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  1. Article ; Online: Cerebral Autoregulation in Healthy Term Newborns: Brief Report.

    Patel, Namrata D / Batra, Maneesh / Udomphorn, Yuthana / Wainwright, Mark / Vavilala, Monica S

    Pediatric neurology

    2022  Volume 135, Page(s) 4–5

    MeSH term(s) Blood Flow Velocity ; Blood Pressure ; Cerebrovascular Circulation/physiology ; Homeostasis/physiology ; Humans ; Infant, Newborn ; Ultrasonography, Doppler, Transcranial
    Language English
    Publishing date 2022-07-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639164-3
    ISSN 1873-5150 ; 0887-8994
    ISSN (online) 1873-5150
    ISSN 0887-8994
    DOI 10.1016/j.pediatrneurol.2022.07.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Accuracy of Early Neuroprognostication in Pediatric Severe Traumatic Brain Injury.

    Sampat, Varun / Whitinger, John / Flynn-O'Brien, Katherine / Kim, Irene / Balakrishnan, Binod / Mehta, Niyati / Sawdy, Rachel / Patel, Namrata D / Nallamothu, Rupa / Zhang, Liyun / Yan, Ke / Zvara, Kimberley / Farias-Moeller, Raquel

    Pediatric neurology

    2024  Volume 155, Page(s) 36–43

    Abstract: Background: Children with severe traumatic brain injury (sTBI) are at risk for neurological sequelae impacting function. Clinicians are tasked with neuroprognostication to assist in decision-making. We describe a single-center study assessing clinicians' ...

    Abstract Background: Children with severe traumatic brain injury (sTBI) are at risk for neurological sequelae impacting function. Clinicians are tasked with neuroprognostication to assist in decision-making. We describe a single-center study assessing clinicians' neuroprognostication accuracy.
    Methods: Clinicians of various specialties caring for children with sTBI were asked to predict their patients' functioning three to six months postinjury. Clinicians were asked to participate in the study if their patient had survived but not returned to baseline between day 4 and 7 postinjury. The outcome tool utilized was the functional status scale (FSS), ranging from 6 to 30 (best-worst function). Predicted scores were compared with actual scores three to six months postinjury. Lin concordance correlation coefficients were used to estimate agreement between predicted and actual FSS. Outcome was dichotomized as good (FSS 6 to 8) or poor (FSS ≥9). Positive and negative predictive values for poor outcome were calculated. Pessimistic prognostic prediction was defined as predicted worse outcome by ≥3 FSS points. Demographic and clinical variables were collected.
    Results: A total of 107 surveys were collected on 24 patients. Two children died. Fifteen children had complete (FSS = 6) or near-complete (FSS = 7) recovery. Mean predicted and actual FSS scores were 10.8 (S.D. 5.6) and 8.6 (S.D. 4.1), respectively. Predicted FSS scores were higher than actual scores (P < 0.001). Eight children had collective pessimistic prognostic prediction.
    Conclusions: Clinicians predicted worse functional outcomes, despite high percentage of patients with near-normal function at follow-up clinic. Certain patient and provider factors were noted to impact accuracy and need to be studied in larger cohorts.
    Language English
    Publishing date 2024-03-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639164-3
    ISSN 1873-5150 ; 0887-8994
    ISSN (online) 1873-5150
    ISSN 0887-8994
    DOI 10.1016/j.pediatrneurol.2024.03.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Physiological Role of a Multigrain Diet in Metabolic Regulations of Lipid and Antioxidant Profiles in Hypercholesteremic Rats: Multigrain diet in hyperlipemia.

    Vasant, Rupal A / Patel, Namrata D / Karn, Sanjay S / V R L Narasimhacharya, Amaravadi

    Journal of pharmacopuncture

    2015  Volume 17, Issue 2, Page(s) 34–40

    Abstract: Objectives: The objective of the present study was to investigate the lipid and the antioxidant regulatory potential of a multigrain diet in laboratory animals with reference to lipid profiles, tissue lipid peroxidation and antioxidant status.: ... ...

    Abstract Objectives: The objective of the present study was to investigate the lipid and the antioxidant regulatory potential of a multigrain diet in laboratory animals with reference to lipid profiles, tissue lipid peroxidation and antioxidant status.
    Methods: Two types of diets, with or without addition of cholesterol, were used in the study - a commercial diet and a formulated multigrain diet (with Sorghum vulgare, Avena sativa, Pennisetum typhoideum, Oryza sativa, Eleusine coracana and Zea mays grains). After a 10-week period of feeding the diets to albino rats the plasma, liver and fecal lipid profiles and the hepatic and renal antioxidant status of the animals that were fed the commercial and the formulated diets (with and without cholesterol addition) were assessed.
    Results: The commercial diet supplemented with cholesterol elevated the levels of plasma total lipids, total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), and very low-density lipoprotein cholesterol (VLDL-C), as well as the atherogenic index (AI). The high-density lipoprotein cholesterol (HDL-C) content and the antioxidant profiles (total ascorbic acid, superoxide dismutase, catalase, glutathione peroxidase reduced glutathione) declined along with increases in lipid peroxidation. The formulated diet (with and without addition of cholesterol) was found to be more efficient than the commercial diet in controlling plasma, hepatic and fecal lipid profiles, as well as hepatic and renal lipid peroxidation and antioxidant status, than of the hypercholesteremic animals.
    Conclusion: The multigrain diet used in the present study is effective in countering the hyperlipidemia and oxidative stress caused by high cholesterol intake.
    Language English
    Publishing date 2015-03-10
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2747301-6
    ISSN 2234-6856 ; 2093-6966
    ISSN (online) 2234-6856
    ISSN 2093-6966
    DOI 10.3831/KPI.2014.17.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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