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  1. Article ; Online: Effects of gender affirming hormone therapy with testosterone on coagulation and hematological parameters in transgender people assigned female at birth: A systematic review and meta-analysis.

    Tienforti, Daniele / Pastori, Daniele / Barbonetti, Arcangelo

    Thrombosis research

    2024  Volume 236, Page(s) 170–178

    Abstract: Background: Hormone replacement therapy is associated with an increased thromboembolic risk. The effects of testosterone (T) on coagulation markers in people assigned female at birth (AFAB) under gender affirming hormone therapy (GAHT) are not well ... ...

    Abstract Background: Hormone replacement therapy is associated with an increased thromboembolic risk. The effects of testosterone (T) on coagulation markers in people assigned female at birth (AFAB) under gender affirming hormone therapy (GAHT) are not well described.
    Methods: Systematic review and meta-analysis on English-language articles retrieved from PubMed, Scopus and Cochrane Library up to April 2023 investigating T therapy in AFAB people. Coagulation parameters included international normalized ratio (INR), fibrinogen, activated partial thromboplastin clotting time (aPTT), plasminogen activator inhibitor-1 (PAI-1); hematological variables included hemoglobin (Hb) and hematocrit (HCT). We also reported the rate of thromboembolic events. Data were combined as mean differences (MD) with a 95 % confidence interval (CI) of pre- vs post-follow-up values, using random-effects models.
    Results: We included 7 studies (6 prospective and 1 retrospective) providing information on 312 subjects (mean age: 23 to 30 years) who underwent GAHT with variable T preparation. T therapy was associated with a significant increase in INR values [MD: 0.02, 95 % confidence interval (CI): 0.01-0.03; p = 0.0001], with negligible heterogeneity (I
    Conclusion: Therapy with T increased blood viscosity in AFAB men. A slight increase in INR values was also found, but the clinical relevance and mechanism(s) of this finding needs to be clarified.
    MeSH term(s) Adult ; Female ; Humans ; Male ; Young Adult ; Fibrinogen/analysis ; Plasminogen Activator Inhibitor 1 ; Prospective Studies ; Retrospective Studies ; Testosterone/adverse effects ; Thromboembolism ; Transgender Persons
    Chemical Substances Fibrinogen (9001-32-5) ; Plasminogen Activator Inhibitor 1 ; Testosterone (3XMK78S47O)
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2024.02.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 863: Show issues Location:
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  2. Article ; Online: Minimizing drug-drug interactions between dabigatran and levetiracetam through clinical management: a case report.

    Menichelli, Danilo / Pastori, Daniele / Pignatelli, Pasquale / Pani, Arianna

    European heart journal. Case reports

    2023  Volume 7, Issue 1, Page(s) ytad006

    Abstract: Background: Direct oral anticoagulants (DOACs) are useful for stroke prevention in atrial fibrillation (AF) patients. However, the concomitant administration of Levetiracetam limited their use in clinical practice, although some authors raise doubts ... ...

    Abstract Background: Direct oral anticoagulants (DOACs) are useful for stroke prevention in atrial fibrillation (AF) patients. However, the concomitant administration of Levetiracetam limited their use in clinical practice, although some authors raise doubts about clinical relevance of the interaction.
    Case summary: We report a case of a 54-year-old male with AF, cirrhosis, and seizures, in which the assessment of Dabigatran plasma concentration was needed due to the concomitant use of Levetiracetam. In this case, no relevant reduction of trough Dabigatran plasma concentration was found. An increased peak serum level of dabigatran may be obtained delaying levetiracetam administration. The patient was then followed in our clinic and during 32 months of follow-up no ischaemic or haemorrhagic events occurred.
    Discussion: The evaluation of DOACs concentration could be helpful to start a tailored therapy in frailty patients.
    Language English
    Publishing date 2023-01-06
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytad006
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  3. Article ; Online: Reply to: The C2HEST and mC2HEST scores to predict the risk of new onset atrial fibrillation after presentation with acute coronary syndrome.

    Biccirè, Flavio Giuseppe / Lip, Gregory Y H / Pastori, Daniele

    International journal of cardiology

    2023  Volume 397, Page(s) 131547

    MeSH term(s) Humans ; Acute Coronary Syndrome/diagnosis ; Acute Coronary Syndrome/epidemiology ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/epidemiology ; Risk Assessment ; Risk Factors
    Language English
    Publishing date 2023-10-21
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2023.131547
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    Zs.A 1673: Show issues Location:
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  4. Article ; Online: Reply to: Prediction scores for new onset atrial fibrillation in patients with acute coronary syndrome undergoing percutaneous coronary intervention: Two sides of the same coin.

