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  1. AU="Patel, Mrinal"
  2. AU="Louis Chauvel"
  3. AU="Jampen, Laurent"
  4. AU="Tan, Jiacheng"
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  1. Article ; Online: Aneurysms of Aortic Sinus of Valsalva Dissecting through the Interventricular Septum With Rupture into the Left Ventricle: Case Series and Literature Review.

    Patel, Mrinal / Patel, Kartik / Gajjar, Trushar / Mishra, Amit

    World journal for pediatric & congenital heart surgery

    2024  Volume 15, Issue 3, Page(s) 340–348

    Abstract: Aneurysm of Aortic sinus of Valsalva (ASOV) dissecting into the interventricular septum (IVS) and rupturing into the left ventricle (LV) is a rare clinical diagnosis. Systemic inflammatory diseases like tuberculosis can aggravate this condition. We ... ...

    Abstract Aneurysm of Aortic sinus of Valsalva (ASOV) dissecting into the interventricular septum (IVS) and rupturing into the left ventricle (LV) is a rare clinical diagnosis. Systemic inflammatory diseases like tuberculosis can aggravate this condition. We describe three cases of ASOV dissecting into the IVS and rupturing into the LV. All three patients underwent surgical intervention; two had a successful outcome. A literature review was conducted and19 previously reported cases were studied. The extent and direction of septal dissection determined the associated cardiac valvular and rhythm problems. Patch closure of the mouth of the aneurysm is the surgical method of choice. In the presence of multiple sinus tracts or if there is recurrence after surgical closure, aortic sinus or root replacement techniques have better outcomes.
    MeSH term(s) Humans ; Sinus of Valsalva/surgery ; Sinus of Valsalva/diagnostic imaging ; Male ; Ventricular Septum/surgery ; Aortic Dissection/surgery ; Aortic Dissection/complications ; Aortic Dissection/diagnosis ; Female ; Heart Ventricles/surgery ; Aortic Aneurysm/surgery ; Aortic Aneurysm/diagnostic imaging ; Aortic Aneurysm/complications ; Aortic Rupture/surgery ; Aortic Rupture/complications ; Echocardiography ; Cardiac Surgical Procedures/methods ; Child
    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Journal Article ; Case Reports ; Review
    ZDB-ID 2550261-X
    ISSN 2150-136X ; 2150-1351
    ISSN (online) 2150-136X
    ISSN 2150-1351
    DOI 10.1177/21501351241241322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Insights into nanomechanical behavior of B. mori silk fibroin-hydroxyapatite bio-nanocomposite using MD simulations: Role of varying hydroxyapatite content.

    Patel, Mrinal / Singh, Satinder Paul / Dubey, Devendra K

    Journal of the mechanical behavior of biomedical materials

    2023  Volume 147, Page(s) 106125

    Abstract: Nanocomposite material composed of Bombyx mori Silk Fibroin and hydroxyapatite (B. mori SF-HA) is a potential biomaterial for bone tissue engineering. Here, Bombyx mori Silk Fibroin (B. mori SF) is a flexible and tough organic, polymer phase, and ... ...

