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  1. Article: Breaking the mould, a first parse at natural language processing in aspergillosis diagnosis.

    Pates, Katharine M / Shang, Zhendan / Periselneris, Jimstan / Shah, Anand

    Journal of thoracic disease

    2023  Volume 15, Issue 1, Page(s) 17–21

    Language English
    Publishing date 2023-01-05
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd-22-1393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Rising incidence of Pneumocystis pneumonia: A population-level descriptive ecological study in England.

    Pates, Katharine / Periselneris, Jimstan / Russell, Mark D / Mehra, Varun / Schelenz, Silke / Galloway, James B

    The Journal of infection

    2023  Volume 86, Issue 4, Page(s) 385–390

    Abstract: Objectives: Pneumocystis pneumonia (PCP) is an opportunistic infection that causes significant morbidity and mortality in the immunocompromised population. This population is growing and diversifying, yet contemporary epidemiology is lacking. We ... ...

    Abstract Objectives: Pneumocystis pneumonia (PCP) is an opportunistic infection that causes significant morbidity and mortality in the immunocompromised population. This population is growing and diversifying, yet contemporary epidemiology is lacking. We investigated the population-level incidence of PCP over the past decade.
    Methods: We conducted a descriptive study of all hospital admissions in England from April 2012 to March 2022. PCP episodes, age, median length of stay, gender and episodes of other respiratory fungal infections were collected. Consumption of Trimethoprim-Sulfamethoxazole was obtained between January 2019 and May 2022.
    Results: The incidence of PCP increased from 2·2-4·5/100,000 population between 2012/2013 and 2019/2020 (p < 0·0001). There was a drop in 2020/2021 to 2·7/100,000 before returning to 3.9/100,000 in 2021/2022. PCP episodes rose as a proportion of all-cause admissions as well as a proportion of episodes due to other fungal infections. The proportion of PCP patients aged 75+ increased from 14% to 26%. The median length of stay was 13.5 days. Consumption of intravenous Trimethoprim-Sulfamethoxazole increased from 0.24 × 100,000 to 0.30 × 100,000 defined daily doses.
    Conclusions: The incidence of PCP is rising rapidly and represents a significant burden to the healthcare system. Further study into who is at risk of PCP is needed to better determine who should be given prophylaxis.
    MeSH term(s) Humans ; Pneumonia, Pneumocystis/epidemiology ; Pneumonia, Pneumocystis/microbiology ; Trimethoprim, Sulfamethoxazole Drug Combination/therapeutic use ; Incidence ; Opportunistic Infections ; England/epidemiology ; Retrospective Studies
    Chemical Substances Trimethoprim, Sulfamethoxazole Drug Combination (8064-90-2)
    Language English
    Publishing date 2023-02-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2023.02.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1501: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 48: Show issues

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  3. Article ; Online: Differential translocation of the fatty acid transporter, FAT/CD36, and the glucose transporter, GLUT4, coordinates changes in cardiac substrate metabolism during ischemia and reperfusion.

    Heather, Lisa C / Pates, Katharine M / Atherton, Helen J / Cole, Mark A / Ball, Daniel R / Evans, Rhys D / Glatz, Jan F / Luiken, Joost J / Griffin, Julian L / Clarke, Kieran

    Circulation. Heart failure

    2013  Volume 6, Issue 5, Page(s) 1058–1066

    Abstract: Background: Fatty acid and glucose transporters translocate between the sarcolemma and intracellular compartments to regulate substrate metabolism acutely. We hypothesised that during ischemia fatty acid translocase (FAT/CD36) would translocate away ... ...

    Abstract Background: Fatty acid and glucose transporters translocate between the sarcolemma and intracellular compartments to regulate substrate metabolism acutely. We hypothesised that during ischemia fatty acid translocase (FAT/CD36) would translocate away from the sarcolemma to limit fatty acid uptake when fatty acid oxidation is inhibited.
    Methods and results: Wistar rat hearts were perfused during preischemia, low-flow ischemia, and reperfusion, using (3)H-substrates for measurement of metabolic rates, followed by metabolomic analysis and subcellular fractionation. During ischemia, there was a 32% decrease in sarcolemmal FAT/CD36 accompanied by a 95% decrease in fatty acid oxidation rates, with no change in intramyocardial lipids. Concomitantly, the sarcolemmal content of the glucose transporter, GLUT4, increased by 90% during ischemia, associated with an 86% increase in glycolytic rates, 45% decrease in glycogen content, and a 3-fold increase in phosphorylated AMP-activated protein kinase. Following reperfusion, decreased sarcolemmal FAT/CD36 persisted, but fatty acid oxidation rates returned to preischemic levels, resulting in a 35% decrease in myocardial triglyceride content. Elevated sarcolemmal GLUT4 persisted during reperfusion; in contrast, glycolytic rates decreased to 30% of preischemic rates, accompanied by a 5-fold increase in intracellular citrate levels and restoration of glycogen content.
    Conclusions: During ischemia, FAT/CD36 moved away from the sarcolemma as GLUT4 moved toward the sarcolemma, associated with a shift from fatty acid oxidation to glycolysis, while intramyocardial lipid accumulation was prevented. This relocation was maintained during reperfusion, which was associated with replenishing glycogen stores as a priority, occurring at the expense of glycolysis and mediated by an increase in citrate levels.
    MeSH term(s) Animals ; CD36 Antigens/metabolism ; Disease Models, Animal ; Energy Metabolism ; Fatty Acids/metabolism ; Glucose Transporter Type 4/metabolism ; Glycogen/metabolism ; Glycolysis ; Male ; Metabolomics ; Myocardial Ischemia/metabolism ; Myocardial Ischemia/therapy ; Myocardial Reperfusion ; Myocardium/metabolism ; Oxidation-Reduction ; Protein Transport ; Rats ; Rats, Wistar ; Sarcolemma/metabolism ; Subcellular Fractions
    Chemical Substances CD36 Antigens ; Fatty Acids ; Glucose Transporter Type 4 ; Slc2a4 protein, rat ; Glycogen (9005-79-2)
    Language English
    Publishing date 2013-08-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2429459-7
    ISSN 1941-3297 ; 1941-3289
    ISSN (online) 1941-3297
    ISSN 1941-3289
    DOI 10.1161/CIRCHEARTFAILURE.112.000342
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6745: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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