LIVIVO - Search results -

Search results

Result 1 - 10 of total 88

Search options

Article: HRTEM characterization in environmental risk assessment of engineered nanoparticles.

Pasricha, Renu

Journal of biomedical nanotechnology

2011 Volume 7, Issue 1, Page(s) 81–82

Abstract: For the purpose of assessing the risk of nanoparticles or of the products incorporating them, it is important to specify clearly the physical and chemical properties of these nanoparticles or products. High resolution transmission electron microscopy ( ... ...

Abstract	For the purpose of assessing the risk of nanoparticles or of the products incorporating them, it is important to specify clearly the physical and chemical properties of these nanoparticles or products. High resolution transmission electron microscopy (HRTEM) offers the unique ability to observe nanoparticles (or any solid material) directly in real space at or close to the atomic scale, i.e., the scale at which they are ultimately defined. With modern HRTEM instruments, lattice or structure images of very small crystals (crystallites) or very small regions in larger crystals can be obtained with 0.2-0.3 nm (2-3 angstroms) resolution (less than 0.2 nm with dedicated intermediate--or high-voltage HRTEM instruments). No general conclusions applicable to all nanoparticle-based products are possible regarding the risks. Therefore, each product and process involving nanoparticles must be considered separately.
MeSH term(s)	Environmental Pollutants/analysis ; Microscopy, Electron, Transmission/methods ; Nanoparticles/toxicity ; Nanoparticles/ultrastructure ; Particle Size ; Risk Assessment/methods ; Risk Factors ; Structure-Activity Relationship
Chemical Substances	Environmental Pollutants
Language	English
Publishing date	2011-04-09
Publishing country	United States
Document type	Journal Article
ISSN	1550-7033
ISSN	1550-7033
DOI	10.1166/jbn.2011.1212
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Synthesis of Self-Assembled Single Atomic Layer Gold Crystals-Goldene.

Sharma, Sudhir Kumar / Pasricha, Renu / Weston, James / Blanton, Thomas / Jagannathan, Ramesh

ACS applied materials & interfaces

2022 Volume 14, Issue 49, Page(s) 54992–55003

Abstract: We report, for the first time, a technique to synthesize free-standing, one-atom thick 2D gold crystals (namely, goldene) and self-assembled 2D periodic arrays of goldene. High-resolution transmission electron microscopy (HRTEM) imaging of goldene ... ...

Abstract	We report, for the first time, a technique to synthesize free-standing, one-atom thick 2D gold crystals (namely, goldene) and self-assembled 2D periodic arrays of goldene. High-resolution transmission electron microscopy (HRTEM) imaging of goldene revealed herringbone and honeycomb lattices, which are primarily gold surface features due to its reconstruction. Imaging of these surface-only features by a nonsurface characterization technique such as HRTEM is an unequivocal proof of the absence of three-dimensionality in goldene. Atomic force microscopy confirmed 1-2 Å thickness of goldene. High-resolution X-ray photoelectron spectroscopy (HR-XPS), selective area electron diffraction, and energy-dispersive X-ray spectroscopy confirmed the chemical identity of goldene. We discovered the phenomenon of electric field-induced self-assembly of goldene supracrystals with a herringbone structure and developed an electric field printing (e-print) technique for goldene arrays. Goldene showed a semiconductor response with a knee voltage of ∼3.2 V, and
Language	English
Publishing date	2022-12-01
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.2c19743
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Peptide-functionalized graphene oxide quantum dots as colorectal cancer theranostics.

Haider, Mohamed / Cagliani, Roberta / Jagal, Jayalakshmi / Jayakumar, Manju N / Fayed, Bahgat / Shakartalla, Sarra B / Pasricha, Renu / Greish, Khaled / El-Awady, Raafat

Journal of colloid and interface science

2022 Volume 630, Issue Pt A, Page(s) 698–713

Abstract: Colorectal cancer (CRC) accounts for approximately 10% of all new cancer cases worldwide with significant morbidity and mortality. The current imaging techniques are lacking diagnostic precision while traditional chemotherapeutic strategies are limited ... ...

