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Article ; Online: Kidney Stone Pathophysiology, Evaluation and Management: Core Curriculum 2023.

Shastri, Shani / Patel, Jiten / Sambandam, Kamalanathan K / Lederer, Eleanor D

American journal of kidney diseases : the official journal of the National Kidney Foundation

2023 Volume 82, Issue 5, Page(s) 617–634

Abstract: Kidney stone disease, also known as nephrolithiasis or urolithiasis, is a disorder in which urinary solutes precipitate to form aggregates of crystalline material in the urinary space. The incidence of nephrolithiasis has been increasing, and the ... ...

Abstract	Kidney stone disease, also known as nephrolithiasis or urolithiasis, is a disorder in which urinary solutes precipitate to form aggregates of crystalline material in the urinary space. The incidence of nephrolithiasis has been increasing, and the demographics have been evolving. Once viewed as a limited disease with intermittent exacerbations that are simply managed by urologists, nephrolithiasis is now recognized as a complex condition requiring thorough evaluation and multifaceted care. Kidney stones are frequently manifestations of underlying systemic medical conditions such as the metabolic syndrome, genetic disorders, or endocrinopathies. Analysis of urine chemistries and stone composition provide a window into pathogenesis and direct ancillary studies to uncover underlying diseases. These studies allow providers to devise individualized strategies to limit future stone events. Given its complexity, kidney stone disease is best addressed by a team led by nephrologists and urologists with input from multiple other health professionals including dietitians, endocrinologists, interventional radiologists, and endocrine surgeons. In this installment of AJKD's Core Curriculum in Nephrology, we provide a case-based overview of nephrolithiasis, divided by the individual stone types. The reader will gain a pragmatic understanding of the pathophysiology, evaluation, and management of this condition.
Language	English
Publishing date	2023-08-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	604539-x
ISSN	1523-6838 ; 0272-6386
ISSN (online)	1523-6838
ISSN	0272-6386
DOI	10.1053/j.ajkd.2023.03.017
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Article: Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK.

Bowman, Caitlyn E / Neinast, Michael D / Jang, Cholsoon / Patel, Jiten / Blair, Megan C / Mirek, Emily T / Jonsson, William O / Chu, Qingwei / Merlo, Lauren / Mandik-Nayak, Laura / Anthony, Tracy G / Rabinowitz, Joshua D / Arany, Zolt

bioRxiv : the preprint server for biology

2024

Abstract: The activation of branched chain amino acid (BCAA) catabolism has garnered interest as a potential therapeutic approach to improve insulin sensitivity, enhance recovery from heart failure, and blunt tumor growth. Evidence for this interest relies in part ...

Abstract	The activation of branched chain amino acid (BCAA) catabolism has garnered interest as a potential therapeutic approach to improve insulin sensitivity, enhance recovery from heart failure, and blunt tumor growth. Evidence for this interest relies in part on BT2, a small molecule that promotes BCAA oxidation and is protective in mouse models of these pathologies. BT2 and other analogs allosterically inhibit branched chain ketoacid dehydrogenase kinase (BCKDK) to promote BCAA oxidation, which is presumed to underlie the salutary effects of BT2. Potential "off-target" effects of BT2 have not been considered, however. We therefore tested for metabolic off-target effects of BT2 in
Language	English
Publishing date	2024-03-10
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.03.05.582974
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Article ; Online: Hyperphosphatemia and its relationship with blood pressure, vasoconstriction, and endothelial cell dysfunction in hypertensive hemodialysis patients.

Jung, Jinwoo / Jeon-Slaughter, Haekyung / Nguyen, Hang / Patel, Jiten / Sambandam, Kamalanathan K / Shastri, Shani / Van Buren, Peter Noel

BMC nephrology

2022 Volume 23, Issue 1, Page(s) 291

Abstract: Background: Hyperphosphatemia occurs frequently in end-stage renal disease patients on hemodialysis and is associated with increased mortality. Hyperphosphatemia contributes to vascular calcification in these patients, but there is emerging evidence ... ...

