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  1. Article: Reversal of insulin resistance by Ficus benghalensis bark in fructose-induced insulin-resistant rats

    Khanal, Pukar / Patil, B.M.

    Journal of ethnopharmacology. 2022 Feb. 10, v. 284

    2022  

    Abstract: Bark of Ficus benghalensis L. (family: Moraceae), commonly known as Banyan is recorded as Nyagrodha in Ayurvedic Pharmacopeia of India to manage burning sensation, obesity, diabetes, bleeding disorders, thirst, skin diseases, wounds, and dysmenorrhoea. ... ...

    Abstract Bark of Ficus benghalensis L. (family: Moraceae), commonly known as Banyan is recorded as Nyagrodha in Ayurvedic Pharmacopeia of India to manage burning sensation, obesity, diabetes, bleeding disorders, thirst, skin diseases, wounds, and dysmenorrhoea. However, the effect of F. benghalensis bark over glycolysis, gluconeogenesis, and appetite regulation in insulin-resistant pathogenesis has not been reported yet.The present study aimed to investigate the effect of hydroalcoholic extract of F. benghalensis bark in gluconeogenesis, glycolysis, and appetite regulation in fructose-induced insulin resistance in experimental rats.Male Wister rats were supplemented with fructose in drinking water (10% w/v for 42 days and 20% w/v for next 12 days; a total of 54 days); insulin resistance was confirmed via the elevated area under the curve of the glucose during oral glucose tolerance test after 54 days and was subjected with extract treatment for next 30 days. After 30 days of treatment, animals were fasted to perform oral glucose and insulin tolerance test to estimate glucose and insulin levels. The blood sample was collected for biochemical estimation and the liver homogenate was prepared to estimate hepatic enzymes and enzymatic and non-enzymatic anti-oxidant biomarkers followed by histopathological evaluation. Also, glycogen content was quantified in gastrocnemius muscle and liver homogenates. Further, reported bioactives from the F. benghalensis were retrieved from the ChEBI database and docked against hexokinase, phosphofructokinase, glucose-6-phosphatase, lactate dehydrogenase, and fructose-1,6-biphosphatase to identify the probable lead hits against the enzymes involved in gluconeogenesis.Treatment with the F. benghalensis bark extract significantly increased the body weight and food intake and significantly decreased fructose supplemented water intake. Further, treatment with extract significantly increased the exogenous glucose clearance and well responded to the exogenous insulin. Further, extract treatment improved lipid metabolism, ameliorated plasma leptin, and multiple enzymatic and non-enzymatic antioxidant biomarkers. Likewise, it also improved gluconeogenesis mediated pathogenesis of non-alcoholic fatty liver injury. Additionally, molecular docking also identified mucusisoflavone A and B as lead hits in downregulating gluconeogenesis.Hydroalcoholic extract of F. benghalensis bark may prevent insulin resistance by downregulating gluconeogenesis and improving the appetite in fructose-induced insulin-resistant rats.
    Keywords Ficus benghalensis ; antioxidant biomarkers ; bark ; bark extracts ; bioactive compounds ; blood sampling ; databases ; diabetes ; fatty liver ; food intake ; fructose ; gluconeogenesis ; glucose ; glucose tolerance tests ; glucose-6-phosphatase ; glycogen ; glycolysis ; hexokinase ; histopathology ; insulin ; insulin resistance ; insulin tolerance test ; lactate dehydrogenase ; lead ; leptin ; lipid metabolism ; liver ; muscles ; obesity ; pathogenesis ; phosphofructokinases ; sensation ; thirst ; traditional medicine ; India
    Language English
    Dates of publication 2022-0210
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2021.114761
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    In stock of ZB MED Bonn / Germany

    Z 90/710: Show issues

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  2. Article ; Online: Reversal of insulin resistance by Ficus benghalensis bark in fructose-induced insulin-resistant rats.

    Khanal, Pukar / Patil, B M

    Journal of ethnopharmacology

    2021  Volume 284, Page(s) 114761

    Abstract: Ethnopharmacological relevance: Bark of Ficus benghalensis L. (family: Moraceae), commonly known as Banyan is recorded as Nyagrodha in Ayurvedic Pharmacopeia of India to manage burning sensation, obesity, diabetes, bleeding disorders, thirst, skin ... ...

