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  1. Article ; Online: Invasive Mechanical Ventilation.

    Szafran, Jennifer C / Patel, Bhakti K

    Critical care clinics

    2024  Volume 40, Issue 2, Page(s) 255–273

    Abstract: Invasive mechanical ventilation allows clinicians to support gas exchange and work of breathing in patients with respiratory failure. However, there is also potential for iatrogenesis. By understanding the benefits and limitations of different modes of ... ...

    Abstract Invasive mechanical ventilation allows clinicians to support gas exchange and work of breathing in patients with respiratory failure. However, there is also potential for iatrogenesis. By understanding the benefits and limitations of different modes of ventilation and goals for gas exchange, clinicians can choose a strategy that provides appropriate support while minimizing harm. The ventilator can also provide crucial diagnostic information in the form of respiratory mechanics. These, and the mechanical ventilation strategy, should be regularly reassessed.
    MeSH term(s) Humans ; Respiration, Artificial ; Respiratory Mechanics
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1006423-0
    ISSN 1557-8232 ; 0749-0704
    ISSN (online) 1557-8232
    ISSN 0749-0704
    DOI 10.1016/j.ccc.2024.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: When Should We Intubate in Hypoxemic Respiratory Failure?

    Yarnell, Christopher J / Patel, Bhakti K

    NEJM evidence

    2023  Volume 2, Issue 3, Page(s) EVIDtt2200305

    Abstract: Intubation during Hypoxemic Respiratory FailureThere is little evidence to guide the common and high-stakes decision to initiate invasive ventilation in hypoxemic respiratory failure. In this Tomorrow's Trial, Yarnell and Patel propose a randomized trial ...

    Abstract Intubation during Hypoxemic Respiratory FailureThere is little evidence to guide the common and high-stakes decision to initiate invasive ventilation in hypoxemic respiratory failure. In this Tomorrow's Trial, Yarnell and Patel propose a randomized trial of different physiological thresholds for the initiation of invasive ventilation.
    MeSH term(s) Humans ; Hypoxia ; Noninvasive Ventilation ; Respiratory Insufficiency ; Intubation ; Respiratory Rate
    Language English
    Publishing date 2023-02-28
    Publishing country United States
    Document type Journal Article
    ISSN 2766-5526
    ISSN (online) 2766-5526
    DOI 10.1056/EVIDtt2200305
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: To Intubate or Not Intubate, That Is the Question.

    Ajmani, Gaurav S / Patel, Bhakti K

    American journal of respiratory and critical care medicine

    2022  Volume 207, Issue 3, Page(s) 233–235

    MeSH term(s) Humans ; Cohort Studies ; Noninvasive Ventilation ; Respiratory Insufficiency ; Intubation, Intratracheal ; Respiration
    Language English
    Publishing date 2022-09-27
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202209-1823ED
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  4. Article ; Online: Helmet noninvasive ventilation in acute hypoxic respiratory failure.

    Buell, Kevin G / Patel, Bhakti K

    Current opinion in critical care

    2022  Volume 29, Issue 1, Page(s) 8–13

    Abstract: Purpose of review: Invasive mechanical ventilation is a lifesaving intervention for patients with severe acute hypoxic respiratory failure (AHRF), but it is associated with neuromuscular, cognitive, and infectious complications. Noninvasive ventilation ( ...

    Abstract Purpose of review: Invasive mechanical ventilation is a lifesaving intervention for patients with severe acute hypoxic respiratory failure (AHRF), but it is associated with neuromuscular, cognitive, and infectious complications. Noninvasive ventilation (NIV) may provide sufficient respiratory support without these complications. The helmet interface for NIV could address concerns raised for the use of NIV as first-line therapy in AHRF. This review will summarize and appraise the current evidence for helmet NIV in AHRF.
    Recent findings: There are only six randomized controlled trials comparing helmet NIV to standard nasal cannula, facemask NIV, or high-flow nasal oxygen in patients with AHRF. Lower rates of endotracheal intubations and fewer days of mechanical ventilation were reported, with inconsistent findings on patient survival. Facemask NIV may worsen preexisting lung injury, delay intubations, and be inferior at delivering lung protective ventilation strategies compared with mechanical ventilation. The helmet interface could circumvent some of these concerns through the delivery of higher positive end expiratory pressure and more uniform distribution of negative pleural pressure.
    Summary: There is limited evidence to support or refute the use of helmet NIV in AHRF. Further studies investigating the interface of helmet in NIV as a separate clinical entity are needed.
    MeSH term(s) Humans ; Noninvasive Ventilation/adverse effects ; Respiration, Artificial/adverse effects ; Respiratory Insufficiency/therapy ; Respiratory Insufficiency/etiology ; Positive-Pressure Respiration/adverse effects ; Oxygen ; Respiratory Distress Syndrome/therapy ; Respiratory Distress Syndrome/complications ; Hypoxia/therapy ; Oxygen Inhalation Therapy/adverse effects
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2022-12-09
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000001008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Helmet trials: resolving the puzzle.