Abstract	Background: Hyperphosphatemia occurs frequently in end-stage renal disease patients on hemodialysis and is associated with increased mortality. Hyperphosphatemia contributes to vascular calcification in these patients, but there is emerging evidence that it is also associated with endothelial cell dysfunction. Methods: We conducted a cross-sectional study in hypertensive hemodialysis patients. We obtained pre-hemodialysis measurements of total peripheral resistance index (TPRI, non-invasive cardiac output monitor) and plasma levels of endothelin-1 (ET-1) and asymmetric dimethylarginine (ADMA). We ascertained the routine peridialytic blood pressure (BP) measurements from that treatment and the most recent pre-hemodialysis serum phosphate levels. We used generalized linear regression analyses to determine independent associations between serum phosphate with BP, TPRI, ET-1, and ADMA while controlling for demographic variables, parathyroid hormone (PTH), and interdialytic weight gain. Results: There were 54 patients analyzed. Mean pre-HD supine and seated systolic and diastolic BP were 164 (27), 158 (21), 91.5 (17), and 86.1 (16) mmHg. Mean serum phosphate was 5.89 (1.8) mg/dL. There were significant correlations between phosphate with all pre-hemodialysis BP measurements (r = 0.3, p = .04; r = 0.4, p = .002; r = 0.5, p < .0001; and r = 0.5, p = .0003.) The correlations with phosphate and TPRI, ET-1, and ADMA were 0.3 (p = .01), 0.4 (p = .007), and 0.3 (p = .04). In our final linear regression analyses controlling for baseline characteristics, PTH, and interdialytic weight gain, independent associations between phosphate with pre-hemodialysis diastolic BP, TPRI, and ET-1 were retained (β = 4.33, p = .0002; log transformed β = 0.05, p = .005; reciprocal transformed β = -0.03, p = .047). Conclusions: Serum phosphate concentration is independently associated with higher pre-HD BP, vasoconstriction, and markers of endothelial cell dysfunction. These findings demonstrate an additional negative impact of hyperphosphatemia on cardiovascular health beyond vascular calcification. Trial registration: The study was part of a registered clinical trial, NCT01862497 (May 24, 2013).
MeSH term(s)	Blood Pressure/physiology ; Cross-Sectional Studies ; Endothelial Cells ; Humans ; Hyperphosphatemia ; Hypertension/complications ; Hypertension/epidemiology ; Kidney Failure, Chronic/complications ; Parathyroid Hormone ; Phosphates ; Renal Dialysis/adverse effects ; Vascular Calcification/complications ; Vasoconstriction ; Weight Gain
Chemical Substances	Parathyroid Hormone ; Phosphates
Language	English
Publishing date	2022-08-23
Publishing country	England
Document type	Clinical Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	2041348-8
ISSN	1471-2369 ; 1471-2369
ISSN (online)	1471-2369
ISSN	1471-2369
DOI	10.1186/s12882-022-02918-0
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Article ; Online: Safety and Feasibility of Photodynamic Therapy for Ablation of Peripheral Lung Tumors.

Bansal, Sandeep / Bechara, Rabih I / Patel, Jiten D / Mehta, Hiren J / Ferguson, J Scott / Witt, Benjamin L / Murgu, Septimiu D / Yasufuku, Kazuhiro / Casal, Roberto F

Journal of bronchology & interventional pulmonology

2023 Volume 30, Issue 2, Page(s) 135–143

Abstract: Background: Newer navigational bronchoscopy technologies render peripheral lung lesions accessible for biopsy and potential treatment. We investigated whether photodynamic therapy (PDT) delivered via navigational bronchoscopy is feasible and safe for ... ...

