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Article: Henri Petit (1932-2014)

Pasquier, F

2015 Volume 171, Issue 2, Page(s) 121–124

Title translation	Henri Petit (1932-2014).
MeSH term(s)	Belgium ; Biomedical Research/history ; France ; History, 20th Century ; History, 21st Century ; Humans ; Neurology/history ; Neurology/organization & administration ; Psychiatry/history ; Translational Medical Research/history
Language	French
Publishing date	2015-12-16
Publishing country	France
Document type	Biography ; Historical Article ; Journal Article ; Portrait
ZDB-ID	4593-7
ISSN	2213-0004 ; 0035-3787
ISSN (online)	2213-0004
ISSN	0035-3787
DOI	10.1016/j.neurol.2015.02.003
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Article: New behavioural variant FTD criteria and clinical practice.

Pasquier, F

Revue neurologique

2013 Volume 169, Issue 10, Page(s) 799–805

Abstract: Since the first descriptions of circumscribed frontotemporal atrophies, and the first statement published by the Lund and Manchester groups, consensus clinical and pathological criteria for frontotemporal dementia (FTD) have been increasingly refined. ... ...

Abstract	Since the first descriptions of circumscribed frontotemporal atrophies, and the first statement published by the Lund and Manchester groups, consensus clinical and pathological criteria for frontotemporal dementia (FTD) have been increasingly refined. The last international behavioural variant FTD criteria (FTDC) (Rascovsky et al., 2011) are the most sensitive, operational and reliable, for the clinical syndrome. Previously exclusion features, like early and severe amnestic syndrome or spatial disorientation, which turn out to be not so rare, are taken into account, as well as imaging, and biomarkers suggestive of other pathologies like Alzheimer's disease. So far, clinical features do not seem very helpful in predicting the underlying histopathology, although there are some clues, mainly related to neurological features (e.g. motor neuron disease, extra-pyramidal symptoms or language disorders), or associated disorders (e.g. Paget disease of bone) or genetics. BvFTD remains a difficult diagnosis at very early stage, which accounts for the delay of diagnosis, especially in late onset, where the frontotemporal atrophy may not be striking. At very young onset, psychiatric diseases must be ruled out. More systematic assessment of social cognition could be helpful. Further biomarkers are expected. Systematic use of recent criteria, for BvFTD and other neurodegenerative diseases especially AD, will contribute to make early and correct diagnoses in excluding or suggesting alternative diagnoses. Post-mortem assessment, with detailed recording of clinical information, is essential to progress.
MeSH term(s)	Consensus ; Diagnosis, Differential ; Diagnostic Techniques, Neurological/standards ; Frontotemporal Dementia/classification ; Frontotemporal Dementia/complications ; Frontotemporal Dementia/diagnosis ; Humans ; Mental Disorders/diagnosis ; Mental Disorders/etiology ; Practice Guidelines as Topic ; Professional Practice
Language	English
Publishing date	2013-10
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	4593-7
ISSN	2213-0004 ; 0035-3787
ISSN (online)	2213-0004
ISSN	0035-3787
DOI	10.1016/j.neurol.2013.08.002
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Article: Autocatalysis in protein systems.

PASQUIER, F

Comptes rendus hebdomadaires des seances de l'Academie des sciences

2010 Volume 224, Issue 14, Page(s) 1070

Title translation	Autocatalyse dans les systèmes protéiques.
MeSH term(s)	Catalysis
Language	French
Publishing date	2010-02-28
Publishing country	France
Document type	Journal Article
ZDB-ID	215733-0
ISSN	0001-4036
ISSN	0001-4036
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Article ; Online: Diabetes and cognitive impairment: how to evaluate the cognitive status?

Pasquier, F

Diabetes & metabolism

2010 Volume 36 Suppl 3, Page(s) S100–5

Abstract: Aim: Patients with diabetes have shown lower performance in tests of cognitive function especially those testing memory, executive functions, and psychomotor efficiency. They also have an elevated risk of both vascular dementia and Alzheimer's disease. ... ...

