Article ; Online: Disease-Associated Mutations in Tau Encode for Changes in Aggregate Structure Conformation.
ACS chemical neuroscience
2023 Volume 14, Issue 24, Page(s) 4282–4297
Abstract: The accumulation of tau fibrils is associated with neurodegenerative diseases, which are collectively termed tauopathies. Cryo-EM studies have shown that the packed fibril core of tau adopts distinct structures in different tauopathies, such as Alzheimer' ...
| Abstract | The accumulation of tau fibrils is associated with neurodegenerative diseases, which are collectively termed tauopathies. Cryo-EM studies have shown that the packed fibril core of tau adopts distinct structures in different tauopathies, such as Alzheimer's disease, corticobasal degeneration, and progressive supranuclear palsy. A subset of tauopathies are linked to missense mutations in the tau protein, but it is not clear whether these mutations impact the structure of tau fibrils. To answer this question, we developed a high-throughput protein purification platform and purified a panel of 37 tau variants using the full-length 0N4R splice isoform. Each of these variants was used to create fibrils |
|---|---|
| MeSH term(s) | Humans ; tau Proteins/metabolism ; Tauopathies/metabolism ; Alzheimer Disease/metabolism ; Mutation/genetics |
| Chemical Substances | tau Proteins |
| Language | English |
| Publishing date | 2023-12-06 |
| Publishing country | United States |
| Document type | Journal Article |
| ISSN | 1948-7193 |
| ISSN (online) | 1948-7193 |
| DOI | 10.1021/acschemneuro.3c00422 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Inter-library loan at ZB MED
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.