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  1. Article ; Online: KRAS mutations, autoimmunity and female sex in chronic myelomonocytic leukemia.

    Osman, Afaf E G / Rets, Anton / Patel, Ami B

    Leukemia research

    2024  Volume 138, Page(s) 107466

    MeSH term(s) Female ; Humans ; Autoimmunity/genetics ; DNA-Binding Proteins/genetics ; Leukemia, Myelomonocytic, Chronic/genetics ; Mutation ; Proto-Oncogene Proteins p21(ras)/genetics
    Chemical Substances DNA-Binding Proteins ; KRAS protein, human ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
    Language English
    Publishing date 2024-02-22
    Publishing country England
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 752396-8
    ISSN 1873-5835 ; 0145-2126
    ISSN (online) 1873-5835
    ISSN 0145-2126
    DOI 10.1016/j.leukres.2024.107466
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    Zs.A 1321: Show issues Location:
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  2. Article ; Online: Genetic complexity of chronic myelomonocytic leukemia.

    Patel, Ami B / Deininger, Michael W

    Leukemia & lymphoma

    2020  Volume 62, Issue 5, Page(s) 1031–1045

    Abstract: In recent years CMML has received increased attention as the most commonly observed MDS/MPN overlap syndrome. Renewed interest has occurred in part due to widespread adoption of next-generation sequencing panels that help render the diagnosis in the ... ...

    Abstract In recent years CMML has received increased attention as the most commonly observed MDS/MPN overlap syndrome. Renewed interest has occurred in part due to widespread adoption of next-generation sequencing panels that help render the diagnosis in the absence of morphologic dysplasia. Although most CMML patients exhibit somatic mutations in epigenetic modifiers, spliceosome components, transcription factors and signal transduction genes, it is increasingly clear that a small subset harbors an inherited predisposition to CMML and other myeloid neoplasms. More intriguing is the fact that the mutational spectrum observed in CMML is found in other types of myeloid leukemias, begging the question of how similar genetic backgrounds can lead to such divergent clinical phenotypes. In this review we present a contemporary snapshot of the genetic complexity inherent to CMML, explore the relationship between genotype-phenotype and present a stepwise model of CMML pathogenesis and progression.
    MeSH term(s) Humans ; Leukemia, Myelomonocytic, Chronic/diagnosis ; Leukemia, Myelomonocytic, Chronic/genetics ; Leukemia, Myelomonocytic, Juvenile ; Mutation ; Myelodysplastic-Myeloproliferative Diseases ; Myeloproliferative Disorders
    Language English
    Publishing date 2020-12-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2020.1856837
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  3. Article ; Online: JAK2 R683S Mutation Resulting in Dual Diagnoses of Chronic Eosinophilic Leukemia and Myelodysplastic/Myeloproliferative Overlap Syndrome.

    Krah, Nathan M / Miotke, Laura / Li, Peng / Patel, Jay L / Bowen, Anneli R / Pomicter, Anthony D / Patel, Ami B

    Journal of the National Comprehensive Cancer Network : JNCCN

    2024  Volume 21, Issue 12, Page(s) 1218–1223

    Abstract: A 66-year-old male presented with hypereosinophilia, thrombocytosis, extensive thrombosis refractory to direct oral anticoagulant therapy, and evidence of end-organ damage, including rash, splenic infarcts, and pulmonary infiltrates. Bone marrow biopsy ... ...

    Abstract A 66-year-old male presented with hypereosinophilia, thrombocytosis, extensive thrombosis refractory to direct oral anticoagulant therapy, and evidence of end-organ damage, including rash, splenic infarcts, and pulmonary infiltrates. Bone marrow biopsy revealed myeloid malignancy consistent with both chronic eosinophilic leukemia and myelodysplastic/myeloproliferative neoplasms (MDS/MPN) with SF3B1 mutation and thrombocytosis. Next-generation sequencing of the patient's eosinophils and neutrophil compartments revealed pathologic variants in EZH2 and SF3B1 in addition to a noncanonical JAK2 R683S mutation that has not been previously described in myeloproliferative disorders or other chronic myeloid neoplasms. These mutations were not present in the patient's lymphoid cell fraction, suggesting that the hematopoietic malignancy arose in a myeloid-committed progenitor cell. Based on this case and previous work from our group, we propose that noncanonical JAK2 mutations may permit signal transduction that biases toward eosinophilic differentiation in chronic myeloid neoplasms. Although the patient's blood counts initially responded to ruxolitinib and hydroxyurea, the response was not durable. Early referral for allogenic bone marrow transplant appears necessary to prevent long-term complications and disease progression in myeloid neoplasms with clonal hypereosinophilia driven by noncanonical JAK2 mutations.
    MeSH term(s) Male ; Humans ; Aged ; Diagnosis, Dual (Psychiatry) ; Myelodysplastic Syndromes/genetics ; Leukemia ; Myeloproliferative Disorders/diagnosis ; Myeloproliferative Disorders/genetics ; Myeloproliferative Disorders/therapy ; Thrombocytosis/diagnosis ; Thrombocytosis/genetics ; Thrombocytosis/pathology ; Mutation ; Eosinophilia ; Janus Kinase 2/genetics
    Chemical Substances JAK2 protein, human (EC 2.7.10.2) ; Janus Kinase 2 (EC 2.7.10.2)
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2250759-0
    ISSN 1540-1413 ; 1540-1405
    ISSN (online) 1540-1413
    ISSN 1540-1405
    DOI 10.6004/jnccn.2023.7068
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  4. Article ; Online: Here to stay: rapid nucleic acid tests for group A streptococcus pharyngitis.

    Patel, Ami B / Shulman, Stanford T / Tanz, Robert R

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2021  Volume 27, Issue 12, Page(s) 1718–1720

    MeSH term(s) Humans ; Nucleic Acids ; Pharyngitis/diagnosis ; Streptococcus pyogenes/genetics
    Chemical Substances Nucleic Acids
    Language English
    Publishing date 2021-08-04
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2021.07.037
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    Zs.MO 284: Show issues

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  5. Article: Intestinal Absorption of Lipids Using a Pancreatic Enzyme-Free Nutritional Supplement in Patients with Cystic Fibrosis: A Randomized, Double-Blind, Crossover Pilot Trial

    Barto, Tara L. / Morency, Clarissa F. / Schaap, Nicoline / Patel, Ami B. / Monticello, Daniel J.

    Nutrients. 2022 Feb. 05, v. 14, no. 3

    2022  

    Abstract: Nutritional supplements for patients with exocrine pancreatic insufficiency (EPI) typically utilize pancreatic enzyme replacement therapy (PERT) which is associated with gastrointestinal side effects. We evaluated serum triglyceride levels in patients ... ...

    Abstract Nutritional supplements for patients with exocrine pancreatic insufficiency (EPI) typically utilize pancreatic enzyme replacement therapy (PERT) which is associated with gastrointestinal side effects. We evaluated serum triglyceride levels in patients with cystic fibrosis following consumption of an enzyme-modified oil oral nutritional supplement (EMO-ONS) versus a standard triacylglycerol-based ONS product (TAG-ONS) used concomitantly with PERT and patient tolerability between the two approaches. Ten subjects with CF and EPI taking PERT were enrolled in a single-center, double-blind, cross-over proof of concept trial. Five subjects randomized to Arm 1 were administered a PERT placebo and EMO-ONS and 5 subjects in Arm 2 were administered TAG-ONS+PERT. After 4 to 14 days, subjects received the opposite ONS. Serum triglyceride levels were measured at baseline and hourly for 6 h. Following the above, subjects were randomly assigned to receive 2 daily servings of EMO-ONS+PERT placebo or TAG-ONS+PERT at home for 7-days, self-reporting gastrointestinal symptoms daily. Mean change in peak serum triglyceride levels were similar for both groups (EMO-ONS = 41.9 ± 46.7 mg/dL vs. TAG-ONS+PERT = 46.4 ± 44.1 mg/L; p = 0.85). There was no difference in mean ratio of the serum triglyceride AUC between the two groups (p = 0.58) or self-reported gastrointestinal tolerance. EMO-based products may provide a PERT-free alternative to traditional ONS products in patients with cystic fibrosis.
    Keywords blood serum ; cystic fibrosis ; enzyme replacement therapy ; gastrointestinal system ; intestinal absorption ; oils ; patients ; placebos ; triacylglycerols
    Language English
    Dates of publication 2022-0205
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14030680
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Intestinal Absorption of Lipids Using a Pancreatic Enzyme-Free Nutritional Supplement in Patients with Cystic Fibrosis: A Randomized, Double-Blind, Crossover Pilot Trial.

    Barto, Tara L / Morency, Clarissa F / Schaap, Nicoline / Patel, Ami B / Monticello, Daniel J

    Nutrients

    2022  Volume 14, Issue 3

    Abstract: Nutritional supplements for patients with exocrine pancreatic insufficiency (EPI) typically utilize pancreatic enzyme replacement therapy (PERT) which is associated with gastrointestinal side effects. We evaluated serum triglyceride levels in patients ... ...

    Abstract Nutritional supplements for patients with exocrine pancreatic insufficiency (EPI) typically utilize pancreatic enzyme replacement therapy (PERT) which is associated with gastrointestinal side effects. We evaluated serum triglyceride levels in patients with cystic fibrosis following consumption of an enzyme-modified oil oral nutritional supplement (EMO-ONS) versus a standard triacylglycerol-based ONS product (TAG-ONS) used concomitantly with PERT and patient tolerability between the two approaches. Ten subjects with CF and EPI taking PERT were enrolled in a single-center, double-blind, cross-over proof of concept trial. Five subjects randomized to Arm 1 were administered a PERT placebo and EMO-ONS and 5 subjects in Arm 2 were administered TAG-ONS+PERT. After 4 to 14 days, subjects received the opposite ONS. Serum triglyceride levels were measured at baseline and hourly for 6 h. Following the above, subjects were randomly assigned to receive 2 daily servings of EMO-ONS+PERT placebo or TAG-ONS+PERT at home for 7-days, self-reporting gastrointestinal symptoms daily. Mean change in peak serum triglyceride levels were similar for both groups (EMO-ONS = 41.9 ± 46.7 mg/dL vs. TAG-ONS+PERT = 46.4 ± 44.1 mg/L;
    MeSH term(s) Cystic Fibrosis/complications ; Cystic Fibrosis/drug therapy ; Exocrine Pancreatic Insufficiency/diagnosis ; Humans ; Intestinal Absorption ; Pilot Projects ; Triglycerides/pharmacology
    Chemical Substances Triglycerides
    Language English
    Publishing date 2022-02-05
    Publishing country Switzerland
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14030680
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  7. Article: Lysozyme nephropathy in chronic myelomonocytic leukemia.

    Patel, Ami B / Miles, Rodney R / Deininger, Michael W

    Clinical case reports

    2019  Volume 7, Issue 6, Page(s) 1263–1264

    Abstract: Lysozyme nephropathy is a frequently unrecognized cause of renal disease in chronic myelomonocytic leukemia and may serve as a novel indication for treatment in this patient population. We demonstrate that in newly diagnosed CMML patients, plasma ... ...

    Abstract Lysozyme nephropathy is a frequently unrecognized cause of renal disease in chronic myelomonocytic leukemia and may serve as a novel indication for treatment in this patient population. We demonstrate that in newly diagnosed CMML patients, plasma lysozyme levels are positively correlated with both absolute monocyte count and serum creatinine.
    Language English
    Publishing date 2019-05-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.2188
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  8. Article ; Online: A survey of severe acute respiratory coronavirus virus 2 (SARS-CoV-2)-positive healthcare providers: Household prevention measures and stress early in the pandemic.

    Otero, Sebastian / Mithal, Leena B / Khan, Anum I / Willnow, Antonia S / Patel, Ami B / Arshad, Mehreen

    Antimicrobial stewardship & healthcare epidemiology : ASHE

    2021  Volume 1, Issue 1, Page(s) e57

    Abstract: Measures to prevent coronavirus disease 2019 (COVID-19) spread to household members was assessed by surveying COVID-19-positive physicians and advanced practice providers. Showering and changing were more common than physical distancing. Half of ... ...

    Abstract Measures to prevent coronavirus disease 2019 (COVID-19) spread to household members was assessed by surveying COVID-19-positive physicians and advanced practice providers. Showering and changing were more common than physical distancing. Half of respondents reported a symptomatic household member. Most reported increased stress, worsening of mental health, and concerns about illness and impact on family.
    Language English
    Publishing date 2021-11-26
    Publishing country England
    Document type Journal Article
    ISSN 2732-494X
    ISSN (online) 2732-494X
    DOI 10.1017/ash.2021.221
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  9. Article ; Online: Retapamulin Activity Against Pediatric Strains of Mupirocin-resistant Methicillin-resistant Staphylococcus aureus.

    Patel, Ami B / Lighter, Jennifer / Fulmer, Yi / Copin, Richard / Ratner, Adam J / Shopsin, Bo

    The Pediatric infectious disease journal

    2021  Volume 40, Issue 7, Page(s) 637–638

    Abstract: Retapamulin activity against 53 isolates obtained from a mupirocin-resistant community-acquired methicillin-resistant Staphylococcus aureus pediatric disease cluster was evaluated using broth microdilution. All strains were susceptible to retapamulin ... ...

    Abstract Retapamulin activity against 53 isolates obtained from a mupirocin-resistant community-acquired methicillin-resistant Staphylococcus aureus pediatric disease cluster was evaluated using broth microdilution. All strains were susceptible to retapamulin with minimum inhibitory concentrations ≤ 0.5 μg/mL. DNA sequence analysis of rplC and cfr identified one rplC strain variant that did not demonstrate reduced phenotypic susceptibility to retapamulin. These results demonstrate that retapamulin may be a useful alternative therapy for mupirocin-resistant community-acquired methicillin-resistant S. aureus, especially in disease clusters.
    MeSH term(s) Adolescent ; Anti-Bacterial Agents/pharmacology ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Child ; Child, Preschool ; Community-Acquired Infections/drug therapy ; Community-Acquired Infections/microbiology ; Diterpenes/pharmacology ; Humans ; Infant ; Infant, Newborn ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Methicillin-Resistant Staphylococcus aureus/genetics ; Microbial Sensitivity Tests ; Mupirocin/pharmacology ; Sequence Analysis, DNA ; Staphylococcal Infections/drug therapy
    Chemical Substances Anti-Bacterial Agents ; Bridged Bicyclo Compounds, Heterocyclic ; Diterpenes ; retapamulin (4MG6O8991R) ; Mupirocin (D0GX863OA5)
    Language English
    Publishing date 2021-03-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000003123
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    Zs.A 1852: Show issues Location:
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  10. Article ; Online: Coronavirus disease 2019 vaccine hesitancy among children's hospital staff: A single-center survey.

    Kociolek, Larry K / Elhadary, Jenny / Jhaveri, Ravi / Patel, Ami B / Stahulak, Brian / Cartland, Jenifer

    Infection control and hospital epidemiology

    2021  Volume 42, Issue 6, Page(s) 775–777

    MeSH term(s) Adult ; COVID-19/prevention & control ; COVID-19 Vaccines/therapeutic use ; Chicago ; Female ; Hospitals, Pediatric/statistics & numerical data ; Humans ; Male ; Personnel, Hospital/psychology ; Personnel, Hospital/statistics & numerical data ; Surveys and Questionnaires ; Vaccination Refusal/psychology ; Vaccination Refusal/statistics & numerical data
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2021.58
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