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  1. AU="Patel, Monica"
  2. AU=Passariello Margherita
  3. AU=Saikia Bedangshu
  4. AU="Dion, Dominique"
  5. AU="Magami, Shunsuke"
  6. AU="Wagner, Henrik"

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  1. Article ; Online: What's age got to do with it? A study of the implementation of the discharge medicines service for paediatric patients.

    Trivedi, Ashifa / Bhatti, Afaq / Patel, Bhavisha / Patel, Monica

    The International journal of pharmacy practice

    2024  Volume 32, Issue 3, Page(s) 229–236

    Abstract: Objectives: The discharge medicines service (DMS) was introduced as an essential service for all community pharmacies in England through the Community Pharmacy Contractual Framework (CPCF) in February 2021. This study aimed to describe the ... ...

    Abstract Objectives: The discharge medicines service (DMS) was introduced as an essential service for all community pharmacies in England through the Community Pharmacy Contractual Framework (CPCF) in February 2021. This study aimed to describe the implementation of this service for paediatric patients and to identify any barriers to referrals.
    Methods: The study was undertaken in a 24-bed paediatric ward in a District General Hospital from September 2022 to February 2023. All paediatric inpatients on long-term medications were eligible for inclusion. Out of 169 eligible participants, 149 were referred. Community pharmacists accessed referrals through PharmOutcomes® and could accept, complete, or reject referrals on this platform.
    Key findings: Of the 149 referred patients, 24 (16.1%) were accepted but not yet actioned; 63 (42.3%) were fully or partially completed; 19 (12.8%) were rejected, and 43 (28.9%) there was no response (remained as referred). Younger children (<2 years) were more likely to have their referral rejected than older children (6 years and older). The feedback from parents was overwhelmingly positive (93.5%) and two families reported that they believed the DMS service prevented readmission to the hospital for their children. No children were involved in the community pharmacist consultation. Barriers to referrals included patients not having a nominated pharmacy and a lack of confidence in completing paediatric referrals.
    Conclusions: This study demonstrates the value of completing referrals for paediatric patients. More research is required to explore how community pharmacists can be supported to complete paediatric DMS referrals.
    MeSH term(s) Humans ; Child ; Patient Discharge/statistics & numerical data ; Child, Preschool ; Community Pharmacy Services/organization & administration ; Referral and Consultation/statistics & numerical data ; Referral and Consultation/organization & administration ; Male ; Female ; England ; Pharmacists/organization & administration ; Infant ; Age Factors ; Adolescent ; Professional Role
    Language English
    Publishing date 2024-03-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1087040-4
    ISSN 2042-7174 ; 0961-7671
    ISSN (online) 2042-7174
    ISSN 0961-7671
    DOI 10.1093/ijpp/riae012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: AIO INTEGA Provides Further Support for Immunotherapy in Patients With Advanced ERBB2-Positive Gastroesophageal Adenocarcinoma.

    Patel, Monica / Uboha, Nataliya

    JAMA oncology

    2022  Volume 8, Issue 8, Page(s) 1158–1159

    MeSH term(s) Adenocarcinoma/pathology ; Adenocarcinoma/therapy ; Esophageal Neoplasms/pathology ; Esophageal Neoplasms/therapy ; Esophagogastric Junction/pathology ; Humans ; Immunotherapy ; Receptor, ErbB-2 ; Stomach Neoplasms/pathology ; Stomach Neoplasms/therapy
    Chemical Substances ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2022-06-23
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2022.2008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Iris Bombé, Hypotony, and Silicone Oil after Complex Retinal Detachment Surgeries.

    Saleh, Ibrahim / Patel, Monica / Kooner, Karanjit

    Ophthalmology. Glaucoma

    2023  Volume 7, Issue 1, Page(s) 92

    MeSH term(s) Humans ; Retinal Detachment/surgery ; Silicone Oils/adverse effects ; Iris Diseases ; Intraocular Pressure ; Iris
    Chemical Substances Silicone Oils
    Language English
    Publishing date 2023-11-30
    Publishing country United States
    Document type Journal Article
    ISSN 2589-4196
    ISSN (online) 2589-4196
    DOI 10.1016/j.ogla.2023.10.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Treatment Approach to Adenocarcinoma of the Ampulla of Vater.

    Patel, Monica / Uboha, Nataliya V

    Current treatment options in oncology

    2021  Volume 22, Issue 11, Page(s) 103

    Abstract: Opinion statement: ACs are rare tumors, and thus, there is a lack of prospective trials supporting treatment decisions. Moreover, although anatomically uniform, ACs comprise of biologically distinct entities, depending on what cell type they arise from. ...

    Abstract Opinion statement: ACs are rare tumors, and thus, there is a lack of prospective trials supporting treatment decisions. Moreover, although anatomically uniform, ACs comprise of biologically distinct entities, depending on what cell type they arise from. This makes the interpretation of limited data even more challenging. Overall, the clinical outcomes of patients with AC are better than those with pancreatic cancer. However, recurrence rates remain high after curative resection. Despite the absence of definitive evidence, we believe that these high recurrence rates are a rational justification for consideration of adjuvant therapy in resected disease, and therapy selection should take tumor biology, stage, resection margins, as well as patient comorbidities and performance status into account. Largely extrapolating from pancreas cancer, we recommend consideration of adjuvant chemotherapy with 6 months of dose-modified FOLFIRINOX in fit patients with pancreatobiliary subtype tumors. Alternative regimens include gemcitabine in combination with capecitabine. If chemoradiotherapy is being added, 6 weeks of radiotherapy in conjunction with 5-FU or capecitabine can be considered. For intestinal subtypes, we recommend 3-6 months of adjuvant FOLFOX. Future studies are needed to evaluate the role of contemporary, multi-agent chemotherapy and chemoradiotherapy in patients with resected and advanced ampullary adenocarcinoma. However, the logistics of performing large randomized trials in patients with a rare cancer is challenging, and the data collection, even in a carefully designed study, would likely take many years. As such, relying on data from basket trials and retrospective analysis will likely serve as guidance for treatment decisions in the near future. Treatment of metastatic disease should employ regimens that are typically used to treat pancreas cancer for tumors of pancreatobiliary subtype and 5-FU-based regimens for intestinal subtypes. Studies specific for patients with advanced AC are much needed. Molecular testing using next-generation sequencing and testing for microsatellite instability (MSI) should be performed on all tumors. We now have disease agnostic options based on these results. Pembrolizumab is approved for MSI-H tumors and tumors with high tumor mutational burden regardless of the primary site. Larotrectinib is approved for tumors with NTRK fusions. At a time when numerous therapeutic agents are in development, for example, those targeting specific K-RAS alterations or NRG fusions, identifying molecular aberrations can significantly impact patient outcomes as well as provide further insights into the biology of disease. In addition, based on recent data suggesting a significant prevalence of germline alterations in patients with ampullary tumors, referral to genetics counselors and germline testing is warranted in a significant proportion of patients with AC.
    MeSH term(s) Adenocarcinoma/diagnosis ; Adenocarcinoma/etiology ; Adenocarcinoma/mortality ; Adenocarcinoma/therapy ; Ampulla of Vater/pathology ; Clinical Decision-Making ; Combined Modality Therapy/adverse effects ; Combined Modality Therapy/methods ; Common Bile Duct Neoplasms/diagnosis ; Common Bile Duct Neoplasms/etiology ; Common Bile Duct Neoplasms/mortality ; Common Bile Duct Neoplasms/therapy ; Disease Management ; Disease Susceptibility ; Humans ; Prognosis ; Treatment Outcome
    Language English
    Publishing date 2021-09-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057351-0
    ISSN 1534-6277 ; 1527-2729
    ISSN (online) 1534-6277
    ISSN 1527-2729
    DOI 10.1007/s11864-021-00894-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Investigating selectivity and bias for G protein subtypes and β-arrestins by synthetic cannabinoid receptor agonists at the cannabinoid CB

    Ryalls, Beth / Patel, Monica / Sparkes, Eric / Banister, Samuel D / Finlay, David B / Glass, Michelle

    Biochemical pharmacology

    2024  Volume 222, Page(s) 116052

    Abstract: The cannabinoid ... ...

    Abstract The cannabinoid CB
    MeSH term(s) Cannabinoid Receptor Agonists/pharmacology ; Cannabinoid Receptor Agonists/metabolism ; beta-Arrestins/metabolism ; Receptors, Cannabinoid/metabolism ; beta-Arrestin 1/metabolism ; Ligands ; GTP-Binding Proteins/metabolism ; Cannabinoids/pharmacology ; Receptor, Cannabinoid, CB1/metabolism ; Receptor, Cannabinoid, CB2/metabolism
    Chemical Substances Cannabinoid Receptor Agonists ; beta-Arrestins ; Receptors, Cannabinoid ; beta-Arrestin 1 ; Ligands ; GTP-Binding Proteins (EC 3.6.1.-) ; Cannabinoids ; Receptor, Cannabinoid, CB1 ; Receptor, Cannabinoid, CB2
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 208787-x
    ISSN 1873-2968 ; 0006-2952
    ISSN (online) 1873-2968
    ISSN 0006-2952
    DOI 10.1016/j.bcp.2024.116052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Training partnerships between United States and Indian eye institutions.

    Kalva, Praneeth / Patel, Monica D / Kakkilaya, Akash / Kooner, Karanjit S

    Indian journal of ophthalmology

    2023  Volume 71, Issue 3, Page(s) 1048

    MeSH term(s) Humans ; United States ; India ; Internationality ; Academies and Institutes
    Language English
    Publishing date 2023-03-21
    Publishing country India
    Document type Letter
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/IJO.IJO_2984_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Fusobacterium nucleatum: More Than Just an Oral Anaerobe.

    Patel, Akash / Patel, Monica / Glowacki, Joseph

    Cureus

    2022  Volume 14, Issue 7, Page(s) e26989

    Abstract: Fusobacterium ... ...

    Abstract Fusobacterium nucleatum
    Language English
    Publishing date 2022-07-18
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.26989
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Molecular Targets and Therapies for Ampullary Cancer.

    Patel, Monica Arun / Kratz, Jeremy D / Carlson, Alexander S / Ascencio, Ysaith Orellana / Kelley, Broc S / LoConte, Noelle K

    Journal of the National Comprehensive Cancer Network : JNCCN

    2024  , Page(s) 1–8

    Abstract: Ampullary carcinomas are rare but increasing in incidence. Ampullary cancers have molecular alterations that guide choice of therapy, particularly in nonresectable cases. These alterations can be more common by subtype (intestinal, pancreaticobiliary, or ...

    Abstract Ampullary carcinomas are rare but increasing in incidence. Ampullary cancers have molecular alterations that guide choice of therapy, particularly in nonresectable cases. These alterations can be more common by subtype (intestinal, pancreaticobiliary, or mixed), and next-generation sequencing is recommended for all patients who cannot undergo surgery. In this article, we review the approach to tissue acquisition and consideration for molecular testing. Common molecular targets of interest in ampullary cancer are also discussed in this review, including HER2/ERBB2, HER3, tumor mutational burden, microsatellite instability, KRAS, and germline BRCA and ATM mutations, along with emerging and rarer alterations.
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2250759-0
    ISSN 1540-1413 ; 1540-1405
    ISSN (online) 1540-1413
    ISSN 1540-1405
    DOI 10.6004/jnccn.2023.7051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Evaluating signaling bias for synthetic cannabinoid receptor agonists at the cannabinoid CB

    Patel, Monica / Grimsey, Natasha L / Banister, Samuel D / Finlay, David B / Glass, Michelle

    Pharmacology research & perspectives

    2023  Volume 11, Issue 6, Page(s) e01157

    Abstract: The rapid structural evolution and emergence of novel synthetic cannabinoid receptor agonists (SCRAs) in the recreational market remains a key public health concern. Despite representing one of the largest classes of new psychoactive substances, ... ...

    Abstract The rapid structural evolution and emergence of novel synthetic cannabinoid receptor agonists (SCRAs) in the recreational market remains a key public health concern. Despite representing one of the largest classes of new psychoactive substances, pharmacological data on new SCRAs is limited, particularly at the cannabinoid CB
    MeSH term(s) Humans ; Cannabinoid Receptor Agonists/pharmacology ; Cannabinoid Receptor Agonists/chemistry ; Receptors, Cannabinoid ; Ligands ; HEK293 Cells ; Cannabinoids/pharmacology
    Chemical Substances Cannabinoid Receptor Agonists ; Receptors, Cannabinoid ; Ligands ; Cannabinoids
    Language English
    Publishing date 2023-11-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2740389-0
    ISSN 2052-1707 ; 2052-1707
    ISSN (online) 2052-1707
    ISSN 2052-1707
    DOI 10.1002/prp2.1157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Quantification of vascular morphology in optical coherence tomography angiography in primary open angle glaucoma.

    Kalva, Praneeth / Akram, Rubeel / Mekala, Priya / Patel, Monica / Suresh, Sruthi / Kooner, Karanjit S

    Advances in ophthalmology practice and research

    2023  Volume 3, Issue 3, Page(s) 119–125

    Abstract: Purpose: To quantitatively measure and compare the vascular morphology in healthy eyes and eyes with primary open-angle glaucoma (POAG) using optical coherence tomography angiography (OCTA) scans.: Methods: This is a retrospective and cross-sectional ...

    Abstract Purpose: To quantitatively measure and compare the vascular morphology in healthy eyes and eyes with primary open-angle glaucoma (POAG) using optical coherence tomography angiography (OCTA) scans.
    Methods: This is a retrospective and cross-sectional study which include healthy individuals and individuals with POAG that underwent OCTA imaging at an academic center's glaucoma clinic. We analyzed OCTA scans of the macula and optic nerve head (ONH) of one eye from each subject to quantitatively measure vessel density (VD), vessel length density (VLD), and branchpoint density (BPD). We compared these 3 parameters between the healthy and POAG groups and used logistic regression classification models to determine their diagnostic value in differentiating healthy and glaucomatous eyes.
    Results: We included 49 healthy subjects and 49 subjects with POAG. After age-adjusted analysis, the parameters of VD, VLD, and BPD were significantly reduced in eyes with POAG (
    Conclusions: We found that VD, VLD, and BPD were reduced in glaucomatous eyes. The morphologic parameters of VLD and BPD had similar performances to the traditional parameter of VD in RPC layers. Our results suggest that vascular morphology parameters may provide additional value in the diagnosis and evaluation of glaucoma.
    Language English
    Publishing date 2023-05-12
    Publishing country United States
    Document type Journal Article
    ISSN 2667-3762
    ISSN (online) 2667-3762
    DOI 10.1016/j.aopr.2023.05.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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