    Abstract Nanocomposite material composed of Bombyx mori Silk Fibroin and hydroxyapatite (B. mori SF-HA) is a potential biomaterial for bone tissue engineering. Here, Bombyx mori Silk Fibroin (B. mori SF) is a flexible and tough organic, polymer phase, and hydroxyapatite (HA) is hard and stiff mineral phase. Knowledge about mechanical deformation behavior together with governing mechanisms, and the role of the two phases (SF and HA phase) and interfacial interactions between them, in B. mori SF-HA biomaterial, at fundamental level is an important factor to consider while developing the tissue grafts. Such nanometer scale behavior is often preferably investigated using molecular dynamics method. Present study aims at understanding the mechanical deformation behavior and associated physical mechanisms in B. mori SF-HA bio-nanocomposite, at nanoscale. For this purpose, computational atomistic models of B. mori SF-HA bio-nanocomposite are developed with varying HA content. Mechanical behavior analysis of these composite models under tensile loading were performed using Molecular Dynamics (MD) simulations. Elastic modulus and tensile strength values in the range of 7-20 GPa and 200-700 MPa, respectively, are obtained for B. mori SF-HA composite, in case of different HA contents, wherein, increased mechanical properties are observed with increase in HA content. Analyses of the deformation trajectories show that the deformation flow behavior in B. mori SF-HA bio-nanocomposites is mainly defined by the soft SF phase. However, energetics analyses show that, the HA phase and SF-HA interfacial interactions also play a considerable role in mechanical performance of B. mori SF-HA bio-nanocomposite. Additionally, interfacial shear strength values in B. mori SF-HA bio-nanocomposite, for different HA contents, have also been obtained. The observations made and insights gained in present work has contribution and impact in gaining an insight into the mechanistic interactions occurring at nanoscale between SF and HA phases in B. mori SF-HA bio-composite.
    MeSH term(s) Animals ; Fibroins ; Durapatite ; Molecular Dynamics Simulation ; Biocompatible Materials ; Bombyx ; Nanocomposites ; Silk
    Chemical Substances Fibroins (9007-76-5) ; Durapatite (91D9GV0Z28) ; Biocompatible Materials ; Silk
    Language English
    Publishing date 2023-09-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2378381-3
    ISSN 1878-0180 ; 1751-6161
    ISSN (online) 1878-0180
    ISSN 1751-6161
    DOI 10.1016/j.jmbbm.2023.106125
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  3. Article ; Online: Molecular mechanics and failure mechanisms in B. mori Silk Fibroin-hydroxyapatite composite interfaces: Effect of crystal thickness and surface characteristics.

    Patel, Mrinal / Dubey, Devendra K / Singh, Satinder Paul

    Journal of the mechanical behavior of biomedical materials

    2023  Volume 143, Page(s) 105910

    Abstract: Bombyx mori Silk Fibroin-hydroxyapatite (B. mori SF-HA) bio-nanocomposite is a prospective biomaterial for tissue engineered graft for bone repair. Here, B. mori SF is primarily a soft and tough organic phase, and HA is a hard and stiff mineral phase. In ...

    Abstract Bombyx mori Silk Fibroin-hydroxyapatite (B. mori SF-HA) bio-nanocomposite is a prospective biomaterial for tissue engineered graft for bone repair. Here, B. mori SF is primarily a soft and tough organic phase, and HA is a hard and stiff mineral phase. In biomaterial design, an understanding about the nanoscale mechanics of SF-HA interface, such as interfacial interaction and interface debonding mechanisms between the two phases is essential for obtaining required functionality. To investigate such nanoscale behavior, molecular dynamics method is a preferred approach. Present study focuses on understanding of the interface debonding mechanisms at SF-HA interface in B. mori SF-HA bio-nanocomposite at nanometer length scale. For this purpose, nanoscale atomistic models of SF-HA interface are also developed based on the HA crystal size and HA surface type (Ca
    MeSH term(s) Animals ; Fibroins/chemistry ; Durapatite/chemistry ; Molecular Dynamics Simulation ; Prospective Studies ; Biocompatible Materials/metabolism ; Bombyx/chemistry ; Bombyx/metabolism ; Nanocomposites ; Silk/chemistry
    Chemical Substances Fibroins (9007-76-5) ; Durapatite (91D9GV0Z28) ; Biocompatible Materials ; Silk
    Language English
    Publishing date 2023-05-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2378381-3
    ISSN 1878-0180 ; 1751-6161
    ISSN (online) 1878-0180
    ISSN 1751-6161
    DOI 10.1016/j.jmbbm.2023.105910
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Aortic Origin of a Branch Pulmonary Artery: Early and Mid-Term Single Center Outcomes.

    Patel, Herin / Malhotra, Pulkit / Patel, Kartik / Patel, Mrinal / Gajjar, Trushar / Mishra, Amit / Sheth, Megha

    World journal for pediatric & congenital heart surgery

    2024  Volume 15, Issue 3, Page(s) 365–370

    Abstract: Background: Anomalous origin of pulmonary artery (AOPA) is a rare congenital cardiac anomaly. It requires early surgical intervention (<6 months) to prevent irreversible pulmonary vaso-occlusive disease. This study was conducted to determine the ... ...

