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  1. Article ; Online: Ketogenic Diets and Mitochondrial Function: Benefits for Aging But Not for Athletes.

    Pathak, Suraj J / Baar, Keith

    Exercise and sport sciences reviews

    2022  Volume 51, Issue 1, Page(s) 27–33

    Abstract: As humans age, we lose skeletal muscle mass, even in the absence of disease (sarcopenia), increasing the risk of death. Low mitochondrial mass and activity contributes to sarcopenia. It is our hypothesis that a ketogenic diet improves skeletal muscle ... ...

    Abstract As humans age, we lose skeletal muscle mass, even in the absence of disease (sarcopenia), increasing the risk of death. Low mitochondrial mass and activity contributes to sarcopenia. It is our hypothesis that a ketogenic diet improves skeletal muscle mitochondrial mass and function when they have declined because of aging or disease, but not in athletes where mitochondrial quality is high.
    MeSH term(s) Humans ; Diet, Ketogenic ; Muscle, Skeletal/metabolism ; Sarcopenia ; Aging ; Mitochondria
    Language English
    Publishing date 2022-09-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 187040-3
    ISSN 1538-3008 ; 0091-6331
    ISSN (online) 1538-3008
    ISSN 0091-6331
    DOI 10.1249/JES.0000000000000307
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  2. Article ; Online: An analysis of demographics, lifestyle factors and comorbidities of pemphigus in underrepresented groups: A cross-sectional study of the All of Us database.

    Pathak, Gaurav N / Pathak, Suraj S / Chandy, Rithi J / Wachuku, Christopher / Feldman, Steven R

    Experimental dermatology

    2024  Volume 33, Issue 1, Page(s) e14989

    MeSH term(s) Humans ; Pemphigus/epidemiology ; Cross-Sectional Studies ; Population Health ; Life Style ; Demography
    Language English
    Publishing date 2024-01-29
    Publishing country Denmark
    Document type Letter
    ZDB-ID 1130936-2
    ISSN 1600-0625 ; 0906-6705
    ISSN (online) 1600-0625
    ISSN 0906-6705
    DOI 10.1111/exd.14989
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    Zs.A 3508: Show issues Location:
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  3. Article ; Online: Organic chiral nano- and microfilaments: types, formation, and template applications.

    Gowda, Ashwathanarayana / Pathak, Suraj Kumar / Rohaley, Grace A R / Acharjee, Gourab / Oprandi, Andrea / Williams, Ryan / Prévôt, Marianne E / Hegmann, Torsten

    Materials horizons

    2024  Volume 11, Issue 2, Page(s) 316–340

    Abstract: Organic chiral nanofilaments are part of an important class of nanoscale chiral materials that has recently been receiving significant attention largely due to their potential use in applications such as optics, photonics, metameterials, and potentially ... ...

    Abstract Organic chiral nanofilaments are part of an important class of nanoscale chiral materials that has recently been receiving significant attention largely due to their potential use in applications such as optics, photonics, metameterials, and potentially a range of medical as well as sensing applications. This review will focus on key examples of the formation of such nano- and micro-filaments based on carbon nanofibers, polymers, synthetic oligo- and polypeptides, self-assembled organic molecules, and one prominent class of liquid crystals. The most critical aspects discussed here are the underlying driving forces for chiral filament formation, potentially answering why specific sizes and shapes are formed, what molecular design strategies are working equally well or rather differently among these materials classes, and what uses and applications are driving research in this fascinating field of materials science.
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2744250-0
    ISSN 2051-6355 ; 2051-6347
    ISSN (online) 2051-6355
    ISSN 2051-6347
    DOI 10.1039/d3mh01390a
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  4. Article ; Online: Keloids and associated comorbidities in underrepresented populations: a cross-sectional analysis of the All of Us database.

    Pathak, Gaurav N / Pathak, Suraj S / Truong, Thu M / Sanabria, Bianca / Rao, Babar

    Archives of dermatological research

    2023  Volume 316, Issue 1, Page(s) 9

    MeSH term(s) Humans ; Keloid/epidemiology ; Keloid/pathology ; Cross-Sectional Studies ; Population Health ; Comorbidity ; Databases, Factual
    Language English
    Publishing date 2023-12-01
    Publishing country Germany
    Document type Letter
    ZDB-ID 130131-7
    ISSN 1432-069X ; 0340-3696
    ISSN (online) 1432-069X
    ISSN 0340-3696
    DOI 10.1007/s00403-023-02757-5
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  5. Article ; Online: Pyoderma gangrenosum in underrepresented patient populations: An All of Us database analysis.