Abstract	Background: Newer navigational bronchoscopy technologies render peripheral lung lesions accessible for biopsy and potential treatment. We investigated whether photodynamic therapy (PDT) delivered via navigational bronchoscopy is feasible and safe for ablation of peripheral lung tumors. Methods: Two studies evaluated PDT in patients with solid peripheral lung tumors followed by clinical follow-up (nonresection study, N=5) or lobectomy (resection study, N=10). Porfimer sodium injection was administered 40 to 50 hours before navigational bronchoscopy. Lesion location was confirmed by radial probe endobronchial ultrasonography. An optical fiber diffuser was placed within or adjacent to the tumor under fluoroscopic guidance; laser light (630 nm wavelength) was applied at 200 J/cm of diffuser length for 500 seconds. Tumor response was assessed by modified Response Evaluation Criteria in Solid Tumors at 3 and 6 months postprocedure (nonresection study) and pathologically (resection study). Results: There were no deaths, discontinuations for adverse events, or serious or grade ≥3 adverse events related to study treatments. Photosensitivity reactions occurred in 8 of 15 patients: 6 mild, 1 moderate, 1 severe (elevated porphyrins noted in blood after treatment). Among 5 patients with clinical follow-up, 1 had complete response, 3 had stable disease, and 1 had progressive disease at 6 months follow-up. Among 10 patients who underwent lobectomy, 1 had no evidence of tumor at resection (complete response), 3 had 40% to 50% tumor cell necrosis, 2 had 20% to 35%, and 4 had 5% to 10%. Conclusion: PDT for nonthermal ablation of peripheral lung tumors was feasible and safe in this small study. Further study is warranted to evaluate efficacy and corroborate the safety profile.
MeSH term(s)	Humans ; Photochemotherapy/adverse effects ; Feasibility Studies ; Dihematoporphyrin Ether/therapeutic use ; Lung Neoplasms/drug therapy ; Lung Neoplasms/surgery ; Light ; Photosensitizing Agents/therapeutic use
Chemical Substances	Dihematoporphyrin Ether (97067-70-4) ; Photosensitizing Agents
Language	English
Publishing date	2023-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2478320-1
ISSN	1948-8270 ; 1944-6586
ISSN (online)	1948-8270
ISSN	1944-6586
DOI	10.1097/LBR.0000000000000889
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Article ; Online: Microbiological Evaluation of the Extension Wire and Percutaneous Epidural Lead Anchor Site Following a "2-Stage Cut-Down" Spinal Cord Stimulator Procedure.

Lalkhen, Abdul Ghaaliq / Chincholkar, Mahindra / Patel, Jiten

Pain practice : the official journal of World Institute of Pain

2017 Volume 17, Issue 7, Page(s) 886–891

Abstract: Objectives: There are concerns regarding bacterial colonization of the temporary extension leads and subsequent infection risk using the 2-stage cut-down approach in spinal cord stimulation (SCS). We sought to quantify the extent of bacterial ... ...

Abstract	Objectives: There are concerns regarding bacterial colonization of the temporary extension leads and subsequent infection risk using the 2-stage cut-down approach in spinal cord stimulation (SCS). We sought to quantify the extent of bacterial colonization of the temporary extension wire and percutaneous epidural lead anchor site. Materials and methods: We conducted a cross-sectional observational study recruiting a pragmatic sample of 25 consecutive patients listed for a cut-down trial of SCS. We excluded patients undergoing revision procedures and those who had previously received a spinal cord stimulator. The primary outcome measure was the rate and type of colonization of the extension wires and lead anchor site. Results: No surgical site infections were recorded in any of the patients and no late infections subsequent to insertion of the implantable pulse generator. Overall, 24% of patients grew organisms from the temporary extension wire. Five patients grew coagulase-negative Staphylococcus aureus, and 1 patient grew Enterococcus faecalis. There were no positive wound cultures from the anchor site of the epidural lead. Conclusions: Despite the high colonization rate of the temporary extension wire, there were no surgical site infections. We conclude that provided appropriate strategies for the management of surgical site infections are implemented, the 2-stage cut-down procedure is a safe approach that is not associated with a higher incidence of infection.
MeSH term(s)	Aged ; Cross-Sectional Studies ; Electrodes/microbiology ; Epidural Space/microbiology ; Female ; Humans ; Male ; Microbiological Techniques/methods ; Middle Aged ; Retrospective Studies ; Spinal Cord/physiology ; Spinal Cord Stimulation/adverse effects ; Spinal Cord Stimulation/instrumentation ; Spinal Cord Stimulation/methods ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/etiology ; Staphylococcus aureus/isolation & purification ; Surgical Wound Infection/diagnosis ; Surgical Wound Infection/etiology
Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2151272-3
ISSN	1533-2500 ; 1530-7085
ISSN (online)	1533-2500
ISSN	1530-7085
DOI	10.1111/papr.12537
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Article ; Online: Molecular Signatures of Diabetic Kidney Disease Hiding in a Patient with Hypertension-Related Kidney Disease: A Clinical Pathologic Molecular Correlation.

Patel, Jiten / Torrealba, Jose R / Poggio, Emilio D / Bebiak, Jack / Alpers, Charles E / Grewenow, Stephanie M / Toto, Robert D / Eadon, Michael T

Clinical journal of the American Society of Nephrology : CJASN

2021 Volume 17, Issue 4, Page(s) 594–601

Abstract: The Kidney Precision Medicine Project (KPMP) seeks to establish a molecular atlas of the kidney in health and disease and improve our understanding of the molecular drivers of CKD and AKI. Herein, we describe the case of a 66-year-old woman with CKD who ... ...

Abstract	The Kidney Precision Medicine Project (KPMP) seeks to establish a molecular atlas of the kidney in health and disease and improve our understanding of the molecular drivers of CKD and AKI. Herein, we describe the case of a 66-year-old woman with CKD who underwent a protocol KPMP kidney biopsy. Her clinical history included well-controlled diabetes mellitus, hypertension, and proteinuria. The patient's histopathology was consistent with modest hypertension-related kidney injury, without overt diabetic kidney disease. Transcriptomic signatures of the glomerulus, interstitium, and tubular subsegments were obtained from laser microdissected tissue. The molecular signatures that were uncovered revealed evidence of early diabetic kidney disease adaptation and ongoing active tubular injury with enriched pathways related to mesangial cell hypertrophy, glycosaminoglycan biosynthesis, and apoptosis. Molecular evidence of diabetic kidney disease was found across the nephron. Novel molecular assays can supplement and enrich the histopathologic diagnosis obtained from a kidney biopsy.
MeSH term(s)	Aged ; Diabetes Mellitus ; Diabetic Nephropathies/etiology ; Diabetic Nephropathies/genetics ; Female ; Humans ; Hypertension/complications ; Hypertension, Renal ; Nephritis ; Proteinuria ; Renal Insufficiency, Chronic
Language	English
Publishing date	2021-12-15
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2226665-3
ISSN	1555-905X ; 1555-9041
ISSN (online)	1555-905X
ISSN	1555-9041
DOI	10.2215/CJN.10350721
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Article ; Online: Using dipstick urinalysis to predict development of acute kidney injury in patients with COVID-19.

McAdams, Meredith C / Li, Michael / Xu, Pin / Gregg, L Parker / Patel, Jiten / Willett, Duwayne L / Velasco, Ferdinand / Lehmann, Christoph U / Hedayati, S Susan

BMC nephrology

2022 Volume 23, Issue 1, Page(s) 50

Abstract: Background: Acute kidney injury (AKI) is a common complication in patients hospitalized with COVID-19 and may require renal replacement therapy (RRT). Dipstick urinalysis is frequently obtained, but data regarding the prognostic value of hematuria and ... ...

Abstract	Background: Acute kidney injury (AKI) is a common complication in patients hospitalized with COVID-19 and may require renal replacement therapy (RRT). Dipstick urinalysis is frequently obtained, but data regarding the prognostic value of hematuria and proteinuria for kidney outcomes is scarce. Methods: Patients with positive severe acute respiratory syndrome-coronavirus 2 (SARS-CoV2) PCR, who had a urinalysis obtained on admission to one of 20 hospitals, were included. Nested models with degree of hematuria and proteinuria were used to predict AKI and RRT during admission. Presence of Chronic Kidney Disease (CKD) and baseline serum creatinine were added to test improvement in model fit. Results: Of 5,980 individuals, 829 (13.9%) developed an AKI during admission, and 149 (18.0%) of those with AKI received RRT. Proteinuria and hematuria degrees significantly increased with AKI severity (P < 0.001 for both). Any degree of proteinuria and hematuria was associated with an increased risk of AKI and RRT. In predictive models for AKI, presence of CKD improved the area under the curve (AUC) (95% confidence interval) to 0.73 (0.71, 0.75), P < 0.001, and adding baseline creatinine improved the AUC to 0.85 (0.83, 0.86), P < 0.001, when compared to the base model AUC using only proteinuria and hematuria, AUC = 0.64 (0.62, 0.67). In RRT models, CKD status improved the AUC to 0.78 (0.75, 0.82), P < 0.001, and baseline creatinine improved the AUC to 0.84 (0.80, 0.88), P < 0.001, compared to the base model, AUC = 0.72 (0.68, 0.76). There was no significant improvement in model discrimination when both CKD and baseline serum creatinine were included. Conclusions: Proteinuria and hematuria values on dipstick urinalysis can be utilized to predict AKI and RRT in hospitalized patients with COVID-19. We derived formulas using these two readily available values to help prognosticate kidney outcomes in these patients. Furthermore, the incorporation of CKD or baseline creatinine increases the accuracy of these formulas.
MeSH term(s)	Acute Kidney Injury/ethnology ; Acute Kidney Injury/etiology ; Acute Kidney Injury/therapy ; Aged ; Area Under Curve ; COVID-19/complications ; COVID-19/ethnology ; Confidence Intervals ; Creatinine/blood ; Female ; Hematuria/diagnosis ; Hospitalization ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Predictive Value of Tests ; Proteinuria/diagnosis ; Renal Insufficiency, Chronic/diagnosis ; Renal Replacement Therapy/statistics & numerical data ; Urinalysis/methods
Chemical Substances	Creatinine (AYI8EX34EU)
Language	English
Publishing date	2022-02-01
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2041348-8
ISSN	1471-2369 ; 1471-2369
ISSN (online)	1471-2369
ISSN	1471-2369
DOI	10.1186/s12882-022-02677-y
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Article ; Online: Hemodialysis catheter insertion: is increased PO2 a sign of arterial cannulation? A case report.

Chirinos, Julio C / Neyra, Javier A / Patel, Jiten / Rodan, Aylin R

BMC nephrology

2014 Volume 15, Page(s) 127

Abstract: Background: Ultrasound-guided Central Venous Catheterization (CVC) for temporary vascular access, preferably using the right internal jugular vein, is widely accepted by nephrologists. However CVC is associated with numerous potential complications, ... ...