    Abstract Ethnopharmacological relevance: Bark of Ficus benghalensis L. (family: Moraceae), commonly known as Banyan is recorded as Nyagrodha in Ayurvedic Pharmacopeia of India to manage burning sensation, obesity, diabetes, bleeding disorders, thirst, skin diseases, wounds, and dysmenorrhoea. However, the effect of F. benghalensis bark over glycolysis, gluconeogenesis, and appetite regulation in insulin-resistant pathogenesis has not been reported yet.
    Aim of the study: The present study aimed to investigate the effect of hydroalcoholic extract of F. benghalensis bark in gluconeogenesis, glycolysis, and appetite regulation in fructose-induced insulin resistance in experimental rats.
    Materials and methods: Male Wister rats were supplemented with fructose in drinking water (10% w/v for 42 days and 20% w/v for next 12 days; a total of 54 days); insulin resistance was confirmed via the elevated area under the curve of the glucose during oral glucose tolerance test after 54 days and was subjected with extract treatment for next 30 days. After 30 days of treatment, animals were fasted to perform oral glucose and insulin tolerance test to estimate glucose and insulin levels. The blood sample was collected for biochemical estimation and the liver homogenate was prepared to estimate hepatic enzymes and enzymatic and non-enzymatic anti-oxidant biomarkers followed by histopathological evaluation. Also, glycogen content was quantified in gastrocnemius muscle and liver homogenates. Further, reported bioactives from the F. benghalensis were retrieved from the ChEBI database and docked against hexokinase, phosphofructokinase, glucose-6-phosphatase, lactate dehydrogenase, and fructose-1,6-biphosphatase to identify the probable lead hits against the enzymes involved in gluconeogenesis.
    Results: Treatment with the F. benghalensis bark extract significantly increased the body weight and food intake and significantly decreased fructose supplemented water intake. Further, treatment with extract significantly increased the exogenous glucose clearance and well responded to the exogenous insulin. Further, extract treatment improved lipid metabolism, ameliorated plasma leptin, and multiple enzymatic and non-enzymatic antioxidant biomarkers. Likewise, it also improved gluconeogenesis mediated pathogenesis of non-alcoholic fatty liver injury. Additionally, molecular docking also identified mucusisoflavone A and B as lead hits in downregulating gluconeogenesis.
    Conclusion: Hydroalcoholic extract of F. benghalensis bark may prevent insulin resistance by downregulating gluconeogenesis and improving the appetite in fructose-induced insulin-resistant rats.
    MeSH term(s) Animals ; Body Weight/drug effects ; Feeding Behavior/drug effects ; Ficus/chemistry ; Fructose/toxicity ; Insulin Resistance ; Male ; Plant Bark/chemistry ; Plant Extracts/chemistry ; Plant Extracts/therapeutic use ; Rats ; Rats, Wistar
    Chemical Substances Plant Extracts ; Fructose (30237-26-4)
    Language English
    Publishing date 2021-10-20
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2021.114761
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1494: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Consolidation of network and experimental pharmacology to divulge the antidiabetic action of

    Khanal, Pukar / Patil, B M

    3 Biotech

    2021  Volume 11, Issue 5, Page(s) 238

    Abstract: A total of 21 different bioactives were identified from : Supplementary information: The online version contains supplementary material available at 10.1007/s13205-021-02788-7. ...

    Abstract A total of 21 different bioactives were identified from
    Supplementary information: The online version contains supplementary material available at 10.1007/s13205-021-02788-7.
    Language English
    Publishing date 2021-04-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2600522-0
    ISSN 2190-5738 ; 2190-572X
    ISSN (online) 2190-5738
    ISSN 2190-572X
    DOI 10.1007/s13205-021-02788-7
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  4. Article: Consolidation of network and experimental pharmacology to divulge the antidiabetic action of Ficus benghalensis L. bark

    Khanal, Pukar / Patil, B. M

    3 Biotech. 2021 May, v. 11, no. 5

    2021  

    Abstract: A total of 21 different bioactives were identified from F. benghalensis in which 3 molecules, i.e., apigenin, 3′,4′,5,7-tetrahydroxy-3-methoxyflavone, and kaempferol were predicted to target the highest number of proteins involved in diabetic ... ...

