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Article ; Online: Flavonol dioxygenase chemistry mediated by a synthetic nickel superoxide.

Khamespanah, F / Patel, N M / Forney, A K / Heitger, D R / Amarasekarage, C M / Springer, L E / Belecki, K / Lucas, H R

2022 Volume 238, Page(s) 112021

Abstract: Nature exploits transition metal centers to enhance and tune the oxidizing power of natural oxidants such as ... ...

Abstract	Nature exploits transition metal centers to enhance and tune the oxidizing power of natural oxidants such as O
MeSH term(s)	Nickel/chemistry ; Superoxides ; Quercetin ; Hydrogen Peroxide ; Dioxygenases/chemistry ; Flavonols/chemistry ; Oxygen/chemistry
Chemical Substances	Nickel (7OV03QG267) ; Superoxides (11062-77-4) ; Quercetin (9IKM0I5T1E) ; Hydrogen Peroxide (BBX060AN9V) ; Dioxygenases (EC 1.13.11.-) ; Flavonols ; Oxygen (S88TT14065)
Language	English
Publishing date	2022-10-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	162843-4
ISSN	1873-3344 ; 0162-0134
ISSN (online)	1873-3344
ISSN	0162-0134
DOI	10.1016/j.jinorgbio.2022.112021
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Article ; Online: Hiding in Plain Sight: A Case of Ornithine Transcarbamylase Deficiency Unmasked Post-Liver Transplantation.

Ramanathan, M / Uppalapu, S / Patel, N M

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2017 Volume 17, Issue 5, Page(s) 1405–1408

Abstract: Ornithine transcarbamylase deficiency represents the most common inherited defect of the urea cycle. This enzyme, predominantly found in the liver, plays a crucial role in recycling free ammonia, with deficiencies often leading to fatal complications. ... ...

Abstract	Ornithine transcarbamylase deficiency represents the most common inherited defect of the urea cycle. This enzyme, predominantly found in the liver, plays a crucial role in recycling free ammonia, with deficiencies often leading to fatal complications. Here, we present the case of a 63-year-old man with alcoholic cirrhosis who underwent orthotopic liver transplantation, gradual worsening of his mental status, and progressive elevation of ammonia levels. Liver allograft function was deemed normal, raising concern for a donor-derived metabolic disorder of the urea cycle. Evaluation of the donor patient's blood revealed that the donor was heterozygous for the OTC gene. Posttransplantation changes in mental status should prompt a clinician to consider the most likely causes; however, once these have been ruled out, it is important to consider the less common causes of metabolic derangements. The rarity of these disorders makes expertise of diagnosis, standardization of evaluation, and treatment strategies challenging.
MeSH term(s)	Brain Edema/enzymology ; Brain Edema/etiology ; Humans ; Hyperammonemia/enzymology ; Hyperammonemia/etiology ; Liver Transplantation/adverse effects ; Male ; Middle Aged ; Ornithine Carbamoyltransferase/metabolism ; Ornithine Carbamoyltransferase Deficiency Disease/complications ; Prognosis ; Tissue Donors ; Transplantation, Homologous
Chemical Substances	Ornithine Carbamoyltransferase (EC 2.1.3.3)
Language	English
Publishing date	2017-02-06
Publishing country	United States
Document type	Case Reports
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1111/ajt.14174
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Article ; Online: A systematic review update of a single-gene etiology theory for Adolescent Idiopathic Scoliosis.

Maqsood, A / Frome, D K / Gibly, R F / Larson, J E / Patel, N M / Sarwark, J F

Studies in health technology and informatics

2021 Volume 280, Page(s) 250

MeSH term(s)	Adolescent ; Causality ; Humans ; Scoliosis/genetics
Language	English
Publishing date	2021-06-30
Publishing country	Netherlands
Document type	Journal Article ; Systematic Review
ISSN	1879-8365
ISSN (online)	1879-8365
DOI	10.3233/SHTI210480
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Article ; Online: A REVIEW ON INDUSTRIAL SAFETY AND HEALTH

Patel Govind / Patel P.M / Patel N.M

International Journal of Research in Ayurveda and Pharmacy, Vol 2, Iss 5, Pp 1505-

2011 Volume 1509

Abstract: Progress of the industrial safety and occupational health movements in the United States toward their common goal of protecting the physical welfare of workers is discussed in this article. When these activities and workmen's compensation began, about a ... ...

