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Article ; Online: Post processing of low cost Aligners fabricated by additive manufacturing process to enhance the surface quality and functionality.

Rajput, Atul Singh / Patil, Abhishek / Das, Manas / Kapil, Sajan

Journal of the mechanical behavior of biomedical materials

2023 Volume 144, Page(s) 106003

Abstract: Additive Manufacturing (AM) processes have ample advantages compared to traditional manufacturing processes, including mass customization, material efficiency, bioprinting, and fabrication of complex geometries with reduced lead time. Despite such ... ...

Abstract	Additive Manufacturing (AM) processes have ample advantages compared to traditional manufacturing processes, including mass customization, material efficiency, bioprinting, and fabrication of complex geometries with reduced lead time. Despite such benefits, it suffers most from staircase effects that deteriorate the fabricated part's surface quality. Nowadays, additively manufactured aligners are suitable for treating malocclusion and temporomandibular defects of teeth. Fused Deposition Modelling (FDM) is one of the best substitutes for clear aligners production to reduce per-unit cost. Glycol-modified Polyethylene Terephthalate (PETG) is opted as the material to fabricate the clear aligners due to its biocompatibility and non-toxicity. However, the poor surface quality of the additively manufactured is a major challenge in developing clear aligners with the FDM. A novel experimental setup is designed and developed to enable Chemical Vapor Smoothing (CVS) to enhance the surface quality of the clear aligners. Furthermore, based on the Surface roughness, the comparison is made between the surface quality polished with various chemicals (namely methylethylketone (also known as 2-butanone), toluene and, cyclohexanone). Moreover, Response Surface Methodology (RSM) is used to analyze the impact of different process parameters (i.e., the chemical volume, exposure time, and workpiece orientation) on the surface quality of the clear aligners. Moreover, RSM shows that the impact of the clear aligners orientation on %ΔR
MeSH term(s)	Cyclohexanones ; Polyethylene Glycols ; Polyethylene Terephthalates
Chemical Substances	phenylethylthio-beta-galactopyranoside (63407-54-5) ; cyclohexanone (5QOR3YM052) ; Cyclohexanones ; methylethyl ketone (6PT9KLV9IO) ; Polyethylene Glycols (3WJQ0SDW1A) ; Polyethylene Terephthalates
Language	English
Publishing date	2023-06-29
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2378381-3
ISSN	1878-0180 ; 1751-6161
ISSN (online)	1878-0180
ISSN	1751-6161
DOI	10.1016/j.jmbbm.2023.106003
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Article ; Online: An Algorithm for Task Allocation and Planning for a Heterogeneous Multi-Robot System to Minimize the Last Task Completion Time.

Patil, Abhishek / Bae, Jungyun / Park, Myoungkuk

Sensors (Basel, Switzerland)

2022 Volume 22, Issue 15

Abstract: This paper proposes an algorithm that provides operational strategies for multiple heterogeneous mobile robot systems utilized in many real-world applications, such as deliveries, surveillance, search and rescue, monitoring, and transportation. ... ...

Abstract	This paper proposes an algorithm that provides operational strategies for multiple heterogeneous mobile robot systems utilized in many real-world applications, such as deliveries, surveillance, search and rescue, monitoring, and transportation. Specifically, the authors focus on developing an algorithm that solves a min-max multiple depot heterogeneous asymmetric traveling salesperson problem (MDHATSP). The algorithm is designed based on a primal-dual technique to operate given multiple heterogeneous robots located at distinctive depots by finding a tour for each robot such that all the given targets are visited by at least one robot while minimizing the last task completion time. Building on existing work, the newly developed algorithm can solve more generalized problems, including asymmetric cost problems with a min-max objective. Though producing optimal solutions requires high computational loads, the authors aim to find reasonable sub-optimal solutions within a short computation time. The algorithm was repeatedly tested in a simulation with varying problem sizes to verify its effectiveness. The computational results show that the algorithm can produce reliable solutions to apply in real-time operations within a reasonable time.
MeSH term(s)	Algorithms ; Computer Simulation ; Robotics/methods ; Transportation
Language	English
Publishing date	2022-07-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22155637
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Article ; Online: Age-related and individual variations in altered prefrontal and cerebellar connectivity associated with the tendency of developing internet addiction.

