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  1. Article ; Online: Age-related and individual variations in altered prefrontal and cerebellar connectivity associated with the tendency of developing internet addiction.

    Patil, Abhishek Uday / Madathil, Deepa / Huang, Chih-Mao

    Human brain mapping

    2021  Volume 42, Issue 14, Page(s) 4525–4537

    Abstract: Internet addiction refers to problematic patterns of internet use that continually alter the neural organization and brain networks that control impulsive behaviors and inhibitory functions. Individuals with elevated tendencies to develop internet ... ...

    Abstract Internet addiction refers to problematic patterns of internet use that continually alter the neural organization and brain networks that control impulsive behaviors and inhibitory functions. Individuals with elevated tendencies to develop internet addiction represent the transition between healthy and clinical conditions and may progress to behavioral addictive disorders. In this network neuroscience study, we used resting-state functional magnetic resonance imaging (rs-fMRI) to examine how and whether individual variations in the tendency of developing internet addiction rewire functional connectivity and diminish the amplitude of spontaneous low-frequency fluctuations in healthy brains. The influence of neurocognitive aging (aged over 60 years) on executive-cerebellar networks responsible for internet addictive behavior was also investigated. Our results revealed that individuals with an elevated tendency of developing internet addiction had disrupted executive-cerebellar networks but increased occipital-putamen connectivity, probably resulting from addiction-sensitive cognitive control processes and bottom-up sensory plasticity. Neurocognitive aging alleviated the effects of reduced mechanisms of prefrontal and cerebellar connectivity, suggesting age-related modulation of addiction-associated brain networks in response to compulsive internet use. Our findings highlight age-related and individual differences in altered functional connectivity and the brain networks of individuals at a high risk of developing internet addictive disorders. These results offer novel network-based preclinical markers of internet addictive behaviors for individuals of different ages.
    MeSH term(s) Adolescent ; Adult ; Aged ; Biological Variation, Individual ; Brain/diagnostic imaging ; Brain/physiopathology ; Cognitive Aging/physiology ; Connectome ; Female ; Humans ; Individuality ; Internet Addiction Disorder/diagnostic imaging ; Internet Addiction Disorder/physiopathology ; Male ; Middle Aged ; Young Adult
    Language English
    Publishing date 2021-06-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1197207-5
    ISSN 1097-0193 ; 1065-9471
    ISSN (online) 1097-0193
    ISSN 1065-9471
    DOI 10.1002/hbm.25562
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Healthy Aging Alters the Functional Connectivity of Creative Cognition in the Default Mode Network and Cerebellar Network.

    Patil, Abhishek Uday / Madathil, Deepa / Huang, Chih-Mao

    Frontiers in aging neuroscience

    2021  Volume 13, Page(s) 607988

    Abstract: Creativity is a higher-order neurocognitive process that produces unusual and unique thoughts. Behavioral and neuroimaging studies of younger adults have revealed that creative performance is the product of dynamic and spontaneous processes involving ... ...

    Abstract Creativity is a higher-order neurocognitive process that produces unusual and unique thoughts. Behavioral and neuroimaging studies of younger adults have revealed that creative performance is the product of dynamic and spontaneous processes involving multiple cognitive functions and interactions between large-scale brain networks, including the default mode network (DMN), fronto-parietal executive control network (ECN), and salience network (SN). In this resting-state functional magnetic resonance imaging (rs-fMRI) study, group independent component analysis (group-ICA) and resting state functional connectivity (RSFC) measures were applied to examine whether and how various functional connected networks of the creative brain, particularly the default-executive and cerebro-cerebellar networks, are altered with advancing age. The group-ICA approach identified 11 major brain networks across age groups that reflected age-invariant resting-state networks. Compared with older adults, younger adults exhibited more specific and widespread dorsal network and sensorimotor network connectivity within and between the DMN, fronto-parietal ECN, and visual, auditory, and cerebellar networks associated with creativity. This outcome suggests age-specific changes in the functional connected network, particularly in the default-executive and cerebro-cerebellar networks. Our connectivity data further elucidate the critical roles of the cerebellum and cerebro-cerebellar connectivity in creativity in older adults. Furthermore, our findings provide evidence supporting the default-executive coupling hypothesis of aging and novel insights into the interactions of cerebro-cerebellar networks with creative cognition in older adults, which suggest alterations in the cognitive processes of the creative aging brain.
    Language English
    Publishing date 2021-02-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2021.607988
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Review of EEG-based neurofeedback as a therapeutic intervention to treat depression.

    Patil, Abhishek Uday / Lin, Chemin / Lee, Shwu-Hua / Huang, Hsu-Wen / Wu, Shun-Chi / Madathil, Deepa / Huang, Chih-Mao

    Psychiatry research. Neuroimaging

    2023  Volume 329, Page(s) 111591

    Abstract: Depression, or major depressive disorder, is a common mental disorder that affects individuals' behavior, mood, and physical health, and its prevalence has increased during the lockdowns implemented to curb the COVID-19 pandemic. There is an urgent need ... ...

