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  1. Book ; Online: Mitogen Activated Protein Kinases : Functions in Signal Transduction and Human Diseases

    Tikkanen, Ritva / Nikolic-Paterson, David

    2020  

    Keywords Research & information: general ; Biology, life sciences ; Rabdosia inflexa ; inflammation ; gastric ulcer ; cytokines ; MAPK ; NF-κB ; extracellular signal-regulated kinases 1/2 ; hyperoxia ; bronchopulmonary dysplasia ; HPAECs ; angiogenesis ; cell cycle ; SIRT1 ; oxidative stress ; psoriasis ; antimicrobial peptide ; cecropin A ; tight junction protein ; MEK/ERK signaling ; porcine intestinal epithelial cell ; extracellular signal-regulated kinase 5 (ERK5) ; Kv4.2 ; PC12 cells ; infantile myofibromatosis ; receptor tyrosine kinases ; platelet-derived growth factor receptor ; protein kinase inhibitors ; sunitinib ; erlotinib ; FR180204 ; U0126 ; targeted therapy ; apoptosis ; ERK1/2 ; JNKs ; mitochondrial dysfunction ; neurodegeneration ; neuro-inflammation ; p38 MAPKs ; Parkinson's disease ; mitogen-activated protein kinases (MAPKs) ; MAPK kinetics ; osteoclast differentiation ; bone remodeling ; DAPK ; ERK ; p38 ; JNK ; mitogen-activated protein kinase pathway (MAPK pathway) ; protein tyrosine phosphatase interacting protein 51 (PTPIP51) ; protein-protein interaction (PPI) ; cancer signaling ; SR ; CR ; Compatibility ; T2DM ; metabolic profiling ; MAPK/PI3K/Akt signaling pathway ; reactive oxygen species ; PTPN6 ; SRC ; DOK4 ; MKK4 ; MKK7 ; p53 ; DUSP1 ; SIRT2 ; atherosclerosis ; aortic valve sclerosis ; aortic valve stenosis ; naphthalimide-metal complex conjugates ; N-heterocyclic carbene ; mitochondria ; ROS ; p38 MAPK ; cancer ; FGF-induced signaling ; FRS2 ; phosphorylation ; downregulation ; n/a
    Size 1 electronic resource (276 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021043983
    ISBN 9783039280711 ; 3039280716
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Antibacterial agents active against Gram Negative Bacilli in phase I, II, or III clinical trials.

    Paterson, David L

    Expert opinion on investigational drugs

    2024  Volume 33, Issue 4, Page(s) 371–387

    Abstract: Introduction: Antimicrobial resistance is a major threat to modern healthcare, and it is often regarded that the antibiotic pipeline is 'dry.': Areas covered: Antimicrobial agents active against Gram negative bacilli in Phase I, II, or III clinical ... ...

    Abstract Introduction: Antimicrobial resistance is a major threat to modern healthcare, and it is often regarded that the antibiotic pipeline is 'dry.'
    Areas covered: Antimicrobial agents active against Gram negative bacilli in Phase I, II, or III clinical trials were reviewed.
    Expert opinion: Nearly 50 antimicrobial agents (28 small molecules and 21 non-traditional antimicrobial agents) active against Gram-negative bacilli are currently in clinical trials. These have the potential to provide substantial improvements to the antimicrobial armamentarium, although it is known that 'leakage' from the pipeline occurs due to findings of toxicity during clinical trials. Significantly, a lack of funding for large phase III clinical trials is likely to prevent trials occurring for the indications most relevant to loss of life attributed to antimicrobial resistance such as ventilator-associated pneumonia. Non-traditional antimicrobial agents face issues in clinical development such as a lack of readily available and reliable susceptibility tests, and the potential need for superiority trials rather than non-inferiority trials. Most importantly, concrete plans must be made during clinical development for access of new antimicrobial agents to areas of the world where resistance to Gram negative bacilli is most frequent.
    MeSH term(s) Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents ; Gram-Negative Bacteria ; Gram-Negative Bacterial Infections/microbiology ; Microbial Sensitivity Tests ; Clinical Trials, Phase I as Topic ; Clinical Trials, Phase II as Topic ; Clinical Trials, Phase III as Topic
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents
    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1182884-5
    ISSN 1744-7658 ; 0967-8298 ; 1354-3784
    ISSN (online) 1744-7658
    ISSN 0967-8298 ; 1354-3784
    DOI 10.1080/13543784.2024.2326028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3739: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Book ; Online: Advances and Challenges in Microphytobenthos Research: From Cell Biology to Coastal Ecosystem Function

    Serôdio, João / Paterson, David M. / Meleder, Vona / Vyverman, Wim

    2020  

    Keywords Science: general issues ; Oceanography (seas) ; microphytobenthos ; diatoms ; primary productivity ; biodiversity ; estuaries
    Size 1 electronic resource (311 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021231601
    ISBN 9782889662968 ; 2889662969
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book ; Online: Advances in Mechanisms of Renal Fibrosis

    Lan, Hui Y. / Nikolic-Paterson, David J.