    Abstract A total of 21 different bioactives were identified from F. benghalensis in which 3 molecules, i.e., apigenin, 3′,4′,5,7-tetrahydroxy-3-methoxyflavone, and kaempferol were predicted to target the highest number of proteins involved in diabetic pathogenesis in which protein tyrosine phosphatase 1b was primarily targeted. Similarly, a docking study identified ursolic acid to have the highest binding affinity with protein tyrosine phosphatase 1b. The combined synergic network analysis identified PI3K/Akt signaling pathway to be primarily modulated followed by the calcium signaling pathway. Similarly, in oral glucose tolerance test, we observed the efficacy of hydroalcoholic extract of F. benghalensis to lower the total area under the curve of glucose and increase total area under curve of insulin for 2 hours. Likewise, hydroalcoholic extract reversed the altered homeostatic hepatic enzymes after 28 days of treatments. Similarly, the extract also enhanced the antioxidant enzymes level like catalase and superoxide dismutase in liver homogenate. In summary, hydroalcoholic extract of F. benghalensis bark may act as an antidiabetic agent by enhancing the glycolysis, decreasing gluconeogenesis, promoting glucose uptake, enhancing insulin secretion, and maintaining pancreatic β-cell mass via PI3K/Akt signaling pathway and downregulating the function of protein tyrosine phosphatase 1b.
    Keywords Ficus benghalensis ; apigenin ; bark ; bioactive compounds ; calcium ; catalase ; gluconeogenesis ; glucose ; glucose tolerance tests ; glycolysis ; hypoglycemic agents ; insulin ; insulin secretion ; kaempferol ; liver ; pathogenesis ; pharmacology ; protein-tyrosine-phosphatase ; superoxide dismutase ; ursolic acid
    Language English
    Dates of publication 2021-05
    Size p. 238.
    Publishing place Springer International Publishing
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2600522-0
    ISSN 2190-5738 ; 2190-572X
    ISSN (online) 2190-5738
    ISSN 2190-572X
    DOI 10.1007/s13205-021-02788-7
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  5. Article: Gene ontology enrichment analysis of α-amylase inhibitors from

    Khanal, Pukar / Patil, B M

    Journal of diabetes and metabolic disorders

    2020  Volume 19, Issue 2, Page(s) 735–747

    Abstract: Background: Although α-amylase is the choice of target to manage postprandial hyperglycemia, inhibitors of this enzyme may get absorbed into the systemic circulation and modulate proteins involved in the pathogenesis of diabetes mellitus. Hence, the ... ...

    Abstract Background: Although α-amylase is the choice of target to manage postprandial hyperglycemia, inhibitors of this enzyme may get absorbed into the systemic circulation and modulate proteins involved in the pathogenesis of diabetes mellitus. Hence, the present study aimed to identify α-amylase inhibitors from
    Methods: α-amylase inhibitory activity of hydroalcoholic extract/fractions (s) and pure compounds from
    Results: Fraction rich in flavonoids showed the highest α-amylase inhibitory activity with a IC
    Conclusions: The α-amylase inhibitors from
    Language English
    Publishing date 2020-06-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2680289-2
    ISSN 2251-6581
    ISSN 2251-6581
    DOI 10.1007/s40200-020-00554-9
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  6. Article: Integration of in silico, in vitro and ex vivo pharmacology to decode the anti-diabetic action of

    Khanal, Pukar / Patil, B M

    Journal of diabetes and metabolic disorders

    2020  Volume 19, Issue 2, Page(s) 1325–1337

    Abstract: Background: Traditionally, : Methods: Enzyme inhibitory activity, glucose uptake in rat hemidiaphragm, and glucose permeability, and adsorption assays were performed using in vitro and ex vivo methods as applicable. Further, the PASS was used to ... ...

    Abstract Background: Traditionally, 
    Methods: Enzyme inhibitory activity, glucose uptake in rat hemidiaphragm, and glucose permeability, and adsorption assays were performed using in vitro and ex vivo methods as applicable. Further, the PASS was used to identify the probable lead enzyme inhibitors. The presence of predicted enzyme inhibitors was confirmed via the LC-MS. Similarly, the docking of ligands with respective targets was performed using autodock4.0.
    Results: Flavonoids rich fraction possessed the highest α-amylase, and α-glucosidase inhibitory activity followed by maximum efficacy for glucose uptake in rat hemidiaphragm. Similarly, the hydroalcoholic extract showed the highest efficacy to inhibit glucose diffusion. Likewise, 3,4-dihydroxybenzoic acid was predicted for the highest pharmacological activity for α-amylase, ursolic acid for PTP1B, and apigenin for α-glucosidase inhibition respectively. The LC-MS analysis also identified the presence of the above hit molecules in the hydroalcoholic extract.
    Conclusion: The analogs of 3,4-dihydroxybenzoic acid, apigenin, and ursolic acid could be the choice of lead hits as the α-amylase, α-glucosidase, and PTP1B inhibitors respectively. Additionally, the majority of secondary metabolites from the hydroalcoholic extract of
    Language English
    Publishing date 2020-10-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2680289-2
    ISSN 2251-6581
    ISSN 2251-6581
    DOI 10.1007/s40200-020-00651-9
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  7. Article: Beneficial effect of