    Abstract Background: Anomalous origin of pulmonary artery (AOPA) is a rare congenital cardiac anomaly. It requires early surgical intervention (<6 months) to prevent irreversible pulmonary vaso-occlusive disease. This study was conducted to determine the surgical outcomes of this rare and intriguing anomaly.
    Methods: From January 2015 to 2022, we have studied, 20 patients who underwent surgical correction for this anomaly with a mean age of 6.25 ± 3.7 months. There were 12 patients of <6 months of age. Their preoperative, intraoperative, and postoperative data were collected. They were followed up at every three months for the first year, every six months for two years, and then annually.
    Results: Among three early mortalities, two were operated before six months of age and one was older than six months (ten months). Those patients presented after six months had longer ventilation time (
    Conclusion: Surgical correction of AOPA in patients beyond six months is still feasible with a higher early morbidity and comparable mortality with good clinical and echocardiographical outcomes at mid-term follow-up.
    MeSH term(s) Humans ; Pulmonary Artery/surgery ; Pulmonary Artery/abnormalities ; Infant ; Female ; Male ; Retrospective Studies ; Treatment Outcome ; Heart Defects, Congenital/surgery ; Heart Defects, Congenital/mortality ; Cardiac Surgical Procedures/methods ; Follow-Up Studies ; Time Factors ; Aorta, Thoracic/surgery ; Aorta, Thoracic/abnormalities
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2550261-X
    ISSN 2150-136X ; 2150-1351
    ISSN (online) 2150-136X
    ISSN 2150-1351
    DOI 10.1177/21501351231221467
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Subpulmonary pseudoaneurysm-a rare complication following surgical ventricular septal defect closure.

    Patel, Mrinal / Patel, Kartik / Gajjar, Trushar

    Indian journal of thoracic and cardiovascular surgery

    2022  Volume 38, Issue 5, Page(s) 525–529

    Abstract: In this report, we describe the surgical management of a subpulmonary pseudoaneurysm following surgical closure of ventricular septal defect in an infant. Diagnosis, pathogenesis, and surgical considerations for management of this complication are ... ...

    Abstract In this report, we describe the surgical management of a subpulmonary pseudoaneurysm following surgical closure of ventricular septal defect in an infant. Diagnosis, pathogenesis, and surgical considerations for management of this complication are discussed.
    Language English
    Publishing date 2022-05-18
    Publishing country India
    Document type Case Reports
    ZDB-ID 2164386-6
    ISSN 0973-7723 ; 0970-9134
    ISSN (online) 0973-7723
    ISSN 0970-9134
    DOI 10.1007/s12055-022-01366-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Aortic valve replacement for moderate aortic stenosis during mitral surgery improves survival free from severe stenosis.

    Weingarten, Noah / Rekhtman, David / Iyengar, Amit / Song, Cindy / Patel, Mrinal / Atluri, Pavan

    Asian cardiovascular & thoracic annals

    2023  Volume 31, Issue 6, Page(s) 475–482

    Abstract: Background: Optimal management of moderate aortic stenosis during surgery for another indication is unclear. We assessed the effects of surgical aortic valve replacement for moderate aortic stenosis during mitral surgery.: Methods: An institutional ... ...

    Abstract Background: Optimal management of moderate aortic stenosis during surgery for another indication is unclear. We assessed the effects of surgical aortic valve replacement for moderate aortic stenosis during mitral surgery.
    Methods: An institutional mitral surgery database was queried for patients with preoperative moderate aortic stenosis. Patients were stratified by whether they underwent concomitant surgical aortic valve replacement. Morbidity was analyzed using Student's
    Results: Of 85 mitral surgery recipients with moderate aortic stenosis from 2012 to 2019, 62 (73%) underwent concomitant surgical aortic valve replacement. Surgical aortic valve replacement recipients were more likely to have bicuspid (11% vs. 0%,
    Conclusions: Surgical aortic valve replacement for moderate aortic stenosis at time of mitral surgery is a well-tolerated strategy to reduce aortic disease progression.
    MeSH term(s) Humans ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Constriction, Pathologic/complications ; Constriction, Pathologic/surgery ; Mitral Valve Insufficiency/surgery ; Heart Valve Prosthesis Implantation ; Treatment Outcome ; Retrospective Studies ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Aortic Valve Stenosis/complications
    Language English
    Publishing date 2023-07-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1400468-9
    ISSN 1816-5370 ; 0218-4923
    ISSN (online) 1816-5370
    ISSN 0218-4923
    DOI 10.1177/02184923231186850
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5193: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Short stature is a risk factor for heart transplant morbidity and mortality.

