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  1. Article ; Online: COVID-19 imported cases and severity: expected information from genomic characterization of SARS-CoV-2 strains in Mozambique.

    Sumbana, José / Passanduca, Alfeu / Rubino, Salvatore

    Journal of infection in developing countries

    2021  Volume 15, Issue 12, Page(s) 1792–1800

    Abstract: Introduction: The novel coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), etiological agent of coronavirus disease 2019 (COVID-19) was first reported in China in December 2019 and spread worldwide. As of March 6th, 2021, there ... ...

    Abstract Introduction: The novel coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), etiological agent of coronavirus disease 2019 (COVID-19) was first reported in China in December 2019 and spread worldwide. As of March 6th, 2021, there have been 116,670,105 million confirmed cases globally including 2,592,085 deaths. COVID-19 cases have been reported in 219 countries and territories, creating global panic. Mozambique has witnessed the evolution of COVID-19 epidemic associated with the weakness of health system, mostly in terms of laboratory diagnosis capacity, concerns on compliance to effective public health measures including physical distancing, use of masks in crowded indoor areas, hand hygiene, isolation and quarantine of people.
    Methodology: The data included in this study were collected from published articles regarding COVID-19 imported cases and severity in Africa, especially in Mozambique. Additionally, official documents of COVID-19 epidemiology from Minister of Health and National Institute of Health of Mozambique from 22nd of March 2020 to 1st of August 2020 were included.
    Results: The SARS-CoV-2 strains imported mainly from South Africa and European countries might have been playing an important role on COVID-19 epidemic evolution in Mozambique.
    Conclusions: These circulating strains in the country, might be similar enough to the strains found in other countries, yet the genomic characterization is needed particularly during the phase of borders reopening through understanding the source of infections and guiding the implementation of containment and mitigation measures in the country.
    MeSH term(s) Africa/epidemiology ; COVID-19/epidemiology ; Communicable Diseases, Imported/epidemiology ; Female ; Global Health ; Humans ; Male ; Mozambique/epidemiology ; Pandemics ; Patient Acuity ; SARS-CoV-2
    Language English
    Publishing date 2021-12-31
    Publishing country Italy
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2394024-4
    ISSN 1972-2680 ; 2036-6590
    ISSN (online) 1972-2680
    ISSN 2036-6590
    DOI 10.3855/jidc.14316
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Prevalence of sexually transmitted infections (STIs), associations with sociodemographic and behavioural factors, and assessment of the syndromic management of vaginal discharge in women with urogenital complaints in Mozambique.

    Manjate, Alice / Sergon, Gladys / Kenga, Darlenne / Golparian, Daniel / Tyulenev, Yuriy / Loquilha, Osvaldo / Mausse, Fabião / Guschin, Alexander / Langa, José Carlos / Passanduca, Alfeu / Sacarlal, Jahit / Unemo, Magnus

    Frontiers in reproductive health

    2024  Volume 6, Page(s) 1323926

    Abstract: In Mozambique, sexually transmitted infections (STIs) are estimated to be prevalent, but diagnosis and treatment of curable STIs rely only on syndromic management. We examined the prevalence of four non-viral STIs and HIV-1/2, based on etiological ... ...

    Abstract In Mozambique, sexually transmitted infections (STIs) are estimated to be prevalent, but diagnosis and treatment of curable STIs rely only on syndromic management. We examined the prevalence of four non-viral STIs and HIV-1/2, based on etiological diagnosis, associations with sociodemographic and behavioural factors, and the STI diagnostic accuracy of the vaginal discharge syndromic management in women with urogenital complaints in Maputo, Mozambique. A cross-sectional study was performed in Maputo, Mozambique, February 2018-January 2019, enrolling 924 women of reproductive age with urogenital complaints. Endocervical/vaginal swabs were sampled and chlamydia, gonorrhoea, trichomoniasis and
    Language English
    Publishing date 2024-04-18
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-3153
    ISSN (online) 2673-3153
    DOI 10.3389/frph.2024.1323926
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  3. Article ; Online: Brief Report: Suboptimal Lopinavir Exposure in Infants on Rifampicin Treatment Receiving Double-dosed or Semisuperboosted Lopinavir/Ritonavir: Time for a Change.

