    Publishing date 2024-04-08
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.4c00721
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Vitrification and nanowarming enable long-term organ cryopreservation and life-sustaining kidney transplantation in a rat model.

    Han, Zonghu / Rao, Joseph Sushil / Gangwar, Lakshya / Namsrai, Bat-Erdene / Pasek-Allen, Jacqueline L / Etheridge, Michael L / Wolf, Susan M / Pruett, Timothy L / Bischof, John C / Finger, Erik B

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 3407

    Abstract: Banking cryopreserved organs could transform transplantation into a planned procedure that more equitably reaches patients regardless of geographical and time constraints. Previous organ cryopreservation attempts have failed primarily due to ice ... ...

    Abstract Banking cryopreserved organs could transform transplantation into a planned procedure that more equitably reaches patients regardless of geographical and time constraints. Previous organ cryopreservation attempts have failed primarily due to ice formation, but a promising alternative is vitrification, or the rapid cooling of organs to a stable, ice-free, glass-like state. However, rewarming of vitrified organs can similarly fail due to ice crystallization if rewarming is too slow or cracking from thermal stress if rewarming is not uniform. Here we use "nanowarming," which employs alternating magnetic fields to heat nanoparticles within the organ vasculature, to achieve both rapid and uniform warming, after which the nanoparticles are removed by perfusion. We show that vitrified kidneys can be cryogenically stored (up to 100 days) and successfully recovered by nanowarming to allow transplantation and restore life-sustaining full renal function in nephrectomized recipients in a male rat model. Scaling this technology may one day enable organ banking for improved transplantation.
    MeSH term(s) Male ; Rats ; Animals ; Vitrification ; Kidney Transplantation ; Cryopreservation/methods ; Kidney ; Organ Preservation/methods
    Language English
    Publishing date 2023-06-09
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-38824-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Injectable and Repeatable Inductive Heating of Iron Oxide Nanoparticle-Enhanced "PHIL" Embolic toward Tumor Treatment.

    Pasek-Allen, Jacqueline L / Kantesaria, Saurin / Gangwar, Lakshya / Shao, Qi / Gao, Zhe / Idiyatullin, Djaudat / Han, Zonghu / Etheridge, Michael L / Garwood, Michael / Jagadeesan, Bharathi D / Bischof, John C

    ACS applied materials & interfaces

    2022  Volume 14, Issue 37, Page(s) 41659–41670

    Abstract: Deep-seated tumors of the liver, brain, and other organ systems often recur after initial surgical, chemotherapeutic, radiation, or focal treatments. Repeating these treatments is often invasive and traumatic. We propose an iron oxide nanoparticle (IONP)- ...

    Abstract Deep-seated tumors of the liver, brain, and other organ systems often recur after initial surgical, chemotherapeutic, radiation, or focal treatments. Repeating these treatments is often invasive and traumatic. We propose an iron oxide nanoparticle (IONP)-enhanced precipitating hydrophobic injectable liquid (PHIL, MicroVention inc.) embolic as a localized dual treatment implant for nutrient deprivation and multiple repeatable thermal ablation. Following a single injection, multiple thermal treatments can be repeated as needed, based on monitoring of tumor growth/recurrence. Herein we show the ability to create an injectable stable PHIL-IONP solution, monitor deposition of the PHIL-IONP precipitate dispersion by μCT, and gauge the IONP distribution within the embolic by magnetic resonance imaging. Once precipitated, the implant could be heated to reach therapeutic temperatures >8 °C for thermal ablation (clinical temperature of ∼45 °C), in a model disk and a 3D tumor bed model. Heat output was not affected by physiological conditions, multiple heating sessions, or heating at intervals over a 1 month duration. Further, in ex vivo mice hind-limb tumors, we could noninvasively heat the embolic to an "ablative" temperature elevation of 17 °C (clinically 54 °C) in the first 5 min and maintain the temperature rise over +8 °C (clinically a temperature of 45 °C) for longer than 15 min.
    MeSH term(s) Animals ; Dimethyl Sulfoxide ; Embolization, Therapeutic/methods ; Heating ; Magnetic Iron Oxide Nanoparticles ; Mice ; Neoplasms/drug therapy ; Polyvinyls/therapeutic use
    Chemical Substances Polyvinyls ; Dimethyl Sulfoxide (YOW8V9698H)
    Language English
    Publishing date 2022-09-07
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.2c05941
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Injectable and Repeatable Inductive Heating of Iron Oxide Nanoparticle-Enhanced “PHIL” Embolic toward Tumor Treatment

    Pasek-Allen, Jacqueline L. / Kantesaria, Saurin / Gangwar, Lakshya / Shao, Qi / Gao, Zhe / Idiyatullin, Djaudat / Han, Zonghu / Etheridge, Michael L. / Garwood, Michael / Jagadeesan, Bharathi D. / Bischof, John C.

    ACS applied materials & interfaces. 2022 Sept. 07, v. 14, no. 37

    2022  

    Abstract: Deep-seated tumors of the liver, brain, and other organ systems often recur after initial surgical, chemotherapeutic, radiation, or focal treatments. Repeating these treatments is often invasive and traumatic. We propose an iron oxide nanoparticle (IONP)- ...

    Abstract Deep-seated tumors of the liver, brain, and other organ systems often recur after initial surgical, chemotherapeutic, radiation, or focal treatments. Repeating these treatments is often invasive and traumatic. We propose an iron oxide nanoparticle (IONP)-enhanced precipitating hydrophobic injectable liquid (PHIL, MicroVention inc.) embolic as a localized dual treatment implant for nutrient deprivation and multiple repeatable thermal ablation. Following a single injection, multiple thermal treatments can be repeated as needed, based on monitoring of tumor growth/recurrence. Herein we show the ability to create an injectable stable PHIL-IONP solution, monitor deposition of the PHIL-IONP precipitate dispersion by μCT, and gauge the IONP distribution within the embolic by magnetic resonance imaging. Once precipitated, the implant could be heated to reach therapeutic temperatures >8 °C for thermal ablation (clinical temperature of ∼45 °C), in a model disk and a 3D tumor bed model. Heat output was not affected by physiological conditions, multiple heating sessions, or heating at intervals over a 1 month duration. Further, in ex vivo mice hind-limb tumors, we could noninvasively heat the embolic to an “ablative” temperature elevation of 17 °C (clinically 54 °C) in the first 5 min and maintain the temperature rise over +8 °C (clinically a temperature of 45 °C) for longer than 15 min.
    Keywords brain ; drug therapy ; heat ; hindlimbs ; hydrophobicity ; iron oxides ; liquids ; liver ; magnetism ; models ; nanoparticles ; neoplasms ; temperature
    Language English
    Dates of publication 2022-0907
    Size p. 41659-41670.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1944-8252
    DOI 10.1021/acsami.2c05941
    Database NAL-Catalogue (AGRICOLA)

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