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  1. Artikel ; Online: A comprehensive review on the pharmacological role of gut microbiome in neurodegenerative disorders: potential therapeutic targets.

    Aziz, Namra / Wal, Pranay / Patel, Aman / Prajapati, Harshit

    Naunyn-Schmiedeberg's archives of pharmacology

    2024  

    Abstract: Neurological disorders, including Alzheimer and Parkinson's, pose significant challenges to public health due to their complex etiologies and limited treatment options. Recent advances in research have highlighted the intricate bidirectional ... ...

    Abstract Neurological disorders, including Alzheimer and Parkinson's, pose significant challenges to public health due to their complex etiologies and limited treatment options. Recent advances in research have highlighted the intricate bidirectional communication between the gut microbiome and the central nervous system (CNS), revealing a potential therapeutic avenue for neurological disorders. Thus, this review aims to summarize the current understanding of the pharmacological role of gut microbiome in neurological disorders. Mounting evidence suggests that the gut microbiome plays a crucial role in modulating CNS function through various mechanisms, including the production of neurotransmitters, neuroactive metabolites, and immune system modulation. Dysbiosis, characterized by alterations in gut microbial composition and function, has been observed in many neurological disorders, indicating a potential causative or contributory role. Pharmacological interventions targeting the gut microbiome have emerged as promising therapeutic strategies for neurological disorders. Probiotics, prebiotics, antibiotics, and microbial metabolite-based interventions have shown beneficial effects in animal models and some human studies. These interventions aim to restore microbial homeostasis, enhance microbial diversity, and promote the production of beneficial metabolites. However, several challenges remain, including the need for standardized protocols, identification of specific microbial signatures associated with different neurological disorders, and understanding the precise mechanisms underlying gut-brain communication. Further research is necessary to unravel the intricate interactions between the gut microbiome and the CNS and to develop targeted pharmacological interventions for neurological disorders.
    Sprache Englisch
    Erscheinungsdatum 2024-05-11
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Review
    ZDB-ID 121471-8
    ISSN 1432-1912 ; 0028-1298
    ISSN (online) 1432-1912
    ISSN 0028-1298
    DOI 10.1007/s00210-024-03109-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Factors Associated with Research Productivity and National Institutes of Health Funding in Academic Otology.

    Revercomb, Lucy / Patel, Aman M / Tripathi, Om B / Filimonov, Andrey

    The Laryngoscope

    2024  

    Abstract: Objectives: Bibliometrics, such as the Hirsch index (h-index) and the more recently developed relative citation ratio (RCR), are utilized to evaluate research productivity. Our study evaluates demographics, research productivity, and National Institutes ...

    Abstract Objectives: Bibliometrics, such as the Hirsch index (h-index) and the more recently developed relative citation ratio (RCR), are utilized to evaluate research productivity. Our study evaluates demographics, research productivity, and National Institutes of Health (NIH) funding in academic otology.
    Methods: Academic otologists were identified, and their demographics were collected using institutional faculty profiles (N = 265). Funding data were obtained using the NIH Research Portfolio Online Reporting Tools Expenditures and Reports Database. The h-index was calculated using Scopus and mean (m-RCR) and weighted RCR (w-RCR) were calculated using the NIH iCite tool.
    Results: H-index (aOR 1.18, 95% CI 1.10-1.27, p < 0.001), but not m-RCR (aOR 1.50, 95% CI 0.97-2.31, p = 0.069) or w-RCR (aOR 1.00, 95% CI 0.99-1.00, p = 0.231), was associated with receiving NIH funding. Men had greater h-index (16 vs. 9, p < 0.001) and w-RCR (51.8 vs. 23.0, p < 0.001), but not m-RCR (1.3 vs. 1.3, p = 0.269) than women. Higher academic rank was associated with greater h-index and w-RCR (p < 0.001). Among assistant professors, men had greater h-index than women (9.0 vs. 8.0, p = 0.025). At career duration 11-20 years, men had greater h-index (14.0 vs. 8.0, p = 0.009) and w-RCR (52.7 vs. 25.8, p = 0.022) than women.
    Conclusion: The h-index has a strong relationship with NIH funding in academic otology. Similar h-index, m-RCR, and w-RCR between men and women across most academic ranks and career durations suggests production of similarly impactful research. The m-RCR may correct some deficiencies of time-dependent bibliometrics and its consideration in academic promotion and research funding allocation may promote representation of women in otology.
    Level of evidence: N/A Laryngoscope, 2024.
    Sprache Englisch
    Erscheinungsdatum 2024-03-26
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.31408
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  3. Artikel ; Online: Neurovascular Interventions for Neurotrauma: From Treatment of Injured Vessels to Treatment of the Injured Brain?