    Weingarten, Noah / Iyengar, Amit / Patel, Mrinal / Kim, Samuel T / Shin, Max / Atluri, Pavan

    Asian cardiovascular & thoracic annals

    2023  Volume 31, Issue 8, Page(s) 682–690

    Abstract: Background: Short stature is associated with mortality after cardiac surgery and may increase size mismatch risk among transplant recipients. Yet, stature's impact on heart transplant outcomes is not well-characterized.: Methods: The Scientific ... ...

    Abstract Background: Short stature is associated with mortality after cardiac surgery and may increase size mismatch risk among transplant recipients. Yet, stature's impact on heart transplant outcomes is not well-characterized.
    Methods: The Scientific Registry of Transplant Recipients was queried for data on all adult heart transplants in the United States from 2000 to 2022. Recipients were stratified into five cohorts by sex-corrected stature. Morbidity was assessed with Kruskal-Wallis and chi-squared tests. Mortality was analyzed using Kaplan-Meier estimation. Risk factors for mortality were assessed with multivariable Cox regression.
    Results: Among 43,420 transplant recipients, 5321 (12.2%) had short stature (females >4'11″ & ≤5'1″; males >5'4″ & ≤5'7″) and 765 (1.8%) had very short stature (females ≤4'11″; males ≤5'4″). Very short stature patients had higher waitlist status (1A and 1), more congenital heart disease, and received more oversized donor hearts than other cohorts (all
    Conclusions: Short stature confers increased mortality risk for heart transplant recipients and merits inclusion in prognostic models.
    MeSH term(s) Adult ; Male ; Female ; Humans ; United States/epidemiology ; Heart Transplantation/adverse effects ; Tissue Donors ; Proportional Hazards Models ; Risk Factors ; Heart Defects, Congenital ; Retrospective Studies ; Registries
    Language English
    Publishing date 2023-09-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1400468-9
    ISSN 1816-5370 ; 0218-4923
    ISSN (online) 1816-5370
    ISSN 0218-4923
    DOI 10.1177/02184923231197691
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5193: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Center Volume Predicts Improved Early Outcomes in Multiorgan Heart Transplantation.

    Song, Cindy / Weingarten, Noah / Rekhtman, David / Iyengar, Amit / Patel, Mrinal / Herbst, David Alan / Helmers, Mark / Cevasco, Marisa / Atluri, Pavan

    Transplantation proceedings

    2024  Volume 56, Issue 1, Page(s) 135–144

    Abstract: Purpose: Center volume is associated with improved survival after isolated heart transplant, but its impact on multiorgan heart transplant (MHT) outcomes is unknown. This study examines the impact of institutional MHT volume on MHT outcomes.: Methods!# ...

    Abstract Purpose: Center volume is associated with improved survival after isolated heart transplant, but its impact on multiorgan heart transplant (MHT) outcomes is unknown. This study examines the impact of institutional MHT volume on MHT outcomes.
    Methods: Adult patients undergoing first time MHT from 2011 to 2021 were identified in the United Network for Organ Sharing database. Transplant centers were annually classified as low-, medium-, or high-volume if they performed <3, 3 to 5, or ≥6 MHTs that year, respectively. Graft failure was defined as death, failure, or re-transplantation of any allograft.
    Results: A total of 1860 MHTs were performed at 104 centers, including 482 (26%) at low-, 601 (32%) at medium-, and 777 (42%) at high-MHT volume centers. Noncardiac allografts included kidney (83%), liver (16%), and lung (2%). The proportion of MHTs performed at high-volume centers increased from 10% in 2011 to 62% in 2021. Recipient age, race, and body mass index did not vary by center volume (all P > .05). Patients at high-volume centers were more likely to be in the intensive care unit pre-transplant (58% vs 44%, P < .001) and have shorter waitlist times (47 vs 92 days, P < .001) than those at low-volume centers. 30-day graft survival was higher in combined medium- and high-volume compared with low-volume centers (95% vs 92%, P = .004). Increasing center MHT volume was protective against 30-day graft failure (adjusted hazard ratio 0.93 [0.88-0.98]) on multivariate Cox regression.
    Conclusions: Higher MHT volume is associated with improved early graft survival after MHT, which may justify centralizing the performance of MHTs to high-volume centers.
    MeSH term(s) Adult ; Humans ; Treatment Outcome ; Retrospective Studies ; Transplantation, Homologous ; Kidney Transplantation ; Graft Survival ; Heart Transplantation/adverse effects
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2023.11.001
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 835: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Investigations into the role of water concentration on mechanical behavior and nanomechanics of Bombyx mori silk fibroin using molecular dynamics simulations