    2018  

    Abstract: Scarring of the glomerular and tubulointerstitial compartments is a hallmark of progressive kidney disease. Renal fibrosis involves a complex interplay between kidney cells, leukocytes and fibroblasts in which transforming growth factor-β (TGF-β) plays a ...

    Abstract Scarring of the glomerular and tubulointerstitial compartments is a hallmark of progressive kidney disease. Renal fibrosis involves a complex interplay between kidney cells, leukocytes and fibroblasts in which transforming growth factor-β (TGF-β) plays a key role. This eBook provides a comprehensive update on TGF-β signalling pathways and introduces a range of cellular and molecular mechanisms involved in renal fibrosis both upstream and downstream of TGF-β. The wide variety of potential new targets described herein bodes well for the future development of effective therapies to tackle the major clinical problem of progressive renal fibrosis
    Keywords Science (General) ; Physiology
    Size 1 electronic resource (84 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020101814
    ISBN 9782889454990 ; 2889454991
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Book: Serious infections in the intensive care unit: Pseudomonas aeruginosa and Acinetobacter baumannii

    Paterson, David

    (Clinical infectious diseases ; 43, Suppl. 2)

    2006  

    Author's details guest ed: David Paterson
    Series title Clinical infectious diseases ; 43, Suppl. 2
    Collection
    Language English
    Size S. S41 - S121 : graph. Darst.
    Publisher Univ. of Chicago Press
    Publishing place Chicago, Ill
    Publishing country United States
    Document type Book
    HBZ-ID HT014841032
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 1505 -43,Suppl.2- not available for loan Zeitschriften-Lesesaal

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  6. Article ; Online: "Real-World" Evidence, Target Trial Emulation, and Randomized Clinical Trials-Which Data Should Clinicians Rely on When Choosing Antibiotics?

    Paterson, David L / Sulaiman, Helmi Bin

    JAMA network open

    2024  Volume 7, Issue 1, Page(s) e2352250

    MeSH term(s) Humans ; Randomized Controlled Trials as Topic ; Anti-Bacterial Agents/administration & dosage
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.52250
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Epidemiology and clinical significance of carbapenemases in Australia: a narrative review.

    Aslan, Abdullah Tarik / Paterson, David L

    Internal medicine journal

    2024  Volume 54, Issue 4, Page(s) 535–544

    Abstract: Carbapenemase-producing gram-negative bacteria (CP-GNB) infections threaten public health with high mortality, morbidity and treatment costs. Although frequencies remain low in Australia (total number of CP-GNB infections reported was 907 in 2022), ... ...

    Abstract Carbapenemase-producing gram-negative bacteria (CP-GNB) infections threaten public health with high mortality, morbidity and treatment costs. Although frequencies remain low in Australia (total number of CP-GNB infections reported was 907 in 2022), bla
    MeSH term(s) Humans ; Escherichia coli ; Clinical Relevance ; beta-Lactamases ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Carbapenems/pharmacology ; Carbapenems/therapeutic use ; Microbial Sensitivity Tests ; Bacterial Proteins
    Chemical Substances carbapenemase (EC 3.5.2.6) ; beta-Lactamases (EC 3.5.2.6) ; Anti-Bacterial Agents ; Carbapenems ; Bacterial Proteins
    Language English
    Publishing date 2024-04-08
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 2045436-3
    ISSN 1445-5994 ; 1444-0903
    ISSN (online) 1445-5994
    ISSN 1444-0903
    DOI 10.1111/imj.16374
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 792: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 424: Show issues

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  8. Article ; Online: Bioelectronics for neurocardiology: diagnosis and therapeutics.

    Paterson, David J / Shivkumar, Kalyanam

    European heart journal

    2023  Volume 44, Issue 46, Page(s) 4822–4825

    Language English
    Publishing date 2023-11-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad624
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1563: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 640: Show issues

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  9. Article ; Online: Host response signature trends in bacteraemia - authors' response.

    Peri, Anna Maria / Harris, Patrick N A / Paterson, David L

    Infectious diseases (London, England)

    2024  Volume 56, Issue 5, Page(s) 418–420

    MeSH term(s) Humans ; Bacteremia
    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2839775-7
    ISSN 2374-4243 ; 2374-4235
    ISSN (online) 2374-4243
    ISSN 2374-4235
    DOI 10.1080/23744235.2024.2326591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 600: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article: Copy of a Letter from Mr David Paterson to the Navy Medical Board, on the Good Effects of Nitrous Vapour.

    Paterson, David

    Annals of medicine, for the year ... : exhibiting a concise view of the latest and most important discoveries in medicine and medical philosophy

    2018  Volume 3, Page(s) 409–442

    Language English
    Publishing date 2018-10-30
    Publishing country Scotland
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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