    Jacobs, Tom G / Mumbiro, Vivian / Chitsamatanga, Moses / Namuziya, Natasha / Passanduca, Alfeu / Domínguez-Rodríguez, Sara / Tagarro, Alfredo / Nathoo, Kusum J / Nduna, Bwendo / Ballesteros, Alvaro / Madrid, Lola / Mujuru, Hilda A / Chabala, Chishala / Buck, W Chris / Rojo, Pablo / Burger, David M / Moraleda, Cinta / Colbers, Angela

    Journal of acquired immune deficiency syndromes (1999)

    2023  Volume 93, Issue 1, Page(s) 42–46

    Abstract: Background: Although super-boosted lopinavir/ritonavir (LPV/r; ratio 4:4 instead of 4:1) is recommended for infants living with HIV and receiving concomitant rifampicin, in clinical practice, many different LPV/r dosing strategies are applied due to ... ...

    Abstract Background: Although super-boosted lopinavir/ritonavir (LPV/r; ratio 4:4 instead of 4:1) is recommended for infants living with HIV and receiving concomitant rifampicin, in clinical practice, many different LPV/r dosing strategies are applied due to poor availability of pediatric separate ritonavir formulations needed to superboost. We evaluated LPV pharmacokinetics in infants with HIV receiving LPV/r dosed according to local guidelines in various sub-Saharan African countries with or without rifampicin-based tuberculosis (TB) treatment.
    Methods: This was a 2-arm pharmacokinetic substudy nested within the EMPIRICAL trial (#NCT03915366). Infants aged 1-12 months recruited into the main study were administered LPV/r according to local guidelines and drug availability either with or without rifampicin-based TB treatment; during rifampicin cotreatment, they received double-dosed (ratio 8:2) or semisuperboosted LPV/r (adding a ritonavir 100 mg crushed tablet to the evening LPV/r dose). Six blood samples were taken over 12 hours after intake of LPV/r.
    Results: In total, 14/16 included infants had evaluable pharmacokinetic curves; 9/14 had rifampicin cotreatment (5 received double-dosed and 4 semisuperboosted LPV/r). The median (IQR) age was 6.4 months (5.4-9.8), weight 6.0 kg (5.2-6.8), and 10/14 were male. Of those receiving rifampicin, 6/9 infants (67%) had LPV Ctrough <1.0 mg/L compared with 1/5 (20%) in the control arm. LPV apparent oral clearance was 3.3-fold higher for infants receiving rifampicin.
    Conclusion: Double-dosed or semisuperboosted LPV/r for infants aged 1-12 months receiving rifampicin resulted in substantial proportions of subtherapeutic LPV levels. There is an urgent need for data on alternative antiretroviral regimens in infants with HIV/TB coinfection, including twice-daily dolutegravir.
    MeSH term(s) Male ; Infant ; Humans ; Child ; Female ; Lopinavir/therapeutic use ; Ritonavir/therapeutic use ; Rifampin/therapeutic use ; HIV Infections/drug therapy ; Anti-HIV Agents/therapeutic use ; HIV Protease Inhibitors/therapeutic use
    Chemical Substances Lopinavir (2494G1JF75) ; Ritonavir (O3J8G9O825) ; Rifampin (VJT6J7R4TR) ; Anti-HIV Agents ; HIV Protease Inhibitors
    Language English
    Publishing date 2023-04-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 645053-2
    ISSN 1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
    ISSN (online) 1944-7884 ; 1077-9450
    ISSN 0897-5965 ; 0894-9255 ; 1525-4135
    DOI 10.1097/QAI.0000000000003168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2442: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Twice-Daily Dosing of Dolutegravir in Infants on Rifampicin Treatment: A Pharmacokinetic Substudy of the EMPIRICAL Trial.