    Doron, Omer / Patel, Aman B / Hawryluk, Gregory W J

    Operative neurosurgery (Hagerstown, Md.)

    2023  Band 26, Heft 3, Seite(n) 247–255

    Abstract: Traumatic brain injury is often associated with a direct or secondary neurovascular pathology. In this review, we present recent advancements in endovascular neurosurgery that enable accurate and effective vessel reconstruction with emphasis on its role ... ...

    Abstract Traumatic brain injury is often associated with a direct or secondary neurovascular pathology. In this review, we present recent advancements in endovascular neurosurgery that enable accurate and effective vessel reconstruction with emphasis on its role in early diagnosis, the expanding use of flow diversion in pseudoaneurysms, and traumatic arteriovenous fistulas. In addition, future directions in which catheter-based interventions could potentially affect traumatic brain injury are described: targeting blood brain barrier integrity using the advantages of intra-arterial drug delivery of blood brain barrier stabilizers to prevent secondary brain edema, exploring the impact of endovascular venous access as a means to modulate venous outflow in an attempt to reduce intracranial pressure and augment brain perfusion, applying selective intra-arterial hypothermia as a neuroprotection method mitigating some of the risks conferred by systemic cooling, trans-vessel wall delivery of regenerative therapy agents, and shifting attention using multimodal neuromonitoring to post-traumatic vasospasm to further characterize the role it plays in secondary brain injury. Thus, we believe that the potential of endovascular tools can be expanded because they enable access to the "highways" governing perfusion and flow and call for further research focused on exploring these routes because it may contribute to novel endovascular approaches currently used for treating injured vessels, harnessing them for treatment of the injured brain.
    Mesh-Begriff(e) Humans ; Brain/pathology ; Brain Injuries, Traumatic ; Brain Edema/pathology ; Brain Neoplasms/pathology
    Sprache Englisch
    Erscheinungsdatum 2023-11-17
    Erscheinungsland United States
    Dokumenttyp Review ; Journal Article
    ZDB-ID 2767575-0
    ISSN 2332-4260 ; 2332-4252
    ISSN (online) 2332-4260
    ISSN 2332-4252
    DOI 10.1227/ons.0000000000000980
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  4. Artikel ; Online: Covered stent delivery in tortuous internal carotid artery for treatment of direct carotid cavernous fistula.

    Gorjian, Mehrnoush / Raymond, Scott / Koch, Matthew / Patel, Aman

    Neurocirugia (English Edition)

    2023  Band 34, Heft 2, Seite(n) 97–100

    Abstract: Direct carotid cavernous fistulas (dCCF) are high-flow shunts between the internal carotid artery (ICA) and cavernous sinus and are commonly caused by traumatic injuries. Endovascular intervention using detachable coils, with or without stenting, is ... ...

    Abstract Direct carotid cavernous fistulas (dCCF) are high-flow shunts between the internal carotid artery (ICA) and cavernous sinus and are commonly caused by traumatic injuries. Endovascular intervention using detachable coils, with or without stenting, is often the treatment of choice; however, migration or compaction of the coils can occur due to high-flow nature of dCCFs. Alternatively, deployment of a covered stent in ICA can be considered for treatment of dCCFs. We report a case of dCCF with tortuous intracranial ICA successfully treated by placement of a covered stent graft and we will illustrate the technical aspects of the procedure. In the presence of a tortuous ICA navigation and deployment of covered stents is technically complicated and requires modified maneuvers.
    Mesh-Begriff(e) Humans ; Carotid-Cavernous Sinus Fistula ; Carotid Artery, Internal ; Stents
    Sprache Englisch
    Erscheinungsdatum 2023-02-10
    Erscheinungsland Spain
    Dokumenttyp Case Reports
    ISSN 2529-8496
    ISSN (online) 2529-8496
    DOI 10.1016/j.neucie.2022.11.002
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  5. Artikel: Extranodal extension in laryngeal squamous cell carcinoma.