    Biccirè, Flavio Giuseppe / Lip, Gregory Y H / Pastori, Daniele

    International journal of cardiology

    2023  Volume 392, Page(s) 131305

    MeSH term(s) Humans ; Acute Coronary Syndrome/diagnosis ; Acute Coronary Syndrome/surgery ; Acute Coronary Syndrome/drug therapy ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/surgery ; Atrial Fibrillation/drug therapy ; Anticoagulants ; Platelet Aggregation Inhibitors ; Percutaneous Coronary Intervention/adverse effects ; Fibrinolytic Agents/therapeutic use
    Chemical Substances Anticoagulants ; Platelet Aggregation Inhibitors ; Fibrinolytic Agents
    Language English
    Publishing date 2023-09-01
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2023.131305
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    Zs.A 1673: Show issues Location:
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  5. Article ; Online: Endotoxemia and Platelets: 2 Players of Intrahepatic Microthrombosis in NAFLD.

    Violi, Francesco / Pastori, Daniele / Pignatelli, Pasquale / Cammisotto, Vittoria

    JACC. Basic to translational science

    2023  Volume 9, Issue 3, Page(s) 404–413

    Abstract: Gut dysbiosis-related intestinal barrier dysfunction with increased translocation of bacterial products such as lipopolysaccharide (LPS) into systemic circulation is emerging as pathogenic factor of nonalcoholic fatty liver disease (NAFLD). Experimental ... ...

    Abstract Gut dysbiosis-related intestinal barrier dysfunction with increased translocation of bacterial products such as lipopolysaccharide (LPS) into systemic circulation is emerging as pathogenic factor of nonalcoholic fatty liver disease (NAFLD). Experimental and clinical studies suggested a potential role of LPS as a trigger eliciting in situ liver inflammation upon interaction with its receptor toll-like receptor 4. Also, LPS has been reported to prime platelets to respond to the common agonists indicating that it behaves as a prothrombotic molecule. Of note, recent studies suggested platelet-related intrahepatic thrombosis triggered by LPS as a mechanism implicated in the process of liver inflammation. This review describes: 1) the impact of gut barrier dysfunction and endotoxemia in the process of NAFLD; 2) the relationship between endotoxemia and platelet activation in NAFLD; 3) clinical evidence for the use of antiplatelet drugs in NAFLD/nonalcoholic steatohepatitis patients; and 4) the potential therapeutic approach to modulate endotoxemia and eventually platelet activation.
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2023.07.003
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  6. Article ; Online: Aging and Antithrombotic Treatment.

    Valeriani, Emanuele / Bartimoccia, Simona / Pignatelli, Pasquale / Pastori, Daniele

    Antioxidants & redox signaling

    2023  

    Abstract: Significance: ...

    Abstract Significance:
    Language English
    Publishing date 2023-10-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1483836-9
    ISSN 1557-7716 ; 1523-0864
    ISSN (online) 1557-7716
    ISSN 1523-0864
    DOI 10.1089/ars.2023.0373
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    Zs.A 5488: Show issues Location:
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  7. Article ; Online: Risk Scores for Death in Patients with Cancer-related Venous Thromboembolism: Still a Long Road Ahead.

    Pastori, Daniele / Agnelli, Giancarlo

    Thrombosis and haemostasis

    2021  Volume 121, Issue 6, Page(s) 700–702

    MeSH term(s) Humans ; Neoplasms/complications ; Neoplasms/epidemiology ; Risk Factors ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/epidemiology
    Language English
    Publishing date 2021-04-22
    Publishing country Germany
    Document type Journal Article ; Comment
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/s-0041-1727244
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    Uh III Zs.192: Show issues Location:
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    Zs.MO 433: Show issues

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  8. Article: Anticoagulation Control and Major Adverse Clinical Events in Patients with Operated Valvular Heart Disease with and without Atrial Fibrillation Receiving Vitamin K Antagonists.

    Zulkifly, Hanis H / Pastori, Daniele / Lane, Deirdre A / Lip, Gregory Y H

    Journal of clinical medicine

    2023  Volume 12, Issue 3

    Abstract: Background: Good quality anticoagulation among patients with operated valvular heart disease is needed to reduce ischaemic and thromboembolic complications. There is limited evidence regarding factors that affect anticoagulation control in patients ... ...

