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  1. Article ; Online: Are seminal plasma microRNAs the next biomarkers for nonobstructive azoospermia?

    Lo, Sharon P / Patel, Darshan P

    Fertility and sterility

    2021  Volume 115, Issue 5, Page(s) 1159

    MeSH term(s) Azoospermia/diagnosis ; Azoospermia/genetics ; Biomarkers ; Humans ; Male ; MicroRNAs/genetics ; Semen ; Testis
    Chemical Substances Biomarkers ; MicroRNAs
    Language English
    Publishing date 2021-05-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80133-1
    ISSN 1556-5653 ; 0015-0282
    ISSN (online) 1556-5653
    ISSN 0015-0282
    DOI 10.1016/j.fertnstert.2021.03.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 73: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Emerging concepts in male contraception: a narrative review of novel, hormonal and non-hormonal options.

    Service, C Austin / Puri, Dhruv / Hsieh, Tung-Chin / Patel, Darshan P

    Therapeutic advances in reproductive health

    2023  Volume 17, Page(s) 26334941221138323

    Abstract: Access to reliable contraception is a pillar of modern society. The burden of unintended pregnancy has fallen disproportionately on the mother throughout human history; however, recent legal developments surrounding abortion have sparked a renewed ... ...

    Abstract Access to reliable contraception is a pillar of modern society. The burden of unintended pregnancy has fallen disproportionately on the mother throughout human history; however, recent legal developments surrounding abortion have sparked a renewed interest in male factor contraceptives beyond surgical sterilization and condoms. Modern efforts to develop reversible male birth control date back nearly a century and initially focused on altering the hypothalamic-pituitary-testes axis. These hormonal contraceptives faced multiple barriers, including systemic side effects, challenging dosing regimens, unfavorable routes of delivery, and the public stigma surrounding steroid use. Novel hormonal agents are seeking to overcome these barriers by limiting the side effects and simplifying use. Non-hormonal contraceptives are agents that target various stages of spermatogenesis; such as inhibitors of retinoic acid, Sertoli cell-germ cell interactions, sperm ion channels, and other small molecular targets. The identification of reproductive tract-specific genes associated with male infertility has led to more targeted drug development, made possible by advances in CRISPR and proteolysis targeting chimeras (PROTACs). Despite multiple human trials, no male birth control agents have garnered regulatory approval in the United States or abroad. This narrative review examines current and emerging male contraceptives, including hormonal and non-hormonal agents.
    Language English
    Publishing date 2023-03-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 3041683-8
    ISSN 2633-4941 ; 2633-4941
    ISSN (online) 2633-4941
    ISSN 2633-4941
    DOI 10.1177/26334941221138323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A case of unprovoked segmental proximal partial thrombosis of the corpus cavernosum.

    Nguyen, Vi / Patel, Darshan P / Hsieh, Tung-Chin / Javier-Desloges, Juan

    Urology case reports

    2023  Volume 48, Page(s) 102426

    Abstract: Partial thrombosis of the corpus cavernosum is an extremely rare and likely underdiagnosed urologic condition. We discuss a case of a 25-year-old male who presented with severe perineal pain and was diagnosed with idiopathic proximal partial thrombosis ... ...

    Abstract Partial thrombosis of the corpus cavernosum is an extremely rare and likely underdiagnosed urologic condition. We discuss a case of a 25-year-old male who presented with severe perineal pain and was diagnosed with idiopathic proximal partial thrombosis of the corpus cavernosum via ultrasound and MRI. The patient experienced symptom resolution with evidence of disease regression on follow up MRI after treatment with direct oral anticoagulation. Further studies are needed to fully delineate the pathophysiology of this condition to facilitate development of standardized diagnostic and treatment algorithms.
    Language English
    Publishing date 2023-05-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2745459-9
    ISSN 2214-4420
    ISSN 2214-4420
    DOI 10.1016/j.eucr.2023.102426
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  4. Article ; Online: Erectile Dysfunction: Could It Be Genetic?

    Patel, Darshan P / Hotaling, James M

    The journal of sexual medicine

    2020  Volume 17, Issue 7, Page(s) 1239–1241

    Language English
    Publishing date 2020-05-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2251959-2
    ISSN 1743-6109 ; 1743-6095
    ISSN (online) 1743-6109
    ISSN 1743-6095
    DOI 10.1016/j.jsxm.2020.03.016
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    Zs.A 6417: Show issues Location:
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    Zs.MO 505: Show issues

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  5. Article ; Online: Con: Does COVID Impact Men's Health?