    Patel, Aman M / Vedula, Sudeepti / Shaari, Ariana L / Choudhry, Hannaan S / Filimonov, Andrey

    Laryngoscope investigative otolaryngology

    2024  Band 9, Heft 2, Seite(n) e1232

    Abstract: Objective: Although large retrospective database studies have associated extranodal extension (ENE) with worse survival in several head and neck cancers, the prognostic significance of ENE in laryngeal squamous cell carcinoma (LSCC) remains unclear. Our ...

    Abstract Objective: Although large retrospective database studies have associated extranodal extension (ENE) with worse survival in several head and neck cancers, the prognostic significance of ENE in laryngeal squamous cell carcinoma (LSCC) remains unclear. Our study examines ENE and overall survival (OS) in LSCC.
    Methods: The 2006-2017 National Cancer Database was queried for patients with LSCC undergoing surgical resection and neck dissection, with or without adjuvant therapy. Kaplan-Meier and multivariable Cox regression survival analyses were implemented to identify the independent impacts of pathologic nodal (pN) classification and ENE on OS.
    Results: Of 4208 patients satisfying inclusion criteria, 2343 (55.7%) were pN0/ENE-negative, 1059 (25.2%) were pN1-2/ENE-negative, and 806 (19.2%) were pN1-2/ENE-positive. The 5-year OS of pN0/ENE-negative, pN1-2/ENE-negative, and pN1-2/ENE-positive patients was 62.8%, 56.7%, and 32.9%, respectively (
    Conclusion: ENE-positivity has prognostic significance in LSCC and is associated with worse OS than ENE-negativity. pN classification did not have prognostic significance independent of ENE. ENE should be carefully considered when determining the prognosis of LSCC and selecting adjuvant therapy.
    Level of evidence: 4.
    Sprache Englisch
    Erscheinungsdatum 2024-03-25
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2378-8038
    ISSN 2378-8038
    DOI 10.1002/lio2.1232
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  6. Artikel ; Online: Penultimate proof for posterior occlusions: a commentary on "Focused update to guidelines for endovascular therapy for emergent large vessel occlusion: basilar artery occlusion patients".

    Ahmed, Rashid A / Hirsch, Joshua A / Leslie-Mazwi, Thabele M / Patel, Aman B / Regenhardt, Robert W

    Journal of neurointerventional surgery

    2024  

    Sprache Englisch
    Erscheinungsdatum 2024-05-10
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2514982-9
    ISSN 1759-8486 ; 1759-8478
    ISSN (online) 1759-8486
    ISSN 1759-8478
    DOI 10.1136/jnis-2024-021870
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  7. Artikel ; Online: Patterns and Trends in Adjuvant Therapy for Major Salivary Gland Cancer.

    Patel, Aman M / Haleem, Afash / Choudhry, Hassaam S / Povolotskiy, Roman / Roden, Dylan F

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

    2024  

    Abstract: Objective: To investigate adjuvant therapy indications, utilization, and associated survival disparities in major salivary gland cancer (MSGC).: Study design: Retrospective cohort study.: Setting: The 2006 to 2017 National Cancer Database.: ... ...

    Abstract Objective: To investigate adjuvant therapy indications, utilization, and associated survival disparities in major salivary gland cancer (MSGC).
    Study design: Retrospective cohort study.
    Setting: The 2006 to 2017 National Cancer Database.
    Methods: Patients with surgically resected MSGC were included (N = 11,398). pT3-4 classification, pN2-3 classification, lymphovascular invasion, pathologic extranodal extension (pENE), and positive surgical margin (PSM) were considered indications for adjuvant radiotherapy (aRT). pENE and PSM were considered possible indications for adjuvant chemotherapy. Multivariable logistic and Cox regression models were implemented.
    Results: Among 6694 patients with
    Conclusion: Missed aRT in MSGC occurs frequently and portends poorer OS. Further studies clarifying indications for aCRT are required.
    Sprache Englisch
    Erscheinungsdatum 2024-03-14
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0161-6439 ; 0194-5998
    ISSN (online) 1097-6817
    ISSN 0161-6439 ; 0194-5998
    DOI 10.1002/ohn.715
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  8. Artikel: Cardiovascular Complications are Common in Patients with Juvenile Dermatomyositis in a Cross-Sectional Analysis of the 2016 Kids Inpatient Database.