    Abstract Background: Good quality anticoagulation among patients with operated valvular heart disease is needed to reduce ischaemic and thromboembolic complications. There is limited evidence regarding factors that affect anticoagulation control in patients implanted with mechanical or tissue prosthetic valve(s).
    Aim: To examine the quality of and factors that affect anticoagulation control, major adverse clinical events and all-cause death in operated valvular heart disease patients with and without atrial fibrillation who are receiving a vitamin K antagonist.
    Methods: Quality of anticoagulation were retrospectively assessed among 456 operated valvular heart disease patients [164 (36%) with AF and 290 (64%) without AF] via time in therapeutic range (TTR) (Rosendaal method) and percentage of INRs in range (PINRR) over a median of 6.2 (3.3-8.5) years. VHD was defined by the presence of a mechanical or tissue prosthetic valve at the mitral, aortic, or both sites.
    Results: Mean age 51 (14.7), 64.5% men. Most (96.1%) had a mechanical prosthesis and 64% had aortic valve replacement. Overall, mean TTR was 58.5% (14.6) and PINRR was 50.1% (13.8). Operated valvular heart disease patients with AF had significantly lower mean TTR and PINRR (TTR: 55.7% (14.2) vs. 60.1% (14.6);
    Conclusions: Operated valvular heart disease patients with AF at baseline have poorer anticoagulation control compared to those without AF. The presence of concomitant AF, anaemia/bleeding history and female sex independently predicted poor TTR. Stringent INR monitoring is needed to improve anticoagulation control and prevent major adverse clinical events in patients with operated valvular heart disease.
    Language English
    Publishing date 2023-02-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12031141
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  9. Article ; Online: Gut barrier dysfunction and endotoxemia in heart failure: A dangerous connubium?

    Violi, Francesco / Castellani, Valentina / Menichelli, Danilo / Pignatelli, Pasquale / Pastori, Daniele

    American heart journal

    2023  Volume 264, Page(s) 40–48

    Abstract: Heart failure (HF) is a leading cause of death worldwide despite recent advances in pharmacological treatments. Gut microbiota dysbiosis and gut barrier dysfunction with consequent bacterial translocation and increased blood endotoxemia has gained much ... ...

    Abstract Heart failure (HF) is a leading cause of death worldwide despite recent advances in pharmacological treatments. Gut microbiota dysbiosis and gut barrier dysfunction with consequent bacterial translocation and increased blood endotoxemia has gained much attention as one of the key pathogenetic mechanisms contributing to increased mortality of patients at risk or with cardiovascular disease. Indeed, increased blood levels of lipopolysaccharide (LPS), a glycolipid of outer membrane of gut gram-negative bacteria, have been detected in patients with diabetes, obesity and nonalcoholic fatty liver disease or in patients with established coronary disease such as myocardial infarction or atrial fibrillation, suggesting endotoxemia as aggravating factor via systemic inflammation and eventually vascular damage. Upon interaction with its receptor Toll-like receptor 4 (TLR4) LPS may, in fact, act at different cellular levels so eliciting formation of proinflammatory cytokines or exerting a procoagulant activity. Increasing body of evidence pointed to endotoxemia as factor potentially deteriorating the clinical course of patients with HF, that, in fact, is associated with gut dysbiosis-derived changes of gut barrier functionality and eventually bacteria or bacterial product translocation into systemic circulation. The aim of this review is to summarize current experimental and clinical evidence on the mechanisms linking gut dysbiosis-related endotoxemia with HF, its potential negative impact with HF progression, and the therapeutic strategies that can counteract endotoxemia.
    MeSH term(s) Humans ; Endotoxemia/complications ; Endotoxemia/microbiology ; Lipopolysaccharides/therapeutic use ; Dysbiosis/complications ; Obesity/complications ; Heart Failure/complications
    Chemical Substances Lipopolysaccharides
    Language English
    Publishing date 2023-06-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80026-0
    ISSN 1097-6744 ; 0002-8703
    ISSN (online) 1097-6744
    ISSN 0002-8703
    DOI 10.1016/j.ahj.2023.06.002
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  10. Article ; Online: From the Dining Room to the Atrium: Can We Modulate Atrial Fibrillation Risk With Micronutrients?

    Carnevale, Roberto / Biondi-Zoccai, Giuseppe / Giordano, Arturo / Pastori, Daniele

    Journal of cardiovascular pharmacology

    2022  Volume 80, Issue 2, Page(s) 197–199

    MeSH term(s) Atrial Fibrillation/diagnosis ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/epidemiology ; Catheter Ablation ; Heart Atria ; Humans ; Micronutrients
    Chemical Substances Micronutrients
    Language English
    Publishing date 2022-08-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 391970-5
    ISSN 1533-4023 ; 0160-2446
    ISSN (online) 1533-4023
    ISSN 0160-2446
    DOI 10.1097/FJC.0000000000001306
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    Zs.A 1471: Show issues Location:
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