Abstract	Progress of the industrial safety and occupational health movements in the United States toward their common goal of protecting the physical welfare of workers is discussed in this article. When these activities and workmen's compensation began, about a half century ago, it was anticipated that they would be "complementary and mutually sustaining." Besides presenting historical accounts of the safety and health movements, the authors evaluate the current problems and relationships among safety, health, and compensation activities. This article constitutes part of a broader study by the authors to be published under the title "Workmen's Compensation and Occupational Disability." (Author's abstract courtesy EBSCO. This Article will examine that historical perspective, covering both state and federal law, and will comprehensively detail the current law relating to occupational safety and health in the State of Washington.)
Keywords	industrial safety and health ; occupational ; executive. ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R ; DOAJ:Pharmacy and materia medica ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	360
Language	English
Publishing date	2011-05-01T00:00:00Z
Publisher	International Journal of Research in Ayurveda and Pharmacy
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: REVIEW ON QUALITY SAFETY AND LEGISLATION FOR HERBAL PRODUCTS

Patel Vishal / Patel N.M. / Patel P.M.

International Journal of Research in Ayurveda and Pharmacy, Vol 2, Iss 5, Pp 1486-

2011 Volume 1489

Abstract: In the last few decades, there has been exponential growth in the field of herbal medicine. The growing use of botanicals (drug and other products derived from plants) by the public is forcing moves to evaluate the health claims of these agents and to ... ...

Abstract	In the last few decades, there has been exponential growth in the field of herbal medicine. The growing use of botanicals (drug and other products derived from plants) by the public is forcing moves to evaluate the health claims of these agents and to develop standards of quality and manufacture. It is clear that the herbal industry needs to follow strict guidelines and that regulations are needed. This article presents the element of methods of different aspects on quality control and standardization of herbal drugs and formulation. It is followed by international guidelines of WHO for manufacture quality control and evaluation of botanicals. Herbal drugs regulations in India is discussed in detail, followed by an overview of regulatory status of herbal medicine in USA, China, Australia, Brazil, Canada and Germany.
Keywords	Herbal Medicine ; Regulatory Requirements ; WHO. ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R ; DOAJ:Pharmacy and materia medica ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2011-05-01T00:00:00Z
Publisher	International Journal of Research in Ayurveda and Pharmacy
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A REVIEW ON MODIFICATION OF ANALYTICAL TECHNIQUES IN HERBAL RESEARCH

Rathod Shobhen / Patel N.M / Patel P.M

International Journal of Research in Ayurveda and Pharmacy, Vol 2, Iss 5, Pp 1483-

2011 Volume 1485

Abstract: As the demand and commercial value of the Herbal Medicines is increasing tremendously, assurance of safety, quality and efficacy of medicinal plants and herbal products is becoming a crucial issue. The need of the hour is to develop a systematic approach ...

Abstract	As the demand and commercial value of the Herbal Medicines is increasing tremendously, assurance of safety, quality and efficacy of medicinal plants and herbal products is becoming a crucial issue. The need of the hour is to develop a systematic approach and well-designed methodologies for the standardization of herbal raw materials and herbal formulations. Standardization methods should take into consideration all aspects contributing to the quality of the herbal drugs. Herbal Medicines are composed of many constituents and are therefore very capable of variation. Hence it is very important to obtain reliable chromatographic fingerprints that represent pharmacologically active and chemically characteristic components of the Herbal Medicine. The information generated based on this chromatographic pattern has a potential application in the identification of an authentic drug, in excluding the adulterants and in maintaining the quality and consistency of the drug. Several analytical techniques have been developed for obtaining fingerprinting profiles of the herbal medicines and have assured to be a valuable tool for proving constant composition of herbal preparations by establishing relevant criteria for uniformity. This paper deals with the advanced extraction as well as chromatographic techniques with the help of which qualitative and quantitative evaluation of Herbal Medicines and formulations can be carried out. The advancement of analytical techniques is thus bringing a new era of development which will serve as a rapid and tool in the herbal research thereby allowing the manufacturers to set quality standards and specifications so as to seek marketing approval from regulatory authorities.
Keywords	Standardization ; Herbal Medicine ; Chromatographic fingerprinting ; modification. ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R ; DOAJ:Pharmacy and materia medica ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2011-05-01T00:00:00Z
Publisher	International Journal of Research in Ayurveda and Pharmacy
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: WHO GUIDELINES ON QUALITY CONTROL OF HERBAL MEDICINES

Patel N. M. / Patel Parthik / Patel P. M.