Abstract	Aim: Patients with diabetes have shown lower performance in tests of cognitive function especially those testing memory, executive functions, and psychomotor efficiency. They also have an elevated risk of both vascular dementia and Alzheimer's disease. Cognitive impairment may have consequence on treatment compliance. Methods and results: This article provides indication for holding an interview, and reports a few screening bedside tests to detect a cognitive impairment. Some neuropsychological tests useful for characterizing the cognitive profile of a patient are described, as well as the main cognitive profiles expected in patients with diabetes and cognitive decline. Conclusion: A systematic assessment of cognition with a rapid interview and screening tests in patients with diabetes, especially the oldest, with a long history of diabetes, co-morbidities, or with unexplained poor metabolic control would be a good clinical practice. Patients with cognitive decline may be referred to memory clinics for identifying the cause of the decline and contribute to provide appropriate medical and medicosocial management.
MeSH term(s)	Cognition Disorders/diagnosis ; Cognition Disorders/etiology ; Dementia/etiology ; Diabetes Complications/complications ; Diabetes Complications/diagnosis ; Humans ; Interviews as Topic ; Memory Disorders/etiology
Language	English
Publishing date	2010-10
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	1315751-6
ISSN	1878-1780 ; 1262-3636 ; 0338-1684
ISSN (online)	1878-1780
ISSN	1262-3636 ; 0338-1684
DOI	10.1016/S1262-3636(10)70475-4
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Zs.A 1267: Show issues

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Article ; Online: The Impact of Multisession Sleep-Hygiene Strategies on Sleep Parameters in Elite Swimmers.

Pasquier, Florane / Pla, Robin / Bosquet, Laurent / Sauvet, Fabien / Nedelec, Mathieu

International journal of sports physiology and performance

2023 Volume 18, Issue 11, Page(s) 1304–1312

Abstract: Purpose: Short sleep duration and poor sleep quality are common in swimmers. Sleep-hygiene strategies demonstrated beneficial effects on several sleep parameters. The present study assessed the impact of a multisession sleep-hygiene training course on ... ...

Abstract	Purpose: Short sleep duration and poor sleep quality are common in swimmers. Sleep-hygiene strategies demonstrated beneficial effects on several sleep parameters. The present study assessed the impact of a multisession sleep-hygiene training course on sleep in elite swimmers. Methods: Twenty-eight elite swimmers (17 [2] y) participated. The sleep-hygiene strategy consisted of 3 interventions. Sleep was measured by actigraphy for 7 days before the beginning of the intervention (baseline), after the first collective intervention (postintervention), after the second collective intervention (postintervention 2), and, finally, after the individual intervention (postintervention 3). The Epworth Sleepiness Scale (ESS) was completed concurrently. Swimmers were classified into 2 groups: nonsomnolent (baseline ESS score ≤ 10, n = 13) and somnolent (baseline ESS score ≥ 11, n = 15). Results: All swimmers had a total sleep time of <8 hours per night. Sixty percent of swimmers were moderately morning type. Later bedtime, less time in bed, and total sleep time were observed in the somnolent group compared with the nonsomnolent group at baseline. An interaction between training course and group factors was observed for bedtime, with a significant advance in bedtime between baseline, postintervention 2, and postintervention 3 for the somnolent group. Conclusions: The present study confirms the importance of implementing sleep-hygiene strategies, particularly in athletes with an ESS score ≥11. A conjunction of individual and collective measures (eg, earlier bedtime, napping, and delaying morning training session) could favor the total sleep time achieved.
MeSH term(s)	Humans ; Sleep ; Sleep Hygiene ; Athletes ; Sleep Duration ; Hygiene
Language	English
Publishing date	2023-09-14
Publishing country	United States
Document type	Journal Article
ISSN	1555-0273
ISSN (online)	1555-0273
DOI	10.1123/ijspp.2023-0018
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Article ; Online: Increased training load promotes sleep propensity and slow-wave sleep in endurance runners: Can a high-heat-capacity mattress topper modulate this effect?

Chauvineau, Maxime / Pasquier, Florane / Duforez, François / Guilhem, Gaël / Nedelec, Mathieu

Journal of sleep research

2023 , Page(s) e14132

Abstract: The present study aimed to: (1) investigate sleep architecture in response to an overload training and taper periods among endurance runners; and (2) assess the sleep benefits of a high-heat-capacity mattress topper. Twenty-one trained male endurance ... ...

