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  1. Article: Combined Topography-Guided Trans-Epithelial PRK and PTK for Recalcitrant Recurrent Corneal Erosions in Lattice Corneal Dystrophy.

    Pignatelli, Francesco / Passidomo, Fedele / Buonamassa, Rosa / Niro, Alfredo / Addabbo, Giuseppe

    International medical case reports journal

    2023  Volume 16, Page(s) 275–280

    Abstract: Purpose: To report morphologic and functional changes after topography-guided trans-epithelial photorefractive keratectomy (PRK) combined with phototherapeutic keratectomy (PTK) for recalcitrant recurrent corneal erosions in Lattice Corneal Dystrophy ( ... ...

    Abstract Purpose: To report morphologic and functional changes after topography-guided trans-epithelial photorefractive keratectomy (PRK) combined with phototherapeutic keratectomy (PTK) for recalcitrant recurrent corneal erosions in Lattice Corneal Dystrophy (LCD).
    Methods: One case report.
    Results: A 78-year-old man presented us with decreased visual acuity [20/100 in right eye (RE), and 20/400 in left eye (LE)], and redness with foreign body sensation in both eyes. Clinical examination revealed epithelial erosions, and linear stromal opacities involving the center of the cornea in both eyes, supporting the diagnosis of LCD. Several medical approaches including autologous serum, amniotic membrane extract, and nerve growth factor eye drops allowed a temporary improvement in symptoms. A single-step topography-guided trans-epithelial PRK combined with PTK (CIPTA
    Conclusion: Recalcitrant corneal erosions and stromal opacities in LCD may be successfully treated using combined topography-guided trans-epithelial PRK and PTK.
    Language English
    Publishing date 2023-05-10
    Publishing country New Zealand
    Document type Case Reports
    ZDB-ID 2495077-4
    ISSN 1179-142X
    ISSN 1179-142X
    DOI 10.2147/IMCRJ.S403451
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Topical Liposomal Ozonated Oil in Complicated Corneal Disease: A Report on Three Clinical Cases.

    Passidomo, Fedele / Pignatelli, Francesco / Addabbo, Giuseppe / Costagliola, Ciro

    International medical case reports journal

    2021  Volume 14, Page(s) 327–332

    Abstract: Infectious and traumatic corneal diseases require adequate therapy against infection and promote re-epithelialization. The appearance of multidrug-resistant bacterial strains, induced by excessive use of antibiotics in the treatment of infectious ... ...

    Abstract Infectious and traumatic corneal diseases require adequate therapy against infection and promote re-epithelialization. The appearance of multidrug-resistant bacterial strains, induced by excessive use of antibiotics in the treatment of infectious diseases, has urged researchers to study new antimicrobial formulations. Ozonated oils have demonstrated antiseptic (antibacterial, antifungal and antiviral) and reparative properties and can be proposed for the prevention and treatment of acute and chronic local infections, as an alternative to conventional topical antimicrobials. In ocular treatment, ozonated oil can exert tissue repair and anti-inflammatory and bactericidal activity. Moreover, its specific formulation makes it well tolerated and biocompatible with the ocular surface. Herein, we report on three cases of corneal inflammation (dendritic epithelial keratitis, corneal injuries caused by olive leaves, and neurotrophic corneal ulcer), treated with liposomal ozonated oil (Ozodrop
    Language English
    Publishing date 2021-05-14
    Publishing country New Zealand
    Document type Case Reports
    ZDB-ID 2495077-4
    ISSN 1179-142X
    ISSN 1179-142X
    DOI 10.2147/IMCRJ.S311839
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Intravitreal Dexamethasone Implant at the Time of Silicon Oil Removal to Treat Persistent Macular Edema after Rhegmatogenous Retinal Detachment Repair.

    Pignatelli, Francesco / Nacucchi, Annalisa / Niro, Alfredo / Gigliola, Samuele / Passidomo, Fedele / Donghia, Rossella / Addabbo, Giuseppe

    Journal of clinical medicine

    2023  Volume 12, Issue 4

    Abstract: Background: An intravitreal dexamethasone implant (DEX-I) was found to be effective and safe for the treatment of cystoid macular edema (CME) after vitrectomy for rhegmatogenous retinal detachment (RRD) and in silicone oil (SO)-filled eyes. We aimed to ... ...