Patil, Abhishek Uday / Madathil, Deepa / Huang, Chih-Mao

Human brain mapping

2021 Volume 42, Issue 14, Page(s) 4525–4537

Abstract: Internet addiction refers to problematic patterns of internet use that continually alter the neural organization and brain networks that control impulsive behaviors and inhibitory functions. Individuals with elevated tendencies to develop internet ... ...

Abstract	Internet addiction refers to problematic patterns of internet use that continually alter the neural organization and brain networks that control impulsive behaviors and inhibitory functions. Individuals with elevated tendencies to develop internet addiction represent the transition between healthy and clinical conditions and may progress to behavioral addictive disorders. In this network neuroscience study, we used resting-state functional magnetic resonance imaging (rs-fMRI) to examine how and whether individual variations in the tendency of developing internet addiction rewire functional connectivity and diminish the amplitude of spontaneous low-frequency fluctuations in healthy brains. The influence of neurocognitive aging (aged over 60 years) on executive-cerebellar networks responsible for internet addictive behavior was also investigated. Our results revealed that individuals with an elevated tendency of developing internet addiction had disrupted executive-cerebellar networks but increased occipital-putamen connectivity, probably resulting from addiction-sensitive cognitive control processes and bottom-up sensory plasticity. Neurocognitive aging alleviated the effects of reduced mechanisms of prefrontal and cerebellar connectivity, suggesting age-related modulation of addiction-associated brain networks in response to compulsive internet use. Our findings highlight age-related and individual differences in altered functional connectivity and the brain networks of individuals at a high risk of developing internet addictive disorders. These results offer novel network-based preclinical markers of internet addictive behaviors for individuals of different ages.
MeSH term(s)	Adolescent ; Adult ; Aged ; Biological Variation, Individual ; Brain/diagnostic imaging ; Brain/physiopathology ; Cognitive Aging/physiology ; Connectome ; Female ; Humans ; Individuality ; Internet Addiction Disorder/diagnostic imaging ; Internet Addiction Disorder/physiopathology ; Male ; Middle Aged ; Young Adult
Language	English
Publishing date	2021-06-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1197207-5
ISSN	1097-0193 ; 1065-9471
ISSN (online)	1097-0193
ISSN	1065-9471
DOI	10.1002/hbm.25562
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Article: Healthy Aging Alters the Functional Connectivity of Creative Cognition in the Default Mode Network and Cerebellar Network.

Patil, Abhishek Uday / Madathil, Deepa / Huang, Chih-Mao

Frontiers in aging neuroscience

2021 Volume 13, Page(s) 607988

Abstract: Creativity is a higher-order neurocognitive process that produces unusual and unique thoughts. Behavioral and neuroimaging studies of younger adults have revealed that creative performance is the product of dynamic and spontaneous processes involving ... ...

Abstract	Creativity is a higher-order neurocognitive process that produces unusual and unique thoughts. Behavioral and neuroimaging studies of younger adults have revealed that creative performance is the product of dynamic and spontaneous processes involving multiple cognitive functions and interactions between large-scale brain networks, including the default mode network (DMN), fronto-parietal executive control network (ECN), and salience network (SN). In this resting-state functional magnetic resonance imaging (rs-fMRI) study, group independent component analysis (group-ICA) and resting state functional connectivity (RSFC) measures were applied to examine whether and how various functional connected networks of the creative brain, particularly the default-executive and cerebro-cerebellar networks, are altered with advancing age. The group-ICA approach identified 11 major brain networks across age groups that reflected age-invariant resting-state networks. Compared with older adults, younger adults exhibited more specific and widespread dorsal network and sensorimotor network connectivity within and between the DMN, fronto-parietal ECN, and visual, auditory, and cerebellar networks associated with creativity. This outcome suggests age-specific changes in the functional connected network, particularly in the default-executive and cerebro-cerebellar networks. Our connectivity data further elucidate the critical roles of the cerebellum and cerebro-cerebellar connectivity in creativity in older adults. Furthermore, our findings provide evidence supporting the default-executive coupling hypothesis of aging and novel insights into the interactions of cerebro-cerebellar networks with creative cognition in older adults, which suggest alterations in the cognitive processes of the creative aging brain.
Language	English
Publishing date	2021-02-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2021.607988
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Article: Do Tofacitinib Generics Exhibit Conventional Synthetic Disease-Modifying Anti-rheumatic Drug and Non-steroidal Anti-inflammatory Drug-Sparing Ability in the Management of Axial Spondyloarthritis?