Abstract	Background: Ultrasound-guided Central Venous Catheterization (CVC) for temporary vascular access, preferably using the right internal jugular vein, is widely accepted by nephrologists. However CVC is associated with numerous potential complications, including death. We describe the finding of a rare left-sided partial anomalous pulmonary vein connection during central venous catheterization for continuous renal replacement therapy (CRRT). Case presentation: Ultrasound-guided cannulation of a large bore temporary dual-lumen Quinton-Mahurkar catheter into the left internal jugular vein was performed for CRRT initiation in a 66 year old African-American with sepsis-related oliguric acute kidney injury. The post-procedure chest X-ray suggested inadvertent left carotid artery cannulation. Blood gases obtained from the catheter showed high partial pressure of oxygen (PO2) of 140 mmHg and low partial pressure of carbon dioxide (PCO2) of 22 mmHg, suggestive of arterial cannulation. However, the pressure-transduced wave forms appeared venous and Computed Tomography Angiography located the catheter in the left internal jugular vein, but demonstrated that the tip of the catheter was lying over a left pulmonary vein which was abnormally draining into the left brachiocephalic (innominate) vein rather than into the left atrium. Conclusion: Although several mechanical complications of dialysis catheters have been described, ours is one of the few cases of malposition into an anomalous pulmonary vein, and highlights a sequential approach to properly identify the catheter location in this uncommon clinical scenario.
MeSH term(s)	Aged ; Catheterization, Central Venous/adverse effects ; Catheterization, Peripheral/adverse effects ; Catheters, Indwelling/adverse effects ; Fatal Outcome ; Humans ; Male ; Oxygen/blood ; Partial Pressure ; Renal Dialysis/adverse effects ; Renal Dialysis/instrumentation
Chemical Substances	Oxygen (S88TT14065)
Keywords	covid19
Language	English
Publishing date	2014-07-29
Publishing country	England
Document type	Case Reports ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2041348-8
ISSN	1471-2369 ; 1471-2369
ISSN (online)	1471-2369
ISSN	1471-2369
DOI	10.1186/1471-2369-15-127
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Article ; Online: Dicoumarol complexes of Cu(II) based on 1,10-phenanthroline: synthesis, X-ray diffraction studies, thermal behavior and biological evaluation.

Dholariya, Hitesh R / Patel, Ketan S / Patel, Jiten C / Patel, Kanuprasad D

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2013 Volume 108, Page(s) 319–328

Abstract: A series of Cu(II) complexes containing dicoumarol derivatives and 1, 10-phenanthroline have been synthesized. Structural and spectroscopic properties of ligands were studied on the basis of mass spectra, NMR ((1)H and (13)C) spectra, FT-IR ... ...

Abstract	A series of Cu(II) complexes containing dicoumarol derivatives and 1, 10-phenanthroline have been synthesized. Structural and spectroscopic properties of ligands were studied on the basis of mass spectra, NMR ((1)H and (13)C) spectra, FT-IR spectrophotometry and elemental analysis, while physico-chemical, spectroscopic and thermal properties of mixed ligand complexes have been studied on the basis of infrared spectra, mass spectra, electronic spectra, powder X-ray diffraction, elemental analysis and thermogravimetric analysis. X-ray diffraction study suggested the suitable octahedral geometry for hexa-coordinated state. The kinetic parameters such as order of reaction (n), energy of activation (Ea), entropy (S()), pre-exponential factor (A), enthalpy (H()) and Gibbs free energy (G(*)) have been calculated using Freeman-Carroll method. Ferric-reducing antioxidant power (FRAP) of all complexes were measured. All the compounds were screened for their antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Streptococcus pyogenes and Bacillus subtilis, while antifungal activity against Candida albicans and Aspergillus niger have been carried out. Also compounds against Mycobacterium tuberculosis shows clear enhancement in the anti-tubercular activity upon copper complexation.
MeSH term(s)	Anti-Infective Agents/chemical synthesis ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/pharmacology ; Antioxidants/pharmacology ; Antitubercular Agents/pharmacology ; Bacteria/drug effects ; Copper/pharmacology ; Dicumarol/chemical synthesis ; Dicumarol/chemistry ; Dicumarol/pharmacology ; Elements ; Fungi/drug effects ; Kinetics ; Ligands ; Magnetic Phenomena ; Mass Spectrometry ; Microbial Sensitivity Tests ; Models, Molecular ; Phenanthrolines/chemical synthesis ; Phenanthrolines/chemistry ; Phenanthrolines/pharmacology ; Spectroscopy, Fourier Transform Infrared ; Temperature ; Thermogravimetry ; X-Ray Diffraction
Chemical Substances	Anti-Infective Agents ; Antioxidants ; Antitubercular Agents ; Elements ; Ligands ; Phenanthrolines ; Copper (789U1901C5) ; Dicumarol (7QID3E7BG7) ; 1,10-phenanthroline (W4X6ZO7939)
Language	English
Publishing date	2013-05
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2012.09.096
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Article ; Online: Multiple heating rate kinetic parameters, thermal, X-ray diffraction studies of newly synthesized octahedral copper complexes based on bromo-coumarins along with their antioxidant, anti-tubercular and antimicrobial activity evaluation.