    Jacobs, Tom G / Mumbiro, Vivian / Cassia, Uneisse / Zimba, Kevin / Nalwanga, Damalie / Ballesteros, Alvaro / Domínguez-Rodríguez, Sara / Tagarro, Alfredo / Madrid, Lola / Mutata, Constantine / Chitsamatanga, Moses / Bwakura-Dangarembizi, Mutsa / Passanduca, Alfeu / Buck, W Chris / Nduna, Bwendo / Chabala, Chishala / Najjingo, Elizabeth / Musiime, Victor / Moraleda, Cinta /
    Colbers, Angela / Mujuru, Hilda A / Rojo, Pablo / Burger, David M

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  Volume 78, Issue 3, Page(s) 702–710

    Abstract: Background: We evaluated dolutegravir pharmacokinetics in infants with human immunodeficiency virus (HIV) receiving dolutegravir twice daily (BID) with rifampicin-based tuberculosis (TB) treatment compared with once daily (OD) without rifampicin.: ... ...

    Abstract Background: We evaluated dolutegravir pharmacokinetics in infants with human immunodeficiency virus (HIV) receiving dolutegravir twice daily (BID) with rifampicin-based tuberculosis (TB) treatment compared with once daily (OD) without rifampicin.
    Methods: Infants with HIV aged 1-12 months, weighing ≥3 kg, and receiving dolutegravir BID with rifampicin or OD without rifampicin were eligible. Six blood samples were taken over 12 (BID) or 24 hours (OD). Dolutegravir pharmacokinetic parameters, HIV viral load (VL) data, and adverse events (AEs) were reported.
    Results: Twenty-seven of 30 enrolled infants had evaluable pharmacokinetic curves. The median (interquartile range) age was 7.1 months (6.1-9.9), weight was 6.3 kg (5.6-7.2), 21 (78%) received rifampicin, and 11 (41%) were female. Geometric mean ratios comparing dolutegravir BID with rifampicin versus OD without rifampicin were area under curve (AUC)0-24h 0.91 (95% confidence interval, .59-1.42), Ctrough 0.95 (0.57-1.59), Cmax 0.87 (0.57-1.33). One infant (5%) receiving rifampicin versus none without rifampicin had dolutegravir Ctrough <0.32 mg/L, and none had Ctrough <0.064 mg/L. The dolutegravir metabolic ratio (dolutegravir-glucuronide AUC/dolutegravir AUC) was 2.3-fold higher in combination with rifampicin versus without rifampicin. Five of 82 reported AEs were possibly related to rifampicin or dolutegravir and resolved without treatment discontinuation. Upon TB treatment completion, HIV viral load was <1000 copies/mL in 76% and 100% of infants and undetectable in 35% and 20% of infants with and without rifampicin, respectively.
    Conclusions: Dolutegravir BID in infants receiving rifampicin resulted in adequate dolutegravir exposure, supporting this treatment approach for infants with HIV-TB coinfection.
    MeSH term(s) Female ; Humans ; Infant ; Male ; Heterocyclic Compounds, 3-Ring/pharmacokinetics ; HIV ; HIV Infections ; Oxazines ; Piperazines ; Pyridones ; Rifampin/therapeutic use
    Chemical Substances dolutegravir (DKO1W9H7M1) ; Heterocyclic Compounds, 3-Ring ; Oxazines ; Piperazines ; Pyridones ; Rifampin (VJT6J7R4TR)
    Language English
    Publishing date 2023-10-26
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad656
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1505: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 480: Show issues

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  5. Article ; Online: First-Line Antituberculosis Drug Concentrations in Infants With HIV and a History of Recent Admission With Severe Pneumonia.