    Ullagaddi, Mrityunjaya B / Patil, B M / Khanal, Pukar

    Journal of diabetes and metabolic disorders

    2021  Volume 20, Issue 1, Page(s) 41–48

    Abstract: Aim: The present study aimed to investigate the effect of : Methods: The hydroalcoholic extract of ZO was prepared by macerating the coarse dry powder in 70% v/v ethanol for 7 days, filtered, and concentrated under reduced pressure. Animals were ... ...

    Abstract Aim: The present study aimed to investigate the effect of
    Methods: The hydroalcoholic extract of ZO was prepared by macerating the coarse dry powder in 70% v/v ethanol for 7 days, filtered, and concentrated under reduced pressure. Animals were divided into six groups containing six animals in each. Three doses of extract (100, 200, and 400 mg/kg, p.o.) were co-administered with olanzapine 2 mg/kg i.p for 21 days. Bodyweight and food intake were recorded at the interval of three days and locomotor activity once a week. At the end of the study oral glucose tolerance test was performed followed by the estimation of lipid profile.
    Results: Co-administration of hydroalcoholic extract of ZO with olanzapine ameliorated olanzapine-induced weight gain and hyperphagia. Similarly, ZO extract also improved pancreatic β-cell function and glucose and lipid metabolism.
    Conclusions: ZO extract ameliorated olanzapine-induced weight gain and hyperphagia by improving pancreatic β-cell functions and lipid metabolism.
    Language English
    Publishing date 2021-01-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2680289-2
    ISSN 2251-6581
    ISSN 2251-6581
    DOI 10.1007/s40200-020-00695-x
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  8. Article ; Online: Cyperus rotundus L. reverses the olanzapine-induced weight gain and metabolic changes-outcomes from network and experimental pharmacology.

    Kanagali, Shivprakash Nagaraj / Patil, B M / Khanal, Pukar / Unger, Banappa S

    Computers in biology and medicine

    2021  Volume 141, Page(s) 105035

    Abstract: Cyperus rotundus L. is used to treat multiple clinical conditions like inflammation, diarrhea, pyrosis, and metabolic disorders including diabetes and obesity. The present study aimed to predict the interaction of reported bioactives from Cyperus ... ...

    Abstract Cyperus rotundus L. is used to treat multiple clinical conditions like inflammation, diarrhea, pyrosis, and metabolic disorders including diabetes and obesity. The present study aimed to predict the interaction of reported bioactives from Cyperus rotundus against obesity via network pharmacology and to evaluate the efficacy of hydroalcoholic extract of Cyperus rotundus against the olanzapine-induced weight gain and metabolic disturbances in experimental animals. Reported phytochemicals of Cyperus rotundus were retrieved from the open-source database(s) and published literature and their targets were predicted using SwissTargetPrediction, enriched in STRING, and bioactives-proteins-pathways network was constructed using Cytoscape. Further, the hydroalcoholic extract of Cyperus rotundus (100, 200, and 400 mg/kg/day, p.o.) was co-administered with olanzapine (2 mg/kg, i.p.) for 21 days in Sprague Dawley rats. During treatment, body weight and food intake were recorded; after the successful completion of 21 days of treatment, animals were fasted to perform oral glucose and insulin tolerance tests. Further, the animals were euthanized; blood and abdominal fat were collected for lipid profiling and histopathological examination respectively. Herein, network pharmacology predicted neuroactive ligand-receptor interaction as a primarily modulated pathway and protein tyrosine phosphatase 1b as a majorly triggered protein via the combined action of bioactives. Further, Cyperus rotundus significantly reversed weight gain, cumulative food intake, ameliorated the lipid and glucose metabolism, and promoted energy expenditure.
    MeSH term(s) Animals ; Cyperus ; Olanzapine ; Plant Extracts/pharmacology ; Rats ; Rats, Sprague-Dawley ; Weight Gain
    Chemical Substances Plant Extracts ; Olanzapine (N7U69T4SZR)
    Language English
    Publishing date 2021-11-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2021.105035
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 653: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Field application of Ca-doped ZnO nanoparticles to maize and wheat plants.