    Pathak, Gaurav N / Pathak, Suraj S / Truong, Thu M / Tan, Isabella J / Rao, Babar K

    International wound journal

    2023  Volume 21, Issue 1, Page(s) e14388

    MeSH term(s) Humans ; Pyoderma Gangrenosum/drug therapy ; Population Health ; Patients
    Language English
    Publishing date 2023-09-12
    Publishing country England
    Document type Letter
    ZDB-ID 2170920-8
    ISSN 1742-481X ; 1742-4801
    ISSN (online) 1742-481X
    ISSN 1742-4801
    DOI 10.1111/iwj.14388
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    Zs.A 6006: Show issues Location:
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  6. Article ; Online: Comorbidities of psoriasis in underrepresented patient populations: An All of Us database analysis.

    Pathak, Gaurav N / Chandy, Rithi J / Pathak, Suraj S / Rao, Babar K / Feldman, Steven R

    Journal of the American Academy of Dermatology

    2023  Volume 90, Issue 2, Page(s) e80–e82

    MeSH term(s) Humans ; Population Health ; Comorbidity ; Psoriasis/epidemiology ; Databases, Factual
    Language English
    Publishing date 2023-10-06
    Publishing country United States
    Document type Letter
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2023.08.108
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    Zs.A 1540: Show issues Location:
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  7. Article ; Online: Maintenance of muscle mass in adult male mice is independent of testosterone.

    Davidyan, Arik / Pathak, Suraj / Baar, Keith / Bodine, Sue C

    PloS one

    2021  Volume 16, Issue 3, Page(s) e0240278

    Abstract: Testosterone is considered a potent anabolic agent in skeletal muscle with a well-established role in adolescent growth and development in males. However, the role of testosterone in the regulation of skeletal muscle mass and function throughout the ... ...

    Abstract Testosterone is considered a potent anabolic agent in skeletal muscle with a well-established role in adolescent growth and development in males. However, the role of testosterone in the regulation of skeletal muscle mass and function throughout the lifespan has yet to be fully established. While some studies suggest that testosterone is important for the maintenance of skeletal muscle mass, an understanding of the role this hormone plays in young, adult, and old males with normal and low serum testosterone levels is lacking. We investigated the role testosterone plays in the maintenance of muscle mass by examining the effect of orchiectomy-induced testosterone depletion in C57Bl6 male mice at ages ranging from early postnatal through old age (1.5-, 5-, 12-, and 24-month old mice). Following 28 days of testosterone depletion, we assessed mass and fiber cross-sectional-area (CSA) of the tibialis anterior, gastrocnemius, and quadriceps muscles. In addition, we measured global rates of protein synthesis and degradation using the SuNSET method, western blots, and enzyme activity assays. Twenty-eight days of testosterone depletion resulted in reduced muscle mass in the two youngest cohorts, but had no effect in the two oldest cohorts. Mean CSA decreased only in the youngest cohort and only in the tibialis anterior muscle. Testosterone depletion resulted in a general increase in proteasome activity at all ages. No change in protein synthesis was detected at the terminal time point. These data suggest that within physiological serum concentrations, testosterone may not be critical for the maintenance of muscle mass in mature male mice; however, in young mice testosterone is crucial for normal growth.
    MeSH term(s) Aging ; Animals ; Male ; Mice ; Mice, Inbred C57BL ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Orchiectomy ; Proteasome Endopeptidase Complex/metabolism ; Proteolysis ; Testosterone/blood ; Testosterone/deficiency ; Ubiquitin/metabolism
    Chemical Substances Ubiquitin ; Testosterone (3XMK78S47O) ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
    Language English
    Publishing date 2021-03-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0240278
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  8. Article ; Online: Should surgical treatment of catamenial pneumothorax include diaphragmatic repair?

    Pathak, Suraj / Caruana, Edward / Chowdhry, Fiyaz

    Interactive cardiovascular and thoracic surgery

    2019  Volume 29, Issue 6, Page(s) 906–910

    Abstract: A best evidence topic in cardiothoracic surgery was written according to a structured protocol. The question addressed was whether treatment with hormones or pleural symphysis is better than operative procedures such as diaphragmatic repair with mesh to ... ...

    Abstract A best evidence topic in cardiothoracic surgery was written according to a structured protocol. The question addressed was whether treatment with hormones or pleural symphysis is better than operative procedures such as diaphragmatic repair with mesh to surgically manage recurrent pneumothoraces in patients with catamenial pneumothorax. Diaphragmatic repair with synthetic meshes, hormonal treatment and pleural symphysis are all accepted interventions for the treatment of recurrent catamenial pneumothoraces; however, there is uncertainty over the best combination of treatment. Altogether, 396 papers were found using the reported search, of which 13 represented the best evidence to answer the clinical question. However, it should be noted that the studies included were small in terms of sample size, and have demonstrated significant bias and surgical heterogeneity. Our literature review found that the recurrence rates of pneumothorax were greatly reduced in the treatment group where surgery and hormone therapy were combined (pooled average recurrence rate of 0%); however, the recurrence rates were significantly higher when these interventions were used alone: hormone therapy alone (58.5%), diaphragmatic repair alone (33.3%) and surgery alone (63.3%). Our results therefore demonstrate that a multimodality approach is required to reduce pneumothorax recurrence rates in patients with catamenial pneumothorax.
    MeSH term(s) Adult ; Decision Making ; Diaphragm/surgery ; Female ; Humans ; Pleurodesis/methods ; Pneumothorax/diagnosis ; Pneumothorax/surgery ; Radiography, Thoracic ; Thoracic Surgery, Video-Assisted/methods ; Tomography, X-Ray Computed
    Language English
    Publishing date 2019-09-10
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2095298-3
    ISSN 1569-9285 ; 1569-9293
    ISSN (online) 1569-9285
    ISSN 1569-9293
    DOI 10.1093/icvts/ivz205
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    Zs.A 5730: Show issues Location:
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  9. Article ; Online: Successful clozapine rechallenge in a patient with suspected drug induced lupus.

    Pathak, Suraj / Cherry, Scott / Samad, Samreen / Aftab, Ambreen

    BMJ case reports

    2019  Volume 12, Issue 4

    Abstract: Clozapine is the most effective treatment for patients with refractory schizophrenia. Clozapine is also associated with serious and potentially lethal side effects including drug induced lupus (DIL). There have been four previous published case reports ... ...

    Abstract Clozapine is the most effective treatment for patients with refractory schizophrenia. Clozapine is also associated with serious and potentially lethal side effects including drug induced lupus (DIL). There have been four previous published case reports describing clozapine inducing a lupus-like syndrome including one previous case where a clozapine rechallenge was attempted without success. This case report describes a successful clozapine rechallenge in a patient with suspected DIL.
    MeSH term(s) Antipsychotic Agents/adverse effects ; Clozapine/adverse effects ; Humans ; Lupus Erythematosus, Systemic/chemically induced ; Schizophrenia/drug therapy
    Chemical Substances Antipsychotic Agents ; Clozapine (J60AR2IKIC)
    Language English
    Publishing date 2019-04-03
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2018-228574
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  10. Article ; Online: Spontaneous subdural haematoma in a patient with a total artificial heart on warfarin.

    Moledina, Saadiq / Shanmuganathan, Mayooran / Pathak, Suraj / Simon, Andre

    BMJ case reports

    2019  Volume 12, Issue 9

    Abstract: We present the unusual case of a middle-aged woman who developed a spontaneous subdural haematoma (SSH) while on oral anticoagulation therapy for a total artificial heart (TAH). Headache was followed by paraesthesia and numbness of the left hand. The ... ...

    Abstract We present the unusual case of a middle-aged woman who developed a spontaneous subdural haematoma (SSH) while on oral anticoagulation therapy for a total artificial heart (TAH). Headache was followed by paraesthesia and numbness of the left hand. The diagnosis was made from a CT scan. Symptoms resolved with conservative management and careful control of anticoagulation. In this case report, the risk factors and pathophysiology behind this condition are explored. TAHs in their own entity are a rare phenomenon. Coupled with the highly unusual presentation of an SSH in which only a few cases have been documented, we hope to highlight the management of such a difficult case. After navigating this complication, we were able to successfully bridge this patient to a heart transplant 26 days after the SSH.
    MeSH term(s) Anticoagulants/administration & dosage ; Female ; Heart, Artificial ; Hematoma, Subdural/diagnostic imaging ; Hematoma, Subdural/etiology ; Humans ; Middle Aged ; Risk Factors ; Tomography, X-Ray Computed ; Warfarin/administration & dosage ; Warfarin/adverse effects
    Chemical Substances Anticoagulants ; Warfarin (5Q7ZVV76EI)
    Language English
    Publishing date 2019-09-04
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2019-230519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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