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  1. Book: Frontotemporal dementia

    Pasquier, Florence

    (Current issues in neurodegenerative diseases ; 8)

    1996  

    Author's details ed. by: F. Pasquier
    Series title Current issues in neurodegenerative diseases ; 8
    Collection
    Keywords Dementia / pathology ; Frontal Lobe / pathology ; Stirnhirn ; Demenz
    Subject Anoia ; Dementia ; Chronische Verwirrtheit ; Frontalhirn ; Lobus frontalis cerebri ; Stirnlappen ; Frontallappen ; Scheitellappen
    Language English
    Size VIII, 154 S. : Ill., graph. Darst.
    Publisher ICG Publ
    Publishing place Dordrecht
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT007961219
    ISBN 90-6765-530-9 ; 978-90-6765-530-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1997 A 8741 order for loan Magazin

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  2. Article: Treatment of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia in Adults.

    Saleh, Khalil / Fernandez, Alexis / Pasquier, Florence

    Cancers

    2022  Volume 14, Issue 7

    Abstract: Philadelphia-chromosome positive acute lymphoblastic leukemia (Ph+ ALL) is the most common subtype of B-ALL in adults and its incidence increases with age. It is characterized by the presence of BCR-ABL oncoprotein that plays a central role in the ... ...

    Abstract Philadelphia-chromosome positive acute lymphoblastic leukemia (Ph+ ALL) is the most common subtype of B-ALL in adults and its incidence increases with age. It is characterized by the presence of BCR-ABL oncoprotein that plays a central role in the leukemogenesis of Ph+ ALL. Ph+ ALL patients traditionally had dismal prognosis and long-term survivors were only observed among patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) in first complete remission (CR1). However, feasibility of allo-HSCT is limited in this elderly population. Fortunately, development of increasingly powerful tyrosine kinase inhibitors (TKIs) from the beginning of the 2000's dramatically improved the prognosis of Ph+ ALL patients with complete response rates above 90%, deep molecular responses and prolonged survival, altogether with good tolerance. TKIs became the keystone of Ph+ ALL management and their great efficacy led to develop reduced-intensity chemotherapy backbones. Subsequent introduction of blinatumomab allowed going further with development of chemo free strategies. This review will focus on these amazing recent advances as well as novel therapeutic strategies in adult Ph+ ALL.
    Language English
    Publishing date 2022-04-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14071805
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Les démences fronto-temporales

    Pasquier, Florence / Lebert, Florence

    (Congrès de Psychiatrie et de Neurologie de Langue Franc̨aise <93> ; 2)

    1995  

    Author's details Florence Pasquier ; Florence Lebert
    Series title Congrès de Psychiatrie et de Neurologie de Langue Franc̨aise <93> ; 2
    Congrès de Psychiatrie et de Neurologie de Langue Française
    Congrès de Psychiatrie et de Neurologie de Langue Franc̨aise <93>
    Collection Congrès de Psychiatrie et de Neurologie de Langue Française
    Congrès de Psychiatrie et de Neurologie de Langue Franc̨aise <93>
    Keywords Dementia / congresses ; Frontal Lobe / pathology / congresses ; Temporal Lobe / pathology / congresses ; Demenz ; Stirnhirn
    Subject Frontalhirn ; Lobus frontalis cerebri ; Stirnlappen ; Frontallappen ; Scheitellappen ; Anoia ; Dementia ; Chronische Verwirrtheit
    Language French
    Size 202 S.
    Publisher Masson
    Publishing place Paris u.a.
    Publishing country France
    Document type Book
    HBZ-ID HT007228534
    ISBN 2-225-84877-7 ; 978-2-225-84877-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    1996 A 3597 -2- order for loan Magazin

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  4. Article: CAR T-Cells for the Treatment of B-Cell Acute Lymphoblastic Leukemia.

    Saleh, Khalil / Pasquier, Florence / Bigenwald, Camille / De Botton, Stéphane / Ribrag, Vincent / Castilla-Llorente, Cristina

    Journal of clinical medicine

    2023  Volume 12, Issue 21

    Abstract: B-cell acute lymphoblastic leukemia (B-ALL) is the most common subtype of acute leukemia in the pediatric population. The prognosis and treatment of B-ALL have dramatically improved over the past decade with the adoption of intensive and prolonged ... ...