    Patil, B M / Patil, V L / Bhosale, S R / Bhosale, R R / Ingavale, D R / Patil, S S / Kamble, P D / Bhosale, A G / Mane, Sagar M / Lee, Jaewoong / Vanalakar, S A

    Plant physiology and biochemistry : PPB

    2024  Volume 210, Page(s) 108552

    Abstract: Nanoparticles play a vital role in modern agriculture to provide the nutrients required by plants. Herein, we report the preparation of calcium-doped zinc oxide nanoparticles (CZO NPs) via a simple and cost-effective co-precipitation method, with the aim ...

    Abstract Nanoparticles play a vital role in modern agriculture to provide the nutrients required by plants. Herein, we report the preparation of calcium-doped zinc oxide nanoparticles (CZO NPs) via a simple and cost-effective co-precipitation method, with the aim of realizing increased fertilizer response. The synthesized nanoparticles were analyzed to study their physicochemical properties using various characterization techniques. The X-ray diffraction pattern showed a small shift in peak position towards higher values of 2θ and reduced crystal size after the zinc oxide (ZnO) matrix had been doped with Ca. Field-emission scanning electron microscopy images clearly revealed a grain-like surface morphology. The X-ray photoelectron spectroscopy study produced evidence of Zn
    MeSH term(s) Zinc Oxide/chemistry ; Zinc Oxide/pharmacology ; Triticum/growth & development ; Triticum/drug effects ; Triticum/metabolism ; Zea mays/growth & development ; Zea mays/drug effects ; Zea mays/metabolism ; Calcium/metabolism ; Fertilizers ; Nanoparticles/chemistry ; Metal Nanoparticles/chemistry ; X-Ray Diffraction ; Plant Leaves/drug effects ; Plant Leaves/metabolism ; Plant Leaves/growth & development
    Chemical Substances Zinc Oxide (SOI2LOH54Z) ; Calcium (SY7Q814VUP) ; Fertilizers
    Language English
    Publishing date 2024-03-23
    Publishing country France
    Document type Journal Article
    ZDB-ID 742978-2
    ISSN 1873-2690 ; 0981-9428
    ISSN (online) 1873-2690
    ISSN 0981-9428
    DOI 10.1016/j.plaphy.2024.108552
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    Z 2696: Show issues
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  10. Article: Anthraquinone Derivatives as an Immune Booster and their Therapeutic Option Against COVID-19.

    Khanal, Pukar / Patil, B M / Chand, Jagdish / Naaz, Yasmin

    Natural products and bioprospecting

    2020  Volume 10, Issue 5, Page(s) 325–335

    Abstract: Anthraquinone derivatives are identified for their immune-boosting, anti-inflammatory, and anti-viral efficacy. Hence, the present study aimed to investigate the reported anthraquinone derivatives as immune booster molecules in COVID-19 infection and ... ...

    Abstract Anthraquinone derivatives are identified for their immune-boosting, anti-inflammatory, and anti-viral efficacy. Hence, the present study aimed to investigate the reported anthraquinone derivatives as immune booster molecules in COVID-19 infection and evaluate their binding affinity with three reported targets of novel coronavirus i.e. 3C-like protease, papain-like protease, and spike protein. The reported anthraquinone derivatives were retrieved from an open-source database and filtered based on a positive druglikeness score. Compounds with positive druglikeness scores were predicted for their targets using DIGEP-Pred and the interaction among modulated proteins was evaluated using STRING. Further, the associated pathways were recorded concerning the Kyoto Encyclopedia of Genes and Genomes pathway database. Finally, the docking was performed using autodock4 to identify the binding efficacy of anthraquinone derivatives with 3C-like protease, papain-like protease, and spike protein. After docking the pose of ligand scoring minimum binding energy was chosen to visualize the ligand-protein interaction. Among 101 bioactives, 36 scored positive druglikeness score and regulated multiple pathways concerned with immune modulation and (non-) infectious diseases. Similarly, docking study revealed torososide B to possess the highest binding affinity with papain-like protease and 3C-like protease and 1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-β-D-xylopyranosyl-(1 → 2)-β-D-glucopyranoside with spike protein.
    Keywords covid19
    Language English
    Publishing date 2020-08-08
    Publishing country Germany
    Document type Journal Article
    ISSN 2192-2195
    ISSN 2192-2195
    DOI 10.1007/s13659-020-00260-2
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