    Patel, Darshan P / Mumford, Sunni L / Pastuszak, Alexander W / Hotaling, James M

    The Journal of urology

    2022  Volume 208, Issue 4, Page(s) 788–790

    MeSH term(s) COVID-19 ; Health Promotion ; Humans ; Male ; Men's Health
    Language English
    Publishing date 2022-07-15
    Publishing country United States
    Document type Editorial
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/JU.0000000000002872
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    Zs.MO 331: Show issues

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  6. Article ; Online: Can artificial intelligence drive optimal sperm selection for in vitro fertilization?

    Patel, Darshan P / Gross, Kelli X / Hotaling, James M

    Fertility and sterility

    2021  Volume 115, Issue 4, Page(s) 883

    MeSH term(s) Artificial Intelligence ; Fertilization in Vitro ; Humans ; Male ; Spermatozoa
    Language English
    Publishing date 2021-02-26
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80133-1
    ISSN 1556-5653 ; 0015-0282
    ISSN (online) 1556-5653
    ISSN 0015-0282
    DOI 10.1016/j.fertnstert.2021.02.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 73: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Cost and utilization analysis of concurrent versus staged testicular prosthesis implantation for radical orchiectomy.

    Nguyen, Vi / Walia, Arman / Horns, Joshua J / Paudel, Niraj / Bagrodia, Aditya / Patel, Darshan P / Hsieh, Tung-Chin / Hotaling, James M

    PloS one

    2024  Volume 19, Issue 1, Page(s) e0296735

    Abstract: Purpose: American Urological Association guidelines recommend testicular prosthesis discussion prior to orchiectomy. Utilization may be low. We compared outcomes and care utilization between concurrent implant (CI) and staged implant (SI) insertion ... ...

    Abstract Purpose: American Urological Association guidelines recommend testicular prosthesis discussion prior to orchiectomy. Utilization may be low. We compared outcomes and care utilization between concurrent implant (CI) and staged implant (SI) insertion after radical orchiectomy.
    Materials & methods: The MarketScan Commercial claims database (2008-2017) was queried for men ages >18 years who underwent radical orchiectomy for testicular mass, stratified as orchiectomy with no implant, CI, or SI. 90-day outcomes included rate of reoperation, readmission, emergency department (ED) presentation, and outpatient visits. Regression models provided rate ratio comparison.
    Results: 8803 patients (8564 no implant, 190 CI, 49 SI; 2.7% implant rate) were identified with no difference in age, Charlson Comorbidity Index, insurance plan, additional cancer treatment, or metastasis. Median perioperative cost at orchiectomy (+/- implant) for no implant, CI, and SI were $5682 (3648-8554), $7823 (5403-10973), and $5380 (4130-10521), respectively (p<0.001). Median perioperative cost for SI at implantation was $8180 (4920-14591) for a total cost (orchiectomy + implant) of $13650 (5380 + 8180). CI patients were more likely to have follow-up (p = 0.006) with more visits (p = 0.030) compared to the SI group post-implantation but had similar follow-up (p = 0.065) and less visits (p = 0.025) compared to the SI patients' post-orchiectomy period. Overall explant rates were 4.7% for CI and 14.3% for SI (p = 0.04) with a median time to explant of 166 (IQR: 135-210) and 40 days (IQR: 9.5-141.5; p = 0.06). Median cost of removal was $2060 (IQR: 967-2880).
    Conclusions: CI placement has less total perioperative cost, lower explant rate, and similar postoperative utilization to SI.
    MeSH term(s) Male ; Humans ; Orchiectomy ; Reoperation ; Embryo Implantation ; Prostheses and Implants ; Prosthesis Implantation
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0296735
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  8. Article ; Online: Music from noise-canceling headphones is beneficial against anxiety in male bladder cancer patients undergoing follow-up cystoscopy: A prospective randomized trial.

    Cho, Hyun-Jin / Chung, Ho Seok / Hwang, Eu Chang / Jung, Seung Il / Kwon, Dongdeuk / Park, Kwangsung / Patel, Darshan P / Hsieh, Tung-Chin

    Urologia internationalis

    2024  

    Abstract: Introduction: Bladder cancer, with a greater incidence in males than in females, requires frequent cystoscopies. We aim to evaluate the effect of music played through noise-canceling headphones on male bladder cancer patients during follow-up cystoscopy. ...