    Abstract B-cell acute lymphoblastic leukemia (B-ALL) is the most common subtype of acute leukemia in the pediatric population. The prognosis and treatment of B-ALL have dramatically improved over the past decade with the adoption of intensive and prolonged combination chemotherapy regimens. The advent of novel immunologic agents such as blinatumomab and inotuzumab has changed the treatment landscape of B-ALL. However, patients have continued to relapse, raising the need for novel therapies. Chimeric antigen receptor (CAR) T-cells have achieved a milestone in the treatment of B-ALL. Two CD19-targeting CAR T-cells were approved by the Food and Drug Administration and the European Medicines Agency for the treatment of relapsed and/or refractory B-ALL. In this review, we review the available data regarding CD19-targeting CAR T-cells with their safety profile as well as the mechanism of resistance to these agents and the way to overcome this resistance.
    Language English
    Publishing date 2023-10-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12216883
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  5. Article ; Online: A 3D convolutional neural network to classify subjects as Alzheimer's disease, frontotemporal dementia or healthy controls using brain 18F-FDG PET.

    Rogeau, Antoine / Hives, Florent / Bordier, Cécile / Lahousse, Hélène / Roca, Vincent / Lebouvier, Thibaud / Pasquier, Florence / Huglo, Damien / Semah, Franck / Lopes, Renaud

    NeuroImage

    2024  Volume 288, Page(s) 120530

    Abstract: With the arrival of disease-modifying drugs, neurodegenerative diseases will require an accurate diagnosis for optimal treatment. Convolutional neural networks are powerful deep learning techniques that can provide great help to physicians in image ... ...

    Abstract With the arrival of disease-modifying drugs, neurodegenerative diseases will require an accurate diagnosis for optimal treatment. Convolutional neural networks are powerful deep learning techniques that can provide great help to physicians in image analysis. The purpose of this study is to introduce and validate a 3D neural network for classification of Alzheimer's disease (AD), frontotemporal dementia (FTD) or cognitively normal (CN) subjects based on brain glucose metabolism. Retrospective [18F]-FDG-PET scans of 199 CE, 192 FTD and 200 CN subjects were collected from our local database, Alzheimer's disease and frontotemporal lobar degeneration neuroimaging initiatives. Training and test sets were created using randomization on a 90 %-10 % basis, and training of a 3D VGG16-like neural network was performed using data augmentation and cross-validation. Performance was compared to clinical interpretation by three specialists in the independent test set. Regions determining classification were identified in an occlusion experiment and Gradient-weighted Class Activation Mapping. Test set subjects were age- and sex-matched across categories. The model achieved an overall 89.8 % accuracy in predicting the class of test scans. Areas under the ROC curves were 93.3 % for AD, 95.3 % for FTD, and 99.9 % for CN. The physicians' consensus showed a 69.5 % accuracy, and there was substantial agreement between them (kappa = 0.61, 95 % CI: 0.49-0.73). To our knowledge, this is the first study to introduce a deep learning model able to discriminate AD and FTD based on [18F]-FDG PET scans, and to isolate CN subjects with excellent accuracy. These initial results are promising and hint at the potential for generalization to data from other centers.
    MeSH term(s) Humans ; Alzheimer Disease/diagnostic imaging ; Fluorodeoxyglucose F18 ; Frontotemporal Dementia/diagnostic imaging ; Retrospective Studies ; Brain/diagnostic imaging ; Positron-Emission Tomography/methods ; Neural Networks, Computer
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2024-02-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1147767-2
    ISSN 1095-9572 ; 1053-8119
    ISSN (online) 1095-9572
    ISSN 1053-8119
    DOI 10.1016/j.neuroimage.2024.120530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3664: Show issues Location:
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  6. Article ; Online: Atypical White Matter Hyperintensities Markedly Impact Plasma Neurofilament Light Chain Variability in GRN Patients.

    Vítor, Joana / Saracino, Dario / Ströer, Sebastian / Camuzat, Agnès / Dorgham, Karim / Clot, Fabienne / Martin-Hardy, Philippe / Pasquier, Florence / Le Ber, Isabelle

    Journal of Alzheimer's disease : JAD

    2023  Volume 94, Issue 4, Page(s) 1351–1360

    Abstract: GRN mutations, causing frontotemporal dementia, can be associated with atypical white matter hyperintensities (WMH). We hypothesized that the presence of WMH may impact neurofilament light chain (NfL) levels, markers of neuroaxonal damage. We analyzed ... ...