Abstract	Colorectal cancer (CRC) accounts for approximately 10% of all new cancer cases worldwide with significant morbidity and mortality. The current imaging techniques are lacking diagnostic precision while traditional chemotherapeutic strategies are limited by their adverse side effects and poor response in advanced stages. Targeted nanoparticles (NPs) can specifically bind to surface antigens on cancer cells and provide effective delivery of diagnostic and chemotherapeutic agent. Placenta-specific protein 1 (PLAC-1) is overexpressed in CRC and can be used as a target for detection and treatment of the disease. The aim of this work was to develop a targeted nanotheranostic agent for early diagnosis and inhibition of the malignant progression and metastasis of CRC. Graphene oxide quantum dots (QD) were covalently labeled with a peptide (GILGFVFTL) having high affinity to PLAC-1. The covalent coupling between the QD and the peptide was confirmed using a series of physicochemical and morphological characterization techniques. Confocal microscopy was used to evaluate the uptake of QD and QD-P in HCT-29, HT-116 and LS-180 CRC cell lines. Selective targeting of antigen PLAC-1 overexpressed on HT-29 and HCT-116 cells was measured by immunofluorescence. Cell proliferation, cell invasion and extent of PLAC-1 expression in CRC cells after treatment with QD and QD-P were determined. The prepared QD-P showed a significant increase in targeting and specific uptake in cells expressing the antigen PLAC-1 compared to non-functionalized QD. Treatment with QD-P also increased the cell cytotoxicity, reduced the invasiveness of HT-29 and HCT-116 cells by 38% and 62%, respectively, and downregulated the expression of PLAC-1 by 53% and 33%, respectively. These results highlight the potential use of QD-P as a theranostic agent for the detection and treatment of CRC cells expressing the antigen PLAC-1.
MeSH term(s)	Humans ; Quantum Dots/chemistry ; Precision Medicine ; Peptides/chemistry ; Antineoplastic Agents ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/drug therapy
Chemical Substances	graphene oxide ; Peptides ; Antineoplastic Agents
Language	English
Publishing date	2022-10-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2022.10.045
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 71/707: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: pH-Responsive Upconversion Mesoporous Silica Nanospheres for Combined Multimodal Diagnostic Imaging and Targeted Photodynamic and Photothermal Cancer Therapy.

Palanikumar, L / Kalmouni, Mona / Houhou, Tatiana / Abdullah, Osama / Ali, Liaqat / Pasricha, Renu / Straubinger, Rainer / Thomas, Sneha / Afzal, Ahmed Jawaad / Barrera, Francisco N / Magzoub, Mazin

ACS nano

2023 Volume 17, Issue 19, Page(s) 18979–18999

Abstract: Photodynamic therapy (PDT) and photothermal therapy (PTT) have gained considerable attention as potential alternatives to conventional cancer treatments. However, these approaches remain limited by low solubility, poor stability, and inefficient ... ...

Abstract	Photodynamic therapy (PDT) and photothermal therapy (PTT) have gained considerable attention as potential alternatives to conventional cancer treatments. However, these approaches remain limited by low solubility, poor stability, and inefficient targeting of many common photosensitizers (PSs) and photothermal agents (PTAs). To overcome the aforementioned limitations, we engineered biocompatible and biodegradable tumor-targeted upconversion nanospheres with imaging capabilities. The multifunctional nanospheres consist of a sodium yttrium fluoride core doped with lanthanides (ytterbium, erbium, and gadolinium) and the PTA bismuth selenide (NaYF
Language	English
Publishing date	2023-09-13
Publishing country	United States
Document type	Journal Article
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.3c04564
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: pH-responsive upconversion mesoporous silica nanospheres for combined multimodal diagnostic imaging and targeted photodynamic and photothermal cancer therapy.

Palanikumar, L / Kalmouni, Mona / Houhou, Tatiana / Abdullah, Osama / Ali, Liaqat / Pasricha, Renu / Thomas, Sneha / Afzal, Ahmed J / Barrera, Francisco N / Magzoub, Mazin

bioRxiv : the preprint server for biology

2023

Abstract: Photodynamic therapy (PDT) and photothermal therapy (PTT) have garnered considerable interest as non-invasive cancer treatment modalities. However, these approaches remain limited by low solubility, poor stability and inefficient targeting of many common ...

Abstract	Photodynamic therapy (PDT) and photothermal therapy (PTT) have garnered considerable interest as non-invasive cancer treatment modalities. However, these approaches remain limited by low solubility, poor stability and inefficient targeting of many common photosensitizers (PSs) and photothermal agents (PTAs). To overcome these limitations, we have designed biocompatible and biodegradable tumor-targeted upconversion nanospheres with imaging capabilities. The multifunctional nanospheres consist of a sodium yttrium fluoride core doped with lanthanides (ytterbium, erbium and gadolinium) and bismuth selenide (NaYF
Language	English
Publishing date	2023-05-24
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.05.22.541491
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article: Ultrasound-Triggered Liposomes Encapsulating Quantum Dots as Safe Fluorescent Markers for Colorectal Cancer.