    Patel, Mrinal / Dubey, Devendra K / Singh, Satinder Paul

    Journal of materials science. 2020 Dec., v. 55, no. 36

    2020  

    Abstract: Bombyx mori silk fibroin (B. mori SF) is emerging as a promising biomaterial for its application in biomedical field such as hard and soft tissue engineered grafts considering it is a load-bearing polymer with biocompatible and biodegradable ... ...

    Abstract Bombyx mori silk fibroin (B. mori SF) is emerging as a promising biomaterial for its application in biomedical field such as hard and soft tissue engineered grafts considering it is a load-bearing polymer with biocompatible and biodegradable characteristics. B. mori SF being a biopolymer is made up of amino acids (residues) comprising crystalline and amorphous domains at nanoscale. In general, mechanical behavior of a biomaterial is actively governed by its chemical environment. Extent of water present in silk can significantly affect its mechanical behavior and alter structural functions at the molecular level. Hence, it is essential to understand the mechanical behavior and molecular deformation mechanics of B. mori SF at the building block level under varying hydration conditions. In current investigation, tensile mechanical behavior of two characteristic computational models of B. mori SF, along the fiber axis, under varying hydration levels (0 to 70 wt%) has been studied using molecular dynamics simulations. Elastic modulus values in the range of 7 to 11 GPa and 8 to 13 GPa were obtained for the two models for varying hydration levels. Analyses reveal that the hydrophobic effect has a dominating role at lower hydration levels resulting in an enhanced interaction between protein chains. This results in mechanical strengthening of B. mori SF nanostructure. However, at higher hydration levels, the osmotic pressure plays a dominating role, resulting into screening of interatomic interaction between protein chains thus giving a weakening effect. Overall, this work contributes toward developing an understanding of mechanistic interactions between different protein phases (amorphous and crystalline regions) and water in hydrated B. mori SF nanostructure, which is useful for explorations in silk-based biomaterials.
    Keywords Bombyx mori ; biocompatible materials ; biodegradability ; biopolymers ; deformation ; fibroins ; hydrophobicity ; mechanical properties ; modulus of elasticity ; molecular dynamics ; osmotic pressure ; silk ; tissues
    Language English
    Dates of publication 2020-12
    Size p. 17019-17045.
    Publishing place Springer US
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2015305-3
    ISSN 1573-4803 ; 0022-2461
    ISSN (online) 1573-4803
    ISSN 0022-2461
    DOI 10.1007/s10853-020-05249-3
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Cor Triatriatum Dexter: A Rare Cause of Aneurysmal Right Atrium.

    Patel, Mrinal / Vaidhya, Nikunj / Patel, Kartik / Sheth, Megha / Mishra, Amit

    World journal for pediatric & congenital heart surgery

    2021  Volume 13, Issue 2, Page(s) 253–256

    Abstract: Cor triatriatum dexter (CTD) is a rare congenital cardiac anomaly with a diverse presentation in every age group. We report a case of CTD in a 36-year-old female who presented with palpitations due to giant right atrium (RA), which we managed ... ...

    Abstract Cor triatriatum dexter (CTD) is a rare congenital cardiac anomaly with a diverse presentation in every age group. We report a case of CTD in a 36-year-old female who presented with palpitations due to giant right atrium (RA), which we managed successfully with surgical excision of the membrane and RA reduction.
    MeSH term(s) Adult ; Arrhythmias, Cardiac ; Cor Triatriatum/diagnosis ; Cor Triatriatum/diagnostic imaging ; Female ; Heart Atria/abnormalities ; Heart Atria/diagnostic imaging ; Heart Atria/surgery ; Humans
    Language English
    Publishing date 2021-10-14
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2550261-X
    ISSN 2150-136X ; 2150-1351
    ISSN (online) 2150-136X
    ISSN 2150-1351
    DOI 10.1177/21501351211036648
    Database MEDical Literature Analysis and Retrieval System OnLINE

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