International Journal of Research in Ayurveda and Pharmacy, Vol 2, Iss 4, Pp 1148-

2011 Volume 1154

Abstract: This WHO guidelines present general consideration on potentially hazardous contaminants and residues in herbal medicines and include guiding principles of assessing quality of herbal medicines in terms of major contaminants and residues. It also ... ...

Abstract	This WHO guidelines present general consideration on potentially hazardous contaminants and residues in herbal medicines and include guiding principles of assessing quality of herbal medicines in terms of major contaminants and residues. It also recommends analytical methods for qualitative and quantitative determination of such contaminants and residues.Within overall context of quality assurance these guidelines intended to provide general technical guidance to Member state in assessing quality relating to safety of herbal materials and products classified as medicines with regards to major and common contaminants and residues.The objectives of these guidelines are to provide:Guiding principle for assessing the quality in relation to the safety of herbal medicines with specific reference to contaminants and residuesModel criteria for use in identifying possible contaminants and residuesExample of methods and techniques andExample of practical procedures for controlling the quality of finished herbal products.The scope of these guidelines does not cover issues of adulteration of herbal medicines and/or counterfeit products.The annexes to these guidelines present several example of suitable methodologies found in national or regional pharmacopoeias and WHO documents it should be noted that these methods need to be validated for the material that is to be tested and also for each type of instruments.
Keywords	Herbal medicines ; WHO guidelines ; contamination ; residues. ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R ; DOAJ:Pharmacy and materia medica ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	380
Language	English
Publishing date	2011-04-01T00:00:00Z
Publisher	International Journal of Research in Ayurveda and Pharmacy
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Process standardization for the manufacture of Thabdi Peda.

Modha, H M / Patel, N M / Patel, H G / Patel, K N

Journal of food science and technology

2014 Volume 52, Issue 6, Page(s) 3283–3290

Abstract: Traditional dairy products in India are manufactured using age old methods. Such methods varies from place to place. For industrial production of such products a standardized process is needed. Present study was designed to arrive at a method of ... ...

Abstract	Traditional dairy products in India are manufactured using age old methods. Such methods varies from place to place. For industrial production of such products a standardized process is needed. Present study was designed to arrive at a method of manufacture for Thabdi Peda, a very popular sweet in Saurashtra region of Gujarat. Range of process parameters like fat percent of milk (4 to 8 %), rate of sugar addition (6 to 10 %) and duration of final heat desiccation (20 to 60 min) were studied and optimum values determined using Response Surface Methodology (RSM) with central composite rotatable design (CCRD). The samples obtained from trials were analyzed for sensory, physicochemical, compositional and textural attributes. The optimized process developed with 10 kg batch of milk having 6 % fat, 8.33 % rate of sugar addition and 34 min duration of heating produced most acceptable product. Standardized Thabdi Peda was found to contain on an average 16.80 % fat, 17.48 % moisture, 11.25 % protein, 20.95 % lactose, 29.99 % sucrose, 3.53 % ash and it gave 28.75 % yield. The pH, water activity and HMF (μ Mole/100 g) content were 6.42, 0.807 and 121.91 respectively. Standard plate count, Yeast and Mold counts were observed to be 3.68 log cfu/g, and 2.51 log cfu/g respectively. No coliforms were observed in Thabdi Peda.
Language	English
Publishing date	2014-05-02
Publishing country	India
Document type	Journal Article
ZDB-ID	242498-8
ISSN	0975-8402 ; 0022-1155
ISSN (online)	0975-8402
ISSN	0022-1155
DOI	10.1007/s13197-014-1391-x
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Article ; Online: A REVIEW ON REGULATORY ASPECTS OF BIOTECHNOLOGY DERIVED PRODUCT

Modh Nehal M / Patel.P.M / Patel.N.M

International Journal of Research in Ayurveda and Pharmacy, Vol 2, Iss 5, Pp 1495-

2011 Volume 1500

Abstract: Biotechnology-derived pharmaceuticals are a well established and growing part of the therapeutic armamentarium. Beginning with recombinant versions of products such as insulin that were previously manufactured by extraction from animal and human sources, ...