Patel, Ketan S / Patel, Jiten C / Dholariya, Hitesh R / Patel, Kanuprasad D

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2012 Volume 96, Page(s) 468–479

Abstract: Series of new Cu(II) complexes were synthesized by classical thermal technique. The biologically potent ligands (L) were prepared by refluxing 6-brom 3-acetyl coumarin with aldehydes in the presence of piperidine in ethanol. The Cu(II) complexes have ... ...

Abstract	Series of new Cu(II) complexes were synthesized by classical thermal technique. The biologically potent ligands (L) were prepared by refluxing 6-brom 3-acetyl coumarin with aldehydes in the presence of piperidine in ethanol. The Cu(II) complexes have been synthesized by mixing an aqueous solution of Cu(NO(3))(2) in 1:1 molar ratios with ethanolic bidentate ligands and Clioquinol. The structures of the ligands and their copper complexes were investigated and confirmed by the elemental analysis, FT-IR, (1)H NMR, (13)C NMR, mass spectral and powder X-ray diffraction studies respectively. Thermal behaviour of newly synthesized mixed ligand Cu(II) complexes were investigated by means of thermogravimetry, differential thermogravimetry, differential scanning calorimetry, electronic spectra and magnetic measurements. Dynamic scan of DSC experiments for Cu(II) complexes were taken at different heating rates (2.5-20 °C min(-1)). Kinetic parameters for second step degradation of all complexes obtained by Kissinger's and Ozawa's methods were in good agreement. On the basis of these studies it is clear that ligands coordinated to metal atom in a monobasic bidentate mode, by OO and ON donor system. Thus, suitable octahedral geometry for hexa-coordinated state has been suggested for the metal complexes. Both the ligands as well as its complexes have been screened for their in vitro antioxidant, anti-tubercular and antimicrobial activities. All were found to be significant potent compared to parent ligands employed for complexation.
MeSH term(s)	Anti-Infective Agents/pharmacology ; Antioxidants/pharmacology ; Antitubercular Agents/pharmacology ; Bacteria/drug effects ; Calorimetry, Differential Scanning ; Coordination Complexes/chemical synthesis ; Coordination Complexes/chemistry ; Coordination Complexes/pharmacology ; Copper/chemistry ; Coumarins/chemical synthesis ; Coumarins/chemistry ; Coumarins/pharmacology ; Electrons ; Fungi/drug effects ; Hot Temperature ; Kinetics ; Ligands ; Magnetic Phenomena ; Mass Spectrometry ; Microbial Sensitivity Tests ; Models, Molecular ; Spectroscopy, Fourier Transform Infrared ; Temperature ; Thermogravimetry ; X-Ray Diffraction
Chemical Substances	Anti-Infective Agents ; Antioxidants ; Antitubercular Agents ; Coordination Complexes ; Coumarins ; Ligands ; Copper (789U1901C5)
Language	English
Publishing date	2012-10
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2012.05.057
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In stock of ZB MED Bonn / Germany

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In stock of ZB MED Bonn / Germany

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Inter-library loan at ZB MED