    Desai, Amar D / Patel, Aman M / Shah, Vraj P / Lipner, Shari R

    Dermatology practical & conceptual

    2023  Band 13, Heft 3

    Sprache Englisch
    Erscheinungsdatum 2023-07-01
    Erscheinungsland Austria
    Dokumenttyp Letter
    ZDB-ID 2685397-8
    ISSN 2160-9381
    ISSN 2160-9381
    DOI 10.5826/dpc.1303a163
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  9. Artikel ; Online: The "pipe-anchor" technique: A method for intra-aneurysmal loop reduction using a partially unsheathed pipeline stent.

    Doron, Omer / Vranic, Justin / Regenhardt, Robert / Stapleton, Christopher / Patel, Aman

    Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences

    2023  , Seite(n) 15910199231169851

    Abstract: Purpose: Large aneurysms often present a challenge for endovascular navigation, as they may require utilization of "around-the-world" technique for distal access. In this study, we describe the use of a pipeline stent to stabilize the microcatheter ... ...

    Abstract Purpose: Large aneurysms often present a challenge for endovascular navigation, as they may require utilization of "around-the-world" technique for distal access. In this study, we describe the use of a pipeline stent to stabilize the microcatheter allowing gradual unsheathing and straightening of the microcatheter within the aneurysm enabling stent deployment.
    Methods: A pipeline stent is partially deployed distal to the aneurysm, after using intra-aneurysmal loop ("around-the-world") to cross the aneurysm. Partially unsheathed, using its radial force and vessel wall friction to establish an anchoring point, the microcatheter is stabilized and pulled with the stent locked to gradually to allow loop reduction and microsystem straightening, allowing unsheathing as the microsystem is aligned with the inflow and outflow vessel.
    Results: Two patients harboring cavernous segment aneurysms (measuring 18 × 12 mm and 21 × 24 mm) were treated by 3.75 × 25 mm and 4.25 × 25 mm pipeline devices, respectively, using this technique, deployed through a Phenom 0.027" microcatheter. Patients did well clinically with no thromboembolic complications, as follow-up imaging demonstrated good wall apposition and appreciable contrast stagnation.
    Conclusion: Anchoring for loop reduction was previously described using a non-flow diverter stents or balloon requiring additional devices and exchange maneuvers to deploy a pipeline. The "pipe anchor" technique describes the use of a partially deployed flow diverter system as an anchor. This report suggests that pipeline radial force, albeit low, is sufficient. We believe that this method is worthy of consideration in select cases as a first choice and can be valuable tool in the armamentarium of the endovascular neurosurgeon.
    Sprache Englisch
    Erscheinungsdatum 2023-04-25
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1354913-3
    ISSN 2385-2011 ; 1591-0199 ; 1123-9344
    ISSN (online) 2385-2011
    ISSN 1591-0199 ; 1123-9344
    DOI 10.1177/15910199231169851
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  10. Artikel ; Online: Performance of ChatGPT in Otolaryngology knowledge assessment.

    Revercomb, Lucy / Patel, Aman M / Choudhry, Hassaam S / Filimonov, Andrey

    American journal of otolaryngology

    2023  Band 45, Heft 1, Seite(n) 104082

    Sprache Englisch
    Erscheinungsdatum 2023-10-14
    Erscheinungsland United States
    Dokumenttyp Letter
    ZDB-ID 604541-8
    ISSN 1532-818X ; 0196-0709
    ISSN (online) 1532-818X
    ISSN 0196-0709
    DOI 10.1016/j.amjoto.2023.104082
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