Ganapati, Arvind / Arya, Suvrat / Gupta, Nikhil / Patil, Abhishek / Chebbi, Pramod / Doley, Daisy / Jeevanagi, Sachin R / Sahu, Rahul / Mandal, Santosh K

Cureus

2023 Volume 15, Issue 10, Page(s) e46391

Abstract: Introduction: Tofacitinib has emerged as a therapeutic option for axial spondyloarthritis (axSpA) following successful clinical trials. The evidence on the efficacy of tofacitinib generics in the management of axSpA is limited. In India, the usage of ... ...

Abstract	Introduction: Tofacitinib has emerged as a therapeutic option for axial spondyloarthritis (axSpA) following successful clinical trials. The evidence on the efficacy of tofacitinib generics in the management of axSpA is limited. In India, the usage of conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) is commonplace in the management of axSpA. Our primary aim was to identify the csDMARD and non-steroidal anti-inflammatory drug (NSAID)-sparing role of tofacitinib generics in an axSpA population. Methods: This was a retrospective study in a real-world clinical setting. Data from nine rheumatology centers across India were analyzed for 168 patients with active axSpA who were initiated on generic tofacitinib 5 mg twice daily in conjunction with csDMARDs and NSAIDs, over a duration of six months. Our primary outcome was to evaluate the csDMARD and NSAID-sparing effect of tofacitinib generics, while the secondary outcome assessed safety profiles and efficacy at six months. Results: The median Ankylosing Spondylitis Disease Activity Score (ASDAS) erythrocyte sedimentation rate (ESR) score of the study population was 3.91 (3.26, 4.56). Alongside tofacitinib generics, 121 (72%) patients were co-administered csDMARDs (methotrexate/sulfasalazine/both), and 90 (53.6%) patients were co-administered NSAIDs. The csDMARD, NSAID, and combined csDMARD + NSAID-sparing effects of tofacitinib generics were seen in 85 (50.6%), 156 (92.9%), and 81 (48.2%) patients, respectively. Adverse events were mild and well-tolerated. At six months, 124 (57.9%) patients had attained clinically important improvement in ASDAS ESR score, and the median decrease in ASDAS ESR score was 2.02 (1.18, 2.96). Conclusion: This real-world study provides evidence supporting the csDMARD and NSAID-sparing ability of tofacitinib generics in the treatment of axSpA. Tofacitinib generics displayed a good safety profile and showed signals of efficacy as well.
Language	English
Publishing date	2023-10-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.46391
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Article ; Online: Review of EEG-based neurofeedback as a therapeutic intervention to treat depression.

Patil, Abhishek Uday / Lin, Chemin / Lee, Shwu-Hua / Huang, Hsu-Wen / Wu, Shun-Chi / Madathil, Deepa / Huang, Chih-Mao

Psychiatry research. Neuroimaging

2023 Volume 329, Page(s) 111591

Abstract: Depression, or major depressive disorder, is a common mental disorder that affects individuals' behavior, mood, and physical health, and its prevalence has increased during the lockdowns implemented to curb the COVID-19 pandemic. There is an urgent need ... ...

Abstract	Depression, or major depressive disorder, is a common mental disorder that affects individuals' behavior, mood, and physical health, and its prevalence has increased during the lockdowns implemented to curb the COVID-19 pandemic. There is an urgent need to update the treatment recommendations for mental disorders during such crises. Conventional interventions to treat depression include long-term pharmacotherapy and cognitive behavioral therapy. Electroencephalogram-neurofeedback (EEG-NF) training has been suggested as a non-invasive option to treat depression with minimal side effects. In this systematic review, we summarize the recent literature on EEG-NF training for treating depression. The 12 studies included in our final sample reported that despite several issues related to EEG-NF practices, patients with depression showed significant cognitive, clinical, and neural improvements following EEG-NF training. Given its low cost and the low risk of side effects due to its non-invasive nature, we suggest that EEG-NF is worth exploring as an augmented tool for patients who already receive standard medications but remain symptomatic, and that EEG-NF training may be an effective intervention tool that can be utilized as a supplementary treatment for depression. We conclude by providing some suggestions related to experimental designs and standards to improve current EEG-NF training practices for treating depression.
MeSH term(s)	Humans ; Neurofeedback ; Depressive Disorder, Major ; Depression/therapy ; Pandemics ; COVID-19 ; Communicable Disease Control ; Electroencephalography
Language	English
Publishing date	2023-01-13
Publishing country	Netherlands
Document type	Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	445361-x
ISSN	1872-7506 ; 1872-7123 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7506 ; 1872-7123
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.pscychresns.2023.111591
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Zs.A 1541: Show issues

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Article: Neurofeedback for the Education of Children with ADHD and Specific Learning Disorders: A Review.