Abstract	The present study aimed to: (1) investigate sleep architecture in response to an overload training and taper periods among endurance runners; and (2) assess the sleep benefits of a high-heat-capacity mattress topper. Twenty-one trained male endurance runners performed a 2-week usual training regimen (baseline) followed by 2-week overload and taper periods. From overload to the end of the taper period, they were assigned into two groups based on the mattress topper used: high-heat-capacity mattress topper (n = 11) or low-heat-capacity mattress topper (n = 10). Training load was assessed daily using the session rating of perceived exertion. Following each period, sleep was monitored by polysomnography, and nocturnal core body temperature was recorded throughout the night. Irrespective of the group, awakening episodes > 5 min decreased following overload compared with baseline (-0.48, p = 0.05). Independently of mattress topper, each 100 A.U. increase in 7-day training load prior to polysomnographic recording was associated with higher slow-wave sleep proportion (β = +0.13%; p = 0.05), lower sleep-onset latency (β = -0.49 min; p = 0.05), and a reduction in the probability of transition from N1 sleep stage to wakefulness (β = -0.12%; p = 0.05). Sleeping on a high-heat-capacity mattress topper did not affect any sleep variable compared with a low-heat-capacity mattress topper. Increased training loads promote slow-wave sleep and sleep propensity, highlighting the adaptative nature of sleep to diurnal activity and the role of sleep in physiological recovery. Further studies are required on the potential benefits of high-heat-capacity mattress toppers on sleep architecture among athletes.
Language	English
Publishing date	2023-12-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1122722-9
ISSN	1365-2869 ; 0962-1105
ISSN (online)	1365-2869
ISSN	0962-1105
DOI	10.1111/jsr.14132
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Zs.A 3464: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Treatment of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia in Adults.

Saleh, Khalil / Fernandez, Alexis / Pasquier, Florence

Cancers

2022 Volume 14, Issue 7

Abstract: Philadelphia-chromosome positive acute lymphoblastic leukemia (Ph+ ALL) is the most common subtype of B-ALL in adults and its incidence increases with age. It is characterized by the presence of BCR-ABL oncoprotein that plays a central role in the ... ...

Abstract	Philadelphia-chromosome positive acute lymphoblastic leukemia (Ph+ ALL) is the most common subtype of B-ALL in adults and its incidence increases with age. It is characterized by the presence of BCR-ABL oncoprotein that plays a central role in the leukemogenesis of Ph+ ALL. Ph+ ALL patients traditionally had dismal prognosis and long-term survivors were only observed among patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) in first complete remission (CR1). However, feasibility of allo-HSCT is limited in this elderly population. Fortunately, development of increasingly powerful tyrosine kinase inhibitors (TKIs) from the beginning of the 2000's dramatically improved the prognosis of Ph+ ALL patients with complete response rates above 90%, deep molecular responses and prolonged survival, altogether with good tolerance. TKIs became the keystone of Ph+ ALL management and their great efficacy led to develop reduced-intensity chemotherapy backbones. Subsequent introduction of blinatumomab allowed going further with development of chemo free strategies. This review will focus on these amazing recent advances as well as novel therapeutic strategies in adult Ph+ ALL.
Language	English
Publishing date	2022-04-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14071805
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Article: Recommandations professionnelles pour le diagnostic et la prise en charge de la maladie d'Alzheimer et des maladies apparentées HAS 2008.

Pasquier, F

Revue neurologique

2008 Volume 164, Issue 8-9, Page(s) 753–754

Title translation	Professional guidelines for the diagnosis and management of Alzheimer's disease and related diseases, HAS (Haute Autorité de Santé) 2008.
MeSH term(s)	Aged ; Alzheimer Disease/diagnosis ; Alzheimer Disease/pathology ; Alzheimer Disease/therapy ; Diagnosis, Differential ; Early Diagnosis ; Electroencephalography ; Humans ; Mental Disorders/drug therapy ; Mental Disorders/etiology ; Neurodegenerative Diseases/diagnosis ; Neuropsychological Tests ; Patient Education as Topic ; Practice Guidelines as Topic ; Psychiatric Status Rating Scales ; Survival Analysis ; Terminology as Topic
Language	French
Publishing date	2008-08
Publishing country	France
Document type	Editorial
ZDB-ID	4593-7
ISSN	2213-0004 ; 0035-3787
ISSN (online)	2213-0004
ISSN	0035-3787
DOI	10.1016/S0035-3787(08)00523-7
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Article ; Online: A 3D convolutional neural network to classify subjects as Alzheimer's disease, frontotemporal dementia or healthy controls using brain 18F-FDG PET.