    Abstract Depression, or major depressive disorder, is a common mental disorder that affects individuals' behavior, mood, and physical health, and its prevalence has increased during the lockdowns implemented to curb the COVID-19 pandemic. There is an urgent need to update the treatment recommendations for mental disorders during such crises. Conventional interventions to treat depression include long-term pharmacotherapy and cognitive behavioral therapy. Electroencephalogram-neurofeedback (EEG-NF) training has been suggested as a non-invasive option to treat depression with minimal side effects. In this systematic review, we summarize the recent literature on EEG-NF training for treating depression. The 12 studies included in our final sample reported that despite several issues related to EEG-NF practices, patients with depression showed significant cognitive, clinical, and neural improvements following EEG-NF training. Given its low cost and the low risk of side effects due to its non-invasive nature, we suggest that EEG-NF is worth exploring as an augmented tool for patients who already receive standard medications but remain symptomatic, and that EEG-NF training may be an effective intervention tool that can be utilized as a supplementary treatment for depression. We conclude by providing some suggestions related to experimental designs and standards to improve current EEG-NF training practices for treating depression.
    MeSH term(s) Humans ; Neurofeedback ; Depressive Disorder, Major ; Depression/therapy ; Pandemics ; COVID-19 ; Communicable Disease Control ; Electroencephalography
    Language English
    Publishing date 2023-01-13
    Publishing country Netherlands
    Document type Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 445361-x
    ISSN 1872-7506 ; 1872-7123 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7506 ; 1872-7123
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.pscychresns.2023.111591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Neurofeedback for the Education of Children with ADHD and Specific Learning Disorders: A Review.

    Patil, Abhishek Uday / Madathil, Deepa / Fan, Yang-Tang / Tzeng, Ovid J L / Huang, Chih-Mao / Huang, Hsu-Wen

    Brain sciences

    2022  Volume 12, Issue 9

    Abstract: Neurofeedback (NF) is a type of biofeedback in which an individual's brain activity is measured and presented to them to support self-regulation of ongoing brain oscillations and achieve specific behavioral and neurophysiological outcomes. NF training ... ...

    Abstract Neurofeedback (NF) is a type of biofeedback in which an individual's brain activity is measured and presented to them to support self-regulation of ongoing brain oscillations and achieve specific behavioral and neurophysiological outcomes. NF training induces changes in neurophysiological circuits that are associated with behavioral changes. Recent evidence suggests that the NF technique can be used to train electrical brain activity and facilitate learning among children with learning disorders. Toward this aim, this review first presents a generalized model for NF systems, and then studies involving NF training for children with disorders such as dyslexia, attention-deficit/hyperactivity disorder (ADHD), and other specific learning disorders such as dyscalculia and dysgraphia are reviewed. The discussion elaborates on the potential for translational applications of NF in educational and learning settings with details. This review also addresses some issues concerning the role of NF in education, and it concludes with some solutions and future directions. In order to provide the best learning environment for children with ADHD and other learning disorders, it is critical to better understand the role of NF in educational settings. The review provides the potential challenges of the current systems to aid in highlighting the issues undermining the efficacy of current systems and identifying solutions to address them. The review focuses on the use of NF technology in education for the development of adaptive teaching methods and the best learning environment for children with learning disabilities.
    Language English
    Publishing date 2022-09-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci12091238
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Static and dynamic functional connectivity supports the configuration of brain networks associated with creative cognition.

    Patil, Abhishek Uday / Ghate, Sejal / Madathil, Deepa / Tzeng, Ovid J L / Huang, Hsu-Wen / Huang, Chih-Mao

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 165

    Abstract: Creative cognition is recognized to involve the integration of multiple spontaneous cognitive processes and is manifested as complex networks within and between the distributed brain regions. We propose that the processing of creative cognition involves ... ...

    Abstract Creative cognition is recognized to involve the integration of multiple spontaneous cognitive processes and is manifested as complex networks within and between the distributed brain regions. We propose that the processing of creative cognition involves the static and dynamic re-configuration of brain networks associated with complex cognitive processes. We applied the sliding-window approach followed by a community detection algorithm and novel measures of network flexibility on the blood-oxygen level dependent (BOLD) signal of 8 major functional brain networks to reveal static and dynamic alterations in the network reconfiguration during creative cognition using functional magnetic resonance imaging (fMRI). Our results demonstrate the temporal connectivity of the dynamic large-scale creative networks between default mode network (DMN), salience network, and cerebellar network during creative cognition, and advance our understanding of the network neuroscience of creative cognition.
    MeSH term(s) Brain/diagnostic imaging ; Brain/physiology ; Cognition ; Humans ; Magnetic Resonance Imaging ; Models, Neurological ; Nerve Net/diagnostic imaging ; Nerve Net/physiology
    Language English
    Publishing date 2021-01-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-80293-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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