Patil, Abhishek Uday / Madathil, Deepa / Fan, Yang-Tang / Tzeng, Ovid J L / Huang, Chih-Mao / Huang, Hsu-Wen

Brain sciences

2022 Volume 12, Issue 9

Abstract: Neurofeedback (NF) is a type of biofeedback in which an individual's brain activity is measured and presented to them to support self-regulation of ongoing brain oscillations and achieve specific behavioral and neurophysiological outcomes. NF training ... ...

Abstract	Neurofeedback (NF) is a type of biofeedback in which an individual's brain activity is measured and presented to them to support self-regulation of ongoing brain oscillations and achieve specific behavioral and neurophysiological outcomes. NF training induces changes in neurophysiological circuits that are associated with behavioral changes. Recent evidence suggests that the NF technique can be used to train electrical brain activity and facilitate learning among children with learning disorders. Toward this aim, this review first presents a generalized model for NF systems, and then studies involving NF training for children with disorders such as dyslexia, attention-deficit/hyperactivity disorder (ADHD), and other specific learning disorders such as dyscalculia and dysgraphia are reviewed. The discussion elaborates on the potential for translational applications of NF in educational and learning settings with details. This review also addresses some issues concerning the role of NF in education, and it concludes with some solutions and future directions. In order to provide the best learning environment for children with ADHD and other learning disorders, it is critical to better understand the role of NF in educational settings. The review provides the potential challenges of the current systems to aid in highlighting the issues undermining the efficacy of current systems and identifying solutions to address them. The review focuses on the use of NF technology in education for the development of adaptive teaching methods and the best learning environment for children with learning disabilities.
Language	English
Publishing date	2022-09-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci12091238
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Article ; Online: Matched-Pair Analysis of Magnetic Resonance Images for Location of the Common Peroneal Nerve in Valgus Knees: Comparison with the Varus Knees.

Jung, Kwang Am / Shon, Oog-Jin / Banday, Mohd Irfan / Patil, Abhishek / Kim, Gi Beom

The journal of knee surgery

2020 Volume 35, Issue 8, Page(s) 821–827

Abstract: This study aimed to assess the distance and angular location of the common peroneal nerve (CPN) on axial magnetic resonance imaging (MRI) in the valgus knees and compare the measurements with those obtained from the control group. We compared the ... ...

Abstract	This study aimed to assess the distance and angular location of the common peroneal nerve (CPN) on axial magnetic resonance imaging (MRI) in the valgus knees and compare the measurements with those obtained from the control group. We compared the location of the CPN according to the type of alignment by performing a subgroup analysis. From January 2009 to December 2019, we identified 41 knees with preoperative MRI in patients who underwent total knee arthroplasty (TKA) for valgus deformity (valgus group). We performed one-to-two matched-pair analysis to a cohort of patients who underwent MRI but were not candidates for TKA (control group), according to sex and age. The valgus group was classified according to the grading system reported by Ranawat et al, and the control group was also subdivided according to the hip-knee-ankle (HKA) angle obtained from lower extremity scanography: neutral (-3 to +3 degrees from the neutral mechanical axis), valgus (> +3 degrees), and varus alignment (< -3 degrees). Distance between the CPN and posterolateral cortex of the tibia at the knee joint (distance
MeSH term(s)	Humans ; Knee Joint/diagnostic imaging ; Knee Joint/surgery ; Magnetic Resonance Imaging ; Matched-Pair Analysis ; Osteoarthritis, Knee/diagnostic imaging ; Osteoarthritis, Knee/surgery ; Peroneal Nerve/diagnostic imaging ; Retrospective Studies ; Tibia/diagnostic imaging ; Tibia/surgery
Language	English
Publishing date	2020-10-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2075354-8
ISSN	1938-2480 ; 1538-8506 ; 0899-7403
ISSN (online)	1938-2480
ISSN	1538-8506 ; 0899-7403
DOI	10.1055/s-0040-1718680
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Zs.A 3867: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Occurrence and outcome of COVID-19 in AIRD patients on concomitant treatment with Tofacitinib- results from KRA COVID COHORT (KRACC) subset.

