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Article ; Online: Targeting the Annexin A1-FPR2/ALX pathway for host-directed therapy in dengue disease.

Costa, Vivian Vasconcelos / Sugimoto, Michelle A / Hubner, Josy / Bonilha, Caio S / Queiroz-Junior, Celso Martins / Gonçalves-Pereira, Marcela Helena / Chen, Jianmin / Gobbetti, Thomas / Libanio Rodrigues, Gisele Olinto / Bambirra, Jordana L / Passos, Ingredy B / Machado Lopes, Carla Elizabeth / Moreira, Thaiane P / Bonjour, Kennedy / Melo, Rossana C N / Oliveira, Milton A P / Andrade, Marcus Vinicius M / Sousa, Lirlândia Pires / Souza, Danielle Gloria /
Santiago, Helton da Costa / Perretti, Mauro / Teixeira, Mauro Martins

eLife

2022  Volume 11

Abstract: Host immune responses contribute to dengue's pathogenesis and severity, yet the possibility that failure in endogenous inflammation resolution pathways could characterise the disease has not been contemplated. The pro-resolving protein Annexin A1 (AnxA1) ...

Abstract Host immune responses contribute to dengue's pathogenesis and severity, yet the possibility that failure in endogenous inflammation resolution pathways could characterise the disease has not been contemplated. The pro-resolving protein Annexin A1 (AnxA1) is known to counterbalance overexuberant inflammation and mast cell (MC) activation. We hypothesised that inadequate AnxA1 engagement underlies the cytokine storm and vascular pathologies associated with dengue disease. Levels of AnxA1 were examined in the plasma of dengue patients and infected mice. Immunocompetent, interferon (alpha and beta) receptor one knockout (KO), AnxA1 KO, and formyl peptide receptor 2 (FPR2) KO mice were infected with
MeSH term(s) Animals ; Annexin A1/metabolism ; Dengue/drug therapy ; Humans ; Inflammation/pathology ; Mice ; Peptides/metabolism ; Receptors, Formyl Peptide/metabolism ; Receptors, Lipoxin/metabolism
Chemical Substances Annexin A1 ; FPR2 protein, human ; Peptides ; Receptors, Formyl Peptide ; Receptors, Lipoxin
Language English
Publishing date 2022-03-16
Publishing country England
Document type Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID 2687154-3
ISSN 2050-084X ; 2050-084X
ISSN (online) 2050-084X
ISSN 2050-084X
DOI 10.7554/eLife.73853
Database MEDical Literature Analysis and Retrieval System OnLINE

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