Awad, Nahid S / Haider, Mohamed / Paul, Vinod / AlSawaftah, Nour M / Jagal, Jayalakshmi / Pasricha, Renu / Husseini, Ghaleb A

Pharmaceutics

2021 Volume 13, Issue 12

Abstract: Quantum dots (QDs) are a promising tool to detect and monitor tumors. However, their small size allows them to accumulate in large quantities inside the healthy cells (in addition to the tumor cells), which increases their toxicity. In this study, we ... ...

Abstract	Quantum dots (QDs) are a promising tool to detect and monitor tumors. However, their small size allows them to accumulate in large quantities inside the healthy cells (in addition to the tumor cells), which increases their toxicity. In this study, we synthesized stealth liposomes encapsulating hydrophilic graphene quantum dots and triggered their release with ultrasound with the goal of developing a safer and well-controlled modality to deliver fluorescent markers to tumors. Our results confirmed the successful encapsulation of the QDs inside the core of the liposomes and showed no effect on the size or stability of the prepared liposomes. Our results also showed that low-frequency ultrasound is an effective method to release QDs encapsulated inside the liposomes in a spatially and temporally controlled manner to ensure the effective delivery of QDs to tumors while reducing their systemic toxicity.
Language	English
Publishing date	2021-12-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics13122073
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Anti-tuberculosis drugs used in a directly observed treatment short course (DOTS) schedule alter endocrine patterns and reduce the ovarian reserve and oocyte quality in the mouse

Rao, Arpitha / Nayak, Guruprasad / Ananda, Hanumappa / Sandhyā Kumārī / Dutta, Rahul / Kalthur, Sneha Guruprasad / Mutalik, Srinivas / Thomas, Sneha Ann / Pasricha, Renu / Raghu, Shamprasad Varija / Adiga, Satish Kumar / Kalthur, Guruprasad

Reproduction, Fertility and Development. 2022, v. 34, no. 17 p.1059-1077

2022

Abstract: Context: Tuberculosis is one of the major infectious diseases, with people of reproductive age group having a high risk of infection. Aims: The present study was designed to understand the consequences of anti-tuberculosis drugs (ATDs) used in DOTS ( ... ...

Abstract	Context: Tuberculosis is one of the major infectious diseases, with people of reproductive age group having a high risk of infection. Aims: The present study was designed to understand the consequences of anti-tuberculosis drugs (ATDs) used in DOTS (directly observed treatment short course) schedule on ovarian function. Methods: Adult female Swiss albino mice were orally administered with combinations of ATDs used in the DOTS schedule every day for 4weeks. At 2weeks after the cessation of ATDs administration, the endocrine changes and ovarian function were assessed in mice. Key results: Administration of ATDs to mice resulted in a prolonged estrous cycle, reduced ovarian follicle reserve, alteration in FSH, LH, and progesterone level, and decreased the number of ovulated oocytes. Further, the degree of fragmentation, degeneration, abnormal distribution of cytoplasmic organelles, abnormal spindle organisation, and chromosomal misalignment were higher in oocytes that were ovulated following superovulation. Blastocysts derived from ATDs treated mice had significantly lower total cell numbers and greater DNA damage. A marginal increase in the number of resorbed fetuses was observed in all the ATDs treated groups except in the multidrug resistance treatment group. Male progeny of ATDs treated mice had decreased sperm count and lower progressive motility, while female progeny exhibited a non-significant reduction in the number of oocytes ovulated. Conclusions: Theresults of this study suggest that ATDs can have significant adverse effects on the ovarian reserve, cytoplasmic organisation of oocytes, and can potentially cause transgenerational changes. Implications: The findings of the present study indicate ovarian toxicity of ATDs and warrant further research in the direction of identifying alternate drugs with minimal toxicity, and strategies to mitigate the ovarian toxicity induced by these drugs.
Keywords	DNA damage ; adults ; albino ; blastocyst ; estrous cycle ; females ; males ; mice ; multiple drug resistance ; oocytes ; organelles ; ovarian follicles ; progeny ; progesterone ; risk ; spermatozoa ; superovulation ; toxicity ; tuberculosis ; anti-tuberculosis drugs ; chromosome misalignment ; directly observed treatment short-course ; fetal resorption ; mitochondrial organisation ; ovarian reserve ; spindle defects
Language	English
Size	p. 1059-1077.
Publishing place	CSIRO Publishing
Document type	Article ; Online
ZDB-ID	1019913-5
ISSN	1448-5990 ; 1031-3613
ISSN (online)	1448-5990
ISSN	1031-3613
DOI	10.1071/RD22108
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 5258: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Positive regulation of oxidative phosphorylation by nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice.