    Arabi, Yaseen M / Patel, Bhakti K / Antonelli, Massimo

    Intensive care medicine

    2023  Volume 49, Issue 4, Page(s) 458–461

    MeSH term(s) Humans ; Head Protective Devices ; Respiratory Insufficiency
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07004-z
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  6. Article ; Online: Web Exclusive. Annals for Hospitalists Inpatient Notes - Corticosteroids and COVID-19-Calming the Storm?

    Pearson, Steven D / Patel, Bhakti K

    Annals of internal medicine

    2021  Volume 174, Issue 1, Page(s) HO2–HO3

    Language English
    Publishing date 2021-01-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M20-7671
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  7. Article ; Online: Helmet noninvasive support in hypoxemic respiratory failure.

    Grieco, Domenico Luca / Patel, Bhakti K / Antonelli, Massimo

    Intensive care medicine

    2022  Volume 48, Issue 8, Page(s) 1072–1075

    MeSH term(s) Head Protective Devices ; Humans ; Hypoxia/therapy ; Noninvasive Ventilation ; Respiratory Insufficiency/therapy
    Language English
    Publishing date 2022-06-17
    Publishing country United States
    Document type Editorial
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-022-06737-7
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  8. Article ; Online: Timing of early mobilization to optimize outcomes in mechanically ventilated ICU patients.

    Schweickert, William D / Patel, Bhakti K / Kress, John P

    Intensive care medicine

    2022  Volume 48, Issue 10, Page(s) 1305–1307

    MeSH term(s) Early Ambulation ; Humans ; Intensive Care Units ; Length of Stay ; Respiration, Artificial
    Language English
    Publishing date 2022-08-04
    Publishing country United States
    Document type Editorial
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-022-06819-6
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  9. Article ; Online: Management of Respiratory Failure: Ventilator Management 101 and Noninvasive Ventilation.

    Pearson, Steven D / Koyner, Jay L / Patel, Bhakti K

    Clinical journal of the American Society of Nephrology : CJASN

    2022  Volume 17, Issue 4, Page(s) 572–580

    Abstract: Mechanical ventilation is a lifesaving therapy for critically ill patients with respiratory failure, but like all treatments, it has the potential to cause harm if not administered appropriately. This review aims to give an overview of the basic ... ...

    Abstract Mechanical ventilation is a lifesaving therapy for critically ill patients with respiratory failure, but like all treatments, it has the potential to cause harm if not administered appropriately. This review aims to give an overview of the basic principles of invasive and noninvasive mechanical ventilation. Topics covered include modes of mechanical ventilation, respiratory mechanics and ventilator waveform interpretation, strategies for initial ventilator settings, indications and contraindications for noninvasive ventilation, and the effect of the ventilator on kidney function.
    MeSH term(s) Critical Illness ; Humans ; Noninvasive Ventilation/adverse effects ; Respiration, Artificial ; Respiratory Insufficiency/therapy ; Ventilators, Mechanical
    Language English
    Publishing date 2022-03-10
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.13091021
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  10. Article ; Online: Noninvasive Ventilation for Acute Asthma: The Neglected Sibling.

    Pearson, Steven D / Patel, Bhakti K

    American journal of respiratory and critical care medicine

    2020  Volume 202, Issue 11, Page(s) 1491–1493

    MeSH term(s) Asthma/therapy ; Critical Illness ; Humans ; Noninvasive Ventilation ; Patients ; Respiratory Insufficiency ; Siblings
    Language English
    Publishing date 2020-08-05
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202007-2876ED
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