    Chabala, Chishala / Jacobs, Tom G / Moraleda, Cinta / Ndaferankhande, John M / Mumbiro, Vivian / Passanduca, Alfeu / Namuziya, Natasha / Nalwanga, Damalie / Musiime, Victor / Ballesteros, Alvaro / Domínguez-Rodríguez, Sara / Chitsamatanga, Moses / Cassia, Uneisse / Nduna, Bwendo / Bramugy, Justina / Sacarlal, Jahit / Madrid, Lola / Nathoo, Kusum J / Colbers, Angela /
    Burger, David M / Mulenga, Veronica / Buck, W Chris / Mujuru, Hilda A / Te Brake, Lindsey H M / Rojo, Pablo / Tagarro, Alfredo / Aarnoutse, Rob E

    Journal of the Pediatric Infectious Diseases Society

    2023  Volume 12, Issue 11, Page(s) 581–585

    Abstract: Optimal antituberculosis therapy is essential for favorable clinical outcomes. Peak plasma concentrations of first-line antituberculosis drugs in infants with living HIV receiving WHO-recommended dosing were low compared with reference values for adults, ...

    Abstract Optimal antituberculosis therapy is essential for favorable clinical outcomes. Peak plasma concentrations of first-line antituberculosis drugs in infants with living HIV receiving WHO-recommended dosing were low compared with reference values for adults, supporting studies on increased doses of first-line TB drugs in infants.
    MeSH term(s) Adult ; Infant ; Humans ; Antitubercular Agents ; HIV Infections/complications ; HIV Infections/drug therapy ; Pneumonia/drug therapy ; Reference Values
    Chemical Substances Antitubercular Agents
    Language English
    Publishing date 2023-10-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2668791-4
    ISSN 2048-7207 ; 2048-7193
    ISSN (online) 2048-7207
    ISSN 2048-7193
    DOI 10.1093/jpids/piad088
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  6. Article ; Online: Plasma levels of CRP, neopterin and IP-10 in HIV-infected individuals with and without pulmonary tuberculosis.

    Ciccacci, Fausto / Floridia, Marco / Bernardini, Roberta / Sidumo, Zita / Mugunhe, Remigio Josè / Andreotti, Mauro / Passanduca, Alfeu / Magid, Noorjehan Abdul / Orlando, Stefano / Mattei, Maurizio / Giuliano, Marina / Mancinelli, Sandro / Marazzi, Maria Cristina / Palombi, Leonardo

    Journal of clinical tuberculosis and other mycobacterial diseases

    2019  Volume 16, Page(s) 100107

    Abstract: Introduction: Tuberculosis (TB) is a major cause of morbidity and death worldwide, and disproportionally affects people with HIV. Many cases still remain undiagnosed, and rapid and effective screening strategies are needed to control the TB epidemics. ... ...

    Abstract Introduction: Tuberculosis (TB) is a major cause of morbidity and death worldwide, and disproportionally affects people with HIV. Many cases still remain undiagnosed, and rapid and effective screening strategies are needed to control the TB epidemics. Immunological biomarkers may contribute.
    Methods: Plasma samples from healthy individuals (n: 12) and from HIV-infected individuals with (n: 21) and without pulmonary TB (n: 122) were tested for C-reactive protein (CRP), neopterin, and interferon-gamma-inducible protein-10 (IP-10). Increased levels of biomarkers and WHO 4-symptom-screening were compared with the presence of pulmonary TB. Survival status at 12 months was recorded. Associations with CD4 count, BMI, haemoglobin, disease severity, and mortality were analysed.
    Results: The plasma levels of the biomarkers were significantly higher in TB-positive (
    Conclusion: This study showed significant associations of the biomarkers analysed with TB infection and mortality, that could have potential clinical relevance. Biomarker levels may be included in operational research on TB screening and diagnosis.
    Language English
    Publishing date 2019-06-05
    Publishing country England
    Document type Journal Article
    ISSN 2405-5794
    ISSN (online) 2405-5794
    DOI 10.1016/j.jctube.2019.100107
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