Abstract	Biotechnology-derived pharmaceuticals are a well established and growing part of the therapeutic armamentarium. Beginning with recombinant versions of products such as insulin that were previously manufactured by extraction from animal and human sources, licensed biotechnology drugs and those in development now span an ever-increasing range of product types and therapeutic categories. As a consequence of this diversity, both general and product class-specific scientific guidelines have been developed on a regional (e.g. EU/US) or international (e.g. ICH – International Conference on Harmonization) basis. The current portfolio of nonclinical guidelines, particularly ICH S6, emphasizes flexibility and adaptability to the specific circumstances of the individual biotechnology product and its intended indication, taking into account factors not generally applicable to small-molecule drugs, such as pharmacodynamic responsiveness of safety and efficacy models, species specificity, and antibody formation. Guidelines developed principally with small-molecule drugs in mind may, nevertheless, have some applicability to biotechnology drugs on issues such as safety pharmacology, as well as on regulatory, procedural and dossier submission requirements. Scientific guidelines, such as those providing nonclinical guidance, are just one, albeit important, component of an increasingly complex legal/scientific environment in drug development.
Keywords	Biotechnology ; Regulatory process ; Research and development. ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R ; DOAJ:Pharmacy and materia medica ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2011-05-01T00:00:00Z
Publisher	International Journal of Research in Ayurveda and Pharmacy
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Determination of polyphenols and free radical scavenging activity of Tephrosia purpurea linn leaves (Leguminosae).

Patel, Avani / Patel, Amit / Patel, N M

Pharmacognosy research

2010 Volume 2, Issue 3, Page(s) 152–158

Abstract: Background: Leaves of Tephrosia purpurea Linn. (sarpankh), belonging to the family Leguminaceae, are used for the treatment of jaundice and are also claimed to be effective in many other diseases. This research work was undertaken to investigate the in ... ...

Abstract	Background: Leaves of Tephrosia purpurea Linn. (sarpankh), belonging to the family Leguminaceae, are used for the treatment of jaundice and are also claimed to be effective in many other diseases. This research work was undertaken to investigate the in vitro antioxidant activity of aqueous and ethanolic extracts of the leaves. Method: The therapeutic effects of tannins and flavonoids can be largely attributed to their antioxidant properties. So, the quantitative determinations were undertaken. All the methods are based on UV-spectrophotometric determination. Result: The total phenolic content of aqueous and ethanolic extracts showed the content values of 9.44 ± 0.22% w/w and 18.44 ± 0.13% w/w, respectively, and total flavonoid estimation of aqueous and ethanolic extracts showed the content values of 0.91 ± 0.08% w/w and 1.56 ± 0.12%w/w, respectively, for quercetin and 1.85 ± 0.08% w/w and 2.54 ± 0.12% w/w, respectively, for rutin. Further investigations were carried out for in vitro antioxidant activity and radical scavenging activity by calculating its percentage inhibition by means of IC(50)values, all the extracts' concentrations were adjusted to fall under the linearity range and here many reference standards like tannic acid, gallic acid, quercetin, ascorbic acid were taken for the method suitability. Conclusion: The results revealed that leaves of this plant have antioxidant potential. The results also show the ethanolic extract to be more potent than the aqueous decoction which is claimed traditionally. In conclusion, T. purpurea Linn. (Leguminosae) leaves possess the antioxidant substance which may be responsible for the treatment of jaundice and other oxidative stress-related diseases.
Language	English
Publishing date	2010-12-29
Publishing country	India
Document type	Journal Article
ZDB-ID	2580264-1
ISSN	0974-8490 ; 0976-4836
ISSN (online)	0974-8490
ISSN	0976-4836
DOI	10.4103/0974-8490.65509
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