    Abstract Background: An intravitreal dexamethasone implant (DEX-I) was found to be effective and safe for the treatment of cystoid macular edema (CME) after vitrectomy for rhegmatogenous retinal detachment (RRD) and in silicone oil (SO)-filled eyes. We aimed to investigate the efficacy and safety of DEX-I at the time of SO removal for the treatment of recalcitrant CME after successful RRD repair.
    Methods: A retrospective review of the medical records was performed on 24 consecutive patients (24 eyes) with recalcitrant CME after RRD repair who were treated with a single 0.7-mg DEX-I at the time of SO removal. The main outcome measures were changes in best-corrected visual acuity (BCVA) and central macular thickness (CMT). A regression model was performed to assess the relationship between BCVA and CMT at 6 months and independent variables.
    Results: In all 24 patients, CME occurred after RRD repair and remained despite topical therapy. The mean time of CME onset was 27.4 ± 7.7 days after vitrectomy. The mean time between vitrectomy and DEX-I was 106.8 ± 10.1 days. The mean CMT was significantly decreased from 429.6 ± 59.1 µm at baseline to 294 ± 46.4 µm at month 6 (
    Conclusions: DEX-I at the time of SO removal had an acceptable safety profile and achieved favorable outcomes in eyes affected by recalcitrant CME that occurred after RRD repair. RRD-related macular status is significantly associated with visual acuity after DEX-I.
    Language English
    Publishing date 2023-02-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12041697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Mid-term safety and effectiveness of macular peeling one month after intravitreal dexamethasone implant for tractional diabetic macular edema.

    Pignatelli, Francesco / Niro, Alfredo / Fallico, Matteo / Passidomo, Fedele / Gigliola, Samuele / Nacucchi, Annalisa / Bonfiglio, Vincenza / Reibaldi, Michele / Addabbo, Giuseppe / Avitabile, Teresio

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 5990

    Abstract: Macular peeling combined or followed by intravitreal dexamethasone implant (DEX-i) was recommended as an efficacy approach for tractional diabetic macular edema (tDME). Knowing the synergistic effect of cataract surgery and DEX-i one month earlier in ... ...

    Abstract Macular peeling combined or followed by intravitreal dexamethasone implant (DEX-i) was recommended as an efficacy approach for tractional diabetic macular edema (tDME). Knowing the synergistic effect of cataract surgery and DEX-i one month earlier in eyes with DME, we compared Epiretinal Membrane/Inner Limiting Membrane (ERM/ILM) peeling preceded by DEX-i one month before versus ERM/ILM peeling alone for the treatment of tDME. A retrospective study on patients affected by tDME who underwent ERM/ILM peeling one month after DEX-i (n = 11; Group A) or ERM/ILM peeling alone (n = 10; Group B) was performed. Longitudinal comparison of best-correct visual acuity (BCVA), central retinal thickness (CRT), and intraocular pressure (IOP) between the time of surgery (T
    MeSH term(s) Humans ; Macular Edema/etiology ; Dexamethasone/adverse effects ; Diabetic Retinopathy/complications ; Retrospective Studies ; Retina ; Epiretinal Membrane/drug therapy ; Epiretinal Membrane/surgery ; Epiretinal Membrane/complications ; Vitrectomy/methods ; Treatment Outcome ; Intravitreal Injections ; Diabetes Mellitus/surgery
    Chemical Substances Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2023-04-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-32780-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Polyhexamethylene biguanide hydrochloride (PHMB)-properties and application of an antiseptic agent. A narrative review.

    Niro, Alfredo / Pignatelli, Francesco / Fallico, Matteo / Sborgia, Alessandra / Passidomo, Fedele / Gigliola, Samuele / Nacucchi, Annalisa / Sborgia, Giancarlo / Boscia, Giacomo / Alessio, Giovanni / Boscia, Francesco / Addabbo, Giuseppe / Reibaldi, Michele / Avitabile, Teresio

    European journal of ophthalmology

    2022  , Page(s) 11206721221124684

    Abstract: The prevention and management of ocular surface infections is still one of the great challenges for ophthalmologists. The spread of antimicrobial resistance makes it necessary to use antiseptic substances with a broad antimicrobial spectrum. ... ...

    Abstract The prevention and management of ocular surface infections is still one of the great challenges for ophthalmologists. The spread of antimicrobial resistance makes it necessary to use antiseptic substances with a broad antimicrobial spectrum. Polyhexamethylene biguanide hydrochloride (Polyhexanide, PHMB) is a broad-spectrum antiseptic with excellent tolerance and a low-risk profile. Its physicochemical action on the phospholipid membrane and DNA replication or repair mechanism, prevents or impedes the development of resistant bacterial strains. PHMB revealed its effective against numerous organisms like viruses, Gram-negative and Gram-positive bacteria, and fungi. Polyhexanide is commonly used as preservative in commercially available disinfecting solutions for contact lens care and in ophthalmic formulations at different concentrations ranging from 1 µg/ml to 50 µg/ml. The administration of 0.02% (200 µg/ml) PHMB is often the first-line therapy of Acanthamoeba keratitis. However, to date, only one close-out randomized controlled study tested the efficacy of 0.02% PHMB in Acanthamoeba keratitis and a phase III study is still ongoing. This paper reviews the antiseptic agent PHMB, focusing on biochemical mechanisms, safety profile and applications in ophthalmology.
    Language English
    Publishing date 2022-09-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1089461-5
    ISSN 1724-6016 ; 1120-6721
    ISSN (online) 1724-6016
    ISSN 1120-6721
    DOI 10.1177/11206721221124684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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