Chebbi, Pramod / Shobha, Vineeta / Rao, Vijay K / Haridas, Vikram / Janardana, Ramya / Pinto, Benzeeta / Kumar, Sharath / Patil, Abhishek / Tekkatte, Roopa / Salanke, Manasa / Mahendranath, K M

BMC rheumatology

2023 Volume 7, Issue 1, Page(s) 22

Abstract: Introduction: We assessed the risk factors and outcome of COVID-19 in patients with autoimmune rheumatic diseases(AIRD) who contracted infection while on background treatment with tofacitinib.: Methods: This is a non-interventional, cross-sectional, ... ...

Abstract	Introduction: We assessed the risk factors and outcome of COVID-19 in patients with autoimmune rheumatic diseases(AIRD) who contracted infection while on background treatment with tofacitinib. Methods: This is a non-interventional, cross-sectional, questionnaire based telephonic study which included consecutive AIRD patients on tofacitinib co-treatment. Data related to the AIRD subset, disease modifying anti rheumatic drugs(DMARDs) including glucocorticoids and comorbidities, was collected from 7 rheumatology centers across Karnataka during the second wave of COVID-19 pandemic. The information about COVID-19 occurrence and COVID-19 vaccination was recorded. Results: During the study period (Jun-July 2021), 335 AIRD patients (80.6% female) on treatment with tofacitinib were included. The mean duration of tofacitinib use was 3.4+/-3.1months. Thirty-six(10.75%) patients developed COVID-19. Diabetes mellitus (p = 0.04 (OR 2.60 (1.13-5.99)) was identified as a risk factor for COVID-19 in our cohort. Almost half of our cohort was COVID-19 vaccinated with at least one dose, with resultant decline in incidence of COVID-19(OR 0.15 (0.06-0.39) among the vaccinated. Recovery amongst COVID-19 infection group was 91.2%. Conclusions: The subset of AIRD patients who were on treatment with tofacitinib were found to have a higher rate of COVID-19 infection as compared to our KRACC cohort. Pre-existing comorbidity of diabetes mellitus was the significant risk factor in our cohort. This subset of the KRACC cohort shows RA patients had a lesser infection and PsA patients had a higher infection.
Language	English
Publishing date	2023-07-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2918121-5
ISSN	2520-1026 ; 2520-1026
ISSN (online)	2520-1026
ISSN	2520-1026
DOI	10.1186/s41927-023-00345-8
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Article ; Online: Deterministic early endosomal maturations emerge from a stochastic trigger-and-convert mechanism.

York, Harrison M / Joshi, Kunaal / Wright, Charles S / Kreplin, Laura Z / Rodgers, Samuel J / Moorthi, Ullhas K / Gandhi, Hetvi / Patil, Abhishek / Mitchell, Christina A / Iyer-Biswas, Srividya / Arumugam, Senthil

Nature communications

2023 Volume 14, Issue 1, Page(s) 4652

Abstract: Endosomal maturation is critical for robust and timely cargo transport to specific cellular compartments. The most prominent model of early endosomal maturation involves a phosphoinositide-driven gain or loss of specific proteins on individual endosomes, ...

Abstract	Endosomal maturation is critical for robust and timely cargo transport to specific cellular compartments. The most prominent model of early endosomal maturation involves a phosphoinositide-driven gain or loss of specific proteins on individual endosomes, emphasising an autonomous and stochastic description. However, limitations in fast, volumetric imaging long hindered direct whole cell-level measurements of absolute numbers of maturation events. Here, we use lattice light-sheet imaging and bespoke automated analysis to track individual very early (APPL1-positive) and early (EEA1-positive) endosomes over the entire population, demonstrating that direct inter-endosomal contact drives maturation between these populations. Using fluorescence lifetime, we show that this endosomal interaction is underpinned by asymmetric binding of EEA1 to very early and early endosomes through its N- and C-termini, respectively. In combination with agent-based simulation which supports a 'trigger-and-convert' model, our findings indicate that APPL1- to EEA1-positive maturation is driven not by autonomous events but by heterotypic EEA1-mediated interactions, providing a mechanism for temporal and population-level control of maturation.
MeSH term(s)	Vesicular Transport Proteins/metabolism ; Transport Vesicles/metabolism ; Endosomes/metabolism
Chemical Substances	Vesicular Transport Proteins
Language	English
Publishing date	2023-08-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-40428-1
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