Venit, Tomas / Sapkota, Oscar / Abdrabou, Wael Said / Loganathan, Palanikumar / Pasricha, Renu / Mahmood, Syed Raza / El Said, Nadine Hosny / Sherif, Shimaa / Thomas, Sneha / Abdelrazig, Salah / Amin, Shady / Bedognetti, Davide / Idaghdour, Youssef / Magzoub, Mazin / Percipalle, Piergiorgio

Nature communications

2023 Volume 14, Issue 1, Page(s) 6328

Abstract: Metabolic reprogramming is one of the hallmarks of tumorigenesis. Here, we show that nuclear myosin 1 (NM1) serves as a key regulator of cellular metabolism. NM1 directly affects mitochondrial oxidative phosphorylation (OXPHOS) by regulating ... ...

Abstract	Metabolic reprogramming is one of the hallmarks of tumorigenesis. Here, we show that nuclear myosin 1 (NM1) serves as a key regulator of cellular metabolism. NM1 directly affects mitochondrial oxidative phosphorylation (OXPHOS) by regulating mitochondrial transcription factors TFAM and PGC1α, and its deletion leads to underdeveloped mitochondria inner cristae and mitochondrial redistribution within the cell. These changes are associated with reduced OXPHOS gene expression, decreased mitochondrial DNA copy number, and deregulated mitochondrial dynamics, which lead to metabolic reprogramming of NM1 KO cells from OXPHOS to aerobic glycolysis.This, in turn, is associated with a metabolomic profile typical for cancer cells, namely increased amino acid-, fatty acid-, and sugar metabolism, and increased glucose uptake, lactate production, and intracellular acidity. NM1 KO cells form solid tumors in a mouse model, suggesting that the metabolic switch towards aerobic glycolysis provides a sufficient carcinogenic signal. We suggest that NM1 plays a role as a tumor suppressor and that NM1 depletion may contribute to the Warburg effect at the onset of tumorigenesis.
MeSH term(s)	Mice ; Animals ; Oxidative Phosphorylation ; Glycolysis/physiology ; Cell Line, Tumor ; Carcinogenesis/genetics ; Cell Transformation, Neoplastic/metabolism ; Myosins/metabolism
Chemical Substances	Myosins (EC 3.6.4.1)
Language	English
Publishing date	2023-10-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-42093-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Light-driven self-assembly of spiropyran-functionalized covalent organic framework.

Das, Gobinda / Prakasam, Thirumurugan / Alkhatib, Nour / AbdulHalim, Rasha G / Chandra, Falguni / Sharma, Sudhir Kumar / Garai, Bikash / Varghese, Sabu / Addicoat, Matthew A / Ravaux, Florent / Pasricha, Renu / Jagannathan, Ramesh / Saleh, Na'il / Kirmizialtin, Serdal / Olson, Mark A / Trabolsi, Ali

Nature communications

2023 Volume 14, Issue 1, Page(s) 3765

Abstract: Controlling the number of molecular switches and their relative positioning within porous materials is critical to their functionality and properties. The proximity of many molecular switches to one another can hinder or completely suppress their ... ...

Abstract	Controlling the number of molecular switches and their relative positioning within porous materials is critical to their functionality and properties. The proximity of many molecular switches to one another can hinder or completely suppress their response. Herein, a synthetic strategy involving mixed linkers is used to control the distribution of spiropyran-functionalized linkers in a covalent organic framework (COF). The COF contains a spiropyran in each pore which exhibits excellent reversible photoswitching behavior to its merocyanine form in the solid state in response to UV/Vis light. The spiro-COF possesses an urchin-shaped morphology and exhibits a morphological transition to 2D nanosheets and vesicles in solution upon UV light irradiation. The merocyanine-equipped COFs are extremely stable and possess a more ordered structure with enhanced photoluminescence. This approach to modulating structural isomerization in the solid state is used to develop inkless printing media, while the photomediated polarity change is used for water harvesting applications.
MeSH term(s)	Humans ; Metal-Organic Frameworks ; Cockayne Syndrome ; Nitro Compounds ; Porosity
Chemical Substances	spiropyran ; Metal-Organic Frameworks ; Nitro Compounds
Language	English
Publishing date	2023-06-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-39402-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Author Correction: Positive regulation of oxidative phosphorylation by nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice.

Nature communications

2023 Volume 14, Issue 1, Page(s) 7878

Language	English
Publishing date	2023-11-30
Publishing country	England
Document type	Published Erratum
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-43936-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito