Article ; Online: Carbapenem-resistant
JAC-antimicrobial resistance
2024 Volume 6, Issue 2, Page(s) dlae050
Abstract: Background: The molecular epidemiology of carbapenem-resistant Enterobacterales in Cape Town remains largely unknown.: Objectives: This study aimed to describe the molecular epidemiology, resistome, virulome and mobilome of carbapenem-resistant : ... ...
| Abstract | Background: The molecular epidemiology of carbapenem-resistant Enterobacterales in Cape Town remains largely unknown. Objectives: This study aimed to describe the molecular epidemiology, resistome, virulome and mobilome of carbapenem-resistant Methods: Eighty-five CRKP isolates from hospitalized patients underwent WGS as part of a prospective, multicentre, cross-sectional study, conducted between 1 November 2020 and 30 November 2022, across public-sector and private-sector hospitals in Cape Town, South Africa. Results: MLST revealed three novel types, ST6785, ST6786 and ST6787, while the most common were ST219, ST307, ST17, ST13 and ST2497. Different predominant clones were noted in each hospital. The most common carbapenemase gene was Conclusions: CRKP epidemiology in Cape Town reflects institutionally dominant, rather than regional, clones. The most prevalent carbapenemase gene was |
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| Language | English |
| Publishing date | 2024-03-25 |
| Publishing country | England |
| Document type | Journal Article ; Comment |
| ISSN | 2632-1823 |
| ISSN (online) | 2632-1823 |
| DOI | 10.1093/jacamr/dlae050 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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