    Abstract GRN mutations, causing frontotemporal dementia, can be associated with atypical white matter hyperintensities (WMH). We hypothesized that the presence of WMH may impact neurofilament light chain (NfL) levels, markers of neuroaxonal damage. We analyzed plasma NfL in 20 GRN patients and studied their association to visually-scored WMH burden. The 12 patients displaying atypical WMH had significantly higher NfL levels (98.4±34.9 pg/mL) than those without WMH (47.2±29.4 pg/mL, p = 0.003), independently from age, disease duration and Fazekas-Schmidt grade. NfL correlated with WMH burden (rho = 0.55, p = 0.01). This study prompts considering WMH burden as a variability factor when evaluating NfL levels in GRN patients.
    MeSH term(s) Humans ; Biomarkers ; Frontotemporal Dementia/genetics ; Intermediate Filaments ; Mutation ; Neurofilament Proteins ; Progranulins/genetics ; White Matter/diagnostic imaging
    Chemical Substances Biomarkers ; GRN protein, human ; Neurofilament Proteins ; Progranulins ; neurofilament protein L
    Language English
    Publishing date 2023-06-23
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-230315
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6084: Show issues Location:
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  7. Article ; Online: Development and Validation of a Scale to Assess Caregiver Management Behaviors in Response to the Decreased Engagement of People with Dementia in Daily Activities.

    Wawrziczny, Emilie / Larochette, Clotilde / Pasquier, Florence / Antoine, Pascal

    Clinical gerontologist

    2019  Volume 45, Issue 3, Page(s) 514–524

    Abstract: ... ...

    Abstract Objective
    MeSH term(s) Caregivers ; Dementia/therapy ; Humans ; Psychometrics ; Reproducibility of Results ; Surveys and Questionnaires
    Language English
    Publishing date 2019-09-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 226146-7
    ISSN 1545-2301 ; 0731-7115
    ISSN (online) 1545-2301
    ISSN 0731-7115
    DOI 10.1080/07317115.2019.1673525
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    Zs.B 2772: Show issues Location:
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  8. Book: La gestion et l'usage de l'eau en agriculture ; mandature 2010 - 2015 ; séance du 23 avril 2013 ; avis du Conseil Économique, Social et Environnemental

    Denier-Pasquier, Florence

    (Journal officiel de la République Française ; Les avis du Conseil Economique, Social et Environnemental ; 2013,11 ; Les éditions des journaux officiels ; 41113,11)

    2013  

    Institution Frankreich / Section de l'Agriculture, de la Pêche et de l'Alimentation
    Author's details présenté par Florence Denier-Pasquier, rapporteure au nom de la Section de l'Agriculture, de la Pêche et de l'Alimentation
    Series title Journal officiel de la République Française
    Les avis du Conseil Economique, Social et Environnemental ; 2013,11
    Les éditions des journaux officiels ; 41113,11
    Keywords Wasserpolitik ; Bewässerung ; Agrarpolitik ; Frankreich
    Language French
    Size 81 S.
    Publisher Conseil Economique, Social et Environnemental
    Publishing place Paris
    Document type Book
    ISBN 9782111209152 ; 2111209155
    Database ECONomics Information System

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  9. Article: The Clinical Value of the Faux Pas Test for Diagnosing Behavioral-Variant Frontotemporal Dementia.

    Delbeuck, Xavier / Pollet, Marianne / Pasquier, Florence / Bombois, Stéphanie / Moroni, Christine

    Journal of geriatric psychiatry and neurology

    2020  Volume 35, Issue 1, Page(s) 62–65

    Abstract: Objective: We studied the clinical value of the faux pas test to diagnose behavioral-variant frontotemporal dementia.: Methods: The faux pas test was administered to patients referred to a memory clinic in a context of behavioral disturbances. The ... ...

    Abstract Objective: We studied the clinical value of the faux pas test to diagnose behavioral-variant frontotemporal dementia.
    Methods: The faux pas test was administered to patients referred to a memory clinic in a context of behavioral disturbances. The diagnosis of behavioral-variant frontotemporal dementia (n = 14) or not (n = 25) was confirmed after a 3 years follow-up.
    Results: The faux pas test displayed a high sensitivity for behavioral-variant frontotemporal dementia (.83) however its specificity was only moderate (.64).
    Conclusions: Our results confirm that the FPT capture's specific cognitive impairments in patients with behavioral-variant frontotemporal dementia. However, some patients with psychiatric disease or other neurological diseases may also show impaired scores.
    MeSH term(s) Frontotemporal Dementia/diagnosis ; Humans ; Neuropsychological Tests
    Language English
    Publishing date 2020-10-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1035760-9
    ISSN 0891-9887
    ISSN 0891-9887
    DOI 10.1177/0891988720964253
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  10. Article ; Online: ANTIBIOSTOP, for all?

    Pasquier, Florence / Khalife-Hachem, Sabine / Micol, Jean-Baptiste

    Infectious diseases (London, England)

    2018  Volume 50, Issue 7, Page(s) 550–553

    Language English
    Publishing date 2018
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2839775-7
    ISSN 2374-4243 ; 2374-4235
    ISSN (online) 2374-4243
    ISSN 2374-4235
    DOI 10.1080/23744235.2018.1438650
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