    Abstract Introduction: Bladder cancer, with a greater incidence in males than in females, requires frequent cystoscopies. We aim to evaluate the effect of music played through noise-canceling headphones on male bladder cancer patients during follow-up cystoscopy.
    Methods: A total of 160 male bladder cancer patients undergoing follow-up flexible cystoscopy were randomly divided into the noise-canceling headphones without music group and the noise-canceling headphones with music group (groups 1 and 2, respectively; n = 80 per group). The patients' clinical characteristics were examined and objective and subjective measurements were compared before and after cystoscopy. The primary outcomes that were evaluated included the visual analog scale (VAS, 0-10) and the state-trait anxiety inventory (STAI, 20-80). Other outcomes, including vital signs and scores for assessing satisfaction and the willingness to repeat the procedure, were also examined.
    Results: The characteristics of the patients in groups 1 and 2, and their pre-cystoscopy status, did not differ significantly. Although post-cystoscopy vital signs for the objective parameters and VAS pain scores were similar between the groups, subjective parameters were not. When compared with group 1, post-cystoscopy STAI-state scores were significantly lower in group 2, whereas patients' satisfaction scores and the willingness to repeat the procedure were significantly higher in group 2 (p = 0.002, 0.001, and 0.001, respectively). Additionally, in group 2, STAI-state scores changed significantly after the procedure when compared with before the procedure (p = 0.002).
    Conclusion: In male bladder cancer patients, music from noise-canceling headphones might have reduced anxiety and improved satisfaction and the willingness to repeat cystoscopy.
    Language English
    Publishing date 2024-05-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 204045-1
    ISSN 1423-0399 ; 0042-1138
    ISSN (online) 1423-0399
    ISSN 0042-1138
    DOI 10.1159/000539312
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    Ui VI Zs.180: Show issues Location:
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  9. Article ; Online: The impact of obesity and metabolic health on male fertility: a systematic review.

    Service, Chad Austin / Puri, Dhruv / Al Azzawi, Sultan / Hsieh, Tung-Chin / Patel, Darshan P

    Fertility and sterility

    2023  Volume 120, Issue 6, Page(s) 1098–1111

    Abstract: The impact of paternal obesity and metabolic disease on semen quality and fertility outcomes is not fully appreciated. With increasing obesity rates, researchers have studied the intricate relationship between paternal body mass index, metabolic health, ... ...

    Abstract The impact of paternal obesity and metabolic disease on semen quality and fertility outcomes is not fully appreciated. With increasing obesity rates, researchers have studied the intricate relationship between paternal body mass index, metabolic health, and male fertility. This systematic review identified 112 articles in the MEDLINE database between 2013 and 2023 that investigated the effects of body mass index, diabetes, metabolic syndrome, exercise, weight loss medication, or bariatric surgery on semen parameters, sperm quality, or fertility outcomes. This review suggests that obesity, diabetes, and metabolic syndrome have a negative impact on various parameters of male fertility, from semen quality to sperm deoxyribonucleic acid integrity. There is also mounting evidence that male obesity is correlated negatively with live births via both natural conception and assisted reproductive technologies. Lifestyle interventions, such as physical exercise, generally appear to improve male fertility markers; however, the type and intensity of exercise may play a crucial role. Pharmacologic treatments for weight loss, such as metformin and glucagon-like peptide 1 agonists, present a more complex picture, with studies suggesting both beneficial and detrimental effects on male reproductive health. Similarly, surgical interventions, such as gastric bypass surgery, show promise in improving hormonal imbalances but have mixed effects on semen parameters. Future research is needed to clarify these associations and inform clinical guidelines. In the interim, health practitioners should incorporate these insights into clinical practices, encouraging proactive lifestyle changes and providing targeted treatments to improve male reproductive health.
    MeSH term(s) Male ; Humans ; Semen Analysis ; Semen ; Metabolic Syndrome/diagnosis ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/etiology ; Obesity/complications ; Obesity/diagnosis ; Obesity/epidemiology ; Infertility, Male/diagnosis ; Infertility, Male/epidemiology ; Infertility, Male/etiology ; Fertility ; Weight Loss ; Diabetes Mellitus
    Language English
    Publishing date 2023-10-14
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 80133-1
    ISSN 1556-5653 ; 0015-0282
    ISSN (online) 1556-5653
    ISSN 0015-0282
    DOI 10.1016/j.fertnstert.2023.10.017
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: The jury is still out: COVID-19 and male reproduction.

    Patel, Darshan P / Guo, Jingtao / Hotaling, James M

    Fertility and sterility

    2020  Volume 114, Issue 2, Page(s) 257–258

    MeSH term(s) Betacoronavirus ; COVID-19 ; Cohort Studies ; Coronavirus Infections ; Humans ; Male ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Semen
    Keywords covid19
    Language English
    Publishing date 2020-06-11
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80133-1
    ISSN 1556-5653 ; 0015-0282
    ISSN (online) 1556-5653
    ISSN 0015-0282
    DOI 10.1016/j.fertnstert.2020.06.013
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