Rogeau, Antoine / Hives, Florent / Bordier, Cécile / Lahousse, Hélène / Roca, Vincent / Lebouvier, Thibaud / Pasquier, Florence / Huglo, Damien / Semah, Franck / Lopes, Renaud

NeuroImage

2024 Volume 288, Page(s) 120530

Abstract: With the arrival of disease-modifying drugs, neurodegenerative diseases will require an accurate diagnosis for optimal treatment. Convolutional neural networks are powerful deep learning techniques that can provide great help to physicians in image ... ...

Abstract	With the arrival of disease-modifying drugs, neurodegenerative diseases will require an accurate diagnosis for optimal treatment. Convolutional neural networks are powerful deep learning techniques that can provide great help to physicians in image analysis. The purpose of this study is to introduce and validate a 3D neural network for classification of Alzheimer's disease (AD), frontotemporal dementia (FTD) or cognitively normal (CN) subjects based on brain glucose metabolism. Retrospective [18F]-FDG-PET scans of 199 CE, 192 FTD and 200 CN subjects were collected from our local database, Alzheimer's disease and frontotemporal lobar degeneration neuroimaging initiatives. Training and test sets were created using randomization on a 90 %-10 % basis, and training of a 3D VGG16-like neural network was performed using data augmentation and cross-validation. Performance was compared to clinical interpretation by three specialists in the independent test set. Regions determining classification were identified in an occlusion experiment and Gradient-weighted Class Activation Mapping. Test set subjects were age- and sex-matched across categories. The model achieved an overall 89.8 % accuracy in predicting the class of test scans. Areas under the ROC curves were 93.3 % for AD, 95.3 % for FTD, and 99.9 % for CN. The physicians' consensus showed a 69.5 % accuracy, and there was substantial agreement between them (kappa = 0.61, 95 % CI: 0.49-0.73). To our knowledge, this is the first study to introduce a deep learning model able to discriminate AD and FTD based on [18F]-FDG PET scans, and to isolate CN subjects with excellent accuracy. These initial results are promising and hint at the potential for generalization to data from other centers.
MeSH term(s)	Humans ; Alzheimer Disease/diagnostic imaging ; Fluorodeoxyglucose F18 ; Frontotemporal Dementia/diagnostic imaging ; Retrospective Studies ; Brain/diagnostic imaging ; Positron-Emission Tomography/methods ; Neural Networks, Computer
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2024-02-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2024.120530
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Zs.MO 7: Show issues

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Article ; Online: Effectiveness of multi-modal home-based videoconference interventions on sleep in older adults: study protocol for a randomized controlled trial.

Milot, Emma / Rehel, Stéphane / Langeard, Antoine / Bigot, Lucile / Pasquier, Florane / Matveeff, Laura / Gauthier, Antoine / Bessot, Nicolas / Quarck, Gaëlle

Frontiers in public health

2024 Volume 12, Page(s) 1326412

Abstract: Aging is characterized by substantial changes in sleep architecture that negatively impact fitness, quality of life, mood, and cognitive functioning. Older adults often fail to reach the recommended level of physical activity to prevent the age-related ... ...

Abstract	Aging is characterized by substantial changes in sleep architecture that negatively impact fitness, quality of life, mood, and cognitive functioning. Older adults often fail to reach the recommended level of physical activity to prevent the age-related decline in sleep function, partly because of geographical barriers. Implementing home-based interventions could surmount these obstacles, thereby encouraging older adults to stay active, with videoconference administration emerging as a promising solution. Increasing the availability of biological rhythms synchronizers, such as physical activity, light exposure, or vestibular stimulation, represents a viable non-pharmacological strategy for entraining circadian rhythms and potentially fortifying the sleep-wake cycle, thereby enhancing sleep in aging. This study aims to (1) assess the impact of remote physical exercise training and its combination with bright light exposure, and (2) investigate the specific contribution of galvanic vestibular stimulation, to sleep quality among healthy older adults with sleep complaints. One hundred healthy older adults aged 60-70 years with sleep complaints will be randomly allocated to one of four groups: a physical exercise training group (
MeSH term(s)	Humans ; Aged ; Middle Aged ; Videoconferencing ; Female ; Male ; Exercise ; Quality of Life ; Sleep/physiology
Language	English
Publishing date	2024-04-15
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Randomized Controlled Trial ; Clinical Trial Protocol
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2024.1326412
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