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  1. Article ; Online: Irregular Rhythm in a Middle-Aged Man Presenting With New-Onset Heart Failure.

    Ali, Hussam / Passarelli, Ilaria / Cappato, Riccardo

    JAMA cardiology

    2024  Volume 9, Issue 1, Page(s) 91–92

    MeSH term(s) Male ; Middle Aged ; Humans ; Heart Failure/diagnosis ; Heart Failure/etiology ; Electrocardiography
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Journal Article
    ISSN 2380-6591
    ISSN (online) 2380-6591
    DOI 10.1001/jamacardio.2023.4249
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The diagnostic process of stable angina: still many doubts since Heberden's first description 250 years ago.

    Raso, Irene / Passarelli, Ilaria / Valenti, Gioacchino / Crimi, Gabriele / de Servi, Stefano

    Journal of cardiovascular medicine (Hagerstown, Md.)

    2018  Volume 19, Issue 2, Page(s) 45–50

    Abstract: Since Heberden's first description, stable angina has represented a challenge for the clinicians. Even the most recent guidelines seem ineffective to correctly identify patients who should be sent to cath labs. Still too many patients who undergo ... ...

    Abstract : Since Heberden's first description, stable angina has represented a challenge for the clinicians. Even the most recent guidelines seem ineffective to correctly identify patients who should be sent to cath labs. Still too many patients who undergo coronary angiography are found not to have significant lesions; moreover, its extensive use as the first diagnostic test leads to revascularizations with uncertain appropriateness and prognostic significance. These considerations underline the importance of noninvasive testing before sending patients to invasive coronary angiography. However, it is still debatable whether it is better to pursue anatomic evaluation of the coronary tree with the use of computed tomography or assessment of myocardial ischemia, a controversy which has not been resolved by recent trials comparing the two diagnostic modalities. A combined approach using both functional and anatomic testing may lead to a more careful risk stratification before invasive coronary angiography. The aim of this article is to discuss the most recent evidence in this field, and its application in clinical practice.
    MeSH term(s) Angina, Stable/diagnostic imaging ; Coronary Angiography ; Coronary Artery Disease/classification ; Coronary Artery Disease/diagnostic imaging ; Exercise Test ; Humans ; Practice Guidelines as Topic ; Risk Assessment ; Tomography, X-Ray Computed
    Language English
    Publishing date 2018-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2223461-5
    ISSN 1558-2035 ; 1558-2027
    ISSN (online) 1558-2035
    ISSN 1558-2027
    DOI 10.2459/JCM.0000000000000610
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5210: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 559: Show issues

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  3. Article ; Online: Para-Hisian Pacing: New Insights of an Old Pacing Maneuver.

    Ali, Hussam / Foresti, Sara / Lupo, Pierpaolo / De Ambroggi, Guido / Mantovani, Riccardo / De Lucia, Carmine / Passarelli, Ilaria / Cappato, Riccardo

    JACC. Clinical electrophysiology

    2019  Volume 5, Issue 11, Page(s) 1233–1252

    Abstract: More than 2 decades ago, para-Hisian pacing was introduced to assess the pattern of retrograde conduction during electrophysiological studies. Although there is no ideal maneuver for every patient and condition, para-Hisian pacing is a valuable and handy ...

    Abstract More than 2 decades ago, para-Hisian pacing was introduced to assess the pattern of retrograde conduction during electrophysiological studies. Although there is no ideal maneuver for every patient and condition, para-Hisian pacing is a valuable and handy strategy to differentiate between retrograde conduction over the atrioventricular node and the accessory pathways. The dynamic behavior of para-Hisian pacing, in a region with unique anatomical features, can produce various activation patterns and intriguing electrophysiological phenomena. Although the demonstration of a retrograde nodal activation pattern during para-Hisian pacing does not rule out the presence of an accessory pathway, evidence of retrograde conduction over an accessory pathway does not prove its active role in the culprit tachycardia. Multipolar His bundle recordings, detailed atrial mapping, and recognition of the truly captured structures and the impact of temporal changes of autonomic tone or pacing rates, are essential keys for accurate interpretation of this maneuver that may ultimately guide judicious catheter ablation of the arrhythmic substrate. This review aims to summarize the practical usefulness and potential pitfalls of the para-Hisian pacing maneuver, focusing on the interpretation of electrocardiograms and intracardiac recordings.
    MeSH term(s) Accessory Atrioventricular Bundle/physiopathology ; Atrioventricular Node/physiopathology ; Bundle of His/physiopathology ; Cardiac Conduction System Disease/diagnosis ; Cardiac Conduction System Disease/surgery ; Cardiac Pacing, Artificial/methods ; Catheter Ablation ; Electrophysiologic Techniques, Cardiac/methods ; Heart Conduction System/physiopathology ; Humans
    Language English
    Publishing date 2019-11-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2846739-5
    ISSN 2405-5018 ; 2405-500X ; 2405-500X
    ISSN (online) 2405-5018 ; 2405-500X
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2019.08.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Nearly fatal ventricular arrhythmia following pacemaker implantation in a young female with complete heart block.

    Ali, Hussam / Lupo, Pierpaolo / Foresti, Sara / De Ambroggi, Guido / Mantovani, Riccardo / De Lucia, Carmine / Passarelli, Ilaria / De Ambroggi, Luigi / Cappato, Riccardo

    Journal of arrhythmia

    2019  Volume 35, Issue 5, Page(s) 766–769

    Abstract: This case concerns a 24-year-old female who developed malignant ventricular tachyarrhythmia a few weeks after pacemaker implantation for complete heart block. Apparently, right ventricular pacing caused significant repolarization abnormalities in both ... ...

    Abstract This case concerns a 24-year-old female who developed malignant ventricular tachyarrhythmia a few weeks after pacemaker implantation for complete heart block. Apparently, right ventricular pacing caused significant repolarization abnormalities in both native and paced rhythms with marked QT prolongation and substantial electrical instability. This case highlights other intriguing phenomena in the puzzle of cardiac repolarization and how pacing therapy may alter this complex process providing arrhythmic substrate in vulnerable subjects. Though such arrhythmic events are clinically rare, vulnerable patients or with suspected myocardial disease that may cause QT prolongation should be carefully followed in the course of pacing therapy.
    Language English
    Publishing date 2019-07-18
    Publishing country Japan
    Document type Case Reports
    ZDB-ID 2696593-8
    ISSN 1883-2148 ; 1880-4276
    ISSN (online) 1883-2148
    ISSN 1880-4276
    DOI 10.1002/joa3.12220
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Impact of SMART Pass filter in patients with ajmaline-induced Brugada syndrome and subcutaneous implantable cardioverter-defibrillator eligibility failure: results from a prospective multicentre study.

    Conte, Giulio / Cattaneo, Fabio / de Asmundis, Carlo / Berne, Paola / Vicentini, Alessandro / Namdar, Mehdi / Scalone, Antonio / Klersy, Catherine / Caputo, Maria Luce / Demarchi, Andrea / Özkartal, Tardu / Salghetti, Francesca / Casu, Gavino / Passarelli, Ilaria / Mameli, Stefano / Shah, Dipen / Burri, Haran / De Ferrari, Gaetano / Brugada, Pedro /
    Auricchio, Angelo

    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

    2021  Volume 24, Issue 5, Page(s) 845–854

    Abstract: Aims: Ajmaline challenge can unmask subcutaneous implantable cardioverter-defibrillator (S-ICD) screening failure in patients with Brugada syndrome (BrS) and non-diagnostic baseline electrocardiogram (ECG). The efficacy of the SMART Pass (SP) filter, a ... ...

    Abstract Aims: Ajmaline challenge can unmask subcutaneous implantable cardioverter-defibrillator (S-ICD) screening failure in patients with Brugada syndrome (BrS) and non-diagnostic baseline electrocardiogram (ECG). The efficacy of the SMART Pass (SP) filter, a high-pass filter designed to reduce cardiac oversensing (while maintaining an appropriate sensing margin), has not yet been assessed in patients with BrS. The aim of this prospective multicentre study was to investigate the effect of the SP filter on dynamic Brugada ECG changes evoked by ajmaline and to assess its value in reducing S-ICD screening failure in patients with drug-induced Brugada ECGs.
    Methods and results: The S-ICD screening with conventional automated screening tool (AST) was performed during ajmaline challenge in subjects with suspected BrS. The S-ICD recordings were obtained before, during and after ajmaline administration and evaluated by the means of a simulation model that emulates the AST behaviour with and without SP filter. A patient was considered suitable for S-ICD if at least one sensing vector was acceptable in all tested postures. A sensing vector was considered acceptable in the presence of QRS amplitude >0.5 mV, QRS/T-wave ratio >3.5, and sense vector score >100. Of the 126 subjects (mean age: 42 ± 14 years, males: 61%, sensing vectors: 6786), 46 (36%) presented with an ajmaline-induced Brugada type 1 ECG. Up to 30% of subjects and 40% of vectors failed the screening during the appearance of Brugada type 1 ECG evoked by ajmaline. The S-ICD screening failure rate was not significantly reduced in patients with Brugada ECGs when SP filter was enabled (30% vs. 24%). Similarly, there was only a trend in reduction of vector-failure rate attributable to the SP filter (from 40% to 36%). The most frequent reason for screening failure was low QRS amplitude or low QRS/T-wave ratio. None of these patients was implanted with an S-ICD.
    Conclusion: Patients who pass the sensing screening during ajmaline can be considered good candidates for S-ICD implantation, while those who fail might be susceptible to sensing issues. Although there was a trend towards reduction of vector sensing failure rate when SP filter was enabled, the reduction in S-ICD screening failure in patients with Brugada ECGs did not reach statistical significance.
    Clinical trial registration: https://clinicaltrials.gov Unique Identifier NCT04504591.
    MeSH term(s) Adult ; Ajmaline/adverse effects ; Arrhythmias, Cardiac ; Brugada Syndrome/diagnosis ; Brugada Syndrome/therapy ; Defibrillators, Implantable ; Electrocardiography/methods ; Humans ; Male ; Middle Aged ; Prospective Studies
    Chemical Substances Ajmaline (1PON08459R)
    Language English
    Publishing date 2021-09-09
    Publishing country England
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1449879-0
    ISSN 1532-2092 ; 1099-5129
    ISSN (online) 1532-2092
    ISSN 1099-5129
    DOI 10.1093/europace/euab230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5434: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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